David Afshartous, Ph.D. e-mail: d.afshartous@vanderbilt.edu, tel: 615-875-3026 Department of Biostatistics, School of Medicine, Vanderbilt University 1161 21 st Avenue South, S2323 MCN, Nashville, TN 37232 EDUCATION - Ph.D. in Statistics (1997) Los Angeles, CA University of California, Los Angeles Advisor: Prof. Jan de Leeuw - M.S. in Political Science (1990), Cambridge, MA Massachusetts Institute of Technology - B.S. in Mathematics (1989) Cambridge, MA Massachusetts Institute of Technology EXPERIENCE Research Associate Professor (9/10 present) Nashville, TN Department of Biostatistics, School of Medicine Research Assistant Professor of Statistics (7/07-8/10) Miami, FL Division of Clinical Pharmacology, Department of Medicine, Miller School of Medicine, University of Miami. - Clinical data management, writing statistical design and analysis plans for research protocols, statistical programming, contributing to entire research protocols, performing statistical analysis of clinical data, developing novel biostatistics methodology, publishing in top clinical and statistical journals. - Research on novel methodology ranges from simple experimental design situations to complex repeated measures studies that require more sophisticated techniques. Assistant Professor of Statistics (8/02-7/07) Miami, FL Department of Management Science, School of Business Administration, University of Miami. - Research: prediction in multilevel and mixed effects models, avoiding data snooping in multiple comparisons of random effects, growth curves for repeated measures. - Teaching: data analysis and statistics, regression; MBA and undergraduate level. Wireless Standards Engineer, Applied Statistician (3/00-8/02) London, U.K Lucent Technologies Bell Labs - Represented and led company s efforts to influence 3G international standards, protecting product position and intellectual property - Negotiated agreements with major wireless vendors to ensure objectives - Designed functionality for load balancing and overload control for 3G systems Network Traffic Systems Engineer, Applied Statistician (11/97-3/00) Naperville, IL Lucent Technologies Bell Labs - Designed functionality to protect switching systems from heavy traffic - Presented offers to telecom operators at VP level; multi-million dollar sales - Led team that investigated packet data traffic on internal Lucent network Statistical Research Associate (1994-1997) Los Angeles, CA UCLA Statistical Consulting Center 1
- General statistical consulting; led five-person team in analyzing very large national educational data set; mathematical modeling of hierarchical data; reports to National Institute of Statistical Sciences (NISS). High School Mathematics Teacher (1990-1991) New York, NY Julia Richman High School, Manhattan Teaching Assistant for Writing (1990) and Calculus (1989) Cambridge, MA Minority Introduction to Engineering and Science Program, M.I.T. REFEREED PUBLICATIONS 1. Afshartous, D., Preston, R.A. (2010). Confidence Intervals for Dependent Data in Clinical Trials: equating overlap with significance. Computational Statistics and Data Analysis, vol 54, 2296-2305. 2. Preston, R.A., Afshartous, D., Garg, D., Medrano S., Alonso A, Rodriguez, R. (2009). Mechanisms of impaired potassium handling with dual renin-angiotensin-aldosterone blockade in chronic kidney disease. Hypertension, vol. 53, 754-760. 3. Afshartous, D., and Preston, R.A. (2009). Recursive estimation method for predicting residual bladder urine volumes to improve accuracy of timed urine collections, Statistical Methods for Medical Research, vol. 18(2), 119-130. 4. Afshartous, D., Guan, Y., Mehrotra, A. (2009). U.S. Coast Guard air station location with respect to distress calls: A spatial statistics and optimization based methodology, European Journal of Operational Research, vol. 196(3), 1086-1096. 