Gerald L. Andriole, MD Professor of Urology, Department of Surgery, Washington University School of Medicine, St. Louis, Missouri

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GUEST EDITOR Joseph E. Oesterling, MD Professor and Urologist-in-Chief; Director, The Michigan Prostate Institute, The University of Per-Anders Abrahamsson, MD, PhD Associate Professor of Urology, University Hospital, Lund, Sweden Gerald L. Andriole, MD Professor of Urology, Department of Surgery, Washington University School of Medicine, St. Carlos G. Arcangeli, MD Resident in Urology, Department of Surgery, Washington University School of Medicine, St. Chris H. Bangma, MD, PhD Resident in Urology, Erasmus University and Academic Hospital, Rotterdam, The Netherlands Georg Bartsch, MD Professor and Chairman of Urology, University of Innsbruck, Innsbruck, Austria Mario C. Beduschi, MD Fellow in Urologic Oncology, and Research Investigator, The Michigan Prostate Institute, The Ronald M. Benoit, MD Division of Urology, Allegheny General Hospital, Pittsburgh, Pennsylvania Emmanuel L. Bravo, MD Staff, Department of Nephrology and Hypertension, Cleveland Clinic Foundation, Cleveland, Ohio Ralph Buttyan, PhD Squier Urology Clinic, and Associate Professor of Urology, Columbia University College of Physicians and Surgeons, New York, New York iii

Peter R. Carroll, MD Associate Professor and Chair of Urology, University of California, San Francisco, School of Medicine, San Francisco, California H. Ballentine Carter, MD Associate Professor of Urology and Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland Daniel W. Chan, PhD, DABCC Director of Clinical Chemistry, and Associate Professor of Pathology and Oncology, Johns Hopkins Medical Institutions, Baltimore, Maryland John A. Connolly, MD Resident in Urology, University of California, San Francisco, School of Medicine, San Francisco, California Glen M. de Vries, BS Research Associate, Squier Urology Clinic, and Department of Urology, Columbia university College of Physicians and Surgeons, New York, New York Eleftherios P. Diamandis, MD, PhD Professor of Clinical Biochemistry and Pathology, University of Toronto Faculty of Medicine, and Head of Clinical Biochemistry, Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada Anas M. El-Mahdi, MD, SCD Professor and Chairman of Radiation Oncology and Biophysics, Virginia Prostate Center of Eastern Virginia Medical School and Sentara Cancer Institute, Norfolk, Virginia Jonathan I. Epstein, MD Professor of Urology and Pathology, James Buchanan Brady Urological Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland William R. Fair, MD Chief, Urology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, and Professor of Urology, Cornell University Mayer Grob, MD Fellow in Urologic Oncology, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York Blake D. Hamilton, MD Fellow in Laparoscopic Surgery, Department of Urology, Cleveland Clinic Foundation, Cleveland, Ohio Ron S. Israeli, MD Fellow in Urologic Oncology, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York Aaron E. Katz, MD Squier Urology Clinic, and Assistant Professor of Urology, Columbia University College of Physicians and Surgeons, New York, New York iv

David W. Keetch, MD Instructor of Urology, Department of Surgery, Washington University School of Medicine, St. Wm. Kevin Kelly, DO Genitourinary Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Lonnie T. Klein, MD Senior Resident in Urology, Columbia University College of Physicians and Surgeons, New York, New York Deborah A. Kuban, MD Professor of Radiation Oncology and Biophysics, Virginia Prostate Center of Eastern Virginia Medical School and Sentara Cancer Institute, Norfolk, Virginia Paul H. Lange, MD Professor and Chairman of Urology, University of Washington Medical Center, Seattle, Washington Cheryl T. Lee, MD Chief Resident in Urology, and Research Investigator, The Michigan Prostate Institute, The Hans Lilja, MD, PhD Associate Professor of Clinical Chemistry, University Hospital, Malmo, Sweden Franklin C. Lowe, MD, MPH Clinical Associate Professor of Urology, Columbia University College of Physicians and Surgeons, and Associate Director of Urology, St. Luke's-Roosevelt Hospital Center, New York, New York Stephanie E. Meyers, MD Resident in Surgery, Section of Urology, The James E. Montie, MD Professor of Urologic Oncology, Section of Urology, The Michigan Prostate Institute, The Michael J. Naslund, MD, MBA Associate Professor of Urology, University of Maryland School of Medicine, and Director, Maryland Prostate Center, Baltimore, Maryland Joseph E. Oesterling, 'MD Professor and Urologist-in-Chief; Director, The Michigan Prostate Institute, The University of Carl A. Olsson, MD Squier Urology Clinic, and Professor and Chairman of Urology, Columbia University College of Physicians and Surgeons, New York, New York V

