The PENN International Rhinology Course David W. Kennedy, MD James N. Palmer, MD Alexander G. Chiu, MD Noam A. Cohen, MD, PhD

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The PENN International Rhinology Course Advances in Management of Sino-nasal Disease March 13-15, 2008 Ritz Carlton Hotel Philadelphia LIVE SURGERY Sponsored by: Course Directors International Faculty U.S. Guest Faculty Rakesh Chandra, MD Rodney P. Lusk, MD Eugenia M. Vining, MD S. James Zinreich, MD Presented by: Space is Limited to 100 Participants Register Early! New! Nasal Endoscopy Workshop for Medical Rhinologists

Course Directors Rhinology Professor Vice Dean, University of Pennsylvania School of Medicine and Philadelphia Veterans Affairs Medical Center Distinguished Visiting Faculty Rakesh Chandra, MD Department of Otolaryngology-Head and Neck Surgery Northwestern University Feinberg School of Medicine Chicago, IL Rodney P. Lusk, MD Director Boys Town Ear, Nose & Throat Institute and Cochlear Implant Center Omaha, NE Medical University of South Carolina Charleston, SC Director, Sao Paulo ENT Center Sao Paulo, Brazil Department of Otorhinolaryngology Helsinki University Hospital and Finnish Institute of Occupational Health Helsinki, Finland Eugenia M. Vining, MD Clinical Instructor Department of Otolaryngology Yale University School of Medicine Associate Chief of Otolaryngology St. Raphael s Hospital, New Haven, CT Professor and Director Micosurgery and Rehabilitation Center for Sinus Disease The American British Cowdray Medical Center Mexico City, Mexico S. James Zinreich, MD Professor, Division of Neuro-Radiology The Johns Hopkins University School of Medicine Baltimore, MD PENN Course Faculty Satish Govindaraj, MD Department of Otolaryngology Mount Sinai Medical Center New York, NY Alexis H. Jackman, MD Department of Otorhinolaryngology- Montefiore Medical Center New York, NY James Kearney, MD Clinical Pennsylvania Hospital, University of Pennsylvania Health System Laurie Loevner, MD Professor of Radiology, Otorhinolaryngology: Head and Neck Surgery and Neurosurgery Bert W. O Malley, Jr., MD Gabriel Tucker Professor and Chair Christine Reger, CRNP Lecturer, Clinical Faculty School of Nursing Department of Otorhinolaryngology- Michael B. Siegel, MD Director Siegel and Bosworth ENT Center Rockville, MD Erica R. Thaler, MD Lawrence W.C. Tom, MD University of Pennsylvania and Children s Hospital of Philadelphia Kevin Welch, MD Lecturer, Rhinology Division Bradford Woodworth, MD Department of Otorhinolaryngology- UAB (University of Alabama at Birmingham) Coding Workshop Randa S. Blackwell Financial Specialist Towson ENT Union Memorial Hospital Baltimore, MD Course Information Target Audience This program is designed for otolaryngologists and medical rhinologists including allergists, infectious disease specialists, and other health care providers including nurse practitioners and physician assistants. Course Overview This comprehensive three-day continuing medical education program in Rhinology features an outstanding national and international faculty. The course focuses on medical and surgical advances in the management of sino-nasal disease. There will be specific emphasis on the frontal and sphenoid sinuses, chronic rhinosinusitis, skull base surgery, medical therapy, pediatric sinusitis, image guidance and powered instrumentation. Difficult cases, prevention, diagnosis and management of complications arising from sinus disease and surgery will be reviewed. Once again we are excited to offer live surgery at the course! Live surgical cases will be telecasted to the Penn Surgical Theatre where participants will be able to interact with Drs. Kennedy and Palmer while they are operating. Additionally, demonstration cadaver dissections will be presented by Drs. Stamm and Chiu using powered instrumentation and stereotactic surgical navigation systems. The course also offers a cadaver dissection laboratory for hands-on experience with powered instrumentation, drills, and imageguidance systems at every station. Objectives Upon completion of the course participants should be able to: Lectures: Describe the role, benefits and