NROSCI/BIOSC 1070 and NROSCI/MSNBIO 2070 Human Physiology (University Honors College) Fall Semester, 2011 Bill, Ph.D. Professor of Otolaryngology and Neuroscience 519 Eye and Ear Institute Office Phone: 647-9614 Cellular Phone: 889-0860 E-mail: byates@pitt.edu Kathleen Ryan, Ph.D. Associate Professor of Cell Biology & Physiology Associate Director of Office of Medical Education M-211 Scaife Hall Phone: 648-8859 E-mail: ryankath@medschool.pitt.edu Alan Sved, Ph.D. Professor and Chairman of Neuroscience A210 Langley Hall Phone: 624-6996 E-mail: sved@pitt.edu Course Director Office Hours: from 5:00-7:00 PM (held in office) from 3:00-3:30 PM or 4:45-6:00 PM (held in the lecture room) or by appointment Other Faculty Jennifer Woodward, Ph.D. Associate Professor of Surgery Administrative Director for Research and Academic Affairs, Thomas E. Starzl Transplantation Institute E1545 Starzl Biomedical Science Tower Phone: 383-8884 E-mail:woodwardje@upmc.edu Teaching Assistants Alex Chacon Waqas Malick Ashley Miller Priya Raghavan E-mail: alchacon24@gmail.com E-mail: wam13@pitt.edu E-mail: acm72@pitt.edu E-mail: pvr1@pitt.edu Class Meetings: Lectures (1070 & 2070):, 3:30-4:45 PM Victoria Hall 117 Lab and PBLs: 3:30-5:25 PM BST-South 120 (1070 Only) Benedum G08 (Labs on 9/7, 9/14, 9/21) Langley A219B (10/26 & 11/16) 500 Eye and Ear Institute (10/12) Journal Club (2070 Only): 1:00-3:00 PM Victoria Hall 117 Textbook: Hall, J.E. Guyton and Hall Textbook of Medical Physiology, 12 th edn. Saunders, Philadelphia, 2011. 1070 Lab Manual: Pflanzer, R.G. Experimental Laboratory Physiology: Biopac Lab Exercises. Kendall/Hunt, Dubuque, IA, 2004. (7 copies are available for loan in Langley Library) Web Site: http://courseweb.pitt.edu/ Course is listed under NROSCI 1070 Page 1
Course Reserve: A number of supplemental materials are on reserve in Langley Library. They include the following supplemental reading for the Immunology Section: Kindt, T.J., Osborne, B.A., and Goldsby, R.A. Kuby Immunology, 6 th edn. Freeman, New York, 2007. ISBN: 1-4292-0211-4 Grading: Your grade will be calculated as follows: 1070 & 2070: 20% from each of 4 exams 1070: 20% from assignments accompanying laboratories and problem-based learning sessions. 2070: 20% from discussion of journal club articles and a written critical analysis of one of those articles. Exams will cover material presented in lectures and handouts. Although textbook readings will not explicitly be covered on examinations, students are highly encouraged to at least skim this material to provide a better understanding of information from lectures. Furthermore, the textbook should be used as a reference while studying lecture notes and handouts and preparing for problem based learning exercises. It is expected that students will be fully-knowledgeable concerning basic principles of control of cell function and membrane transport, which are covered in the prerequisites for this course. Although this material will not be explicitly examined, students must fully understand this information in order to comprehend the principles covered in this course. It is highly recommended that all students review basic cell biology by studying Chapters 1-5 (pp. 3-70) in the Guyton and Hall text. Written assignments associated with laboratories and problem based learning sessions will be due 1 WEEK following the lab or discussion. Although students are encouraged to use all resources at their disposal (including the library, other students, and instructors) in completing these assignments, answers must be written individually, without collaboration from classmates. If a legitimate reason (severe illness, etc.) prevents a student from taking an in-class exam or turning in an assignment on the scheduled date, he or she must notify Dr. in advance and pre-arrange an alternate time to take the exam or turn-in the assignment. If arrangements are not made BEFOREHAND, the student will receive a failing grade for the exam/assignment. Page 2
