2007 Annual Report EVOLUTION OF SCIENCE & MEDICINE

Transcription

1 2007 Annual Report EVOLUTION OF SCIENCE & MEDICINE

2 KNOWING IS NOT ENOUGH; WE MUST APPLY. BEING WILLING IS NOT ENOUGH; WE MUST DO. Leonardo da Vinci Contents A MESSAGE FROM LEADERSHIP BUILDING STRENGTH TRANSFORMING CARE FOSTERING DISCOVERY CULTIVATING INNOVATION CREATING COMMUNITY ADVANCING KNOWLEDGE FINANCIALS LEADERSHIP RECRUITMENT & PROMOTIONS FEDERAL GRANTS PHILANTHROPY IN THE WORLDS OF SCIENCE AND MEDICINE, THE ONLY CONSTANT IS CHANGE. AND AT THE UNIVERSITY OF CHICAGO, THE CONSTANT EVOLUTION OF RESEARCH, TECHNOLOGY AND CLINICAL PRACTICE KEEPS THE MEDICAL CENTER AND THE DIVISION OF BIOLOGICAL SCIENCES AT THE FOREFRONT OF THOSE WORLDS. CHANGE DEMANDS THAT WE EXTEND RESEARCH INTO THE BASIC BIOLOGY OF DISEASE. IT REQUIRES US TO USE NEW TOOLS, SUCH AS ROBOTIC SURGERY, TO IMPROVE TREATMENT. IT PROMPTS US TO COLLABORATE WITH LOCAL HEALTH INSTITUTIONS TO CREATE A NETWORK OF MEDICAL CARE FOR OUR IMMEDIATE NEIGHBORS. TECHNOLOGY TRANSFORMS THE WAY PEOPLE WORK AND LEARN, THE WAY SCIENTISTS CONDUCT RESEARCH, AND THE WAY PATIENTS RECEIVE TREATMENT. SCIENCE AND MEDICINE ARE EVOLVING, AND THE UNIVERSITY OF CHICAGO MEDICAL CENTER IS STEERING THE WAY ANNUAL REPORT 1

3 At the University of Chicago Medical Center, evolution is more than a field of study or classroom discussion. It is an expectation, a way of making things better day after day. Physicians, scientists, nurses, staff, students and administrators here drive institutional evolution. They advance our understanding of the world and of medicine, and apply those advances to patient care. This year the pace of change has quickened. The result is an institution that is constantly adapting to new methods and to novel circumstances. It is an institution that is coming closer together forming innovative, cooperative partnerships with other institutions and collaborating with the community. THIS ALWAYS HAS BEEN A PLACE WHERE RESEARCH AND TEACHING MEET APPLIED MEDICINE. NOW, THEY EVOLVE TOGETHER A SYMBIOTIC RELATIONSHIP IN WHICH STUDENTS LEARN FROM LEADING EXPERTS, PATIENTS BENEFIT FROM THE LATEST INNOVATIONS, AND SCIENTISTS THRIVE WORKING WITH THE MOST ADVANCED TECHNOLOGY AND LEADERS ACROSS FIELDS. One example of this comes from a new book, Your Inner Fish, by Neil Shubin, PhD, associate dean for organismal and evolutionary biology. As a paleontologist, Dr. Shubin studies fish fossils, including a species that evolved to live on land 375 million years ago. It turns out, he wrote, that being a paleontologist is a huge advantage in teaching human anatomy. The best road maps to human bodies lie in the bodies of other animals. The simplest way to teach students the nerves in the human head is to show them the state of affairs in sharks. That sort of cross-boundary thinking also reaches into the realm of patient care and cost efficiency. Medical Center President David Hefner has consolidated, standardized and streamlined many of the Medical Center s complex processes in ways that have improved our patients experiences and outcomes while reducing costs, a key component in the Medical Center s strong financial performance in a difficult fiscal environment. Another evolution in thinking is the growing bond between the Medical Center and the surrounding community. Our work through the South Side Health Collaborative has helped patients find primary care close to home, and the ongoing evolution of that program has inspired us to extend our connections to multiple health care centers and general care hospitals nearby. In research and education, our ties with other institutions are helping us expand our reach. Our deepening relationship with Argonne National Laboratory, a Department of Energy facility 25 miles to the west, has enabled our researchers to exchange ideas and technologies with those at Argonne and to advance research in a variety of fields. Due to these collaborations, our reputation as a leading center for research, teaching and patient care continues to rise. Not only was the Medical Center on the U.S. News & World Report Honor Roll of the nation s best hospitals, but also the Pritzker School of Medicine rose another notch in the education hierarchy, making it the fastest rising medical school in the country, moving up seven slots since At this institution, diverging branches of science and medicine change, evolve and continue to grow together. This is, in fact, written in stone. Valerie B. Jarrett Chair, University of Chicago Medical Center Board of Trustees James L. Madara Chief Executive Officer, University of Chicago Medical Center Vice President for Medical Affairs, University of Chicago Dean of the Division of the Biological Sciences and the Pritzker School of Medicine The words etched into this entryway encapsulate the three branches of the one institutional tree: the University of Chicago Medical Center. The University of Chicago University Clinics is inscribed above, with The Pritzker School of Medicine on one side and The Division of the Biological Sciences on the other. As the three branches intertwine, they distinguish and define the evolving nature of this institution. 2 UNIVERSITY OF CHICAGO MEDICAL CENTER 2007 ANNUAL REPORT 3

4 A pharmacy technician readies chemotherapy treatment; U.S. News & World Report ranks UCMC s cancer program No. 7 nationally. BUILDING STRENGTH INNOVATION IS A HALLMARK OF THE UNIVERSITY OF CHICAGO. THE UNIVERSITY S REPUTATION FOR ADVANCING THE BOUNDARIES OF EDUCATION IS SHARED AND STRENGTHENED BY THE MEDICAL CENTER, THE DIVISION OF BIOLOGICAL SCIENCES AND THE PRITZKER SCHOOL OF MEDICINE. IT S A REPUTATION BUILT ON THE CARE AND INNOVATION THAT FACULTY AND STAFF EXHIBIT EVERY DAY. EVIDENCE OF IT CAN BE FOUND IN THE NATIONAL RANKINGS, GRANT FUNDING AND AWARDS THE INSTITUTION CONTINUES TO ACCRUE. EACH YEAR, U.S. NEWS & WORLD REPORT RANKS THE NATION S HEALTH CARE CENTERS, AS WELL AS COLLEGES AND GRADUATE PROGRAMS. IN 2007, AS IN YEARS PAST, THE UNIVERSITY OF CHICAGO WAS WELL REPRESENTED ON THOSE LISTS. Opening next year, the Jules and Gwen Knapp Center for Biomedical Discovery will house translational research programs in cancer and other medical specialties. Academically, the University of Chicago fared exceedingly well in these rankings. Two bioscience graduate programs paleontology and ecology/evolutionary biology were ranked the best in the nation. The Pritzker School of Medicine was 15 th on the list. Graduate programs in the biological sciences ranked 18 th overall. Of more than 5,400 hospitals evaluated, the Medical Center tied for 17 th, and because the University of Chicago scored highly in so many areas, it earned a spot in the magazine s elite list of Honor Roll hospitals. Two specialty programs were ranked in the top 10 nationally: digestive disorders at No. 6 and cancer at No. 7. Six other programs ranked in the top 25 of their fields: endocrinology (No. 11), neurology and During fiscal year 2007, the University of Chicago Medical Center progressed in several key areas, including revenue and cost control, under the combined leadership of David Hefner (left), president of UCMC, and James Madara, MD, chief executive officer of UCMC and dean of the Biological Sciences Division. neurosurgery (No. 14), kidney disease (No. 22), heart and heart surgery (No. 23), geriatrics (No. 24) and ear, nose and throat (No. 25). Additionally, the gynecology and respiratory disorders programs scored in the top 50. These lists put the University of Chicago in a class of its own in Illinois. NO OTHER HOSPITAL IN THE STATE HAS EVER MADE THE U.S. NEWS HONOR ROLL, AND NO OTHER GRADUATE PROGRAM HAS SCORED IN THE TOP 20 IN MEDICAL EDUCATION OR THE BIOLOGICAL SCIENCES OVERALL. Physicians and professors were not the only Medical Center employees recognized nationally this year. In the United States, the best hospital nursing staffs are honored with Magnet status by the American Nurses Credentialing Center. Fewer than 5 percent of hospitals nationwide have earned that status. In February 2007, Medical Center nurses won that prestigious honor. Magnet status recognizes only hospitals where patient care is at the highest level of excellence, with outstanding patient outcomes and shorter stays. University of Chicago physicians have long been recognized as among the best in the nation. Now, with Magnet status, Medical Center nurses are receiving recognition for their national prominence as well. This was an important step for us as an institution, said Medical Center President David S. Hefner. If we re going to focus on the most difficult cases, we have to provide superb nursing care. Receiving Magnet status is evidence that we do. It provides outside verification of the excellence of our nurses something we are proud of and have always known. 4 UNIVERSITY OF CHICAGO MEDICAL CENTER 2007 ANNUAL REPORT 5

