PHILLIP G. KOPF, PHD ASSISTANT PROFESSOR, MIDWESTERN UNIVERSITY Department of Pharmacology Chicago College of Osteopathic Medicine Midwestern University 555 31 st Street Downer s Grove, IL 60515 Work: (630) 515-6427 Cell: (414) 975-3190 Fax: (630) 515-6295 E-mail: pkopf@midwestern.edu EDUCATION 2009-2012 Postdoctoral Fellow, Department of Pharmacology and Toxicology, Medical College of Wisconsin Research Advisor: William B. Campbell, PhD 2003-2008 PhD in Biomedical Sciences, University of New Mexico, School of Medicine, Albuquerque, New Mexico Research Advisor: Mary K. Walker, PhD Dissertation Title: The Role of Cytochrome P4501A1 in 2,3,7,8-Tetrachlorodibenzo-p-Dioxin- Induced Hypertension Area of Specialization: Toxicology 2008 Passed with Distinction, Dissertation Defense 2006 Passed, Comprehensive Exam 2004 Passed with Honors, Qualifying Exam GPA: 3.96 1997-2001 BS in Biology, Truman State University, Kirksville, Missouri Magna Cum Laude GPA: 3.81 ACADEMIC APPOINTMENTS 2012-present Assistant Adjunct Professor, Department of Pharmacology and Toxicology, Medical College of Wisconsin 2012-present Assistant Professor, Department of Pharmacology, Chicago College of Osteopathic Medicine, Midwestern University HONORS AND PROFESSIONAL ACTIVITIES 2011-2012 Nominated Member, AAAS/Science Program for Excellence in Science 2011 Top-Scoring Abstract, AHA Council for High Blood Pressure Research Conference, Orlando, FL 2010 Top-Scoring Abstract, AHA Council for High Blood Pressure Research Conference, Washington, DC 2010 New Investigator Award, AHA Council for High Blood Pressure Research Conference, Washington, DC 2010 Travel Award, Annual International Winter Eicosanoid Conference, NIEHS 2008 Fellowship, Cardiovascular Physiology Training Grant 2006-2008 Scholarship, Edmund J. & Thelma W. Evans Charitable Trust 2006 Chair, Cardiovascular System: Cardiotoxicity Poster Session, Society of Toxicology Annual Meeting 2006 Travel Award, Biomedical Sciences Graduate Program, University of New Mexico 2005-2006 Fellowship, WERC: A Consortium for Environmental Education and Technology Development
2005 Travel Award, Hypertension Summer School, American Heart Association 2004-2005 Scholarship, Edmund J. & Thelma W. Evans Charitable Trust 2003-2004 Pathology Scholar, Biomedical Sciences Graduate Program, University of New Mexico 2000-present Member, Phi Kappa Phi Honor Society 1999-present Member, Alpha Chi Sigma Professional Honor Society 1999-2000 Chair, Campus Environment Committee, Student Senate, Truman State University 1999-2000 Senator, Student Senate, Truman State University 1998-present Member, Phi Beta Kappa Honor Society 1998-1999 President, Environmental Campus Organization, Truman State University 1997-2001 Scholarship, Combined Ability, Truman State University 1997-2001 Scholarship, Foreign Language, Truman State University 1997-2001 Scholarship, Missouri Higher Education Academic Bright Flight, Truman State University 1997-2001 Scholarship, President s Honorary, Truman State University JOURNAL REFEREE Cardiovascular Toxicology Cell Biology and Toxicology Histology and Histopathology Hypertension Toxicological Sciences Toxicology and Applied Pharmacology PROFESSIONAL MEMBERSHIPS 2011-present The Endocrine Society 2009-present American Society for Pharmacology and Experimental Therapeutics 2009-present American Heart Association 2009-present Society of Toxicology, Midwest