limitations of image-guided sino-nasal surgery. Discuss endoscopic approaches to the frontal and sphenoid sinuses. Identify the anatomy of the paranasal sinuses in children and adults and recognize indications for endoscopic sinus surgery. Formulate strategies and solutions to manage difficult to manage sinonasal disease. Review complications of sinus surgery and their proper management. Laboratory: Perform routine nasal endoscopy for the diagnosis of sino-nasal disease. Describe proper endoscopic instrument handling and surgical techniques. Perform techniques involved in traditional and powered sphenoethmoidectomy. Discuss intricacies of image-guided endoscopic sinus surgery. Identify difficult and critical areas of the paranasal sinuses. Practice various frontal sinus approaches and describe their technical implementation. Accreditation The University of Pennsylvania School of Medicine is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians. Designation of Credit The University of Pennsylvania School of Medicine designates this educational activity for a maximum of 25 AMA PRA Category I Credits. Physicians should only claim credit commensurate with the extent of their participation in the activity. Lecture and Laboratory Group II Attendance: 25.00 credits Lecture and Laboratory Group I Attendance: 23.25 credits Lecture Only Attendance: 20.00 credits Penn Rhinology Lectures/Nasal Endoscopy Workshop: 21.25 credits Nasal Endoscopy Workshop (Saturday only): 7.25 credits

Disclosures University of Pennsylvania School of Medicine Office of Continuing Medical Education adheres to the ACCME Standards for Commercial Support. Faculty disclosure information will be made available during the activity. Faculty members are also expected to disclose to participants any discussion of off-label and/or investigational use of pharmaceutical products or devices during their presentations. Course Registration: It is strongly recommended that you register early for this program. Registration is limited due to seating capacity in the surgical theatre and number of stations in the hands-on laboratory. Registrations will be accepted on a first come, first served basis according to the date registration forms and payments are received. All registrations will be confirmed in writing. If you do not receive a confirmation letter please contact the office at 215-662-2137 or email bonnie.rosen@uphs.upenn.edu. Early Registration Discount: There is a $50.00 discount for all registrations received by January 4, 2008. Please deduct $50.00 from the tuition amount below that applies to you when you send in your payment and registration form. The standard registration fee will apply to all registrations received after this date. Standard Registration Fees: Group 2 2 Lab Sessions, all lectures, live surgery and demo dissections (blue group) $2150.00 Physician $1700.00 Resident Group 1 1 Lab Session, all lectures, live surgery and demo dissections (red group) $1650.00 Physician $1300.00 Resident Lecture only All Lectures, live surgery and demo dissections (no hands-on lab) $900.00 Physician $700.00 Resident Combined Penn Rhinology Lectures/Nasal Endoscopy Workshop Includes all Penn Rhinology Lectures on Thursday and Friday and Nasal Endoscopy Workshop with practicum on Saturday. $700.00 Limited Attendance Nasal Endoscopy Workshop Saturday Workshop only (practicum included) $300.00 Limited Attendance Course tuition fees include continental breakfast each day, lunches, refreshment breaks, course reception, all course and laboratory materials (if applicable), as well as transportation to/from the hospital and university for the live surgery demonstration, cadaver dissection demonstrations and hands-on laboratory portions of the program. Course Cancellation Policy The University reserves the right to cancel or postpone any course due to unforeseen circumstances. In the event of cancellation or postponement by the University, we will refund registration fees, but are not responsible for any related costs, charges or expenses to participants, including cancellation fees assessed by airlines, travel agencies and hotels. If a participant must cancel his/her