Office: CLSB 5S 066 (via South Tower elevators)

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Raymond Phelps
6 years ago
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1 Syllabus BI417/517 Mammalian Physiology Course Number: Bi 417 ~ Section 001 / CRN BI 517 ~ Section 001 / CRN Course Title: Mammalian Physiology Credits: 4 Term/Year: Spring 2016 Meeting Times: T, Th 2-3:50 SRTC 247 *Note: This has changed Professor Name: Contact Information: Dr. Thomas V. Hancock (Ph.D.) Office: CLSB 5S 066 (via South Tower elevators) and SRTC 236 Phone: / thancock@pdx.edu Office Hours: Tuesday 11 am -12 pm SRTC 236 Wednesday 11 am -12 pm CLSB 5S066 Course Description: Physiology of the mammalian cardiovascular, respiratory, and renal systems with emphasis on homeostatic control and integration of these systems in normal and pathophysiological states. NOTE: This is a very human oriented course, not a survey of mammals in general, though all of the principles we discuss apply to mammals. For a more animal-centric view of the world you should strongly consider the Comparative Animal Physiology course offered by our department. Required Materials: Guyton and Hall Textbook of Medical Physiology, 12 th Ed. (ISBN ). Note that I have not required the most recent 13 th edition of this textbook in an effort to decrease textbook costs. Used editions are available online for reasonable prices. If you are interested in owning the latest and greatest 13 th edition or if you would like to have an electronic option, I will fully support that choice by providing reading outlines for both the 12 th and 13 th editions. Regardless of edition, you will primarily rely on your lecture notes and utilize the text for reviewing specific sections in order to better understand the primary lecture material, rather than as a comprehensive textbook where you would read the entire book. I would not recommend relying on an older version, especially since I have seen used editions of the 12 th edition for as low as $20. 1

2 Course Overview: Exam 1: Cellular Homeostasis, Membrane Potential & Cardiovascular System Introductory Information: Organization, homeostasis, membrane physiology, and action potentials Cardiac Physiology: Cardiac myocyte contraction, cardiac cycle, pressurevolume relationships, conduction system of the heart, intrinsic and extrinsic regulation of heart activity including autonomic regulation. Circulatory Physiology: characteristics of blood vessels, pressure-flowresistance, distribution of blood flow through intrinsic and extrinsic mechanisms including autonomic regulation. Exam 2: Capillary exchange, Lymphatics & Renal Capillary exchange and Lymphatics: Transport between capillary and interstitial fluid via diffusion, osmosis, and pressure; lymphatic circulation and edema; hypotension & hypertension. Renal System: Water budgets and volume distribution; renal system and the relationship to the vascular system; endocrine regulation of the renal system; renal tubule regulation of processing of filtrate; and diuretics. Exam 3: Pulmonary System & Acid/Base Physiology Blood gas transport of oxygen and carbon dioxide: Hemoglobin, whole blood, and anemia. Pulmonary ventilation: pressure, flow and resistance of ventilation; lung volumes; total and alveolar ventilatory exchange; pathophysiologies of ventilation. Alveoli and pulmonary capillaries: Flux of gases across the respiratory membrane; partial pressures of gases. Oxygen: Transport, oxygen carrying capacity of blood; saturation kinetics of Hb; hypoxia and anemia. Carbon dioxide: Transport, hypercapnia and hypocapnia, acid/base interactions. Ventilatory Control System: Peripheral and Central mechanisms, nervous pathways, chemical stimuli. Ventilation & Pulmonary Perfusion Matching: Mechnisms of normal matching; pathophysiology of mismatch: insufficient perfusion vs. insufficient ventilation; arterial-alveolar oxygen gap. Acid/Base: Interaction of pulmonary and renal systems; pathophysiology. Activity: Changes in cardiopulmonary activity; changes in oxygen extraction; contribution of anaerobic pathways. 2

3 Outline and Reading: See initial Reading Assignment and Outline below that approximately covers the first week. Reading assignments and outlines will be updated throughout the quarter. Exam 1 Outline A. Introduction and Chapter 1,2 1. What is Physiology? 2. Organization 3. Cells 4. Homeostasis 5. Homeostatic systems 6. Example: Blood Glucose Control a. Increased Blood Sugar Response b. Decreased Blood Sugar response c. Blood Sugar Control Ability B. Chapter 4: Membrane Physiology, Nerve, and Muscle 1. Separation 2. Transport across Cell Membrane a. Diffusion i. electrochemical gradient ii. Permeability? Varies: Selective Permeability b. Osmosis c. Carrier Mediated Transport i. Facilitated Diffusion ii. Active Transport iii. Secondary Active Transport C. Chapter 5 1. Resting Membrane Potential 2. Nernst Equation a. Ex1 Sodium: b. Ex2 Chloride 3. Goldmann-Hodgkin-Katz Equation (GHK) 4. Action Potentials 5. Propagation of AP 6. Other AP examples Exam 1 Reading 12 th Edition Week 1: Chapters 1,2,4,5 Ch. 5: Ignore research method for measuring on page th Edition Week 1: Chapters 1,2,4,5 3