5 Olufunmilayo Olopade, MD, won a 2006 MacArthur Fellowship, commonly called a genius grant. Jeffrey Matthews, MD, chairman of surgery, has been a driving force in surgical innovation. The past year has been a time of transition, as well as honor. In 2006, the hospitals and the Biological Sciences Division reorganized to create the University of Chicago Medical Center. By combining resources and services, the two parts of the institution have been able to work more cooperatively and smoothly under the umbrella leadership of CEO and Dean James Madara. The organizational change is just one sign of how the institution is evolving to create a better place for inquiring, learning and healing. Success in attracting support from public and private sources is another. Chicago physicians and scientists continue to compete successfully for grants and awards that support their work. A $23 million grant recently awarded to Chicago is a prime example. One of 12 Clinical and Translational Science Awards made by NIH nationally, this grant ultimately will enable researchers to provide patients new and better treatments more efficiently and quickly. Chicago will apply that funding in a variety of ways to transform research discoveries into new therapies. 6 UNIVERSITY OF CHICAGO MEDICAL CENTER A recent addition to the faculty, Sudhir Srivastava, MD, is the world leader in totally endoscopic coronary artery bypass surgery, a revolutionary procedure that frees the patient from an invasive, sternum-splitting operation. An $11.5 million grant obtained in the past year has enabled Olufunmilayo Olopade, MD, and a team of doctors to explore new avenues of research in breast cancer. Olopade, a 2006 MacArthur Fellow, and co-principal investigators Gini Fleming, MD, and Maryellen Giger, MD, lead a team of 11 basic, clinical and population-science investigators to focus on more effective ways to prevent and detect an aggressive type breast cancer and treat women at increased risk for it. The University also has become a national leader in health disparities research, and the nonprofit, health-focused Robert Wood Johnson Foundation selected the Medical Center to distribute $6 million in grants for work in this area. Those grants fund numerous ways to study and eventually help remedy the inequities in health care at clinics and research institutions both here and abroad. The Medical Center especially stands out when patients with complex diseases need urgent access to multiple specialists. Since 1983, the University of Chicago Aeromedical Network (UCAN) has transported critically ill or injured neonatal, pediatric and adult patients to the University of Chicago Medical Center or other hospitals from the scenes of emergencies and in inter-hospital transfers. Staffed by specially trained flight nurses, residents, dispatchers and pilots who are prepared to fly at a moment s notice, UCAN is one of only a few such programs in the United States. Individuals at the Medical Center also have earned high honors. In June, Richard Schilsky, MD, an internationally recognized expert in gastrointestinal cancers, cancer pharmacology and drug development, was named president-elect of the American Society of Clinical Oncology, the world s leading professional organization representing physicians who care for people with cancer. Schilsky, who served as associate dean for clinical research at the Medical Center prior to his election, will take office in June And after serving as president-elect, Jeffrey Apfelbaum, MD, the chairman of anesthesia and critical care, recently was installed as president of the American Society of Anesthesiologists during the organization s annual meeting, held this past October. An authority on the surgical treatment of diseases of the pancreas, bile ducts and liver, Jeffrey Matthews, MD, joined the Medical Center team in late As chairman of surgery, Matthews has brought new leadership to an already well-recognized department. Medical Center nurses gained Magnet status in 2007, the nation s highest honor for nursing excellence ANNUAL REPORT 7

6 TRANSFORMING CARE MEDICINE TRANSFORMS THE WAY WE LIVE. NOT SO LONG AGO, WOMEN GAVE BIRTH AT HOME, POLIO LEFT PEOPLE DISABLED, AND VACCINES WERE UNCOMMON. MEDICAL BREAKTHROUGHS WILL CONTINUE TO CHANGE SOCIETY. BUT THE UNIVERSITY OF CHICAGO IS TRANSFORMING LIVES RIGHT NOW THROUGH SPECIALIZED TREATMENT AND ADVANCED CARE. LIKE CHEF GRANT ACHATZ. RENOWNED FOR HIS AVANT-GARDE DISHES, HE HAD BECOME A NATIONAL SENSATION BY SUMMER 2007, WINNING RAVE REVIEWS FOR HIS RESTAURANT, ALINEA, WHICH WAS NAMED AMERICA S BEST RESTAURANT BY GOURMET MAGAZINE. Many women from across the United States who have lost a pregnancy in the second trimester turn to Arthur Haney, MD, for his expertise in performing abdominal cerclage. When a spot on his tongue first appeared, Achatz s dentist told him not to worry. When it got bigger he saw a doctor, but a biopsy came back negative. When it continued to grow and began causing pain, discomfort while eating and impediments to his speech, another doctor found a tumor. Achatz, one of the world s top chefs, had stage 4B squamous cell carcinoma of the oral tongue. Then 33, he consulted with several cancer specialists from across the United States who all told him that his only treatment option was surgery to remove nearly three-quarters of his tongue, which would include his taste buds. Faced with a life-threatening disease and a careerthreatening decision, Achatz turned to University of Chicago oncologist Everett Vokes, MD, for yet another opinion. Vokes, along with several other University of Chicago head and neck cancer experts, suggested a clinical trial that compared two slightly different combinations of chemotherapy and radiation therapy to treat the cancer. If the first-line therapy worked, Achatz would not require surgery saving his taste buds. For Vokes, Achatz s treatment plan was no different from what other University of Chicago patients with advanced, nonmetastatic tongue cancer receive. We re giving Grant what we think should be the first line for the typical patient, Vokes said in the Oct. 22, 2007, issue of People magazine. We don t change that because a famous chef comes here. Though Susan Cohn, MD, and John Cunningham, MD, together have steadily increased the number of pediatric clinical trials at the Medical Center. Achatz is a star in the world of modern cuisine, doctors use the same pioneering treatment for anyone looking for innovative ways to beat cancer. The cancer care at the Medical Center allowed Achatz to continue working at his popular restaurant and assembling a cookbook that is slated to come out this year. His story was featured in many news outlets as he went through treatment. The culinary world and much of the mainstream media seemed to be pulling for the young chef who faced a terrible prospect for his professional future and for his personal well-being. The treatment worked. In December 2007, just a few months after beginning therapy, doctors told Achatz that his cancer was in full remission. Achatz released a statement at the time: Where other doctors at prominent institutions saw little hope of a normal life, let alone a cure, these doctors saw an opportunity to think differently, preserve my tongue and taste, and maintain a long-term high quality of life. Through the use of a new and rigorous chemotherapy and radiation protocol, they were able to achieve a full remission while ensuring that the use of invasive surgery on my tongue was not needed. In its more day-to-day operations as well, the Medical Center is renowned for advanced care and individualized treatments. Modern technology and new research drive new interventions, and patients reap the benefits of those advances. For example, couples have flown from as far as Nigeria and Norway for treatment at the Center for Reproductive Medicine and Fertility, a University of Chicago clinic and laboratory in Chicago s West Loop. Directed by David Cohen, MD, the center serves women and couples who are searching for answers to complex reproductive health and infertility questions. During the past year, the center s doctors and staff have performed more than 300 assisted reproductive technology procedures. But the number of procedures is not what makes the center unique. It is the willingness and ability of the physicians, nurses and staff to individualize treatments. The facility is gaining national and international distinction as clinicians and staff dedicate themselves to care for patients who hope to preserve fertility prior to cancer therapies and for those who require gestational surrogacy or egg donors. 8 UNIVERSITY OF CHICAGO MEDICAL CENTER When chef Grant Achatz was diagnosed with advanced tongue cancer, several renowned specialists suggested he have his tongue removed. But he was able to keep his taste buds thanks to an innovative University of Chicago clinical trial ANNUAL REPORT 9

