WISCONSIN. Bioscience Performance Metrics. Wisconsin Page 1

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WISCONSIN Wisconsin has specialized employment concentrations in two of the four bioscience industry subsectors medical devices and equipment (location quotient of 1.29) and agricultural feedstock and chemicals (1.23). In the State, academic bioscience research and development expenditures totaled $760 million in, which translates into an above average per capita figure. Bioscience academic R&D is primarily in medical sciences and in biological sciences. Wisconsin s postsecondary institutions contribute substantially to the bioscience talent base with 4,099 students graduating with degrees in bioscience related fields in. Venture capital invested in State bioscience companies during the last six years totaled $295 million, led by pharmaceuticals and human biotechnology. The 2,187 bioscience patents issued to Wisconsin inventors over the same six year period were well diversified, led by surgical and medical instruments and biochemistry. Bioscience Performance Metrics Summary of State Performance in Selected Bioscience related Metrics Metrics Wisconsin United States Rank* Bioscience Industry, Total Bioscience Industry Employment, 24,694 1,420,324 II Bioscience Industry Location Quotient, 0.83 n/a III Biosciences Industry Establishments, 752 47,593 II Academic R&D Expenditures, FY Bioscience R&D ($ thousands) $759,863 $31,818,810 14 Bioscience Share of Total R&D 68.0% 61.3% 10 Bioscience R&D Per Capita $135.02 $104.54 9 Change in Bioscience R&D, FY 08 20.8% 22.3% 27 NIH Funding, FY Total, Including ARRA Funds ($ thousands) $440,857 $25,837,590 18 Per Capita Funding $77.96 $84.16 17 Change in Baseline Funding, FY 09** 3.3% 4.7% 29 Change in Total Funding, FY 09 12.2% 14.6% 36 Clinical Trials, Initiated 279 5,299 27 Higher Education Degrees in Bioscience Fields, AY 4,099 161,811 12 Employment in Bioscience related Occupations, 12,890 717,510 19 Bioscience Venture Capital Investments, 09 ($ millions) $295.2 $60,099 21 Bioscience and Related Patents, 09 2,187 75,593 15 *State ranking figures for bioscience industry employment metrics are calculated as quintiles (I=Top Quintile; V=Bottom Quintile). All other metrics are ranked 1 52. **Baseline Funding does not include American Recovery and Reinvestment Act (ARRA) funds for. For source notes, see end of State Profile. Wisconsin Page 1

Bioscience Industry Base, INDUSTRY SUBSECTOR Wisconsin United States 2001 08 Change 2001 08 Change AGRICULTURAL FEEDSTOCK & CHEMICALS Establishments 77 19.7% 2,440 16.0% Employment 2,951 41.8% 114,793 1.9% Location Quotient 1.23 n/a Direct Effect Employment Multiplier 5.99 11.33 Total Employment Impact 17,688 1,284,650 Average Annual Wage $51,577 $72,279 DRUGS & PHARMACEUTICALS Establishments 68 21.4% 2,771 6.4% Employment 3,489 34.0% 311,882 2.3% Location Quotient 0.53 n/a Direct Effect Employment Multiplier 6.36 9.92 Total Employment Impact 22,186 2,873,278 Average Annual Wage $64,187 $93,378 MEDICAL DEVICES & EQUIPMENT Establishments 341 17.6% 15,227 0.4% Employment 11,800 7.8% 435,509 2.0% Location Quotient 1.29 n/a Direct Effect Employment Multiplier 3.87 4.87 Total Employment Impact 45,655 2,029,581 Average Annual Wage $71,015 $63,606 RESEARCH, TESTING, & MEDICAL LABORATORIES Establishments 266 51.8% 27,154 57.7% Employment 6,454 68.1% 558,140 46.1% Location Quotient 0.55 n/a Direct Effect Employment Multiplier 2.30 3.30 Total Employment Impact 14,845 1,853,127 Average Annual Wage $62,745 $80,785 TOTAL BIOSCIENCES INDUSTRY Establishments 752 28.4% 47,593 28.3% Employment 24,694 15.8% 1,420,324 15.8% Location Quotient 0.83 n/a Direct Effect Employment Multiplier 4.06 5.82 Total Employment Impact 100,374 8,040,636 Average Annual Wage $65,566 $77,595 TOTAL PRIVATE SECTOR Establishments 153,678 8.9% 8,860,956 13.8% Employment 2,387,924 2.1% 113,917,377 3.5% Average Annual Wage $38,752 $45,229 Note: U.S. employment metrics include Puerto Rico. Estimates of total employment impacts do not include Puerto Rico. Wisconsin Page 2