course registration, he or she may receive a refund if written notification is sent by February 15, 2008. Refunds will not be processed after this date. All refunds are subject to a $50.00 cancellation fee. Please fax or email your cancellation notification to Bonnie Rosen at fax number: 215-662-4515 or bonnie. rosen@uphs.upenn.edu. For more information please call 215-662-2137. The Ritz Carlton Hotel, Philadelphia 10 Avenue of the Arts Philadelphia, PA 19102 Phone: 215-523-8000 All lecture portions of this course will be held at one of the city s finest hotels. The Ritz Carlton features beautifully appointed guest rooms, fine cuisine and the highest standard of service. Amenities include: multi-line telephones with voice mail, computer and fax hook-ups, an executive business center, a fitness center with sauna, massage and a full service spa. The hotel is located at 10 Avenue of the Arts (on the corner of Broad Street between Market and Chestnut Streets.) It is approximately 20-30 minutes by taxi from Philadelphia International Airport or five to ten minutes by taxi from Amtrak s 30th Street Station. For driving directions please contact the hotel directly at 215-523-8000. Hotel parking is approximately $25.00 for day time valet or $38.00 for overnight valet parking Hotel Accommodations at the Ritz Carlton Rooms are available Wednesday, March 12, 2008 through Sunday, March 16, 2008 at a special meeting rate of $235.00 per night (single or double) plus tax (currently 14%). Reservations can be made by calling the central reservations office at 800-241-3333. You can also fax your registration to the hotel. Fax: 215-568-0942 attn: Reservation Manager. For additional information visit the Ritz Carlton website at www.ritzcarlton.com. When making reservations be certain to identify yourself as a participant of the University of Pennsylvania Rhinology Program. Please book your reservations by February 22, 2008. After this date, rooms may not be available and/or rates are likely to increase. Nondiscrimination Statement The University of Pennsylvania values diversity and seeks talented students, faculty and staff from diverse backgrounds. The University of Pennsylvania does not discriminate on the basis of race, sex, sexual orientation, gender identity, religion, color, national or ethnic origin, age, disability, or status as a Vietnam Era Veteran or disabled veteran in the administration of educational policies, programs or activities; admissions policies; scholarship and loan awards, athletic, or other administered programs or employment. Questions or complaints regarding this policy should be directed to the Executive Director, Office of Affirmative Action, 3600 Chestnut Street, Sansom Place East, Suite 228, Philadelphia, PA 19104-6106 or 215-898-6993 (Voice) or 215-898-7803 (TDD). Services for the Disabled If special arrangements are required for an individual with a disability or anyone with a special request please contact Bonnie Rosen at 215-662-2137 or email bonnie.rosen@uphs.upenn.edu by February 22, 2008. For More Information: Contact Bonnie Rosen-Department of Otorhinolaryngology Phone: 215-662-2137 Fax: 215-662-4515 e-mail: bonnie.rosen@uphs.upenn.edu web site: http://www.uphs.upenn.edu/pennorl

Program Schedule Thursday March 13, 2008 6:45-7:45 AM Course Registration, Continental Breakfast and Exhibit Viewing 7:45-8:00 AM Welcome/Announcements Bert W. O Malley, Jr., MD, and Basics of Chronic Rhinosinusitis Moderator: 8:00-8:25 AM Impact, Causes and Diagnosis of Chronic Rhinosinusitis 8:25-8:30 AM Questions/Answers 8:30-8:45 AM Sinus Anatomy for FESS 8:45-9:00 AM Basic Physiology and Pathophysiology of the Sinuses 9:00-9:05 AM Questions/Answers 9:05-9:25 AM Radiologic Evaluation of Sinus Disease S. James Zinreich, MD 9:25-9:30 AM Questions/Answers 9:30-9:55 AM Basic Surgical and Medical Maneuvers in CRS 9:55-10:00 AM Questions/Answers 10:00-10:30 AM Panel Discussion: Difficult CRS Cases & Audience Case Questions Moderator: Panel: S. James Zinreich, MD 10:30-11:00 AM BREAK and Exhibit Viewing Improving Surgical Outcomes Moderator: 11:00-11:30 AM Refinements in Surgical Technique 11:30-11:50 AM Bleeding