7 Brittany and her parents THE MEDICAL CENTER HAS RECRUITED SEVERAL LEADERS IN PEDIATRIC HEMATOLOGY AND ONCOLOGY WHO BRING AN UNPRECEDENTED LEVEL OF EXPERTISE TO THAT SECTION S RESEARCH AND THERAPIES AND more time to transport the organ. The device may increase the donor supply, too, by allowing a heart that might otherwise have been considered unfit for transplant to stabilize. The University of Chicago is the third medical center in the United States to use the device with patients. WHO ARE SEEKING MORE EFFECTIVE TREATMENTS FOR CANCER AND OTHER CONDITIONS. In early 2007, Susan Cohn, MD, came to Chicago to develop a pediatric clinical trials office. An expert in neuroblastomas (cancerous nerve tumors), Cohn has helped develop the infrastructure for such trials and actively encourages parents to enroll their affected children in the studies. The number of pediatric patients enrolled in cancer clinical trials has increased six fold during the past year with the help of John Cunningham, MD, who joined the Medical Center staff in late Cunningham, section chief of pediatric hematology and oncology, is an internationally known expert in childhood cancers and blood diseases. He was part of a research team at St. Jude Children s Research Hospital that developed a technique enabling physicians to perform parental bone marrow transplants for children without an exact donor match. While typical donor matches require a six-point match on a specific chromosome, the scientists found a way to perform the transplant using a three-point match which a willing, available, biological parent can provide. In the past year, the researchers and doctors in pediatric hematology and oncology have focused on coordinating their efforts with adult-oriented research at the Medical Center. Cohn is teaming up with Christine Hartford, MD, a pediatric cancer specialist, and Mark Ratain, MD, an authority on solid tumors and a specialist in pharmacogenetics, to test new medications on children and young adults with cancer. The new director of pediatric oncology, Stephen Skapek, MD, is tackling kids cancer another way. Skapek studies several types of developing cells, specifically blood vessel cells in developing eyes and immature skeletomuscular cells. His research on how those cells grow or don t will enable him to develop ways to stymie cancer cells. As more patients participate in clinical trials and scientists discover new treatments for pediatric cancers and blood diseases, heart patients also will be helping to break new Valluvan Jeevanandam, MD, holds a mechanical valve currently in clinical trial that may allow patients with replacement valves to stop using blood thinners. ground at the University of Chicago. The cardiac and thoracic surgery section currently is conducting two ongoing trials that take advantage of new technology or therapies. A small piece of equipment about the size of a cardboard moving box, for example, could mean faster recovery times and increased chances for heart transplant patients. The small machine, called the TransMedics Organ Care System, can hold a beating heart and enable doctors like Valluvan Jeevanandam, MD, chief of the cardiac and thoracic surgery section, to transfer a heart without soaking it in a preservative solution and cooling it. Currently, a donor heart goes into a jar filled with such a solution. Sometimes that heart doesn t work well afterward. Another hurdle of heart transplantation is that the donor heart must be transplanted within four hours, limiting the geographic boundaries of recipients. The TransMedics machine keeps the heart beating so that Jeevanandam and other physicians have Cardiac and thoracic surgeons also are exploring the use of a mechanical valve that is durable enough to last many years without replacement and doesn t require the patient to stay on blood thinners indefinitely. This past fall, some Medical Center patients began participating in a study in which they received the On-X (SP) mechanical valve, allowing them to stop taking blood thinners after six months. The FDA has approved the valve for use with blood thinners; this study will determine if patients can safely stop taking that medication. A similar study has been completed successfully in Europe, and Chicago is one of many institutions participating in the U.S. trial. Sometimes the evolution of medicine means using existing technologies for new purposes. Radiologist Abraham Dachman, MD, has been ahead of the pack with the use of the virtual colonoscopy, a procedure that uses a CT scan to look for polyps in the colon. Instead of using an invasive scope, Dachman inflates a patient s colon with carbon dioxide, then acquires images from the CT scan to analyze the intestinal tract. Patients have minimal discomfort during the procedure, and, unlike traditional colonoscopy, they don t have to undergo anesthesia. The evolution of medicine also means improving patient care. Like many other specialties at Chicago, diabetes care has become more individualized for patients. The Kovler Diabetes Center, which opened in January 2007, offers patients examinations, second opinions and educational opportunities. The center also partners with researchers, which could lead to more clinical studies and trials of innovative treatments with patients there. The facility, which brings individual resources together under one umbrella, will help to communicate and foster interaction between the clinical and research halves. Biochemist Christopher Rhodes, PhD, oversees the center s research side. Chicago scientists are investigating wide-ranging aspects of diabetes, including its complications, the effects of new drugs, genetic susceptibility and new forms of this disease. The Goodrich family About four years ago, 13-year-old Brittany Goodrich approached her mother, ready to admit she had a problem. She was 5 5, 94 pounds and obsessed with which foods to eat. Brittany and her parents started seeing a counselor, then a dietician and finally a psychiatrist. But months into treatment for anorexia nervosa, Brittany was not regaining lost weight. When her parents heard about a treatment called the Maudsley approach, which actively involves the family during meal times, the Goodriches sought a practicing doctor and found Daniel le Grange, PhD, who trained at the Maudsley Hospital in London and is the director of the eating disorders program at the University of Chicago. Building on his work on anorexia nervosa, Le Grange recently published a study that shows nearly 40 percent of bulimia nervosa participants in family-based treatment stopped binging and purging, compared to only 18 percent of those who received supportive psychotherapy, the standard therapy. Six months after treatment, almost 30 percent of participants who received family-based treatment were still abstinent compared to only 10 percent of participants who received supportive psychotherapy, which focuses on issues underlying the eating disorder. Parents are in a unique position to help their adolescents with eating disorders, Le Grange said, yet treatment typically excludes them from the process. Now we have substantial evidence that we need to bring them back in. Brittany has progressed at a modest pace and has gained more than 30 pounds in the three years since she has been seeing Le Grange. 10 UNIVERSITY OF CHICAGO MEDICAL CENTER 2007 ANNUAL REPORT 11

8 Slated to open this summer, the University of Chicago Howard T. Ricketts Lab, a new Biosafety Level 3 facility at Argonne National Laboratory, will provide safe and ultramodern space for scientists to conduct advanced research in biodefense and infectious disease. FOSTERING DISCOVERY 12 UNIVERSITY OF CHICAGO MEDICAL CENTER From 21 st century research to fossils that are hundreds of millions of years old, University of Chicago scientists are making discoveries that reach the very foundation of biological evolution. Paleontologist Neil Shubin, PhD, was named associate dean for organismal biology and anatomy at the University and provost of the Field Museum in A few months before, with colleagues from the Academy of Natural Sciences in Philadelphia and Harvard University, Shubin published two reports about Tiktaalik roseae, a 375-million-year-old species that bridges the gap between fish and land animals. Neil Shubin, PhD, has helped the world understand the evolutionary journey of the human body in his new book, Your Inner Fish. Fossils of the creature, found on Ellesmere Island in Arctic Canada, are the most compelling examples yet of an animal that was at the cusp of the fish-tetrapod transition. Tiktaalik s skull, neck, ribs and parts of its limbs are similar to those of four-legged animals known as tetrapods, but Tiktaalik also had fish-like features, such as a primitive jaw, fins and scales. The finding was featured on the cover of Nature and was the subject of back-to-back research papers. It was also the impetus for Shubin s recent book, Your Inner Fish: A Journey Into the 3.5-Billion-Year History of the Human Body. While Shubin was discovering a creature that was bridging an evolutionary gap, Michael Coates, PhD, another evolutionary developmental biologist at Chicago, was examining how one creature seems to defy that scientific process. Coates worked with researchers from the University of Witwatersrand in Johannesburg, South Africa, to show that modern lamprey species have remained much the same throughout at least 360 million years of independent evolutionary history. Lampreys lack jaws, teeth, scales, paired fins, and any trace of bone or hard tissue. Some of the modern forms are parasitic and attach themselves to and feed on other fish. Fossil lampreys are exceptionally rare, and Coates and his colleagues discovery of the earliest known example, found in the Eastern Cape of South Africa, revealed an extraordinary match between ancient and modern forms. Their finding, like Shubin s, was featured in Nature. Research at Chicago often leads to stimulating discussions, whether they focus on evolutionary biology, new technologies and treatments, or better care for patients. And no subject is off limits. The news stories flooded in when Stacy Tessler Lindau, MD, MAPP, and Chicago colleagues released the results of their survey of seniors sex habits in The New England Journal of Medicine. Canada s Globe and Mail trumpeted, Late-life lovin indicates more than just mojo. Even ABC News couldn t resist having a little fun with the headline, Grandma s Still Got It: Sex Persists Into the 80s. The survey found that most people ages 57 to 85 think of sexuality as an important part of life and that the frequency of sexual activity, for those who are active, declines only slightly from the 50s to the early 70s. The study also found that sexual activity is closely tied to overall health, which is even more important than age. As health declines steadily after the early 70s, so does the prevalence of sexual activity, particularly for women. Farr Curlin, MD, tackled an equally attention-grabbing subject: religion. An authority on the religious beliefs of physicians, Curlin explored several facets of medicine and religion, including what types of doctors are most and least religious and how doctors religious commitments influence their decisions to treat underserved populations. Curlin and his colleagues surveyed 1,144 practicing physicians from all specialties. Family physicians are found to be the most religious, psychiatrists the least. But religion appears to play little role in the likelihood of whether a doctor will care for the underserved; less religious doctors are found to serve that population more frequently. Curlin also explored how conscience and religion affect doctors treatment recommendations. DISCOVERY AT CHICAGO ENCOMPASSES MORE THAN SURVEYS AND RESEARCH STUDIES. COLLABORATION IS A MAJOR PART OF THE WORK MANY SCIENTISTS PERFORM HERE, AND THE HOWARD T. RICKETTS REGIONAL BIOCONTAINMENT LABORATORY IS A LEADING EXAMPLE OF CHICAGO S COOPERATION WITH ARGONNE NATIONAL LABORATORY, A DEPARTMENT OF ENERGY FACILITY ANNUAL REPORT 13

