Center for Cancer Research Overview Center to Reduce Cancer Health Disparities Workshop Glenn Merlino, Ph.D. Acting Scientific Director for Basic Research May 2016
CCR is part of the Intramural Research Program (IRP) of NIH EXTRAMURAL Grants Programs Centers INTRA MURAL
VISION Integrate basic, translational, and clinical research to make cancer preventable, curable, or chronically manageable Discovery-driven Basic Research Translational Research Clinical Research Clinical Trials & Patient Care
The CCR in numbers 225 PIs ~ $400M budget Bethesda & Frederick 24 Basic Science Laboratories 19 Clinical Research Branches 226 staff scientists/staff clinicians 430 technical lab staff 3 Goal/Theme- Oriented Programs 767 postdoctoral/ clinical fellows 190 postbaccalaureate/ predoctoral students 335 summer students
A network of Labs/Branches 46 Labs/Branches/Programs NIH Interest Groups - More than 80 Centers of Excellence Chromosome Biology Immunology Genomics Genitourinary Malignancies HIV Initiatives Rare Tumors Advanced Preclinical Research Comparative Oncology Microbiome
The NCI CCR is a distinctive research environment Bottom-up environment: Projects are investigator-driven High-risk, high-impact research and technology development is encouraged Secure resources Highly interactive, interdisciplinary culture amongst basic and clinical scientists Efficient bench-to-bedside-to-bench translation through access to the world s largest clinical research hospital Emphasis on underdeveloped research topics, emerging areas, rare cancers and underserved patient populations
What kind of research do we do? Full spectrum from basic to clinical High-risk, high-reward Long time horizon Creative, innovative, transformational, unique Clinical Translational 51% Basic 49% Work that might not be possible in the extramural environment due to limitations in funding, infrastructure, patient populations
Interdisciplinary Strengths of CCR s Research Portfolio Cancer Biology 7% 5% Immunology 11% 8% 33% Chromosome Biology/Epigenetics Chemistry/Structural Biology/ Biophysics Cell and Developmental Biology 11% 11% 14% HIV/ Cancer Virology Molecular Biology/Biochemistry/ Microbiology Genetics and Genomics
The NCI Intramural Clinical Research Program The NIH is home to the largest clinical research center in the world The NCI is one of its major users The NIH clinical center is not a regular hospital It is dedicated to patient-intensive clinical research and to develop new approaches for prevention, diagnosis, and treatment of cancer The NCI intramural clinical program is a resource for both basic and clinical scientists Translate basic discoveries to the point of first-in-human use
Examples of groundbreaking CCR research Human Papilloma Virus Gene therapy Immunotherapy Imaging methods (basic and clinical) Chromatin biology
CCR Training CCR offers training to young scientists at several levels of education: Training programs exist for: High School students Professor, Scientist, Clinician, Tech, Admin, etc. College students Post Baccalaureate students Veterinary School students Medical and Dental School students Post Doctoral Training -- Ph.D. / D.V.M. Post Doctoral Training -- M.D. Clinical Fellowship Program Junior PI Postdoc Graduate Undergrad Student
Why Train at the NIH? State-of-the-art laboratory facilities, technology, and equipment Scientific and professional skills workshops and training Lectures and courses by eminent scientists Mentoring in a collaborative, team-focused environment Competitive stipends, paid leave, and medical insurance
CCR Cores Animal Resources Bioinformatics/ Computing Cell Banking and Aliquoting Chemistry/ Structural Biology Clinical Research Support Drug Discovery Flow Cytometry Genetics/ Genomics Imaging and Microscopy Metabolomics Nanotechnology Pharmacology
Specialty CCR Programs Johns Hopkins University partnership in Drug Discovery Technologies Associate Clinical Investigator Development Program NCI/FDA Interagency Oncology Task Force (IOTF) Research and Regulatory Review Fellowship Summer Cancer Research Interns (CRI) Program for students from underrepresented groups or disadvantaged backgrounds Comparative Molecular Pathology Research Training Program Sallie Rosen Kaplan fellowship program to retain women in independent science careers Center for Cancer Training, Intramural Workforce Diversity Branch to increase scientific workforce diversity https://ccr.cancer.gov/training
Comparative Biomedical Scientists Training Program Trainees Trainees are graduate D.V.M. veterinarians aiming for a Ph.D. & specialty board certification! Current and Trainees Former - Trainees 2014 Kara&Corps,&D.V.M.( NC(State(University( NINDS( Neuroimmunology(Branch( Trauma&c(Brain(Injury( Amy&McCalla,&D.V.M.( NC(State(University( NCI( Pediatric(Oncology(Branch( Ewing s(sarcoma((( Ian&Moore,&D.V.M.( Michigan(State(University( NIAID( Laboratory(of(Infec:ous( Diseases( Pandemic(Influenza(A( Anne&Sally&Davis,&D.V.M.( NC(State(University( NIAID( Laboratory(of(Infec:ous( Diseases( Pandemic(Influenza(A( Heather&Tillman,&D.V.M.& Diplomate,&ACVP( Michigan(State(University( NCI( Laboratory(of(Cancer(Biology(( and(gene:cs( Metasta&c(Prostate(( Cancer( Leah&Zadrozny,&D.V.M.( NC(State(University( NHLBI( Laboratory(of(Cardiac( Energe:cs( Coronary(Atherosclerosis( Sarah&Cramer,&D.V.M.& Diplomate,&ACVP( University(of(Maryland( NCI( Laboratory(of(Experimental( Immunology( Effects(of(Microbiome( On(Cancer( Tiffany&Lyle,&D.V.M.& Diplomate,&ACVP( Purdue(University( NCI( Laboratory(of(Molecular( Pharmacology( Breast(Cancer(( Metastases(in(Brain( Laura&Baseler,&D.V.M.& Diplomate,&ACVP( Purdue(University( NIAID( Laboratory(of(Virology( Highly(Pathogenic( Viruses( Joy&Gary,&D.V.M.& Diplomate,&ACVP( Michigan(State(University( NCI( Laboratory(of(Cancer(Biology(( and(gene:cs( Plasma(Cell(Tumors( Helen&Michael,&D.V.M.& Diplomate,&ACVP( University(of(Maryland( NCI( ((((Laboratory(of(Cancer(Biology( and(gene:cs( Melanoma( Ryan&Traslavina,&D.V.M.& Diplomate,&ACVP& University(of(Maryland( NINDS& Pathology(Training/( Graduate(Studies( Caroline&Andrews,&D.V.M.& Michigan(State(University( NCI& Pathology(Training/( Graduate(Studies( Jessica&Beck,&D.V.M.& Michigan(State(University( NCI& Pathology(Training/( Graduate(Studies(
Distinctive Alumni CCR is consistently rated among the top ins4tu4ons in which to train* 10 National Academy Members 11 Institute of Medicine Members 11 Academy of Arts & Sciences Members Harold Varmus Former Director NIH, NCI *The Scien4st: Best Places for Postdocs Kenneth Olden Former Director NIEHS
How to start your career with us @NCIResearchCtr ccr.cancer.gov www.cancer.gov https://ccr.cancer.gov/careers