in FESS How to Avoid and Control 11:50-12:10 PM Management of Orbital Complications 12:10-12:30 PM Treatment of CSF Leaks 12:30-12:50 PM Post-Operative Care Rakesh Chandra, MD 12:50-1:00 PM Questions/Answers 1:00-2:00 PM LUNCH/Exhibit Viewing Frontal Sinus Recess Moderator: 2:00-2:20 PM Anatomic Landmarks for Frontal Sinus Surgery 2:20-2:40 PM Endoscopic Approaches 2:40-3:00 PM Extended Endoscopic Approaches 3:00-3:20 PM External Approaches 3:20-3:40 PM Synthesis of Approaches 3:40-4:00 PM Frontal Sinus Panel: Moderator: Panel: 4:00-4:30 PM BREAK and Exhibit Viewing Skull Base Surgery Moderator: 4:30-4:50 PM Endoscopic Approach to Benign Lesions 4:50-5:10 PM Pituitary Surgery: How I Do It 5:10-5:30 PM Endoscopic Approach and Repair of Malignant Lesions 5:30-5:50 PM Open vs. Endoscopic vs. Robotic Skull Base Surgery Bert W. O Malley, Jr., MD 5:50-6:15 PM Skull Base Panel Moderator: Panel: Bert W. O Malley, Jr., MD 6:15-6:30 PM Questions/Answers 7:00-9:00 PM Course Reception

Friday March 14, 2008 6:30-7:10 AM Continental Breakfast and Sign-in (Ritz Carlton Hotel Ballroom area) 7:10-7:25 AM Transportation to University of Pennsylvania for All Course Participants to Penn Surgical Theatre (Bus will be parked at Hotel side entrance) 7:30-8:00 AM Live Surgery Introductions, Pre-Operative Preparation, Case Histories and 8:00-11:30 AM Live Surgery and 11:35-11:45 AM Transportation for everyone back to the Ritz Carlton Hotel 11:45-1:00 PM lunch/exhibit Viewing at Ritz Carlton Lab Group 1 (Red Group) and Lecture Only Group Refinements in Rhinologic Therapy and Pediatric Rhinology Moderator: Eugenia M. Vining, MD 1:00-1:20 PM In Vitro and In Vivo Testing in the Diagnosis of Allergic Rhinitis 1:20-1:40 PM Sublingual vs. Subcutaneous Immunotherapy: Better, Worse or No Difference? 1:40-2:00 PM The Unified Airway Rhinitis and Asthma Elina Toskala, MD. PhD 2:00-2:05 PM Questions and Answers 2:05-2:25 PM BREAK and Exhibit Viewing 2:25-2:55 PM Diagnosis, Medical and Surgical Treatment of Pediatric CRS Rodney Lusk, MD 2:55-3:00 PM Questions and Answers 3:00-3:35 PM CT and MR Applications Laurie Loevner, MD 3:35-3:45 PM Questions and Answers 3:45-4:00 PM Reflux and Rhinology Erica R. Thaler, MD 4:00-4:15 PM Extended Oral Therapies for CRS Eugenia M. Vining, MD 4:15-4:30 PM Extended Topical Therapies for CRS 4:30-4:45 PM Endoscopic Eustacian Tube Surgery 4:45-5:00 PM BREAK ALL PARTICIPANTS 5:00-5:30 PM Video Case Presentations Patient Advocacy in Rhinology (Special Session for U.S. Participants) Moderator: 5:30-5:45 PM Point-of-Service Imaging in Rhinology 5:45-6:15 PM Coding Workshop for ESS Randa Blackwell 6:15-6:45 PM E/M and Endoscopic Sinus Surgery Randa Blackwell Lab Group 2 (Blue Group) 1:00-1:15 PM Transportation to the Lab 1:15-4:30 PM Hands-on Laboratory Instructors: Jackman Palmer Thaler Siegel Kazahaya Woodworth Kennedy Chui Kearney Tom Welch Govindaraj 4:30-4:45 PM Transportation back to the Ritz Carlton Penn Nasal Endoscopy Workshop for Medical Rhinologists (Allergists, Infectious Disease Specialists, Nurse Practitioners and Physician Assistants) We are pleased to offer the Penn Nasal Endoscopy Workshop in conjunction with the Penn International Rhinology Course. Participants may opt to attend all Penn International Rhinology Course lectures or just participate in a one-day workshop on Saturday March 15, 2008. This workshop is designed for medical rhinologists who wish to practice the skills needed to perform rigid nasal endoscopy and directed sinus cultures. Participants will learn the anatomy of the nose and paranasal sinuses, common pathology diagnosed by endoscopy and issues relating to the treatment of chronic sinusitis. A cadaver lab will allow attendees to gain experience in endoscopy techniques in the operated and unoperated patient and a hands-on practicum will allow participants to practice passing a scope. Option #1: Three day program includes: 2 days of lectures with Penn International Rhinology Course and 1 day of specialized nasal endoscopy lectures with cadaver and live patient endoscopy experience. Option #2: One day program of specialized lectures with cadaver and live patient endoscopy