Regional Chapter 2007-2009 Society of Environmental Toxicology and Chemistry 2004-present Society of Toxicology 2004-2009 American Physiology Society 2004-2009 Society of Toxicology, Mountain West Regional Chapter LECTURES 2013-present Cardiovascular and endocrine pharmacology PHAR 1650 Pharmacology Midwestern University, second year medical students PHAR 1641, 1642, 1643 Pharmacology I, II, and III Midwestern University, second year pharmacy students PHAR 1640 Pharmacology for Dental Students Midwestern University, second year dental students PHAR 1430 Cardiovascular Pharmacology Midwestern University, elective BISC 0580 Pathophysiology Midwestern University, elective
RESEARCH SUPPORT 2013 Research Starter Grant, The Role of 12-Lipoxygenase in Aldosterone Secretion, PhRMA Foundation 2011-2012 Postdoctoral Fellowship, The Role of Intraadrenal Angiotensin II Metabolism in Zona Glomerulosa Regulation of Adrenal Blood Flow, American Heart Association Midwest Affiliate (1.40 Priority Score, 8.33 Percentile Rank) 2006-2007 Predoctoral Fellowship, The Effect of Subchronic, Low Level 2,3,7,8-Tetrachlorodibenzo- p- Dioxin (TCDD) on the Development of Cardiovascular Disease, American Foundation for Pharmaceutical Education RESEARCH PAPERS 1. Kopf, PG, Roques, BP, and Campbell, WB. Obligatory Metabolism of Angiotensin II to Angiotenisin III for Zona Glomerulosa Cell-Mediated Relaxations of Adrenal Cortical Arteries. In preparation. 2. Asurudeen, I, Kopf, PG, Gauthier, KM, Bornstein, SR, Cowley, AW, and Campbell, WB. Aldosterone Secretagogues Increase Adrenal Blood Flow in Male Rats. Endocrinology. In press. 3. Kopf, PG and Campbell, WB. Endothelial Metabolism of Angiotensin II to Angiotensin III, Not Angiotensin (1-7), Augments the Vasorelaxation Response in Adrenal Cortical Arteries. Endocrinology. In press. 4. Oki, K, Kopf, PG, Campbell, WB, Lam, ML, Yamazaki, T, Gomez-Sanchez, EP, and Gomez-Sanchez, CE. 2013. Angiotensin II and III Metabolism and Different Effects on Steroid Production in the HAC15 Human Adrenocortical Cell Line. Endocrinology. 154:214-221. 5. Kopf, PG, Gauthier, KM, Zhang, DX, Falck, JR, and Campbell, WB. 2011. Angiotensin II Regulates Adrenal Vascular Tone Through Zona Glomerulosa Cell-Derived EETs and DHETs. Hypertension. 57:323-329. 6. Kopf, PG, Scott, JA, Agbor, LN, Boberg, J, Elased, KM, Huwe, JK, and Walker, MK. 2010. Cytochrome P4501A1 is Required for Vascular Dysfunction and Hypertension Induced by 2,3,7,8-Tetrachlorodibenzo-p- Dioxin. Toxicol Sci. 117:537-546. 7. Kopf, PG, Walker, MK. 2010. 2,3,7,8-Tetrachlorodibenzo-p-Dioxin Increases Reactive Oxygen Species Production in Human Endothelial Cells Via Induction of Cytochrome P4501A1. Toxicol Appl Pharmacol. 245:91-99. 8. Kopf, PG, Zhang, DX, Gauthier, KM, Nithipatikom, K, Yi, XY, Falck, JR, and Campbell, WB. 2010. Adrenic Acid Metabolites as Endogenous Endothelium- and Zona Glomerulosa-Derived Hyperpolarizing Factors. Hypertension. 55:547-554. 9. Kopf, PG, Huwe, JK, and Walker, MK. 2008. Subchronic 2,3,7,8-Tetrachlorodibenzo-p-Dioxin Exposure Induces Hypertension and Cardiac Hypertrophy in Adult Mice. Cardiovasc Toxicol. 8:181-193. 10. Aragon, AC, Kopf, PG, Campen, MJ, Huwe, JK, and Walker, MK. 2008. In Utero and Lactational 2,3,7,8- Tetrachlorodibenzo-p-Dioxin Exposure: Effects of Fetal and Adult Cardiac Gene Expression and Adult Cardiac and Renal Morphology. Toxicol Sci. 101:321-330.
