Required Materials Text: Sherris Medical Microbiology Kenneth J. Ryan and C. George Ray Sixth edition McGraw-Hill, New York, NY

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1 Infectious Diseases: Biol. 840 Course Syllabus Fall 2016 Instructor: Dr. Austin Nuxoll Office: Bruner 314 Phone: Office hours: MWF 8am 9am For off-campus students, please arrange office hour appointments by Course Description This course is an introduction to human host pathogen interactions and microbial pathogenesis. Topics will focus on mechanisms of infectious disease transmission, the immune response to these infections, conventional and alternative antimicrobial treatment, and hot topics in current scientific literature. Course Objectives: Following completion of this course, students should be able to: 1. Understand the complexity and diversity of microbial virulence, specifically understanding different strategies pathogens employ for host manifestation of disease 2. Have a general understanding of the host response to pathogens and different ways pathogens evade the immune response 3. Identify methods of treatment and prevention of infection 4. Relate knowledge learned in this course to critically evaluate primary literature in the field of microbial pathogenesis Required Materials Text: Sherris Medical Microbiology Kenneth J. Ryan and C. George Ray Sixth edition McGraw-Hill, New York, NY Computer and Software: Access to a computer with internet access, Microsoft Word and PowerPoint. Software can be purchased through UNK bookstore at a discount. Communication The best way to reach me is through . I will respond to fairly quickly and if you need to talk to me please me and we can set up a time to talk further. You should frequently check your UNK and Blackboard for course assignments or announcements. Lectures will be posted on Blackboard but you will still be required to watch lectures as additional information provided during lectures will be pertinent. Grading Discussion (10pts/wk 1-3) 30 3 Exams (30pts each) 90 Case Studies (10pts/wk) 70 (8 case studies, lowest will be dropped)

2 Presentation (30pts) 30 Peer review (10pts) 20 Presentation discussion (10pts/wk) 20 Final Paper 30 Total 290 Grades will be assigned using the Department of Biology standard grading scale: follows: A (93-100%), A- (90-92%), B+ (88-89%), B (83-87%), B- (80-82%), C+ (78-79%), C (73-77%), C- (70-72%), D+ (68-69%), D (63-67%), D- (60-62%), and F (below 60%). Discussion I will post questions on Blackboard on Tuesdays and you will have until the following Monday to participate. This is also a good place for students to post questions if they want to discuss the lectures in further detail. To receive full credit, students must have 2 significant contributions weekly. Your responses must contribute something new to the discussion and not simply agree or disagree to the previous response. References will be required to support your statement. Please be considerate of your classmates responses, abusive comments or attacking other student s comments will not receive credit as comments should be constructive even if you strongly disagree with another student. Discussions will be posted and due as follows: Discussion 1: posted Tuesday, August 23; closes Monday, August 29 Discussion 2: posted Tuesday, August 30; closes Monday, September 5 Discussion 3: posted Tuesday, September 6; closes Monday, September 12 Exams Exams will be take home consisting of short answers and worth 30 pts each. Students will be given one week to complete the exam, however there will still be lectures and other assignments at this time so please do not procrastinate. Exam dates are as follows: Exam 1: available Tuesday, Sept 13: due Tuesday, Sept 20 at 8 a.m. CST. Exam 2: available Wednesday, Oct 12; due Wednesday, Oct 19 at 8 a.m. CST. Exam 3: available Tuesday, Nov 15; due Tuesday, November 22 at 8 a.m. CST. Case Studies For the case study assignments, students will work in groups, and each group is assigned the same case study. Everyone in the group needs to participate and students that do not contribute to their group will not receive credit for that assignment. The same guidelines for discussion also apply to participation with the case studies. Case Study 1: posted September 20; closed September 26 Case Study 2: posted September 27; closed October 3 Case Study 3: posted October 4; closed October 10 Case Study 4: posted October 18; closed October 24 Case Study 5: posted October 25; closed October 31 Case Study 6: posted November 1; closed November 7 Case Study 7: posted November 8; closed November 14 Case Study 8: posted November 22; closed November 28

