Progress in Inflammation Research Series editors Michael J. Parnham Fraunhofer IME & Goethe University Frankfurt, Germany Achim Schmidtko Goethe University Frankfurt, Germany
More information about this series at http://www.springer.com/series/4983
Dieter Steinhilber Editor Lipoxygenases in Inflammation
Editor Dieter Steinhilber Institute of Pharmaceutical Chemistry Goethe University Frankfurt Frankfurt am Main Germany Series Editors Michael J. Parnham Fraunhofer IME & Goethe University Frankfurt Germany Achim Schmidtko Goethe University Frankfurt Germany Progress in Inflammation Research ISBN 978-3-319-27764-6 ISBN 978-3-319-27766-0 (ebook) DOI 10.1007/978-3-319-27766-0 Library of Congress Control Number: 2016931316 Springer International Publishing Switzerland 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer International Publishing AG Switzerland
Preface Lipoxygenases oxidize polyunsaturated fatty acids and can generate lipid mediators which have a broad spectrum of physiological and pathophysiological functions. Data gathered during the last decades suggest that lipoxygenase metabolites are involved in host defence reactions and the cardiovascular system and contribute to the development of inflammatory and allergic diseases, cardiovascular disease, and cancer but are also involved in the resolution of inflammation. This Progress in Inflammation Research volume summarizes the physiological and pathophysiological functions of lipoxygenases. v
ThiS is a FM Blank Page
Contents Lipoxygenases: An Introduction... 1 Dieter Steinhilber 5-Lipoxygenase... 7 Oliver Werz and Olof Rådmark Leukotriene A 4 Hydrolase and Leukotriene C 4 Synthase... 31 Agnes Rinaldo-Matthis and Jesper Z. Haeggstr om Catalytic Multiplicity of 15-Lipoxygenase-1 Orthologs (ALOX15) of Different Species... 47 Hartmut Kühn, Felix Karst, and Dagmar Heydeck Platelets and Lipoxygenases... 83 Michael Holinstat, Katrin Niisuke, and Benjamin E. Tourdot Lipoxygenases and Cardiovascular Diseases... 101 Andrés Laguna-Fernández, Marcelo H. Petri, Silke Thul, and Magnus Bäck Role of Lipoxygenases in Pathogenesis of Cancer... 131 J. Roos, B. Kühn, J. Fettel, I.V. Maucher, M. Ruthardt, A. Kahnt, T. Vorup-Jensen, C. Matrone, D. Steinhilber, and T.J. Maier The Physiology and Pathophysiology of Lipoxygenases in the Skin... 159 Peter Krieg and Gerhard Fürstenberger 5-Oxo-ETE and Inflammation... 185 William S. Powell and Joshua Rokach Lipoxins, Resolvins, and the Resolution of Inflammation... 211 Antonio Recchiuti, Eleonora Cianci, Felice Simiele, and Mario Romano Index... 241 vii
ThiS is a FM Blank Page
List of Contributors Magnus Bäck Translational Cardiology, Center for Molecular Medicine, L8:03, Karolinska University Hospital, Stockholm, Sweden Department of Medicine, Karolinska Institutet, Stockholm, Sweden Department of Cardiology, Karolinska University Hospital, Stockholm, Sweden Eleonora Cianci Department of Medical, Oral and Biotechnological Sciences, G. D Annunzio University of Chieti-Pescara, Chieti, Italy Department of Medicine and Aging Sciences, G. D Annunzio University of Chieti- Pescara, Chieti, Italy Center of Excellence on Aging, G. D Annunzio University of Chieti-Pescara, Chieti, Italy Gerhard Fürstenberger Molecular Diagnostics of Oncogenic Infections, German Cancer Research Center, Heidelberg, Germany J. Fettel Institute of Pharmaceutical Chemistry/ZAFES, Goethe-University, Frankfurt/Main, Germany Jesper Z. Haeggstr om Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden Dagmar Heydeck Institute of Biochemistry, Charité University Medicine Berlin, Berlin, Germany Michael Holinstat University of Michigan Medical School, Ann Arbor, MI, USA B. Kühn Institute of Pharmaceutical Chemistry/ZAFES, Goethe-University, Frankfurt/Main, Germany A. Kahnt Institute of Pharmaceutical Chemistry/ZAFES, Goethe-University, Frankfurt/Main, Germany ix
x List of Contributors Felix Karst Institute of Biochemistry, Charité University Medicine Berlin, Berlin, Germany Peter Krieg Molecular Diagnostics of Oncogenic Infections, German Cancer Research Center, Heidelberg, Germany Hartmut Kühn Institute of Biochemistry, Charité University Medicine Berlin, Berlin, Germany Andrés Laguna-Fernández Translational Cardiology, Center for Molecular Medicine, L8:03, Karolinska University Hospital, Stockholm, Sweden Department of Medicine, Karolinska Institutet, Stockholm, Sweden T.J. Maier Department of Biomedicine, Aarhus University, Aarhus C, Denmark C. Matrone Department of Biomedicine, Aarhus University, Aarhus C, Denmark I.V. Maucher Institute of Pharmaceutical Chemistry/ZAFES, Goethe-University, Frankfurt/Main, Germany Katrin Niisuke University of Michigan Medical School, Ann Arbor, MI, USA Marcelo H. Petri Translational Cardiology, Center for Molecular Medicine, L8:03, Karolinska University Hospital, Stockholm, Sweden Department of Medicine, Karolinska Institutet, Stockholm, Sweden William S. Powell Meakins-Christie Laboratories, McGill University Health Centre Research Institute, Centre for Translational Biology, Montreal, QC, Canada Olof Rådmark Division of Chemistry II, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Solna, Sweden Antonio Recchiuti Department of Medical, Oral and Biotechnological Sciences, G. D Annunzio University of Chieti-Pescara, Chieti, Italy Center of Excellence on Aging, G. D Annunzio University of Chieti-Pescara, Chieti, Italy Agnes Rinaldo-Matthis Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden Joshua Rokach Department of Chemistry, Claude Pepper Institute, Florida Institute of Technology, Melbourne, FL, USA Mario Romano Department of Medical, Oral and Biotechnological Sciences, G. D Annunzio University of Chieti-Pescara, Chieti, Italy Center of Excellence on Aging, G. D Annunzio University of Chieti-Pescara, Chieti, Italy J. Roos Institute of Pharmaceutical Chemistry/ZAFES, Goethe-University, Frankfurt/Main, Germany
List of Contributors xi M. Ruthardt Department of Hematology, Goethe University, Frankfurt, Germany Felice Simiele Department of Medical, Oral and Biotechnological Sciences, G. D Annunzio University of Chieti-Pescara, Chieti, Italy Center of Excellence on Aging, G. D Annunzio University of Chieti-Pescara, Chieti, Italy Dieter Steinhilber, Ph.D. Institute of Pharmaceutical Chemistry/ZAFES, Goethe University, Frankfurt/Main, Germany Silke Thul Translational Cardiology, Center for Molecular Medicine, L8:03, Karolinska University Hospital, Stockholm, Sweden Department of Medicine, Karolinska Institutet, Stockholm, Sweden Benjamin E. Tourdot University of Michigan Medical School, Ann Arbor, MI, USA T. Vorup-Jensen Department of Biomedicine, Aarhus University, Aarhus C, Denmark Oliver Werz Chair of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, University Jena, Jena, Germany