Bioscience Performance Metrics Bioscience Academic R&D Expenditures in Wisconsin, FY NIH Awards in Wisconsin, Medical $441,093 $393 Biological $252,199 $388 Agricultural Other Life $44,598 $15,783 $391 $389 $395 Bio/Biomedical Engineering $6,190 ARRA $441 $0 $100,000 $200,000 $300,000 $400,000 $500,000 Academic R&D Expenditures ($ Thousands) $0 $100 $200 $300 $400 $500 NIH Funding ($ Millions) Recent Clinical Trial Activities Clinical Trials by Phase in Wisconsin, Clinical Trials by Major Disease Category in Wisconsin, 100 Phase I Phase II 22 77 80 60 82 70 57 65 Phase III 116 40 20 22 12 42 Phase IV 21 0 30 60 90 120 Clinical Trials 0 Cancer Circulatory Heart Disease Infectious Disease Disease Category Neurologic Nutritional & Metabolic Other Wisconsin Page 3

Bioscience Talent Base Bioscience related Occupational Employment in Wisconsin, Bioscience related Degrees in Wisconsin, AY Agricultural, Food & Nutrition Scientists & Technicians 1,550 Agricultural, Food, & Nutrition Science Biological Scientists & Technicians Medical & Clinical Laboratory Technicians 2,890 7,870 Biological Bio Medical & Engineering Medical & Veterinary Associate's (AA/AAS) Bachelor's (BS/BA) Biomedical & Biochemical Scientists & Engineers 580 Other Life Science Fields Master's (MS/MA) Doctorate (PhD) 0 2,000 4,000 6,000 8,000 10,000 0 500 1,000 1,500 2,000 2,500 Occupational Employment Degrees Bioscience Venture Capital Bioscience related Venture Capital Investments in Wisconsin, Bioscience related Venture Capital Investments in Wisconsin by Segment, $117.1 Biofuels Biosensors $52.4 Biotech Animal $24.8 Biotech Equipment Biotech Human $2.5 $98.5 $43.7 Biotech Industrial Biotech Other $6.4 $3.0 $44.9 Biotech Research $12.4 Med/Health Info Tech Med/Health Products $4.7 $0.5 $0 $20 $40 $60 $80 $100 $120 Med/Health Services $1.0 Venture Capital Investments ($ Millions) Medical Diagnostics $42.2 Medical Therapeutics $29.3 Pharmaceutical $107.2 $0 $20 $40 $60 $80 $100 $120 Venture Capital Investments ($ Millions) Wisconsin Page 4

Bioscience Patents Bioscience related Patents in Wisconsin, Bioscience related Patents by Classification Group in Wisconsin, 361 Agricultural Bioscience 30 331 Biochemistry 468 337 356 379 Biotechnology Drugs & Pharmaceuticals Surgical & Medical Instruments Other Medical Equipment 151 134 383 688 423 Other Bioscience Related 333 0 100 200 300 400 500 0 200 400 600 800 Patents Patents State Bioscience Contact BioForward 455 Science Drive, Suite 160 Madison, WI 53711 P: (608) 236 4693 F: (608) 236 4695 www.wisbiomed.org Source Notes: Employment, Establishment, and Wage Data: U.S. Bureau of Labor Statistics, Quarterly Census of Employment and Wages (QCEW) industry data provided by the Minnesota IMPLAN Group, 2001 and. Employment Multipliers: U.S. Bureau of Economic Analysis RIMS II Employment Multipliers, (most currently available). Academic R&D Expenditures: National Science Foundation (NSF) Survey of Research and Development Expenditures at Universities and Colleges, and. NIH Funding: National Institutes of Health, Office of Extramural Research, Award Trends, Dollars Awarded by State, and. Clinical Trials: National Institutes of Health, Clinicaltrials.gov, trials that were initiated in. Higher Education Degrees: National Center for Educational Statistics, Integrated Postsecondary Education Data System (IPEDS),. Occupational Employment: U.S. Bureau of Labor Statistics, Occupational Employment Statistics (OES) survey data,. Venture Capital: Thomson Reuters VentureXpert Database,, as of January 15, 2010. Patents: U.S. Patent & Trademark Office data as available from the Thomson Reuters Delphion Patent Analysis Database,, as of January 15, 2010. For a more detailed discussion of the data and methodology used, please see the Appendix to the full national report. 2010 Wisconsin Page 5