IPHY 4600 Immunology 3.0 credits Spring 2013 - MWF 2-250pm; Museum Collections (MCOL) W100 INSTRUCTOR Professor Monika Fleshner, PhD Email: fleshner@colorado.edu Office Hours: Wed 1030-1200 Location: Carlson, 202F GRADUATE TEACHING ASSISTANT Robert S. Thompson, MS Email: Robert.S.Thompson@colorado.edu Office Hours: By appointment Location: Clare 111 (middle room) PREREQUISITES Required: IPHY 3430 (Introduction to Human Physiology) or IPHY 3470 (Human Physiology I) Recommended: IPHY 3060 (Cell Physiology) COURSE MATERIALS Required: Optional: Immunobiology textbook & CD (Janeway), 8 th edition, CU Book Store Inkling (ebook version) Promo code for 20% discount - MDTXTBK20 https://www.inkling.com/store/janeways-immunobiology-kenneth-murphy-8th/ iclicker, CU Book Store Lecture notes in Immunology (Todd & Spickett), CU Book Store ICLICKER Students must have an iclicker and register it before class on Monday January 21, 2013. You are responsible for keeping the clicker functional during the semester and are encouraged to bring a spare set of batteries (3 AAA) to class. If for any reason you change clickers, it is your responsibility to email the instructor with the new clicker ID number. Anyone caught voting with two clickers or using someone else s clicker are committing academic fraud that could result in expulsion. Points will not be awarded if you forgot your clicker at home but attended lecture. For technical questions about iclicker registration, please contact IT services at 303-735-4357 (5-HELP) or help@colorado.edu. DESIRE TO LEARN (D2L) Material related to the course including lecture notes and scores, is available at Desire to Learn (http://learn.colorado.edu). Check your scores on D2L periodically during the semester to make sure that the correct values have been entered. NATURE OF THE COURSE This class is designed to introduce basic concepts in Immunology to undergraduate majors in Integrative Physiology. The immune system is comprised of many different cell types that work together in an organism to protect us from disease. The purpose of this course is to provide students with a clear understanding of the basic cellular interactions involved with mounting an appropriate immune response. Immunology 4600 is designed to emphasize cell-to-cell and whole system interactions. Genetic regulation and signal transduction pathways will be de-emphasized.
COURSE OBJECTIVES An overall goal of this course is to provide students with an understanding of basic concepts in cellular immunology. More explicitly, students should be able to: 1) Describe how the immune system is able to discriminate self vs. non-self. 2) Explain how the innate and adaptive immune systems work together to generate an effective immune response against a specific pathogen. 3) Explain how the immune system is able to respond to so many diverse antigens. 4) Describe the various steps and checkpoints involved in lymphocyte development. 5) Explain how and why certain immune cells change their phenotype following activation. 6) Given certain symptoms of a clinical disease or manipulation, predict the immunological cause and consequence of the disorder. REQUIREMENTS & GRADING Your final grade will be based on your performance on examinations, in-class participation, and homework. There are NO extra credit assignments given to improve your grade. It is to your advantage to always attend class, to keep up with the material as we go along, to ask questions in class when you are confused, and to see myself or your TA during office hours when you need help. 1.) Examinations (90% of final grade) Exams will consist of multiple-choice questions derived from the lecture material and reading. There will be five exams. Exam I Monday February 4 2:00-2:50 PM Exam II Monday February 25 2:00-2:50 PM Exam III Friday March 15 2:00-2:50 PM Exam IV Monday April 14 2:00-2:50 PM Exam V Monday May 6 7:30 PM Please note: Exams are only given on the designated dates and times. If you miss an exam FOR ANY REASON, a zero will be assigned. THERE ARE NO MAKE-UP EXAMS. If you miss more than one exam, you should drop the class. 2.) In class participation (10% of final grade) Nearly every lecture will include testing student understanding through in-class questions or group activities. GRADING SCALE A = 93-100%, A- = 90-92.9%, B+ = 87-89.9%, B = 83-86.9%, B- = 80-82.9%, C+ = 77-79.9%, C = 73-76.9%, C- = 70-72.9%, D+ = 67-69.9%, D = 63-66.9%, D- = 60-62.9%, F = below 60% Grades of Incomplete will be assigned according to University guidelines and will only be granted to students who have been unable to complete the course requirements for reasons beyond their control. Students must complete and collect signatures on an Incomplete Form prior to submission to the Dean s Office for approval. Note: An attempt to avoid receiving an undesirable grade does not warrant an Incomplete. ADD/DROP DEADLINES Please see Registrar s web page: http://www.colorado.edu/portal/frames/js.html?url=http://registrar.colorado.edu/calendar/calendars_schedules. html&server=cuconnect.colorado.edu&port= ATTENDANCE Attendance is required for lecture. Absences due to health issues, deaths, official university activities, or major events beyond your control (e.g., a court appearance, car accidents, etc.) may be excused by your Instructor with appropriate documentation. Documentation to request an excusal must be submitted immediately upon returning to class following an unplanned absence. Requests for excusing planned absences must be requested in writing at least one week prior to the scheduled absence. In the case of an excused absence, points for the missed in-class activities will be prorated. An unexcused absence (e.g., family trip/vacation, non-university
