Pharmaceutical Industry Postdoctoral Fellowship Program

WELCOME FROM THE FELLOWSHIP PROGRAM DIRECTOR Dear Prospective Fellow, Thank you for your interest in the Shire Pharmaceutical Industry Postdoctoral Fellowship Program. Shire is the leading global biotechnology company focused on serving people with rare diseases and other highly specialized conditions. We strive to develop best-in-class products across our core therapeutic areas, including Hematology, Immunology, Neuroscience, Ophthalmics, Lysosomal Storage Disorders, Gastrointestinal Disorders/Internal Medicine/Endocrinology, Hereditary Angioedema, and Oncology. Our employees are committed to developing and delivering breakthrough therapies for people affected by rare diseases and other high-need conditions. The Shire Pharmaceutical Industry Postdoctoral Fellowship Program is designed to provide recent PharmD graduates with the opportunity to gain experience and specialized training in Shire s Global Medical Affairs Group. In particular, Fellows will have the opportunity to work on projects in Global Medical Communications and Global Medical Information, with the aim of preparing them for a successful career in this crucial and dynamic area. Maureen Feeney, PharmD, MBA Senior Director, Head Global Medical Communications The Shire Pharmaceutical Industry Postdoctoral Fellowship Program offers Fellows a unique opportunity to enhance their scientific knowledge and communication skills while gaining valuable insights into the pharmaceutical industry. If you have a desire to make a contribution to improving the lives of patients with rare diseases and other highly specialized conditions, we hope you consider applying to join our Postdoctoral Fellowship Program. Thank you, Maureen Feeney, PharmD, MBA Senior Director, Head Global Medical Communications 1

WHO WE ARE Shire was founded in the UK in 1986 and since then the company has enjoyed continued and rapid growth, with a full-year revenue in 2016 of US$11 billion. With nearly 24,000 employees based in over 65 countries, and more than 40 licensed therapies available in over 100 countries, Shire is the leading global biotechnology company focused on serving people with rare diseases and other highly specialized conditions. Shire s global footprint Dublin, Ireland Lexington, MA Group Headquarters Strategic centers Zug, Switzerland 40 marketed products ~40 clinical programs in the pipeline 17 manufacturing sites 90+ plasma collection centers 180+ relationships with patient advocacy $11B+ 2016 full-year revenue In addition to our focus on underserved patient communities, our employees lead the way in ensuring that we are accountable for all our behaviors and our social, economic, and environmental impacts. Our commitment to conducting business according to high standards of ethics and integrity also helps us to earn and maintain the trust of the patients and communities we serve. 2

WHAT WE DO Innovation is fundamental to our success, and the drive to become a leading biotechnology company focused on innovative approaches to the treatment of patients with rare and specialized diseases shapes the foundation of our Research and Development approach. We select therapeutic areas in which we see the greatest opportunity for enhancing patients lives, working closely with globally recognized experts to make cutting-edge breakthroughs that can help to transform the lives of people with these life-altering conditions. Our pipeline includes almost 40 clinical development programs, spanning Gastrointestinal/Metabolic Disorders, Genetic Diseases, Hematology, Immunology, Neuroscience, Oncology, and Ophthalmics. Of the investigational products in our pipeline, 75% have potential rare disease indications. Clinical programs in pipeline (as of July 2017) 1 2 3 R RA Phase 1 Phase 2 Phase 3 Registration Recent approvals NUMBER OF PROGRAMS 7 12 14 5 5 3

FELLOWSHIP PROGRAM OVERVIEW Our 2-year Fellowship Program is designed for PharmD graduates who have an interest in pursuing a challenging and dynamic career in the biopharmaceutical industry. Fellows will gain broad interdepartmental exposure and a firm foundation within the company that will pave the way for a successful industry career path. Program aims To deliver specialized training via key departments in the Shire Global Medical Affairs Group, including Global Medical Information and Global Medical Communications. To enhance scientific knowledge and communication skills while offering valuable insights into the pharmaceutical industry. To make a significant contribution to satisfying customer needs and achieving company goals. To enable Fellows to gain the required skills and experience needed to pursue a successful career within Global Medical Affairs. Program structure Year 1 Fellows will participate in two rotations, of 6 months each, within Global Medical Information and Global Medical Communications. Year 2 Fellows will focus on projects in one specific functional area (either Global Medical Information or Global Medical Communications), based on their own professional goals and the particular needs of the business. Throughout the program, Fellows will have the opportunity to participate in projects within other business areas, such as Global Medical Publications, Health Economics and Outcomes Research (HEOR), Medical Science Liaison (MSL), and Global Regulatory Affairs, as well as within specific therapeutic areas. 4