5. Preston, R.A., Afshartous, D., Alonso A.B., Epstein, M. (2008). Randomized Trial of the Effects of Selective versus Nonselective Cyclooxygenase Inhibition on Dynamic Renal Potassium Excretion, Journal of Clinical Pharmacology and Therapeutics, vol. 84(2), 208-211. 6. Afshartous, D. (2008). Sample size determination for binomial proportion confidence intervals -- an alternative perspective motivated by a legal case, The American Statistician, vol. 62, 27-31. 7. Afshartous, D. and Wolf, Michael (2007). Avoiding Data Snooping in Mixed and Multilevel Models, Journal of the Royal Statistical Society, Series A, vol. 170, 1035-1059. 8. Afshartous, D. and Michailidis, George (2007). Distributed Multilevel Modeling, Journal of Computational and Statistical Graphics, vo1. 16 (4), 901-924. 9. Guan, Y., Afshartous, D. (2007), Test for independence between marks and points of marked point processes, Ecological and Environmental Statistics, vol. 14 (2), 101-111. 10. Afshartous, D., de Leeuw, Jan (2005). A Predictive Density Approach to Predicting Future Observables in the Multilevel Model, Journal of Statistical Planning and Inference, vol. 128, 149-164. 11. Afshartous, D., de Leeuw, Jan (2005). Prediction in Multilevel Models, Journal of Educational and Behavioral Statistics, vol. 30 (2), 109-139. 12. Afshartous, D., de Leeuw, Jan (2005). A Decomposition of Prediction Error for the Multilevel Model, Communications in Statistics Simulation and Computation, vol. 34 (4), 909-928. 13. Afshartous, D., de Leeuw, Jan (2004). An Application of Multilevel Model Prediction to NELS:88, Behaviormetrika, vol. 31 (1), 43-66. 14. Teck, H., Afshartous, D., and Young, G. (2004). Resequencing Performance for N- SAW in UMTS HSDPA, Proceeding of the 2004 World Wireless Congress, San Francisco, CA, May 2004. 2
15. Afshartous, D., Guan, Y., Mehrotra, A., and Magnussen, J. (2004). Optimal Deployment of Resources for the U.S. Coast Guard, Proceedings of the 10 th International Conference on Productivity and Quality Research, Miami, Fl, Feb 2004. 16. Afshartous, D. (1995), Determination of Sample Size for Multilevel Model Design, Perspectives on Statistics for Educational Research: Proceedings of the National Institute for Statistical Sciences (NISS), Technical Report #35, edited by V.S. Williams, L.V. Jones, and I. Olkin. UNDER REVIEW Preston, R.A., Afshartous, D. (2010). Evidence for a novel gastrointestinal-renal signaling axis in humans, submitted to Journal of Clinical Investigation. Afshartous, D., Verbeke, G., Preston, R.A. (2010). Mixed-effects models with variance heterogeneity. Submitted to Computational Statistics and Data Analysis. Afshartous, D. (2010). Key results of interaction models with centering. Submitted to The American Statistician. WORK IN PROGRESS Afshartous, D., Verbeke, G. Preston, R.A. (2009). Multivariate mixed-effects models with dynamic covariance structure. Preston, R.A., Afshartous, D. (2009). Investigation of a novel GI-renal natriuretic signaling axis in humans: roles of the natriuretic prohormones prouroguanylin and proguanylin. Preston, R.A., Dong, C., Zhu, S., Gonzalez, M., Afshartous, D. (2009). Cross-sectional pilot study of endothelial progenitor cells (EPCs) in high risk patients with uncontrolled severe hypertension. Preston, R.A., Afshartous, D., Materson, B.J. (2009). Comparative effects of Nebivolol versus placebo on sodium sensitivity of blood pressure in Hispanic postmenopausal women with hypertension. Preston, R.A., Afshartous, D., Lenz, O., Reiser, J. (2009). Effects of dietary supplement L- Glutamine on 24-hour urine protein excretion in patients with proteinuric renal disease. PATENTS Afshartous, D., Preston, R.A. (2008). U.S. patent application serial number 61/028,640, recursive