9 Lilly Jaffe Changing diabetes care Scientific inquiry and collaboration are key factors in the pursuit of excellent health care. Endocrinologist Louis Philipson, MD, PhD, and geneticist Graeme Bell, PhD, worked together to provide one patient and eventually many others with a better way to treat diabetes. The first was 6-year-old Lilly Jaffe, who spent most of her young life dealing with insulin shots, blood-glucose gauges and constant monitoring of her diet, calories and sugar levels. Diagnosed with Type 1 diabetes when she was just one month old, Lilly became accustomed to a life of interrupted play and frequent visits to the school nurse. But all that changed during the summer of 2006, when Lilly visited physicians at the University of Chicago Medical Center. Before doctors and researchers around the world read about similar cases in the Aug. 3, 2006, issue of The New England Journal of Medicine, British scientist Andrew Hattersley had discovered that sulfonylurea drugs used to treat Type 2 diabetes patients also could work for certain patients with permanent neonatal diabetes, an early-onset form of Type 1 diabetes that can be caused by rare genetic mutations. Within weeks of Hattersley s pre-publication talk in May, a University of Chicago team was preparing to treat Lilly, who had one of those mutations, with sulfonylurea drugs. Over a week-long stay in Chicago s Clinical Research Center, Philipson and Bell watched carefully as Lilly began taking pills and was weaned off of her insulin. Six pills a day now help her pancreas to regulate her insulin levels without shots. Lilly became the first Chicago patient to be treated in this way for neonatal diabetes. In the year since Lilly began her new treatment, Philipson and Bell diagnosed more than 20 children with the same mutation. They also have found a series of new mutations in the insulin gene itself that causes the equivalent of Type 1 diabetes in both children and adults. Many have heard about Lilly s treatment through newspaper articles or television coverage, and they have turned to the University of Chicago for hope. Discovery at Chicago encompasses more than surveys and research studies. Collaboration is a major part of the work many scientists perform here, and the Howard T. Ricketts Regional Biocontainment Laboratory is a leading example of Chicago s cooperation with Argonne National Laboratory, a Department of Energy facility. The Ricketts lab is a new Biosafety Level 3 (BSL3) facility part of the National Strategic Plan for Biodefense and Infectious Disease Research and supported by the National Institutes of Health that will provide biocontainment space vital to scientists conducting advanced research in biodefense and infectious disease. Once construction of the lab is completed in early 2008, researchers there will study the biology of emerging diseases and disease-causing agents, test the usefulness of new drugs and vaccines, and develop novel tools to detect, treat and prevent illness. The facility will meet or exceed the highest standards for biocontainment. Few laboratories in the United States are capable of safely working on multiple microbes that cause diseases such as anthrax, plague and hemorrhagic fever, said Olaf Schneewind, MD, PhD, the Chicago microbiologist who heads the Ricketts project. The lab will support the very best science and technology in a central, state-of-the-art facility to produce drugs, vaccines and diagnostic devices to counter bioterrorism and emerging infectious diseases. Though smaller BSL3 labs are in place at the University and at Argonne, the $31 million, 35,000-square-foot Ricketts facility will enable researchers to study more pathogens in greater depth. Some of the organisms considered for possible study there are anthrax, methicillin-resistant Staphylococcus aureus and Yersinia pestis, which causes plague. The lab named for Howard Taylor Ricketts, a researcher at the University of Chicago who discovered the organisms that cause Rocky Mountain spotted fever and typhus is one of nine Regional Biocontainment Laboratories funded by the National Institute of Allergy and Infectious Disease. Work at the Ricketts lab will support the Great Lakes Center of Excellence, a consortium of 14 NIAID-funded research institutions in the Midwest headed by Schneewind. Further solidifying Chicago s relationship with Argonne, the Institute for Genomics and Systems Biology was created last year. Bridging work from the two research organizations, scientists at the institute work to encourage cutting-edge developments in genomics and systems biology. The institute s director, Kevin White, PhD, already has been awarded a $9.1 million grant from the to study the genome of the fruit fly. The award is part of a $57 million scientific mission the ENCyclopedia Of DNA Elements (ENCODE) to understand every part of the genome needed for organisms to develop and survive. With the help of colleagues, White s research could lead to important developments in how researchers study the human genome because so much of human disease and evolution, such as susceptibility to disease and other differences among individuals, is based on expression of genes. The collaboration between Argonne and Chicago is advantageous for both institutions. Argonne scientists have the opportunity to research topics that are outside the typical realm of the Department of Energy, with easier access to students and fellows. And collectively, both teams have a larger pool of scientists to work with, as well as access to different kinds of projects and a broader scope of programs. Kevin White, PhD, leads the Institute for Genomic and Systems Biology, a joint effort with Argonne National Laboratory. By scanning the human genome in search of variations that may signal recent evolution, Jonathan Pritchard, PhD, found more than 700 genes that appear to have evolved during the past 10,000 years of human evolution and may still be evolving. 14 UNIVERSITY OF CHICAGO MEDICAL CENTER 2007 ANNUAL REPORT 15

10 HHMI investigator Bruce Lahn, PhD, (right) directs an innovative, cross-disciplinary laboratory in the largest science building on campus, constructed to exacting standards so that scientists can pursue research that crosses traditional boundaries among physics, chemistry and biology. CULTIVATING INNOVATION WITHOUT THE RIGHT TOOLS, EVEN THE BEST DOCTORS IN THE WORLD ARE HAMPERED. TO ENSURE THAT MEDICAL CENTER PHYSICIANS, RESEARCHERS AND STAFF CAN WORK AT THE HIGHEST POSSIBLE LEVELS, THE UNIVERSITY OF CHICAGO PROVIDES EQUIPMENT AND FACILITIES THAT FOSTER MEDICAL EVOLUTION BY ADVANCING RESEARCH IN THE BASIC SCIENCES AND OFFERING IMPROVED PATIENT CARE. EVIDENCE OF THIS CAN BE SEEN IN THE GORDON CENTER FOR INTEGRATIVE SCIENCE, WHERE STUDENTS AND FACULTY CONDUCT RESEARCH IN TECHNOLOGICALLY ADVANCED LABS AND IN CLOSE CONJUNCTION WITH THE PHYSICAL SCIENCES. It also can be seen in the pediatric emergency room at Comer Children s Hospital. The hallways are hushed because each consultation or exam room has a sliding glass door, which keeps sound in and out. A curtain inside the room shields the patient from passers-by. The area also includes two trauma rooms, an office for Child Protective Services and social workers, and a pelvic exam room for victims of sexual abuse. Big-screen TVs, computer play stations and lots of toys in the waiting room help distract kids from what ails them. The pediatric ER sees about 100 patients a day. Doctors and nurses slide in and out of the trauma rooms, which are equipped with X-ray machines and virtually all other tools needed in an emergency. The pediatric emergency department among the newest spaces at the Medical Center is just one example of how the University of Chicago is taking advantage of architectural, technological and scientific innovation. And there is more architectural growth on the horizon: The Jules and Gwen Knapp Center for Biomedical Discovery is slated to open in That building at the corner of Drexel Avenue and 57th Street will house researchers studying tailor-made cancer treatments and the Ludwig Center for Metastasis Research, as well as laboratories and office space. Additionally, plans are in the works for the new hospital pavilion, an 11-floor facility that will be integrated into other facilities on the Medical Center campus. The pavilion will provide 240 private patient rooms for adult surgery and hematology/oncology, as well as 28 operating rooms. Cancer care, high-tech imaging, neuroscience and other specialties also will be housed in the pavilion. The design phase of the building is slated for completion in spring The new hospital pavilion, currently in the planning and design process, will combine the latest technology with the best use of space. New high-speed, multi-slice CT scanners let physicians peer into the body in ways they could only dream of a few years ago. THE NEW FACILITIES AT THE MEDICAL CENTER ENABLE DOCTORS AND RESEARCHERS TO TAKE ADVANTAGE OF INNOVATIVE TECHNOLOGY, WHICH IS ONE OF THE REASONS PATIENTS TURN TO THE UNIVERSITY OF CHICAGO FOR SPECIALIZED TREATMENT AND ADVANCED CARE. During the past year, the Medical Center has advanced the use of robotics for a variety of surgeries that allow patients to recover more quickly and with less pain. Doctors use the da Vinci robotic system to make minimal incisions and precise movements during surgeries. Surgeons here use the robot to operate on patients with endometrial cancer and abdominal aortic aneurysms, and to perform cardiac bypasses and prostatectomies. The shorter recovery periods appeal to patients in several departments that use the Medical Center s two da Vinci machines: cardiac, gynecological, pediatrics, transplants, urological and vascular. Doctors here performed 517 robotassisted surgeries in 2007, ranging from removing prostates and cysts to replacing the vaginal vault and performing liver resections. The popularity of robot-assisted procedures has led to frequent logistical discussions during robotic surgery meetings. Though the Medical Center has two of the massive robots, each requiring a room of its own, the increasing demand for robotic surgery means doctors keep them in frequent use. This fall, cardiothoracic surgeon Sudhir Srivastava, MD, joined the staff. Srivastava, a pioneer in robotic surgery, has initiated a program that will enable patients to undergo minimally invasive heart surgery. By way of four to five fingertip-size holes on the side of the chest, he uses the surgical robot to perform coronary bypass surgeries. Patients recover in dramatically less time 16 UNIVERSITY OF CHICAGO MEDICAL CENTER 2007 ANNUAL REPORT 17