experience. Objectives: Upon completion of the workshop, participants should be able to: Lectures: Review the normal anatomy of the paranasal sinus Discuss the techniques of functional endoscopic sinus surgery and recognize the appearance of the post-surgical cavity Explain the utility of endoscopic directed sinus cultures and the organisms involved in chronic sinusitis Formulate strategies to treat difficult to manage sino-nasal disease. Laboratory: Perform routine nasal endoscopy for the diagnosis of sino-nasal disease Demonstrate proper handling of endoscopic instruments Identify endoscopic instruments used for sinus debridement and cultures

Program Schedule, continued Saturday March 15, 2008 6:30-7:10 AM Continental Breakfast and Sign-in (Ritz Carlton Hotel Ballroom area) 7:10-7:25 AM Transportation to University of Pennsylvania for everyone (Hotel side entrance) 7:30-8:20 AM Demonstration Dissection: A Review of Basic Surgical Techniques 8:20-8:30 AM Questions/Answers 8:30-9:30 AM Demonstration Dissection: Advanced Surgical Techniques Lab Group 1 (Red Group) This group will stay at University of Penn for the hands-on lab session (2nd Floor Stemmler Hall) 9:30-12:45 PM Hands-on Laboratory Instructors: Jackman Palmer Thaler Siegel Kazahaya Woodworth Kennedy Chui Kearney Tom Welch Govindaraj 12:45-1:00 PM Transportation back to the Ritz Carlton Hotel 1:00 PM For Lab Group 1 the meeting is adjourned Please complete, sign and return credit request forms and evaluations to the course registration desk before you leave. Please also check to see that you signed in each day in the meeting and in the lab. CME certificates will be mailed 4-6 weeks after the course. 1:00-2:00 PM Lunch (optional) Penn Nasal Endoscopy Workshop Coordinated by: Christine Reger, MSN, CRNP 6:30-7:10 AM Continental breakfast and sign-in at the Ritz Carlton 7:10-7:25 AM Bus Transportation to University of Pennsylvania School of Medicine Reunion Auditorium John Morgan Building 7:30-9:30 AM Demonstration Dissections with Penn International Rhinology Course Basic and Advanced Surgical Techniques 9:30-9:40 AM Walk over to Hospital Department of Otorhinolaryngology 5 Silverstein Lecture Room 9:40-11:40 AM Lectures 11:40-12:15 PM Lunch 12:15-2:15 PM Laboratory: Practice Nasal Endoscopy in Previously Dissected Cadavers 2:15-3:15 PM Hands-on Endscopy Workshop: Practice Nasal Endoscopy and Flexible Fiberoptic Laryngoscopy 3:15-3:30 PM Concluding Remarks Please complete evaluations and credit forms prior to departure Lab Group 2 (Blue Group) and Lecture Only Group 9:30 AM Return to Ritz Carlton Hotel Lecture Only Group is adjourned. Please return credit forms and evaluations to the course registration desk before you leave. Be sure you signed in every day. Certificates will be mailed 4-6 weeks after the course. 9:45-10:00 AM BREAK and Exhibit Viewing Refinements in Rhinologic Therapy and Pediatric Rhinology Moderator: Eugenia M. Vining, MD 10:00-10:20 AM In Vitro and In Vivo Testing in the Diagnosis of Allergic Rhinitis 10:20-10:40 AM Sublingual vs. Subcutaneous Immunotherapy: Better, Worse or No Difference? 10:40-11:00 AM The Unified Airway Rhinitis and Asthma 11:00-11:05 AM BREAK 11:05-11:30 AM Diagnosis, Medical and Surgical Treatment of Pediatric CRS Rodney P. Lusk, MD 11:30-12:00 PM CT and MR Applications in Sinus Disease Laurie Loevner, MD 12:00-12:15 PM Reflux and Rhinology Erica R. Thaler, MD 12:15-12:30 PM Extended Oral Therapies for CRS Eugenia M. Vining, MD 12:30-12:45 PM Extended Topical Therapies for CRS 12:45-1:00 PM Endoscopic Eustacian Tube Surgery 1:00-2:00 PM Lunch 2:00-2:15 PM Transportation to Lab for Group 2 (Blue Group) 2:15-4:30 PM Hands-on Laboratory Instructors: Chandra Kennedy Kearney Yañez Chiu Palmer Woodworth Stamm Cohen Schlosser Jackman Siegel Chandra Welch Govindaraj Vining Kazahaya 4:30-4:45 PM Transportation back to the Ritz Carlton Hotel 4:45 PM For Lab Group 2 the meeting is adjourned Please complete, sign and submit credit request forms and evaluation forms to the course registration desk. Be sure that you signed in each day at the hotel and at the labs. CME certificates will be mailed to you 4-6 weeks after the course.