3 Disease Presentation We will not have the time to cover parasites in this class, to cover this topic, students will be assigned a protozoan or worm. Parasites will be assigned the week of September 12 th. Students will create a PowerPoint presentation and write a case study paper on their topic. PowerPoint presentations will be due November 1 th at 8am CST. Students will be responsible for reviewing two student presentations during the next week. These reviews are due by November 11 th. Students are responsible for ing reviews to students and a copy to me. Students must make the necessary changes based on the students reviews by November 28 th 8am CST. I will post half of the presentations for discussion beginning on November 29 th and discussion will be due by December 5 th. I will post the other half the week of December 6 th with discussion being due by December 12 th. Final case study papers will be due December 14 th by 8am CST. Academic Dishonesty Plagiarism will not be tolerated, please refer to the student handbook or ask me for more clarification on the subject if unsure what constitutes plagiarism. It is expected students work independently on assignments unless otherwise stated by the instructor. Group work where not specified will be considered cheating and students will receive a zero for that assignment. Multiple offenses will result in the student(s) receiving a failing grade for the course and possible removal from the program. Withdraw (W) and Incomplete (I) In unusual circumstances beyond the student s control, an incomplete (I) may be issued. The (I) is issued as a final grade with the student having 12 months to complete the necessary work. If the coursework is not completed in this time the (I) will be converted to a failing grade (F) on the student s transcript. Students may withdraw from the course before 9 weeks have been completed and a (W) will appear on the transcript. Students are responsible for filling out the necessary paperwork to complete this process. Instructors are not able to withdraw students. If the student drops the class, the (W) will not contribute to the student s overall GPA. Student Accommodations Students with Disabilities or Those Who are Pregnant Students with disabilities or those who are pregnant are encouraged to contact me for a confidential discussion of their individual needs for academic accommodation. It is the policy of the University of Nebraska at Kearney to provide flexible and individualized reasonable accommodation to students with documented disabilities or those who are pregnant. To receive accommodation services for a disability, students must be registered with UNK Disabilities Services Coordinator, David Brandt, in the Academic Success Office, 163 Memorial Student Affairs Building, or by brandtdl@unk.edu. For those needing accommodation due to pregnancy, you need to visit with Student Health. The following link provides information for students and faculty regarding pregnancy rights. Attached is the link to the above statement for your convenience.

4 Reporting Student Sexual Harassment, Sexual Violence or Sexual Assault Reporting allegations of rape, domestic violence, dating violence, sexual assault, sexual harassment, and stalking enables the University to promptly provide support to the impacted student(s), and to take appropriate action to prevent a recurrence of such sexual misconduct and protect the campus community. Confidentiality will be respected to the greatest degree possible. Any student who believes she or he may be the victim of sexual misconduct is encouraged to report to one or more of the following resources: Local Domestic Violence, Sexual Assault Advocacy Agency Campus Police (or Security) Title IX Coordinator Retaliation against the student making the report, whether by students or University employees, will not be tolerated If you have questions regarding the information in this please contact Mary Chinnock Petroski, Human Resources Director (petroskimj@unk.edu or phone 8655). Preparation for class Chapter 1 Chapter 5 Dates Schedule Assignment Due Date August 22 August 24 August 26 Chapter 2 August 29 August 31 September 2 Chapter 4 Chapter 24 Chapter 25 Chapter 26 Chapter 27 Chapter 29 Chapter 30 Chapter 32 Chapter 33 September 5 September 7 September 9 September 12 September 14 September 16 September 19 September 21 September 23 September 26 September 28 September 30 October 3 Lecture 0: Syllabus Lecture 1: Introduction to ID Lecture 2: Host-Parasite Interaction Lecture 3: Innate Immunity Lecture 4: Specific Immunity Lecture 5: Vaccination Labor Day Break Lecture 6: Antibiotics Lecture 7: Antibiotic Resistance Exam 1 Lecture 8: Bacterial Diagnosis Lecture 9: Staphylococcus Lecture 10: Streptococcus Lecture 11: Bacillus Lecture 12: Mycobacteria Lecture 13: Clostridia Lecture 14: Neisseria Lecture 15: Helicobacter Lecture 16: Enterobacteriaceae Lecture 17: Pseudomonas Lecture 18: Yersinia Chapter 35 Chapter 36 October 5 October 7 Chapter 39 October 10 Lecture 19: Chlamydia Exam 2 Discussion Discussion Discussion Exam Case Study Case Study Case Study

5 Chapter 9 Chapter 10 Chapter 11 Chapter 12 Chapter 13 Chapter 14 Chapter 16 Chapter 17 Chapter 18 Chapter 19 Chapter 20 Chapter 44 Chapter 45 Chapter 46 October 12 October 14 October 17 October 19 October 21 October 24 October 26 October 28 October 31 November 2 November 4 November 7 November 9 November 14 November 15 November 16 November 18 November 22 November November 28 November 30 December 2 December 5 December 7 December 9 December 12 December 14 Lecture 20: Acute Respiratory Viruses Fall Break Lecture 21: MMR Lecture22: Pox viruses Lecture 23: Enteroviruses Lecture 24: Hepatitis Viruses Lecture 25: Herpesviruses Lecture 26: Arthropod- Borne Viruses Lecture 27: Zoonotic viruses Lecture 28: Retroviruses Lecture 29: Papilloma viruses Lecture 30: Prions Lecture 31: Superficial fungal infections Exam 3 Lecture 32: Opportunistic fungal infections Lecture 33: Systemic fungal infections Thanksgiving Break Exam Case Study Case Study PP 11.1 Case Study PP Reviews Case Study Exam View Student Presentations Case Study Final PP View Student Presentations Final Paper Due PP discussion 12.5 PP discussion Case Study Paper 12.14