11 Brownian dynamics model of OmpF porin Tapestry of Information A lot of brains work overtime at the University of Chicago. The brain in Benoit Roux s computer is so large that it doesn t fit in his 10-by-12-foot office in the Gordon Center for Integrative Science. Instead, the computer is housed at Argonne National Laboratory where it works 24 hours a day, seven days a week. It never sleeps, Roux said. Roux, PhD, studies cells, their membranes and the channels that allow some substances to pass in and out of the tiny structures. The computers he uses at Argonne and other labs work nonstop for months at a time. The one at Argonne, for example, has 1,000 central processing units (an average personal computer has only one) and is typically 95 percent full of jobs. For Roux, the computers are estimating the forces between certain atoms, how atoms or molecules bind or don t bind to each other, and the way certain substances permeate a cell membrane while others don t. Roux and his colleagues combine computational and experimental data from multiple sources. By doing so, they are able to get a more complete story about or a more valid calculation of a particular topic. We try to weave a tapestry of information together, Roux said. That mix of information will change as more and more computer processing is available. For example, this fall, Argonne is starting to assemble the IBM Blue Gene supercomputer, which, when completed in about two years, will be the most powerful civilian computer in the world. Additionally, Roux and his team received a grant from the Department of Energy for 4 million computer hours at another facility in Oak Ridge, Tenn. than with traditional bypass surgery, during which the sternum must be cracked open. And the healing process is far less painful than for traditional surgery, which typically requires weeks of recovery. Srivastava, a world leader for performing the operation, is revolutionizing cardiothoracic surgery by providing life-changing surgery and allowing patients to return to their daily lives quickly. The urology section has become the state leader in robotic prostatectomies, with surgeons performing more than 550 radical prostatectomies this year alone using the da Vinci system. The section, led by Arieh Shalhav, MD, also performs a variety of laparoscopic kidney procedures, robotic surgeries for bladder cancer and numerous other treatments. As with other robotic surgeries, patient recovery is quicker and less painful than with traditional surgeries requiring larger incisions. Sarah Temkin, MD, is one of only a few dozen doctors in the country who use robotic surgery for gynecological cancers. She has performed more than two dozen such surgeries. It s such a great improvement in cancer care, Temkin said. Someone can have major cancer surgery and go home the next day. Vascular surgeon Hisham Bassiouny, MD, has begun to use the robotic system to treat abdominal aortic aneurysm, a condition in which the aorta swells and becomes weak. If the aorta Irving Waxman, MD, performs advanced endoscopic procedures for esophageal, gastric, pancreatic, lung and rectal tumors. ruptures, the patient suffers serious internal hemorrhage and can bleed to death. With traditional surgery to repair such an aneurysm, the hospital stay and recovery time may be up to 10 days. With the robotic procedure, patients can go home in two to three days. Medical Center physicians who specialize in gastroenterology are pioneering ways to use endoscopy for a new generation of procedures. Gastroenterologist Irving Waxman, MD, is a leader in endoscopic ultrasound an evolving technique that uses a probe to capture images of thoracic and abdominal organs. This procedure gives physicians new ways to treat gastrointestinal diseases and is part of the advanced work performed by the team at the Center for Endoscopic Research and Therapeutics. The center is unique in the country for its specialized care, interventional treatments and research investigation. Technological changes have transformed life in day-to-day practices outside of surgery, too. The Medical Center is undergoing a five-year, $70 million effort that is more than a mammoth upgrade of hardware and software; it will overhaul the way the Medical Center processes information, especially patient medical information. The Phoenix Project could not be more aptly named, as it represents a rebirth for the hospitals aging computer systems. Alex Lickerman, MD, the physician sponsor for the upgrade, compares the progress to a submarine emerging from the water. With the updates so far bringing computers from dated, text-based systems to a graphics-based interface the periscope is rising from the water. From now until 2009, the submarine will start to come into view, and doctors and nurses will be able to use the computer system to get a variety of information, including best practices, drug interaction warnings and medical alerts. Sarah Temkin, MD, uses the da Vinci robotic system to perform minimally invasive surgeries for gynecological cancers. 18 UNIVERSITY OF CHICAGO MEDICAL CENTER 2007 ANNUAL REPORT 19

12 CREATING COMMUNITY 20 UNIVERSITY OF CHICAGO MEDICAL CENTER THE UNIVERSITY OF CHICAGO MEDICAL CENTER IS WORKING TO IMPROVE THE QUALITY OF LIFE AND CARE NOT ONLY FOR PATIENTS WHO ENTER ITS DOORS BUT ALSO FOR THOSE IN THE COMMUNITY SURROUNDING THE CAMPUS. THE SOUTH SIDE OF CHICAGO, ONE OF THE PRIMARY AREAS FROM WHICH MEDICAL CENTER PATIENTS COME, IS HOME TO 1.1 MILLION RESIDENTS. BUT THE HEALTH OF THOSE RESIDENTS IS OFTEN RELATIVELY POOR, AS REFLECTED IN EXTRAORDINARILY HIGH RATES OF COMMON DISEASES AND INFANT MORTALITY. Eric Whitaker, MD, MPH, guides efforts to create tighter bonds with the community through progressive programs related to the Urban Health Initiative. Part of a joint effort to create strong medical networks throughout the South Side, University of Chicago s John Hickner, MD, (left) works with local physician Kwame Foucher, MD, at ACCESS Grand Boulevard Health Center. The rates for heart failure, diabetes, renal failure, bronchitis, asthma and hypertension are all higher among those on Chicago s South Side than for people in the state of Illinois as a whole. Infant mortality rates in some South Side neighborhoods are three to four times higher than the state average of 0.73 percent and the Chicago average of 0.9 percent. Since 2004, when the Medical Center renovated and expanded its emergency room, patient visits have increased by 14 percent. The University of Chicago s ER is the second busiest in the city. For these reasons, helping patients who use the ER find a medical home by connecting them to local clinics has become a priority for the Medical Center. More than two years ago, the Medical Center began working to put some of its emergency room patients in touch with primary care physicians in the surrounding areas. After sick patients came to the Medical Center for urgent care, patient advocates helped connect those who didn t have family doctors or regular care to area clinics where they could receive follow-up medical attention. Emergency room physicians, nurses and other staff were relieved to know that their patients could get care after their visits to the Medical Center ER, said James Walter, MD, chief of emergency medicine. BY TEAMING UP WITH 19 COMMUNITY-BASED HEALTH CENTERS, UNIVERSITY OF CHICAGO HAS BEEN ABLE TO HELP PATIENTS FIND FOLLOW-UP TREATMENT OR A REGULAR PHYSICIAN. The health care centers, all on the city s South Side, have been able to meet, coordinate and team up something that had not happened before through the South Side Health Collaborative. The program also has provided a way for the Medical Center to practice more aggressive outreach and to help patients navigate the health care system, overcome barriers and clarify misconceptions about medicine or care. So far, the collaborative has connected more than 1,500 patients with primary care medical homes. Patients have found that the health care facilities are convenient and well resourced. Fifteen of those centers are federally qualified health facilities; the others are a private clinic, a substance abuse and mental health center, and Project Brotherhood, a clinic that serves African-American men. Project Brotherhood now has an even closer tie to the University of Chicago. Its founder, Eric Whitaker, MD, MPH, joined the Medical Center in October as executive vice president for strategic affiliations and associate dean for community-based research. Whitaker, an authority in public health, will be a key player in implementing the Urban Health Initiative, an entity whose aim will be to connect patients to their communities health resources, as well as to each other. As part of the effort to collaborate with community health facilities, the Medical Center has given grants to some of its partners. ACCESS, a health care organization that runs several clinics accessible to South Side residents, received $350,000 to increase the number of exam rooms at one of its sites. At these outside facilities, patients can seek primary care for basic health concerns and also receive treatment in some specialty areas. Pregnant women with a low risk of complications can visit obstetricians and even deliver their babies at some of these partner clinics. The care they receive is every bit as good as what they would receive at the University of Chicago, but the facilities are closer to home and, often, have more beds available. The South Side Health Collaborative, initially led by Michelle Obama, vice president for community and external affairs, has become a model for the Medical Center s work with the Urban Health Initiative. But the emergency room is a gateway to another issue that doctors, nurses, researchers and staff are helping to solve: disparities in health care. We re a canary in the mineshaft, said Thomas Fisher Jr., MD, PhD, an emergency medicine physician and health disparities researcher, speaking of the types of patient ailments seen in the ER. This fall, the Hyde Park native is launching 2007 ANNUAL REPORT 21