Meeting Registration Form The PENN International Rhinology Course: Advances in Management of Sino-nasal Disease March 13 15, 2008 Name (first) (last) M MD M PhD M DO M NP M PA M Other Address (home) or (office) City State Zip Code Country E-mail address Last 4 digits of Social Security # Daytime phone ( ) Fax ( ) Tuition Fees: (Please check one) M $2150.00 Physicians M $1700.00 Residents* Lecture/Laboratory Group 2 Lecture/Laboratory Group 2 M $1650.00 Physicians M $1300.00 Residents* Lecture/Laboratory Group 1 Lecture/Laboratory Group 1 M $900.00 Physicians M $700.00 Residents* Lecture Only Session Lecture Only Session M $700.00 Penn Rhinology Lectures/Nasal Endoscopy Workshop (3 day course) M $300.00 Nasal Endoscopy Workshop (Saturday Only) (1 day course) *Residents are required to submit a verification letter from their department for the reduced fee. $50.00 Discount!!! Save $50 if you register by January 4, 2008. Course Reception: I plan to attend the Course Reception: M Yes M No (free for all course participants) Total Payment $ Date Payment Method: M Check enclosed - Payable to Department of Otorhinolaryngology (US dollars drawn on a US Bank) M Please charge my credit card: M AmEx M Mastercard M Visa Credit Card Number Expiration Date Signature I understand my credit card will be charged for this course tuition. Please Mail or Fax Registration and Payment to: Attention: Bonnie Rosen CME Registration Department of Otorhinolaryngology University of Pennsylvania Medical Center 3400 Spruce Street, 5 Ravdin Philadelphia, PA 19104 Fax: 215-662-4515 All registrations will be confirmed in writing. If you do not receive a confirmation letter, it may indicate that we have not received your registration. To be sure that you are registered, please contact Bonnie Rosen at 215-662-2137 or email bonnie.rosen@uphs.upenn.edu before March 1st.

Upcoming and Ongoing Events Visiting Mini Fellowship in Endoscopic Sinus Surgery at University of Pennsylvania This CME-certified program is designed for practicing Otolaryngologists with a significant interest in endoscopic sinus surgery and management of sinus and nasal problems. The course is a three-day one-on-one clinical experience where two participants may spend time with Dr. David Kennedy, Dr. James Palmer and Dr. Alexander Chiu during their office hours, observing them in surgery, and performing a cadaveric dissection. It will be of particular benefit to Otolaryngologists who have been to didactic courses, developed some experience with FESS and identified specific problem areas in the surgical management of patients with sinus disease. A maximum of two Otolaryngologists is admitted to the mini fellowship at any one time. This allows for a close one-on-one experience with the faculty. Participants are encouraged to present CT scans from their own difficult or interesting patient cases. Mini Fellows are invited to attend our Wednesday evening clinical conferences and Thursday morning Grand Rounds. The University of Pennsylvania School of Medicine is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians. This activity was approved for AMA PRA Category 1 Credits. Rhinology World 2009 Philadelphia, Pennsylvania USA President IRS President-Elect ISIAN James Stankiewicz, MD President ARS April 15-18, 2009 Sheraton Philadelphia City Center Hotel and Four Seasons Hotel www.rhinologyworld.com Phone: 215-662-2137 Email: bonnie.rosen@uphs.upenn.edu Office of External Affairs Department of Otorhinolaryngology University of Pennsylvania Medical Center 5 Ravdin 3400 Spruce Street Philadelphia, PA 19104 Non-Profit Organization U.S. Postage Paid Permit No. 2563 Philadelphia, PA Register Early! Ritz Carlton Hotel Philadelphia, Pennsylvania March 13-15, 2008 Visit our Web Site: http: //www.uphs.upenn.edu/pennorl The PENN International Rhinology Course Advances in Management of Sino-nasal Disease