MD-PhD: Is it Right for Me?

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2018 MD-PhD: Is it Right for Me? Communications Committee of the MD-PhD Section of the Group of Research, Education, and Training (GREAT) AAMC Careers Application Process

Who are biomedical scientists? People who Are fascinated by human biology and disease Have an aptitude for science are curious about how/why things work the way they do Are creative Have the persistence to see a project from small beginnings to great discoveries Biomedical scientists want to use the power of research to understand and cure human disease

Multiple Pathways to become a Biomedical Scientists MD graduates pursue research training during fellowship years PhD graduates conduct research with clinical translational training (www.aamc.org/phd) MD-PhD graduates combine careers of the MD and PhD Mentored, integrated research and medical training Conduct mechanism-based research MD & PhD may be completed separately

MD-PhD s blend discovery of new knowledge with clinical medicine at the intersection of science and medicine Science Medicine

Where is MD-PhD training done? There are ~ 90 MD-PhD programs affiliated with medical schools: 45 programs are partially supported by training grants from NIGMS known as Medical Scientist Training Programs or MSTPs Most MD-PhD programs offer financial support: stipends, tuition waivers and health insurance

MD-PhD Program Overview Goal: Prepare men and woman for a career that combines research and clinical care, with an emphasis on research Years 1-2 Years 3-6 Years 7-8 Mostly Med School Some Grad School Some Med School Mostly Grad School Mostly Med School Some Grad School Curriculum integrates MD and PhD training complete both in 7 or 8 years Many PhD fields are possible, but not all Non-traditional PhD training opportunities Training can be free. Most programs offer extensive financial support

Program Opportunities Student Council MD-PHD specific courses and workshops Visiting scholar seminars Retreats National conferences and organizations Mentoring for Graduate and Residency Training A community, not just a program

Post-Training Pathways ~ 95% of graduates pursue residencies/fellowship training: 3 to 7+ years of training, varies with specialty fellowship offers opportunity to return to research ~75% of graduates become medical school faculty ~65% of graduates continue to do significant (> 50%) research ~40% of NIH grants to MDs are received by MD-PhD Many graduates fill academic leadership roles Alternate pathways include working in industry and at research institutions (NIH, HHMI, etc.).

MD-PhD Careers: long term outcomes Private Other, 3% Practice, 16% Industry, 8% Research Institute, 5% Academia, 68% Brass et al., Acad. Med 85: 692 (2010) K

Careers of Biomedical Scientists José E. Cavazos, MD, PhD, Neurologist, Plasticity of the brain to better treat seizures and epilepsy Dianna Milewicz, MD, PhD, Internal Medicine, studies cardiovascular medicine and genetic diseases of the vascular system Juanita Merchant, MD, PhD, Internal Medicine, studies transcriptional control of gastrointestinal peptides that regulate cell growth and cancer

Applying to MD-PhD Programs

Key Elements in a successful MD-PhD application Applicants with integrity and maturity who show: Creativity Leadership potential and congeniality Address big questions in biomedical research Productive research experience(s) Personal statement why MD-PhD? Letter of recommendation from research mentors Outstanding academic record, including MCAT scores Experience in caring for others Extracurricular activities and life experiences

What constitutes a substantive research experience? Sufficient research experience to understand what you are getting into: Multiple summer projects Senior thesis research One or more years pursuing research activities after undergraduate degree Familiar with the idea of testing a hypothesis

Medical School Matriculants MD-PhD Admissions National Data 21,030 MD-PhD 649 (3%) Data source: AAMC matriculation reports www.aamc.org/phd www.aamc.org/mdphd

MD-PhD Statistics -2017-18* Nationally, there are 5,458 MD-PhD trainees In the 2017-18 entering MD-PhD class 44% of MD-PhD are women (44% of MD-PhD applicant pool are women) 16% are students of diversity ~1/3 of MD-PhD applicants entered an MD-PhD Program 13 applications submitted /applicant (avg.) *AAMC Table B-8/B-9/B-11: MD-PhD Matriculant Tables

MD-PhD Applicant Outcomes (2017-18)* Total Applicant Pool (n= 1,858) Mean Range MCAT 510 472 528 GPA 3.6 2.2-4.0 Matriculants (n= 646) 35% Mean Range MCAT 515 495-528 GPA 3.8 2.8-4.0 Table B-10: MCAT Scores and GPAs for MD-PhD Applicants and Matriculants to U.S. Medical Schools, 2017-2018

Application Timeline to matriculate into an MD-PhD Program: a 4-year effort! Freshman Junior Sophomore Senior Summer Fall-Winter Winter Summer Courses / Research Shadowing / Extracurricular Activity Apply Interview Accept Start

Interviewing at MD-PhD Programs How you are evaluated: Show your positive personality and creativity Have strong communication skills Show interest in the program Describe the details of your research experiences Define your motivation for pursing a dual degree Be able to address all the items in your application Define career goals Have specific questions about the program

What should students look for in an MD-PhD program? Research environment program activities, faculty, students and research opportunities Academic environment science and clinical curricula, program integration Alumni achievement and community involvement Location A sense of belonging or good fit

For more information: - https://www.aamc.org/mdphd - NIH.gov/training - Role models - Knowledgeable people who care about you: Directors and Mentors (Summer Program and Post-Bac) Professors, Lab Heads and Department Chairs MD-PhD Students, Graduate Students and Post-Docs Career Advising Offices PhD and MD-PhD Program Directors