BLOCK 1 -- Cardiovascular/Muscle 29-Aug Course Overview and Logistics; Cardiovascular 1 pp. 157-171 31-Aug Muscle Contraction 1 Striated Muscle pp. 71-89 2-Sep Muscle Contraction 2 pp. 91-98 & Smooth & Cardiac Muscle 101-104 5-Sep Labor Day Holiday--No Class 7-Sep 1070: Laboratory # 1 Biopac Lab Exercises 1,2, & 3 pp. 1-41 9-Sep 2070: Journal Club # 1 9-Sep Control Mechanisms 1 Neural Mechanisms pp. 729-741 12-Sep Control Mechanisms 2 Endocrine Signaling pp. 895-906 14-Sep 1070: Laboratory # 2 Biopac Lab Exercises 6-7 and 12 Lead ECG Handout pp. 65-94 16-Sep 2070: Journal Club # 2 16-Sep Control Mechanisms 3 and Return to Cardiovascular System pp. 307-310 & Integration / Electrical Events and ECG /Cardiac Cycle 115-127 19-Sep Cardiovascular 2 pp. 104-113, 229 Mechanical Aspects of Heart Pumping 241, 265-272 21-Sep 1070: Laboratory # 3 and Overview of 9/28/11 PBL pp. 95-129 Biopac Lab Exercises 8 & 9 23-Sep 2070: Journal Club # 3 23-Sep Cardiovascular 3 pp. 246-248 & Neural Control of Arterial Blood Flow; Special Circulations 201-211 26-Sep Cardiovascular 4 pp. 191-200, Control Mechanisms 2 and Examples 221-224 28-Sep 1070: Problem Based Learning and Overview of 10/19/11 PBL "Post Spaceflight Orthostatic Intolerance" 30-Sep 2070: Journal Club # 4 30-Sep Cardiovascular 5 pp. 171-189 Capillary Dynamics and Venous Return 3-Oct Cardiovascular 6 pp. 213-220,224-228,2 Exercise Cardiovascular Responses; Integrated Responses; Clinical Issues 48-264,273-282 5-Oct EXAM # 1; 8/29-9/23 Lectures (Cardio 1-3/Muscle Contraction/Control Mechanisms) BLOCK 2 --Respiration 7-Oct Respiratory 1 Blood Composition, Clotting, Respiratory Mechanics 11-Oct Respiration 2 Tuesday Mechanics and Pulmonary Circulation 12-Oct Respiration 3 Control Issues 14-Oct Respiration 4 Clinical Aspects & REVIEW pp. 413-422 & 451-461 pp. 465-504 pp. 505-513 pp. 515-540, 379-396 Page 3
BLOCK 3 -- Renal 17-Oct Renal 1 pp. 303-307, Functional Anatomy of the Kidney Sved 310-312 19-Oct 1070: Problem Based Learning and Overview of the 11/02/11 PBL Respiratory PBL 21-Oct 2070: Journal Club # 5 21-Oct Renal 2 Tubular Processing 1 Sved pp. 312-340 24-Oct Renal 3 Tubular Processing 2 Sved pp. 340-378 26-Oct EXAM # 2; 9/26-10/14 Lectures (Cardio 4-6/Respiratory) 28-Oct Renal 4 Regulation of Fluid Osmolarity/Control Mechanisms Sved pp. 397-410 BLOCK 4 -- Immunology 31-Oct Immunology 1 Woodward pp. 423-432 2-Nov 1070: Problem Based Learning and Overview of the 11/9/11 PBL Renal PBL 1 4-Nov 2070: Journal Club # 6 4-Nov Immunology 2 Woodward pp. 433-444 7-Nov Immunology 3 Woodward Supplement 9-Nov 1070: Problem Based Learning and Overview of the 11/16/11 PBL Renal PBL 2 11-Nov 2070: Journal Club # 7 11-Nov Immunology 4 Woodward Supplement BLOCK 5 -- Gastrointestinal, Thermoregulation, and Growth Regulation 14-Nov Gastrointestinal 1 Motility and Control pp. 753-772 16-Nov 1070: Problem Based Learning "Drug Side Effects" 18-Nov 2070: Journal Club # 8 18-Nov Gastrointestinal 2 Secretion and Absorption pp. 773-798 21-Nov Gastrointestinal 3 pp. 799-804, Clinical Issues / Regulation of Appetite 939-954, 843-852 23-Nov 27-Nov Thanksgiving Holiday--No Class 28-Nov Gastrointestinal 4 pp. 809-842, Metabolism and Acid-Base Balance 859-865, 907-937 30-Nov EXAM # 3; 10/17-11/11 Lectures (Renal/Immunology) Page 4
2-Dec pp. 867-877, Temperature and Growth Regulation 955-972 BLOCK 6 -- Reproductive Physiology 5-Dec Reproduction 1 Male Reproductive System Ryan pp. 973-986 7-Dec Reproduction 2 Female Reproductive System Ryan pp.987-1002 9-Dec Reproduction 3 Pregnancy and Contraception Ryan pp. 1003-1017 Exam Week EXAM # 4; 11/14-12/9 Lectures (Growth & Temperature Regulation/Gastrointestinal/ Reproduction) ** session repeated during Journal Club period Page 5