4 Exams & Grading Scheme: Exam Schedule % of Course Grade Lecture Exam 1 Tuesday April 19th (week 4) 30% Lecture Exam 2 Thursday May 12th (week 7) 30% Final Exam Monday June 6 th 10:15 am 11:45 am 40% 100% Assigned Grades will be based on the following scale: A =93-100% B =83-86% C =73-76% D =63-66% A- =90-92% B- =80-82% C- =70-72% D- =60-62% B+ =87-89% C+ =77-79% D+ =67-69% F =<60% ** The instructor reserves the right to curve the course more generously than that stated above. BI 517: If you are taking the course for graduate credit, you will be required to research a topic to be mutually decided between the instructor and yourself, and you willl write a 4-6 page paper (12 point Times New Roman 1 inch margins double spaced), along with a literature review of the topic (minimum 7 papers total, 5 of which must be primary research) and give a presentation on that topic to the class (to be arranged toward the final weeks of the course). This will constitute 10% of your course grade and the exam grades below will be weighted the same proportionally and constitute the other 90% of the grade. Other Information: Exams: Lecture exams will be a combination of multiple choice, fill in the blank, true/false, and short answer questions and definitions. There is NO opportunity for extra credit. The final exam will include a comprehensive portion worth 10% of your overall grade. There are NO makeup exams. Please plan your schedule accordingly. You must take EVERY lecture exam at the assigned time or you cannot earn a passing grade. These can only be made up in the event of documentable emergencies, in which case an incomplete grade will be assigned and the exam will be made up when the course is offered again. 4

5 Academic honesty statement: Cheating or any kind of academic dishonesty will not be tolerated. Students caught cheating will, at a minimum, receive a zero on the exam and be reported to the office of the Dean of Student Life at PSU. If you are unclear about the policies related to academic misconduct and the student conduct code, see: Disability Resource Center: If you are a student with a documented disability and are registered with the Disability Resource Center, please file your paperwork by the first day of class. Contact the testing center immediately to arrange a scheduled exam appointment that overlaps with the exam time in lecture. Contact me (the instructor) to let me know when you have made these arrangements. No accomodations can be made without filing the proper paperwork. D2L: The Desire to Learn online software will be used to communicate important information in the course and to deliver important documents. Please be sure you are aware how to access the course website as soon as the course starts (D2L.pdx.edu). Attendance: Students are expected to attend all lectures, though attendance will not be taken. Please arrive in a timely manner. Problem Sets: Problem sets will be assigned periodically throughout the quarter. These are not turned in or graded and only quantitative answers will be provided. While not comprehensive for the material (not a study guide), examples of most categorical concepts will be included, and most logical or quantitative process based topics will be covered. I will not surprise you with any novel mathematical questions on the exam. Problem sets are a very good indication of the range of material that the instructor finds reasonable to place upon the exams. Study Skills: This is an advanced biology course. Students should be prepared to spend a great deal of outside time on this course. Keeping up on the material is imperative, and studying a lecture within a day will allow you to better comprehend the following lecture. Reading alone will be substantial but reviewing notes and doing problem sets will also require a great deal of time. Lecture material and problem set questions may be reviewed with the instructor during office hours. Mathematics: Math will be utilized within this course though basic algebra is the only applied type of mathematics. You will be required to utilize a basic scientific calculator for exams that is not a graphing calculator with extensive memory but one that can calculate logarithms and exponents. I will have several appropriate calculators at the exam if you are unable to obtain one. 5

6 Prerequisites: Introductory biology, chemistry, and physiology prerequisites are not enforced in this course, but are very helpful for the highly integrative nature of this course. Reading Assignments and Studying for the Course: My general advice for studying is to at least survey the reading beforehand to become familiar with the general systems, and especially to become familiar with the vocabulary so that you will be able to comprehend the lecture which proceeds quickly. Lecture attendance, or obtaining and understanding lecture notes in case of emergency, is imperative in this course. Utilizing the book to further understand the lecture material afterwards and studying problem sets is imperative to your success. All assigned reading may be covered by the exam though the emphasis will be upon the material presented in lecture. 6

Fortis College, Cincinnati Ohio

Fortis College, Cincinnati Ohio COURSE CODE: Bio111 Introduction to Anatomy and Physiology Course Description This course is a basic introduction to the structure (anatomy) and function (physiology) of the human body. Correct medical