REVIEWS 1. Kopf, PG and Walker, MK. 2010. Mechanisms of Xenobiotic-Induced Cardiovascular Toxicology: Halogenated Aromatic Hydrocarbons and Cardiovascular Disease. Comprehensive Toxicology. Second Ed. Elsevier Limited, Oxford. 2. Kopf, PG and Walker, MK. 2009. Overview of developmental heart defects by dioxins, PCBs, and pesticides. J Env Sci Health, Part C. 27:276-285. ABSTRACTS 1. Kopf, PG, Roques, BP, and Campbell, WB. 2011. Obligatory Metabolism of Angiotensin II to Angiotenisin III for Zona Glomerulosa Cell-Mediated Relaxations of Adrenal Cortical Arteries. Abstract for Platform Presentation, Annual High Blood Pressure Research Conference, Orlando, FL. 2. Kopf, PG, Zhang, DX, Gauthier, KM, and Campbell, WB. 2010. Angiotensin II Regulates Adrenal Vascular Tone through Zona Glomerulosa Cell-Derived EETs. Abstract for Poster Presentation, Scientific Sessions, Chicago, IL. 3. Kopf, PG, Zhang, DX, Gauthier, KM, and Campbell, WB. 2010. Angiotensin II Regulates Adrenal Vascular Tone through Zona Glomerulosa Cell-Derived EETs. Abstract for Platform Presentation, Annual High Blood Pressure Research Conference, Washington, DC. 4. Kopf, PG, Agbor, LN, Scott, J, and Walker, MK. 2010. Cytochrome P4501A1 (CYP1A1) is Required to Mediate Vascular Dysfunction, Reactive Oxygen Species, and Hypertension Induced by 2,3,7,8- Tetrachlorodibenzo-p-Dioxin (TCDD). Abstract for Platform Presentation, Salt Lake City, UT. 5. Kopf, PG, Gauthier, KM, Zhang, DX, Nithipatikom, K, and Campbell, WB. 2010. Zona Glomerulosa Cells Regulate Adrenal Vascular Tone by EETs in Response to Angiotension II. Abstract for Poster Presentation. Annual International Winter Eicosanoid Conference, Baltimore, MD. 6. Kopf, PG, Zhang, DX, Gauthier, KM, Nithipatikom, K, Falck, JR, and Campbell, WB. 2009. Adrenic Acid Metabolites as Endothelium- and Zona Glomerulosa-Derived Hyperpolarizing Factors. Abstract for Platform Presentation, Annual High Blood Pressure Research Conference, Chicago, IL. 7. Walker, MK, Kopf, PG, Agbor, LN, and Scott, J. 2009. Hypertension Induced by Exposure to the Environmental Pollutant Dioxin Requires Cytochrome P4501A1, Abstract for Poster Presentation, Annual High Blood Pressure Research Conference, Chicago, IL. 8. Walker, MK, Kanagy, NL, and Kopf, PG. 2008. Loss of Cytochrome P4501A1 Results in Reduced Vasodilatory Responses to Nitic Oxide and Salt-Sensitive Hypertension. Abstract for Platform Presentation, Annual High Blood Pressure Research Conference, Atlanta, GA. 9. Kopf, PG, Walsh, MT, and Walker, MK. 2008. Subacute Activation of the Aryl Hydrocarbon Receptor Results in a Predisposition to Salt-Sensitive Hypertension. Abstract for Poster Presentation, Annual High Blood Pressure Research Conference, Atlanta, GA. 10. Kopf, PG, Huwe, JK, and Walker, MK. 2008. Subchronic Exposure of Adult Mice To 2,3,7,8- Tetrachlorodibenzo-p-Dioxin (TCDD) Increases Blood Pressure and Alters Vascular Reactivity. Abstract for Poster Presentation, Mechanisms of Toxicity Gordon Research Conference, Lewiston, ME.