13 A change agent Thomas Fisher Jr., MD, MPH, with patient Growing up in Hyde Park, Thomas Fisher Jr. saw social and racial imbalances all around him. What I noticed were larger issues of societal inequities, he said, not just disparities related to health care. Education and services were not as available to the poor or to people of color as they were to others. But health care, Fisher said, is different. It s not just about resources. It s intrinsic to the ability of a person to be productive in society. Through undergraduate studies at Dartmouth and medical school at the University of Chicago, Fisher s interest in the subject grew. Before earning his medical degree and completing an emergency medicine residency at the Medical Center, he decided to pursue a master s degree in public health at Harvard. Fisher s interest in health disparities has gone beyond his coursework. He worked with Eric Whitaker, MD, MPH, on Project Brotherhood, a clinic that pledges to improve the health and welfare of African-American men. He also teaches and works at the University s Center for the Study of Race, Politics and Culture. Since he began working as an emergency medicine physician a little more than a year ago, Fisher has initiated a focus group that will both target inequities in community health care and offer solutions. That research, supported by a grant from the Department of Medicine, complements other disparities work throughout the Medical Center. Working at Chicago has given Fisher a chance to return to his roots and pursue his passion. My goal here is to be a change agent, he said. This is work that needs to be done. focus groups both inside and outside of the Medical Center with doctors and administrators, primary care providers and patients. Fisher will be working with a leadership committee of area residents in an effort to encourage community members and health care providers to focus on special needs in the area and to empower the community with tools to fill gaps in health care. To help build that leadership are grants totaling $6 million from the Robert Wood Johnson Foundation. The grants are distributed in part by Marshall Chin, MD, who leads the Finding Answers: Disparities Research for Change program. For the past decade, Chin has worked with the Health Disparities Collaborative, a nationwide network of more than 1,000 health centers that aim to make medical care more equitably accessible for underserved groups. A major review of literature about disparities in health care has been published as a 300-page supplement to the journal Medical Care Research and Review. All 20 authors work at the University of Chicago. Other University researchers have focused on specific conditions that tend to afflict certain races or ethnic groups more than others. Geneticist Rick Kittles, PhD, focuses his research on why black men are more susceptible to prostate cancer than white men. In addition, the Center for Interdisciplinary Health Disparities Research, supported in part by a national SPORE (Specialized Program of Research Excellence) grant and led by researchers Olufunmilayo Olopade, MD, Gini Fleming, MD, and Maryellen Giger, MD, will aim to determine, among other things, why black women are more likely to suffer from an aggressive and more deadly type of breast cancer than white women. The University also has become a leader in educating medical students about health care disparities. In fall 2006, Monica Vela, MD, assistant professor of medicine, led an optional, week-long orientation course on that topic. Two-thirds of the first-year medical students and 30 faculty members participated in lectures and visits to local clinics. It served as an ignition or fuel for them wanting to learn more, Vela said. Students gained a new view of health care and an introduction to the special needs of some communities. Within the past year, Vela has seen an increase in the number of students who attended health disparities conferences or who requested that the Medical Center sponsor more events related to disparities. There also has been more participation in studentdriven free clinics and community roles. This past fall, the health care disparities course was required for incoming students. The Medical Center reaches out to the community in many ways, in addition to clinical initiatives and research. For the past five years, scores of faculty and staff have gathered each May to participate in service projects in surrounding neighborhoods. This year, a record 200 people came to the Day of Service and Reflection, during which they painted fences, planted gardens, cleaned beaches and bonded with community members, co-workers, family and friends. Any year isn t complete without the South Side s Bud Billiken parade, a decades-long tradition each fall during which children parade through the city streets. Hundreds of hospital employees and their friends and family turn out annually to participate in the event. Other employees reach out to high school or middle school students through science fair coaching or judging, job shadowing and mentoring. Nubia Chaidez, a community relations officer for the Medical Center, said the mentoring programs are a way for hospital staff and community members to learn more about each other. The mentoring program, which brings six to eight local high school students to the Medical Center to learn about clinical and non-clinical hospital work, helps create a pipeline to the health care industry. Students learn that they can be lawyers, marketing consultants or other types of hospital administrators not just doctors, nurses or other clinicians. The Salinas family of Calumet City has found a medical home with Chicago Family Health Center, one of 19 South Side Health Collaborative partners. 22 UNIVERSITY OF CHICAGO MEDICAL CENTER Icy Cade-Bell, MD, provides on-location health checks for neighborhood children via the pediatric Mobile Healthcare Van ANNUAL REPORT 23

14 The University of Chicago and Cambridge University are the only sources of access for graduate students interested in HHMI s new biomedical research campus in Virginia, the Janelia Farm Research Cooperative. ADVANCING KNOWLEDGE 24 UNIVERSITY OF CHICAGO MEDICAL CENTER WITH SO MANY BRIGHT, FOCUSED STUDENTS AT THE PRITZKER SCHOOL OF MEDICINE AND IN THE BIOLOGICAL SCIENCES DIVISION, EVOLUTION IS INEVITABLE. EACH CLASS BRINGS A NEW SET OF EXPERIENCES AND KNOWLEDGE, AND STUDENTS ARE HELPING TRANSFORM THE RESEARCH IN THESE CORRIDORS. SINCE HOLLY HUMPHREY, MD, BECAME DEAN FOR MEDICAL EDUCATION IN 2003, APPLICATIONS TO THE MEDICAL SCHOOL HAVE INCREASED 69 PERCENT, COMPARED WITH AN 8 PERCENT INCREASE FOR MEDICAL SCHOOLS NATIONALLY. WHILE THE TOTAL NUMBER OF APPLICANTS HAS BEEN ON THE RISE, SO HAS THE PERCENTAGE OF UNDERREPRESENTED MINORITIES, WHICH HAS INCREASED TO ABOUT 23 PERCENT, FROM 14 PERCENT JUST A FEW YEARS AGO. BOTH INCREASES HAVE RESULTED IN A HIGH-PERFORMING AND DIVERSE CLASS OF STUDENTS. The expertise of Professor Michael LaBarbera, PhD, is one of the reasons University of Chicago students gain a sound knowledge of biology, essential for understanding many of the most pressing problems of modern society. In the past year, Pritzker students have received research funding from the Howard Hughes Medical Institute, the Fogarty International Center for Advanced Study in the Health Sciences and the Fulbright Scholar Program, and have been awarded two Alpha Omega Alpha Student Research Fellowships. Another three students have been named Albert Schweitzer Fellows. The new PhD program in biophysics began this fall with four students who will work toward joint degrees from the Biological Sciences and the Physical Sciences divisions. The program requires each student to team up with two labs and two mentors, and will provide a path for graduate students to study interdisciplinary science. In addition, students in the program will be interface scholars part of the academic and research community with opportunities to attend special seminars and to travel at HHMI, thanks to a grant of $1 million to start the program and its continuing support of the University. Another student, PhD candidate Rudy Faust, is the first Chicago student to be part of HHMI s Janelia Farm Research Cooperative in Ashburn, Va. Faust is studying neuroscience at the $500 million research campus, which is partnered with the University of Chicago and Cambridge University. As HHMI s first freestanding campus, Janelia Farm provides a setting in which small research groups can explore fundamental biomedical questions. The program grants a PhD in biology and features flexible training and the opportunity to research in a collaborative, interdisciplinary environment. Several BSD graduate students and Pritzker medical students have been lead authors on published papers. For example, evolutionary biology graduate student Matt Friedman s discoveries on the coelacanth fossil appeared in Evolution & Development, and fourth-year medical student Rachel Sherman, whose finding that doctors believe placebos can have a therapeutic effect, was detailed in the Journal of General Internal Medicine. Biology student Matt Howard studies aquatic life, part of the hands-on research facet of the University s popular biodiversity class ANNUAL REPORT 25

15 David Meltzer, MD, PhD Pritzker also has begun recognizing, and supporting with grants, outstanding faculty members through the Academy of Distinguished Medical Educators. This spring marked the second time such teachers were recognized for their work in medical education. Doctors of Patient Care This fall, the Department of Medicine added one more section to its roster: Hospital Medicine. The new section, headed by David Meltzer, MD, PhD, specializes in inpatient care. The hospitalist concept, about 10 years old, has gained traction in recent years, and Chicago has been hiring such physicians since its inception. General medicine doctors improve hospital patient care the more they work in it, Meltzer said, but they are also more likely to burn out if they devote too much of their time to hospital care. The academic hospitalist program combines hospital care with research, quality improvement and medical education to help physicians establish sustainable careers that allow them to gain substantial inpatient clinical experience without burning themselves out. Meltzer and his colleagues also developed the Hospitalist Scholars Program to train practicing hospitalists in research, education and quality improvement so they have the tools needed to succeed. The first students to complete the hospitalist program have opted to stay with the University of Chicago after graduation, rejecting job offers from Johns Hopkins and Northwestern, to name a few. The combination of research, education and clinical practice enticed them to stay. Additionally, a $4 million grant from the Agency on Health Care Research and Quality for research on hospital medicine, pharmacogenetics and social networks for physicians will help support research activities in this section. Hospitalists who work at the Medical Center practice both here and at Mercy Hospital, where some of Chicago s emergency room patients choose to register, often finding shorter wait times for common ailments. A Medical Center attending is stationed daily at Mercy, helping to provide exceptional health care with neighboring partners of the University of Chicago. In addition to that recognition, the BSD has retooled the tenure track, opening its doors for more faculty members to strive for that professional accomplishment. Faculty on all three BSD tracks research scholars, clinical scholars and clinician-educators are eligible for tenure; previously, only research scholars were on the tenure track. The new system was developed after a committee recommended the changes in The three tracks apply to different types of faculty work. Research scholars, the traditional tenure track, spend the bulk of their time conducting scholarship that is not directly related to clinical care. Clinical scholars, by contrast, work as both physicians and scholars, and often study human subjects and disease. The third track, for clinician-educators, is for faculty members active in clinical work, as well as teaching or administration. WITH A TRADITION OF INTERDISCIPLINARY SCHOLAR- SHIP, THE UNIVERSITY OF CHICAGO IS COMMITTED TO INTELLECTUAL DISCOVERY THAT CHALLENGES STUDENTS OF EXCEPTIONAL PROMISE TO BECOME LEADERS IN SCIENCE AND MEDICINE. Some learning focuses on finding and training students before they arrive here either as high school students or as undergraduates. Two new programs are giving those younger students a chance to get involved with research or education at the University of Chicago. The Chicago Academic Medicine Program offers underrepresented minority undergraduate students the chance to get a taste of what medical school is like. And the Pritzker School of Medicine Education in Research program gives college juniors and seniors the opportunity to take part in an eight-week research experience on campus. These programs developed from existing ones that the Medical School continues to offer: the Young Scientist Training Program and Training Early Achievers for Careers in Health Research, both of which aim to help students explore the field of medicine. Kerstin Stenson, MD, (center) an expert on surgical treatment of head and neck cancers, leads rounds in Mitchell Hospital with residents, medical students and nurses. Bill McDade, MD, PhD, associate dean of multicultural affairs, works with underrepresented minority undergraduate students in the Chicago Academic Medicine Program, or CAMP, which offers a glimpse of medical school. 26 UNIVERSITY OF CHICAGO MEDICAL CENTER 2007 ANNUAL REPORT 27

