Supplementary Digital Content 1. Study Sites and Number of Randomized Subjects. Site Name and Address Center for Clinical Trials, LLC 16660 Paramount Boulevard Paramount, CA 90723 California Research Foundation 2800 Third Avenue San Diego, CA 923 Clinical Research Center of Nevada 12 East Sahara Avenue Las Vegas, NV 894 Kentucky Pediatric/Adult Research 201 South Fifth Street Bardstown, KY 40004 The Vancouver Clinic 2525 Northeast 139th street Vancouver, WA 98686 Advanced Clinical Research Suite 182 2950 East Magic View Drive Meridian, ID 83642 West Coast Clinical Trials, LLC 5630 Cerritos Avenue Cypress, CA 90630 Lynn Institute of the Rockies Suite 260 1625 Medical Center Point Colorado Springs, CO 80907 Rapid Medical Research, Inc. Suite 300 3619 Park East Drive Cleveland, OH 44122 The Children's Clinic of Jonesboro, PA Suite 400 800 South Church Street Jonesboro, AR 72401 Duke University Medical Center - Duke Health Center 4020 North Roxboro Street Durham, NC 27704 Cincinnati Children's Hospital Medical Center MLC 6014 3333 Burnet Avenue Cincinnati, OH 45229-3039 The Center for Pharmaceutical Research, PC Suite 426 Carondelet Drive Kansas City, MO 64114 Clinical Research Atlanta A 175 Country Club Drive Stockbridge, GA 30281 Number of Randomized Subjects 39 71 93 160 42 41 3 5 95 37 5 43 89 20
Wake Research Associates Suite 304 30 Duraleigh Road Raleigh, NC 27612 Jean Brown Research 45 East 3900 South Salt Lake City, UT 84124 Miami Research Associates 6141 Sunset Drive South Miami, FL 33143 Clinical Research Associates of Tidewater 402 Medical Tower 400 Gresham Drive Norfolk, VA 207 Rochester Clinical Research, Inc. Suite L20 500 Helendale Road Rochester, NY 14609 The Office of Shelly David Senders, MD dba Senders Pediatrics 2054 South Green Road Cleveland, OH 44121 Pennridge Pediatric Associates 711 Lawn Avenue Sellersville, PA 18960 Northpoint Pediatrics, LLC Suite 185 81 Clearvista Parkway Indianapolis, IN 46256 Oklahoma State University Center for Health Sciences - Pediatric Research Houston Center 717 South Houston Avenue Tulsa, OK 74127 Arkansas Pediatric Clinic Suite 200 500 South University Avenue Little Rock, AR 72205 Pediatrics and Adolescent Medicine, P.A. 25 Post Oak Tritt Road Marietta, GA 30062 Cary Pediatric Center 01 Crescent Green Cary, NC 27518 Clinical Trials of Texas Suite 700 7940 Floyd Curl Drive San Antonio, TX 78229 Heartland Research Associates, LLC 1709 South Rock Road Wichita, KS 67207 1 63 22 18 44 121 12 79 28 19 62 36
University of Texas Medical Branch at Galveston 301 University Boulevard Galveston, TX 77555 Murray Pediatrics Suite A-112 164 East 5900 South Murray, UT 847 Coastal Clinical Research Annex Building - Suite 3B 0 Memorial Hospital Drive Mobile, AL 36608 Lynn Health Science Institute Suite 800 55 Northwest 58th Street Oklahoma City, OK 73112 Lynn Institute of Norman (LION) Suite 1 24th Avenue Northwest Norman, OK 73069 Innovis Health, LLC - Innovis Health Fargo 3000 32nd Avenue Fargo, ND 583 Liberty Family Practice 3413 Cherry Street Erie, PA 16508 SUNY Upstate Medical University Department of Pediatrics 750 East Adams Street Syracuse, NY 132 Omega Medical Research 400 Bald Hill Road Warwick, RI 02886 Advances In Health, Inc. Suite 360 75 South Main Houston, TX 77030 Allina Health Bandana Square Clinic 21 Bandana Blvd East St. Paul, MN 558 Pediatric Research of Charlottesville, LLC Suite 3 11 East Jefferson Street Charlottesville, VA 22902 Advanced Pediatrics 0 East Street Southeast Vienna, VA 22180 Benchmark Research Suite 309 East 32nd Street Austin, TX 78705 37 13 26 64 59 48 4 36 63 68 51
Benchmark Research 55 Knickerbocker Road San Angelo, TX 76904 Coastal Carolina Research Center Suite 2 16 Bowman Road Mount Pleasant, SC 29464 Texas Center for Drug Development, Inc. Suite 201 6550 Mapleridge Street Houston, TX 77081 Monroe Clinic 5 22nd Avenue Monroe, WI 566 PMG Research of Charleston Suite 203 180 Wingo Way Mount Pleasant, SC 29464 Quality Clinical Research, Inc. Suite 375 040 Regency Circle Omaha, NE 68114 Bayview Research Group, LLC Suite 201 16444 Paramount Boulevard Paramount, CA 90723 Bayview Research Group, LLC Suite 3 12626 Riverside Drive Valley Village, CA 91607 Mercy Health Research Suite 200 12680 Olive Boulevard St. Louis, MO 63141 Brownsboro Park Pediatrics 6002 Brownsboro Park Boulevard Louisville, KY 40207 Midwest Children's Health Research Institute 3262 Salt Creek Circle Lincoln, NE 68504 Clinical Research Associates, Inc. 00 Church Street Nashville, TN 37203 PMG Research of Raleigh, LLC 21 Haworth Drive Raleigh, NC 27609 Sundance Clinical Research, LLC Suite 5 711 Old Ballas Road St. Louis, MO 63141 40 60 11 9 50 24 74 3 65 22 19 38
Preferred Primary Care Physicians, Inc. 2375 Greentree Road Carnegie, PA 6 Central Kentucky Research Associates, Inc. 3rd Floor 3475 Richmond Road Lexington, KY 40509 Loma Linda University Coleman Pavilion Room A1120 11175 Campus Street Loma Linda, CA 920 Pediatric Care Medical Group Suite 278 17822 Beach Boulevard Huntington Beach, CA 92647 Radiant Research, Inc. Suite 8122 Datapoint Drive San Antonio, TX 78229 Radiant Research, Inc. Suite 208 2081 West Frye Road Chandler, AZ 85224 Pediatric Healthcare of Northwest Houston, PA 27721 Tomball Pkwy Tomball, TX 77375 12 7 73 44 51