Year 1 (start July 2018) Year 2 (finish June 2020) 6-month rotations Specialization in one functional area Global Medical Communications Global Medical Communications Global Medical Information Global Medical Information Opportunities for additional projects in other business areas throughout program Further program details Duration: 2 years Start date: July 9, 2018 Location: Lexington, MA, USA Compensation: US$75,000 (plus other employee benefits) Fellows will be expected to have excellent oral and written communication skills, be able to work collaboratively, and have solid activity planning and management skills. There will be opportunities for national and international travel. 5

GLOBAL MEDICAL AFFAIRS FUNCTIONAL AREAS Global Medical Communications The Global Medical Communications Department works in partnership and collaboration with the Global Medical Affairs Therapeutic Area to provide support to licensed treatments and the research pipeline in terms of medical review of promotional materials, congress planning, symposia development, and creation of medical content. During the 6-month rotation in Medical Communications, Fellows will be given key opportunities to achieve the following. Build a comprehensive knowledge base of products in our portfolio and the current treatment paradigms that govern the relevant disease states. Gain understanding of regulatory and legal guidelines regarding medical communications strategy and execution, as well as medical review of advertising and promotional materials, and scientific and educational materials. Develop an understanding of the scientific communication platforms that serve as the foundation for all medical communications and publication plans, as well as the execution of all tactics associated with such plans. Learn how to collect scientific intelligence at congresses and how, using published literature, to understand and stay abreast of the rapidly evolving competitive landscape. 6

Attend and participate in a major congress, providing integral service as a staff member at our Global Medical Affairs booth. Implement core and state-of-the-art digital technology at congresses and symposia as well as in physician-focused websites, learning in the process about platforms to disseminate information on Shire s portfolio of products. Develop strategies and initiatives to improve and streamline current processes for scientific data and communications services to internal and external stakeholders. Further advance the internal education of medical and non-medical functions at Shire by developing training programs on key data findings, learnings from Shire s published literature, and competitive insights. Support regional and country teams to execute product launches. Develop, implement, and present a research project at a premier Medical Information or Communications meeting. 7

GLOBAL MEDICAL AFFAIRS FUNCTIONAL AREAS Global Medical Information The Global Medical Information Department is responsible for critical medical and scientific information analysis across therapy areas. We are a customer-facing team providing medical and scientific knowledge on all Shire treatments. During the 6-month rotation in Medical Information, Fellows will be provided with enhanced experiences and development opportunities to do the following. Provide accurate, fair, balanced, and current medical information about Shire therapies to healthcare professionals, consumers, and key internal stakeholders. Become proficient in the skill of medical writing by preparing key documents, FAQs, and standard response letters to be shared with our providers, patients, and internal colleagues. Learn how to think critically, analyse data, and communicate effectively when reviewing pertinent literature, generating literature flashes, and conveying information about inquiry trends and unmet medical needs to stakeholders as a way of strategically guiding Medical Information activities. Attend and participate in a major congress, providing integral service as a staff member at our Global Medical Affairs booth. Contribute to multidisciplinary teams and build relationships with other departments (e.g. Global Medical Affairs Therapeutic Area, Regulatory, Medical Communications, and Health Economics). Develop, implement, and present a research project at a premier Medical Information or Communications meeting. Serve as a rotation mentor to pharmacy clerkship students or summer interns and learn about vendor relations and call center oversight. 8

WORKING WITH SHIRE Responsibility is deeply embedded within our organization and underpins everything that we do. Our employees lead the way in ensuring that we are accountable for our behaviors, as well as our social, economic, and environmental impacts. We are committed to supporting our patients, expanding the availability of innovative medicines for rare diseases, and improving access to these medicines via programs that reduce barriers to treatment. By raising awareness of rare diseases and strengthening support networks, we also reduce time to diagnosis. Our global patient assistance programs ensure access to and affordability of our therapies, while collaboration with patient advocacy organizations and partners worldwide further improves our understanding of the patient, family, and caregiver experiences. At Shire, we also recognize that our people and culture are our most valuable assets. We foster a high-performance, patient-focused environment and work to attract and develop the best talent through the creation of a diverse and inclusive workforce and the provision of a safe and healthy workplace. We recruit individuals who are positive, accountable, and results-driven, who take a responsible and ethical approach to their work, and who want to make a difference to the lives of patients across the globe. Managing the environmental and social impacts of our operations, products, and sourcing is also key, so we work to ensure that the products we deliver are well-tolerated, effective, and of the highest quality. We also encourage our business partners, suppliers, and contractors to adopt similarly responsible and sustainable practices. These commitments extend to our Fellows, who will receive in-depth mentoring across departments and learn how to adopt a results-driven approach. Once completed, the Fellowships also provide an opportunity for successful candidates to apply for a permanent position within Shire. 9