16 THE PROCESS OF SCIENTIFIC DISCOVERY IS, IN EFFECT, A CONTINUAL FLIGHT FROM WONDER. Albert Einstein SOMETIMES CHANGE BRINGS UNCERTAINTY. BUT IN THE EVOLUTION OF SCIENCE AND MEDICINE, ONE THING SEEMS CERTAIN: IF THE PAST YEAR HAS SEEN SIGNIFICANT CHANGES AT THE UNIVERSITY OF CHICAGO, THE YEARS TO COME WILL PRODUCE MANY MORE. ANTISEPTICS DID NOT ARRIVE ON THE MEDICAL SCENE UNTIL 1865; ANTIBIOTICS TOOK ANOTHER 63 YEARS TO REACH CLINICAL PRACTICE. TODAY, RESEARCH IN GENETICS MAKES POSSIBLE LEAPS FORWARD THAT USED TO TAKE LIFETIMES. THE SPEED AT WHICH TECHNOLOGY AND SCIENTIFIC RESEARCH ARE MOVING IS BLISTERING. THE MEDICAL CENTER AND THE DIVISION OF BIOLOGICAL SCIENCES ARE WELL PREPARED TO WELCOME AND TO EMBRACE CHANGE. AN INTERDISCIPLINARY SPIRIT, TOP-FLIGHT FACILITIES AND, MOST OF ALL, SKILLED, DEDICATED AND CARING PEOPLE MAKE SUCH CHANGE POSSIBLE. PERHAPS CHANGE ISN T THE ONLY CONSTANT IN SCIENCE AND MEDICINE. AT THE UNIVERSITY OF CHICAGO MEDICAL CENTER, THERE IS ALSO A WILLINGNESS TO ADAPT TO IT, TO LEARN FROM IT AND TO USE IT TO IMPROVE PEOPLE S LIVES. 28 UNIVERSITY OF CHICAGO MEDICAL CENTER 2007 ANNUAL REPORT 29

17 FINANCIAL HIGHLIGHTS FINANCIAL REPORT 2007 AT A TIME OF CHALLENGE AND GREAT OPPORTUNITY FOR ACADEMIC MEDICINE, WE ARE PROUD OF THE COMMITMENT, PROGRESS AND ACHIEVEMENTS MADE BY THE UNIVERSITY OF CHICAGO MEDICAL CENTER AND THE BIOLOGICAL SCIENCES DIVISION, BOTH FOR ITS PATIENT COMMUNITY AND TO SCIENCE. LAST YEAR MARKED A BOLD, NEW BEGINNING FOR THE MEDICAL CENTER AS WE CONSOLIDATED ALL OF THE UNIVERSITY S PATIENT CARE ACTIVITIES UNDER A SINGLE GOVERNANCE AND MANAGEMENT STRUCTURE. OUR HISTORICAL COMMITMENT TO CARING FOR THOSE IN NEED DRIVES A POWERFUL FOCUS IN STRATEGY: LEVERAGING OUR NEW STRUCTURE TO OPTIMIZE OUR DISTINCTION RATHER THAN OUR SIZE, TO ENHANCE OUR PROGRAMMATIC AND FINANCIAL STRENGTH RATHER THAN SIMPLE GROWTH. This strategy has proven to be strong, driving Medical Center increase in revenues and applying the $4 million surplus generated operating income up substantially, to $85 million in fiscal year in Strong investment results and philanthropy drove an A number of factors are responsible for this increase in percent growth in net assets to $1.3 billion at year end. income. First, although overall patient activity in the hospitals and Financial strength is the key to planning an ambitious future, which clinics increased by only about 1 percent, net revenues rose by includes as a top priority the Urban Health Initiative. The Urban 10 percent, reflecting a shift toward complex care for patients Health Initiative is a broad commitment to improve the health of drawn to the Medical Center from the entire region. New insurance contracts and continued improvement in the revenue cycle nearby residents by collaborating in meaningful ways with health care providers and organizations throughout the neighborhoods on also contributed. Additionally, two years of income from the Chicago s South Side. Last year, the Medical Center provided Illinois Medicaid provider tax program was received in 2007, nearly $82 million in charity care, measured at cost, for patients which included $18 million owed from 2006 but delayed due to covered by Medicaid or without insurance, with income from the pending federal government approval. By comparison, operating 2007 Illinois Medicaid provider tax program offsetting $18 million costs increased by less than 3 percent due to more effective of this amount. In a world of finite resources, the Medical Center s deployment of staff. expertise continues to fill a need few others can providing highly Investments also performed well, with investment income of $55 specialized medical care, conducting biomedical research and million and unrealized gains of $49 million. A $35 million educating future physicians and scientists. The Medical Center reduction in liabilities for general reserves, as well as other recognizes that our partner healthcare providers in the community accounting adjustments to reflect more accurately the value of excel in delivering primary and specialty care to a broad range of assets, contributed to the increase in net assets. Altogether net patients. Through the Urban Health Initiative, the intent is to assets increased to $911 million by year end. The Medical Center create a contemporary model that optimizes societal resources continued its annual support of $15 million to the Biological to deliver health care at the right places, at the right time. Sciences Division for the Academic Renewal Fund, which invests The 2007 financial performance reflects enhanced coordination in the basic biological and clinical sciences that underpin the among all of the components of the biomedical enterprise. We are Medical Center s market position At the Forefront of Medicine. focused on supplying the complex care that is most suited to an The budget of the Biological Sciences Division increased by 7 academic medical center, while also linking to a larger network of percent to $580 million, representing continued investment in community-based providers. On this basis, the Medical Center biomedical faculty, graduate and medical education, and groundbreaking research, including the first full year of operations for required for significant investment in new facilities, technology and the Biological Sciences Division are securing the capital the Gordon Center for Integrative Science. This infusion of resources and programs that deliver on our missions and are among the into our academic programs was supported through a 6 percent finest in the nation. UNIVERSITY OF CHICAGO MEDICAL CENTER STATEMENT OF REVENUES AND EXPENSES For the years ended June 30, 2007 and 2006 (in millions of dollars) Operating revenues 1, Compensation, supplies, services and other Provision for doubtful accounts Depreciation and interest Medicaid Provider Tax 62 0 Operating expenses 1, Operating income Investment income and unrestricted gifts, net Other, net 1 0 Excess of revenues over expenses BALANCE SHEET For June 30, 2007 and 2006 (in millions of dollars) Current assets Investments Property, plant and equipment, net Other assets Total assets 1,553 1,321 Current liabilities Long-term debt, less current maturities Other liabilities Total liabilities Net assets Total liabilities and net assets 1,553 1,321 PATIENT ACTIVITY For the years ended June 30, 2007 and Admissions 26,377 26,933 Patient days 165, ,995 Length of stay DCAM visits 402, ,720 ER visits 85,092 79,534 DIVISION OF BIOLOGICAL SCIENCES STATEMENT OF REVENUES AND EXPENSES For the years ended June 30, 2007 and 2006 (in millions of dollars) Revenues Tuition Grants and contracts Endowment and gifts Patient care UCMC transfers for academic renewal Other income Total revenues Expenses Faculty and other academic compensation Grants and contracts Financial aid Facilities and other expenses Total expenses Surplus generated (applied) -4 4 BALANCE SHEET For June 30, 2007 and 2006 (in millions of dollars) Cash and cash equivalents Notes and accounts receivable Investments at market value Land, buildings and equipment, net Total assets 1,563 1,331 Current liabilities Notes and bonds payable Net assets 1,301 1,103 Total liabilities and net assets 1,563 1, UNIVERSITY OF CHICAGO MEDICAL CENTER 2007 ANNUAL REPORT 31