David K. Omstein, MD Resident in Urology, Department of Surgery, Washington University School of Medicine, St. Alan W. Partin, MD, PhD Associate Professor of Urology, James Buchanan Brady Urological Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland Jay D. Pearson, PhD Senior Epidemiologist, Merck Research Division, West Point, Pennsylvania Kenneth J. Pienta, MD Associate Professor of Internal Medicine and Surgery, Division of Hematology and Oncology, Department of Internal Medicine, The Michigan Prostate Institute, The University of Charles R. Pound, MD Resident in Urology, James Buchanan Brady Urological Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland Joseph C. Presti, Jr, MD Assistant Professor of Urology, University of California, San Francisco, School of Medicine, San Francisco, California Michael A. Rees, MD Assistant Professor of Urology, Department of Urology, Medical College of Ohio, Toledo, Ohio Andreas Reissigl, MD Associate Professor of Urology, University of Innsbruck, Innsbruck, Austria Martin I. Resnick, MD Lester Persky Professor of Urology and Chairman, Department of Urology, Case Western Reserve University, Cleveland, Ohio Thomas D. Richardson, MD Chief Resident in Urology, and Research Investigator, The Michigan Prostate Institute, The John B. W. Rietbergen, MD Research Fellow in Urology, Erasmus University and Academic Hospital, Rotterdam, The Netherlands Paul F. Schellhammer, MD Professor and Chairman of Urology, Virginia Prostate Center of Eastern Virginia Medical School and Sentara Cancer Institute, Norfolk, Virginia Howard I. Scher, MD Genitouriiary Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, vi

Fritz H. Schroder, MD, PhD Professor and Chairman of Urology, Erasmus University and Academic Hospital, Rotterdam, The Netherlands Katsuto Shinohara, MD Assistant Professor of Urology, University of California, San Francisco, School of Medicine, San Francisco, California Susan Slovin, MD, PhD Genitourinary Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, David C. Smith, MD Assistant Professor of Internal Medicine, Division of Hematology and Oncology, Department of Internal Medicine, The Michigan Prostate Institute, The University of Michigan, Ann Arbor, Michigan Lori J. Sokoll, PhD Postdoctoral Fellow in Clinical Chemistry, Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland Thomas A. Stamey, MD Professor of Urology, Stanford University Medical Center, Stanford, California Marie-Blanche N. Tchetgen, MD Resident in Urology, and Research Investigator, The Michigan Prostate Institute, The Robert L. Vessella, PhD Associate Professor of Urology, Microbiology, and Pathology, University of Washington Medical Center, and Research Health Scientist, Veterans Administration Medical Center, Seattle, Washington Patrick C. Walsh, MD Urologist-in-Chief, James Buchanan Brady Urological Institute, and Director and David Hall McConnell Professor of Urology, The Johns Hopkins University School of Medicine, Baltimore, Maryland Howard N. Winfield, MD Head of Laparoscopic and Minimally Invasive Surgery, Department of Urology, Cleveland Clinic Foundation, Cleveland, Ohio George L. Wright, Jr, PhD Professor and Chairman of Microbiology and Immunology, and Professor of Urology, Virginia Prostate Center of Eastern Virginia Medical School and Sentara Cancer Institute, Norfolk, Virginia He Yu, MD, PhD Currently, Senior Scientist, Diagnostic Systems Laboratories, Webster, Texas; Formerly, Research Associate in Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada vii