ALUMNI SPOTLIGHT In the unique setting of rare diseases, this Fellowship gave me invaluable opportunities to work alongside, be challenged by, and learn from some of the brightest people in the industry. The multitude of chances to be involved in key projects have allowed me to learn by doing under the guidance of various mentors, enabling me to begin to define my own voice as a Medical Affairs professional. Most importantly, through interactions with patients, patient advocates and providers, Shire and this Fellowship have shown me the responsibility we have to our patients and providers, and the unique position we are in to impact not only a handful of patients but whole communities. Claire Liu, Scientific Publications Fellow 2015 2016 Current role: Shire, Publications Lead, Hematology Throughout my Fellowship experience, I gained valuable knowledge and skill sets that will be the foundation of my future career. The Fellowship is structured in such a way that it allowed me to become an integral member of the US Medical Affairs Immunology therapy area team and exposed me to various collaborative opportunities. Because the Fellowship focuses on strategic thinking, innovation, collaboration, and patient centricity, I am confident that I developed the skills necessary to become a well-rounded professional within the pharmaceutical industry. Dustin Cavida, Immunology Fellow 2015 2016 Current role: Shire, Medical Science Liaison, Gastrointestinal Disorders/Internal Medicine As a Fellow, I was integrated fully with the Medical Information team, and was able to develop a solid foundation of skills and knowledge that I will utilize for the rest of my career. The support and mentorship from my colleagues enabled me to grow as a professional, and facilitated my involvement in several projects with high impact on both our patients and healthcare professionals. Jamie Urbanik, Medical Information Immunology Fellow 2016 2017 The Shire Fellowship afforded diverse opportunities to build the necessary skills for a future career in the pharmaceutical industry. From the start of my Fellowship, I had the benefit of being able to learn from experienced mentors about the different functions, roles and responsibilities as well as to make meaningful contributions that impacted cross-functional teams and, most importantly, our patients. Ihor Sehinovych, Medical Communications Fellow 2016 2017 Current role: Shire, Manager, Medical Communications, Immunology 10

CURRENT FELLOWS So far, my experience as a Shire Fellow has afforded me the opportunity to learn the full role of a Medical Affairs professional hands-on. The dedication to the Fellow is evident throughout the culture at Shire, and I feel as though my voice and knowledge are truly valued. The flexibility the Fellowship offers is fantastic and has allowed me to work on projects that I am genuinely interested in. Overall, the mentorship and dedication of my team has truly aided in my development as a professional. Brian Terreri, PharmD Global Medical Communications Fellow 2017 current Brian Terreri, PharmD Global Medical Communications Fellow 2017 current This Fellowship is the foundation for my future career in industry. As an integral member from the very start, this Fellowship gives me firsthand experiences in Medical Information and the opportunity to truly develop and grow as part of a cross-functional team. Thanks to all my mentors and colleagues who have been so great at guiding me, I am thankful that this is where my career begins. Grace Hsueh, PharmD, Global Medical Information Fellow 2017 current Grace Hsueh, PharmD, Global Medical Information Fellow 2017 current 11

APPLICATION PROCESS AND ELIGIBILITY REQUIREMENTS Shire will be conducting interviews in the Personnel Placement Service (PPS) Exhibit Hall at the American Society of Health-System Pharmacists (ASHP) Midyear Clinical Meeting in December. Candidates are requested to note the following requirements. Fellows for the Shire Pharmaceutical Industry Postdoctoral Fellowship Program are selected on a nationally competitive basis. Candidates must have completed all requirements for graduation from an Accreditation Council for Pharmacy Education (ACPE)-accredited institution before the July 9, 2018 start date. Candidates wishing to apply for the Shire Pharmaceutical Industry Postdoctoral Fellowship Program are strongly encouraged to attend the ASHP Midyear Clinical Meeting and to register through the PPS. We ask that candidates submit a curriculum vitae or résumé through the PPS by November 15, 2017 in order to be considered for interviews at the ASHP Midyear Clinical Meeting. Candidates are encouraged to submit materials immediately to enhance their opportunities for being selected for a Fellowship. Required application materials A letter of intent Two letters of recommendation Curriculum vitae An unofficial transcript from graduate school Please send all your application materials to: shireindustryfellows@shire.com Submission deadline: December 15, 2017 If you have any questions regarding the Fellowship Program, please contact: shireindustryfellows@shire.com 12