11. Kopf, PG, Huwe, JK, and Walker, MK. 2008. Subchronic Exposure of Adult Mice to 2,3,7,8- Tetrachlorodibenzo-p-Dioxin (TCDD) Increases Blood Pressure and Alters Vascular Reactivity. Abstract for Poster Presentation, Society of Toxicology Annual Meeting, Seattle, WA. 12. Kopf, PG and Walker, MK. 2007. Overview of Dioxin-Like Compounds, PCB and Pesticide Exposures Associated with Developmental Heart Effects in Mammals, Fish, and Birds. Abstract for Symposium Lecture, Society of Environmental Toxicology and Chemistry North America Annual Meeting, Milwaukee, WI. 13. Walker, MK, Agbor, LN, Aragon, AC, Walsh, MT, Nunez, B, Kopf, PG, and Goens, MB. 2007. Hypertensive Heart Disease Progresses to Symptoms of Heart Failure in Older Aryl Hydrocarbon Receptor Null Mice. Abstract for Poster Presentation, Annual High Blood Pressure Research Conference, Tucson, AZ. 14. Kopf, PG, Huwe, JK, and Walker, MK. 2007. Chronic Exposure to 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) Increases Blood Pressure and Alters Vascular Reactivity in Adult Mice. Abstract for Poster Presentation, Mountain West Society of Toxicology Annual Meeting, Breckenridge, CO. 15. Kopf, PG, Huwe, JK, and Walker, MK. 2007. Chronic Exposure to a Low Level of 2,3,7,8- Tetrachlorodibenzo-p-Dioxin (TCDD) Increases Blood Pressure in Adult Mice. Abstract for Poster Presentation, International Congress of Toxicology, Montreal, QC. 16. Kopf, PG and Walker, MK. 2006. Sub-Chronic, Low Level 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) Increases Blood Pressure in Adult Mice. Abstract for Platform Presentation, Mountain West Society of Toxicology Annual Meeting, Phoenix, AZ. 17. Kopf, PG and Walker, MK. 2006. Sub-Chronic Low Level Exposure of Adult Male Mice to 2,3,7,8- Tetrachlorodibenzo-p-Dioxin (TCDD) Induces Hypertension. Abstract for Poster Presentation, Mechanisms of Toxicity Gordon Research Conference, Waterville, ME. 18. Kopf, PG, Lund, AK, and Walker, MK. 2006. Exposure of Adult Mice to Sub-Chronic, Low Level 2,3,7,8- Tetrachlorodibenzo-p-Dioxin (TCDD) Increases Blood Pressure and Body Weight. Abstract for Poster Presentation, Society of Toxicology Annual Meeting, San Diego, CA. 19. Aragon, AC, Kopf, PG, Goens, B, and Walker, MK. 2006. 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) Exposure During Fetal Development Predisposes Male Offspring to Cardiac Dysfunction in Adulthood. Abstract for Poster Presentation, Society of Toxicology Annual Meeting, San Diego, CA. 20. Kopf, PG, Lund, AK, and Walker MK. 2005. Exposure of Adult Mice to Sub-Chronic, Low Level 2,3,7,8- Tetrachlorodibenzo-p-Dioxin (TCDD) Increases Blood Pressure and Body Weight. Abstract for Platform Presentation, Mountain West Society of Toxicology Annual Meeting, Santa Fe, NM. 21. Kopf, PG, Lund AK, and Walker, MK. 2005. Sub-Chronic, Low Level 2,3,7,8-Tetrachlorodibenzo-p- Dioxin (TCDD) Exposure Increases Blood Pressure in Adult Mice as Measured by Telemetry. Abstract for Poster Presentation, Society of Toxicology Annual Meeting, New Orleans, LA. 22. Kopf, PG, Vitt, P, and Wagenius, S. Fluctuating Asymmetry as a Measure of Inbreeding Depression. 2001. Abstract for Poster Presentation, Midwestern Plant Conservation Conference and Task Force Meeting, Chicago, IL.
23. Kopf, PG and Kelrick, MI. Seed Ecology of Warea carteri. 2001. Abstract for Platform Presentation, National Conference for Undergraduate Research, Lexington, KY.
REFERENCES Walter C. Prozialeck, PhD Professor and Chairman Department of Pharmacology, Chicago College of Osteopathic Medicine, Midwestern University (630) 515-6381 wprozi@midwestern.edu William B. Campbell, PhD Professor and Chairman Department of Pharmacology and Toxicology, Medical College of Wisconsin (414) 955-8267 wbcamp@mcw.edu Garrett J. Gross, PhD Professor Department of Pharmacology and Toxicology, Medical College of Wisconsin (414) 955-8627 ggross@mcw.edu Kathryn M. Gauthier, PhD Assistant Professor Department of Pharmacology and Toxicology, Medical College of Wisconsin (414) 955-8612 kgauth@mcw.edu Mary K. Walker, PhD Professor College of Pharmacy, University of New Mexico Health Sciences Center (505) 272-0580 mwalker@salud.unm.edu Matthew J. Campen, PhD Associate Professor College of Pharmacy, University of New Mexico Health Sciences Center (505) 925-7778 mcampen@salud.unm.edu