sponsored activity, tardiness, truancy) will result in a score of zero for the day. UNIVERSITY OF COLORADO POLICY STATEMENTS DISABILITIES: If you qualify for accommodations because of a disability, please submit a letter from Disability Services to me in a timely manner so that your needs can be addressed. Disability Services determines accommodations based on documented disabilities. Contact: 303-492-8671, Center for Community N200, and http://www.colorado.edu/disabilityservices. If you have a temporary medical condition or injury, see guidelines at http://www.colorado.edu/disabilityservices/go.cgi?select=temporary.html. Disability Services' letters for students with disabilities indicate legally mandated reasonable accommodations. The syllabus statements and answers to Frequently Asked Questions can be found at http://www.colorado.edu/disabilityservices ACADEMIC INTEGRITY: All students of the University of Colorado at Boulder are responsible for knowing and adhering to the academic integrity policy of this institution. Violations of this policy may include: cheating, plagiarism, aid of academic dishonesty, fabrication, lying, bribery, and threatening behavior. All incidents of academic misconduct shall be reported to the Honor Code Council (honor@colorado.edu; 303-725-2273). Students who are found to be in violation of the academic integrity policy will be subject to both academic sanctions from the faculty member and non-academic sanctions (including but not limited to university probation, suspension, or expulsion). Additional information on the Honor Code can be found at: http://www.colorado.edu/policies/honor.html and http://www.colorado.edu/academics/honorcode/. RELIGIOUS OBSERVANCES: Campus policy regarding religious observances requires that faculty make every effort to deal reasonably and fairly with all students who, because of religious obligations, have conflicts with scheduled exams, assignments or required attendance. In this class, you must inform the instructor within the first two weeks of class if you have a conflict due to a religious observance. See full details at http://www.colorado.edu/policies/fac_relig.html. CLASSROOM BEHAVIOR: Students and faculty each have responsibility for maintaining an appropriate learning environment. Those who fail to adhere to such behavioral standards may be subject to discipline. Professional courtesy and sensitivity are especially important with respect to individuals and topics dealing with differences of race, color, culture, religion, creed, politics, veteran's status, sexual orientation, gender, gender identity and gender expression, age, disability, and nationalities. Class rosters are provided to the instructor with the student's legal name. I will gladly honor your request to address you by an alternate name or gender pronoun. Please advise me of this preference early in the semester so that I may make appropriate changes to my records. See policies at http://www.colorado.edu/policies/classbehavior.html and at http://www.colorado.edu/studentaffairs/judicialaffairs/code.html#student_code. DISCRIMINATION AND HARASSMENT: The University of Colorado at Boulder Discrimination and Harassment Policy and Procedures, the University of Colorado Sexual Harassment Policy and Procedures, and the University of Colorado Conflict of Interest in Cases of Amorous Relationships policy apply to all students, staff, and faculty. Any student, staff, or faculty member who believes s/he has been the subject of sexual harassment or discrimination or harassment based upon race, color, national origin, sex, age, disability, creed, religion, sexual orientation, or veteran status should contact the Office of Discrimination and Harassment (ODH) at 303-492-2127 or the Office of Student Conduct (OSC) at 303-492-5550. Information about the ODH, the above referenced policies, and the campus resources available to assist individuals regarding discrimination or harassment can be obtained at http://www.colorado.edu/odh.
IMMUNOLOGY COURSE CALENDAR Readings and Dates Material covered exam schedule Introduction Monday 1/14 Syllabus Chapter 1 Wednesday 1/16 Basic Concepts in Immunology EXAM I Monday 2/4 Chapter 1 Chapter 2 Wednesday 2/6 Innate Immunity: The First Lines of Defense Chapter 3 Monday 2/11 Induced Responses of Innate Immunity Chapter 4 Wednesday 2/20 Antigen Recognition by B-cell and T-cell Receptors Chapter 5 Friday 2/22 The Generation of Lymphocyte Antigen Receptors EXAM II Monday 2/25 Chapters 2, 3, 4 & 5 Chapter 6/15 Wednesday 2/27 Antigen Presentation to T Lymphocytes Chapter 8/15 Wednesday 3/6 The Development & Survival of Lymphocytes EXAM III Friday 3/15 Chapters 6, 8 & 15 Chapter 9 Monday 3/18 T Cell-Mediated Immunity Friday 3/22 Friday 3/29 No classes Thanksgiving Break Chapter 9 cont Monday 4/1 T Cell-Mediated Immunity Chapter 10/16 Friday 4/5 The Humoral Immune Response EXAM IV Monday 4/14 Chapters 9 & 10 Chapter 11 Wednesday 4/17 Dynamics of Adaptive Immunity Chapter 12 Wednesday 4/24 Mucosal Immunity Chapter 13 Monday 4/29 Failures of Host Defense EXAM V Monday 5/6 at 7:30 PM Chapters 11, 12 & 13
LEARNING GOALS & IMPORTANT VOCABULARY All activities in lecture and recitation will be based on the learning goals for the course. These goals are organized by chapter and can be downloaded from Desire to Learn. What is a learning goal anyway? A learning goal establishes what the instructor would like the students to achieve by the end of the course. Sample learning goal: Diagram and explain the time course of a typical antibody and effector T cell response. Covers the content or topics that will be covered (e.g., time course of typical antibody and effector T cell response) Defines the learning level expectation, or skill level, you will be performing to achieve that goal (e.g., diagram and explain) Learning goals help students see what is expected of him or her, while they help faculty stay focused on what topics are most important. INSIDER TIP: Faculty use the learning goals to write their quizzes and exam questions. If you want to know what is going to be on the test, use the learning goals to guide your studying!!! It s important to note that there is no answer key for the learning goals. These are goals for you to achieve, not your teaching assistant! The teaching assistants are here to help you reach your learning goals. Based on a recent Science Education Initiative survey (Fall 2010), most IPHY students use learning goals to: 1. Focus on what to study 2. Reorganize their notes 3. Actively quiz themselves on certain topics 4. Guide their reading of the textbook 5. Preview upcoming lecture material 6. Review important vocabulary terms In addition to learning goals, all students will be required to learn the vocabulary words associated with each chapter. Please review these vocabulary terms prior to coming to class.