estimation method for predicting residual bladder urine volumes to improve accuracy of timed urine collections Afshartous, D., Cao, Q., Young, G. (2002). European Patent No. 02253221.2: Sequence Number Checking in Communicating Messages in a Universal Mobile Telecommunications (UMTS) Network. PROFESSIONAL Funded Research Performed: 3 rd Generation High Speed Wireless Protocol Performance, MacLamore Research Grant, University of Miami, 2004. Role: Principal Investigator (20k). Avoiding Data Snooping in Mixed and Multilevel Models, MacLamore Summer Research Grant, University of Miami, 2006. Role: Principal Investigator (20k). Packet Data Analysis Project, Lucent Technologies Dept. #10001107 Grant, 1998-1999. Role: Principal Investigator (10k). Multilevel Modeling of National Educational Longitudinal Study of 1988 (NELS:88) data, National Institute of Statistics (NISS), 1995-1997. Role: Statistician (500k). 3
Submitted Funding Applications (not funded): University of Miami Stanley J. Glaser Research Support Grant, Development of Predictive Mixed Effects Models in the Presence of Random Effects Heterogeneity: Mathematical Modeling and Prediction of Renal Potassium Excretion. Role: Principal Investigator (6k). National Institute of Health, RC1 Challenge Grant, Enhancing Clinical Trials 104 (07-DK- 101), Multivariate Mixed-effects Models with Dynamic Covariance Structure. Role: Principal Investigator (700k). Honors and Awards: Best Clinical Paper 2009, Clinical Pharmacology and Therapeutics, co-author Pauley Fellowship recipient, U.C.L.A., 1992 1997. Best Ph.D. Qualifying Exam Paper, Department of Political Science, U.C.L.A, 1993. Conferences and Meetings: Presented a paper at Joint Statistical Meetings, Washington DC, 2009. Delegate at 2008 International Biometrics Conference, Dublin, Ireland, Jul 2008. Delegate at 2007 FDA-Industry Statistics Workshop, Arlington, VA, Sep 2007. Presented a paper at Joint Statistical Meetings, Salt Lake City, UT, Aug 2007. Presented a paper at the 6th Amsterdam Conference on Multilevel Analysis, Apr 2007. Presented a paper at Institute of Mathematical Statistics annual meeting, Rio de Janeiro, Brazil, Aug 2006. Presented a paper at Joint Statistical Meetings, San Francisco, CA, 2003. Presented a paper at Joint Statistical Meetings, Baltimore, MD, 1999. Presented a paper at Joint Statistical Meetings, Dallas, TX, 1998. Presented a paper at Joint Statistical Meetings, Anaheim, CA, 1997. Presented a paper at American Educational Research Association (AERA), San Fr, CA, 1995. Presented an invited paper at Perspectives on Statistics for Educational Research workshop, the National Institute for Statistical Sciences (NISS), Research Triangle Park, NC, 1995. Delegate, Lucent Technologies Bell Labs, 3 rd Generation Partnership Project (3GPP) International Standards, Radio Access Network Work Group 2 (RAN WG2) Pusan, Korea, May 2001. Berlin, Germany, Jul 2001. Helsinki, Finland, Aug 2001. New York, NY, Oct 2001. Makuhari, Japan, Nov 2001. Sophia-Antipolis, France, Jan 2002. Orlando, FL, Feb 2002. Kobe, Japan, Apr 2002. Gyeoung-Ju, Korea, May 2002. Turin, Italy, Jul 2002. _ COMPUTER EXPERIENCE C, FORTRAN, JAVA, HTML, SAS, SPSS, R, S-PLUS, NONMEM, LaTeX, WinBUGS MS Windows Office, UNIX, Mac 4
ADVANCED TRAINING M210-W Essentials of Population PKPD Modeling & Simulation (1 semester), Metrium Institute Genetic Analysis of Complex Human Diseases (4 days), Miami Institute for Human Genomics _ FOREIGN LANGUAGES Spanish, oral and written; Business presentations to telecom operators in Mexico. Farsi, oral and written Greek, oral and written Turkish, oral and written ACTIVITIES Track Club Miami, founder and coach, 2006 present. Corporate Olympics finalist, 5k 10k run, 1997 2000. Track Club Los Angeles, founder and coach, 1994 1997. Drumming. 5