18 THE UNIVERSITY OF CHICAGO MEDICAL CENTER DIVISION OF THE BIOLOGICAL SCIENCES & PRITZKER SCHOOL OF MEDICINE MEDICAL CENTER BOARD OF TRUSTEES OFFICERS LEADERSHIP Valerie B. Jarrett, Chair Paul F. Anderson Robert H. Bergman Edward McC. Blair, Jr. Ellen Block Otis W. Brawley, MD Deborah A. Bricker Kevin J. Brown John Bucksbaum Frank M. Clark James S. Crown (ex officio) Allison S. Davis Craig J. Duchossois James S. Frank Stanford J. Goldblatt Rodney L. Goldstein Linda H. Heagy David S. Hefner (ex officio) William J. Hunckler III Jeffrey D. Jacobs Kenneth Lehman Carol Levy Barry L. MacLean James L. Madara, MD (ex officio) Cheryl Mayberry-McKissack Dane A. Miller Ralph G. Moore Christopher J. Murphy III Emily Nicklin Brien M. O Brien Timothy K. Ozark Nicholas K. Pontikes James Reynolds, Jr. Thomas A. Reynolds III Thomas F. Rosenbaum (ex officio) Jeffrey T. Sheffield Jorge A. Solis John A. Svoboda Michael Tang Christina M. Tchen J. Richard Thistlethwaite, MD (ex officio) MarrGwen Townsend James C. Tyree Terry L. Van Der Aa Kelly R. Welsh Bruce W. White Paula Wolff Robert J. Zimmer (ex officio) LIFE TRUSTEES Marshall Bennett Lindy Bergman Sidney Epstein Robert Feitler Jules F. Knapp Howard G. Krane John D. Mabie Marjorie I. Mitchell Michael Rosenberg Robert G. Schloerb Robert G. Weiss JAMES L. MADARA, MD CEO, University of Chicago Medical Center Sara and Harold Lincoln Thompson Distinguished Service Professor Dean, Division of the Biological Sciences and Pritzker School of Medicine University Vice President for Medical Affairs DAVID S. HEFNER Medical Center President LAWRENCE J. FURNSTAHL Chief Financial and Strategy Officer Treasurer MEDICAL STAFF ORGANIZATION J. RICHARD THISTLETHWAITE, MD, PhD President STEPHEN G. WEBER, MD, MS Vice President P. ALLAN KLOCK, JR., MD Secretary SANDRA CULBERTSON, MD Councilor FRED OVSIEW, MD Councilor MAYA BORDEAUX (Interim) Vice President and Chief Human Resources Officer THOMAS CUTTER, MD Medical Director of Perioperative Services MARTIN FEDER, PhD Faculty Dean of Academic Affairs JEFFREY A. FINESILVER Vice President and Director, Comer Children s Hospital MAYUMI FUKUI Vice President for Managed Care and Program Development HARVEY GOLOMB, MD Dean of Clinical Affairs Chief Medical Officer D. ALLAN GRAY Vice President for Perioperative Services DAVID HICKS Chief Pharmacy Officer DAVID HO Vice President for Finance HOLLY HUMPHREY Dean of Medical Education Chair, Education Committee VICKIE L. HUMPHREY Vice President for Support Services DEPARTMENT CHAIRS ANESTHESIA AND CRITICAL CARE Jeffrey Apfelbaum, MD BEN MAY DEPARTMENT FOR CANCER RESEARCH Marsha Rosner, PhD BIOCHEMISTRY AND MOLECULAR BIOLOGY Anthony Kossiakoff, PhD ECOLOGY AND EVOLUTION Joy Bergelson, PhD FAMILY MEDICINE Bernard Ewigman, MD, MPH HEALTH STUDIES Ronald Thisted, PhD HUMAN GENETICS T. Conrad Gilliam, PhD MICHAEL J. KOETTING Vice President for Planning VINAY KUMAR, MD Executive Vice Dean Chair of Pathology BRUCE MINSKY, MD Associate Dean for Clinical Quality Chief Quality Officer MICHELLE R. OBAMA Vice President for Community and External Affairs JAMIE M. O MALLEY Vice President and Chief Nursing Officer, Patient Services JOSÉ QUINTANS, MD, PhD Associate Dean and Master, Biological Sciences Collegiate Division MICHELE SCHIELE Associate Dean and Vice President for Development NANCY SCHWARTZ, PhD Dean of Graduate Affairs ANN SCHWIND Associate Dean for Administration SANDRA SENTI Chief Information Officer MEDICINE Joe G.N. Garcia, MD MICROBIOLOGY Olaf Schneewind, MD, PhD MOLECULAR GENETICS AND CELL BIOLOGY Richard Fehon, PhD NEUROBIOLOGY S. Murray Sherman, PhD NEUROLOGY Christopher Gomez, MD, PhD OBSTETRICS AND GYNECOLOGY Arthur Haney, MD OPHTHALMOLOGY AND VISUAL SCIENCES William Mieler, MD KENNETH SHARIGIAN Associate Dean and Vice President for Organizational Strategy and Planning SUSAN S. SHER Vice President for Legal and Governmental Affairs General Counsel NEIL SHUBIN, PhD Associate Dean for Organismal and Evolutionary Biology Provost of the Field Museum JULIAN SOLWAY, MD Associate Dean for Translational Medicine WALTER STADLER, MD Associate Dean of Clinical Research KELLY M. SULLIVAN Vice President for Communications and Marketing MARK A. URQUHART Vice President for Facilities, Design and Construction ERIC WHITAKER, MD, MPH Executive Vice President of Strategic Affiliations Associate Dean for Community-Based Research CAROLYN WILSON Associate Dean and Vice President for Faculty Practice Administration ERIC B. YABLONKA Vice President and Chief Information Officer ORGANISMAL BIOLOGY AND ANATOMY Jan-Marino Ramirez, PhD PATHOLOGY Vinay Kumar, MD PEDIATRICS Michael Schreiber, MD (Acting) PSYCHIATRY Emil Coccaro, MD RADIATION AND CELLULAR ONCOLOGY Ralph Weichselbaum, MD RADIOLOGY Richard Baron, MD SURGERY Jeffrey Matthews, MD 32 UNIVERSITY OF CHICAGO MEDICAL CENTER 2007 ANNUAL REPORT 33

19 DIVISIONAL OVERSIGHT AND GOVERNANCE EXECUTIVE COMMITTEE CLINICAL CHAIRS COMMITTEE RESEARCH ADVISORY COMMITTEE James Madara, UCMC Executive Office, Chair Holly Humphrey, Medical Education Olaf Schneewind, Microbiology Jeffery Apfelbaum, Anesthesia and Critical Care Vinay Kumar, Pathology, Chair Jeffrey Apfelbaum, Anesthesia and Critical Care David Jablonski, Evolutionary Biology Michael Schreiber, Pediatrics Richard Baron, Radiology Joe Garcia, Medicine Richard Baron, Radiology Albert Bendelac, Immunology Joy Bergelson, Ecology and Evolution Eric Beyer, Cell Physiology Douglas Bishop, Genetics Emil Coccaro, Psychiatry Bernard Ewigman, Family Medicine Martin Feder, Academic Affairs Richard Fehon, Molecular Genetics and Cell Biology Lawrence Furnstahl, UCMC Executive Office Joe Garcia, Medicine Maryellen Giger, Medical Physics T. Conrad Gilliam, Human Genetics Harvey Golomb, UCMC Executive Office Christopher Gomez, Neurology Geoffrey Greene, Cancer Biology Arthur Haney, Obstetrics and Gynecology David Hefner, UCMC Executive Office Stephen Kent, Institute for Biophysical Dynamics Anthony Kossiakoff, Biochemistry and Molecular Biology Vinay Kumar, Pathology Michelle Le Beau, Cancer Research Center Peggy Mason, Committee on Neurobiology Jeffery Matthews, Surgery Elizabeth McNally, Institute for Cardiovascular Research William Mieler, Ophthalmology and Visual Science Victoria Prince, Developmental Biology José Quintans, Collegiate Division Jan-Marino Ramirez, Organismal Biology and Anatomy Mark Ratain, Clinical Pharmacology and Pharmacogenomics Marsha Rosner, Ben May Department for Cancer Research Michele Schiele, Development Eric Schwartz, Neurobiology, Pharmacology and Physiology Nancy Schwartz, Graduate Affairs and Kennedy Center Ann Schwind, UCMC Executive Office Michele Seidl, UCMC Executive Office Kenneth Sharigian, UCMC Executive Office S. Murray Sherman, Neurobiology Neil Shubin, Organismal and Evolutionary Biology Julian Solway, Translational Research Walter Stadler, Clinical Research Ronald Thisted, Health Studies J. Richard Thistlethwaite, Medical Staff Office Philip Ulinski, Computational Neuroscience Ralph Weichselbaum, Radiation and Cellular Oncology Roy Weiss, Clinical Research Center Carolyn Wilson, UCMC Executive Office Emil Coccaro, Psychiatry Bernard Ewigman, Family Medicine Joe Garcia, Medicine Christopher Gomez, Neurology Arthur Haney, Obstetrics and Gynecology David Hefner, UCMC Executive Office Holly Humphrey, UCMC Executive Office Vinay Kumar, UCMC Executive Office and Pathology Jeffery Matthews, Surgery William Mieler, Ophthalmology and Visual Science Michael Schreiber, Pediatrics Ralph Weichselbaum, Radiation and Cellular Oncology Carolyn Wilson, UCMC Executive Office BSD VISITING COMMITTEE M. Roy Schwarz, Co-Chair Janice Katz T. Conrad Gilliam, Human Genetics Christopher Gomez, Neurology Jeffery Matthews, Surgery Jan-Marino Ramirez, Organismal Biology and Anatomy Marsha Rosner, Ben May Department for Cancer Research Michele Seidl, UCMC Executive Office (ex officio) Kenneth Sharigian, UCMC Executive Office (ex officio) Neil Shubin, Organismal and Evolutionary Biology Trisha Rooney Alden Douglass B. Given, Co-Chair Elliott Kieff Paul S. Russell Christopher Alafi Gwen Knapp Catherine Ryan EDUCATION COMMITTEE BASIC SCIENCE CHAIRS COMMITTEE Diane Patricia Atwood Douglas S. Basler Victoria Mitchell Kohn H. Jonathan Kovler David R. Schwartz Carole Segal Holly Humphrey, Chair José Quintans Nancy Schwartz Ann Schwind (ex officio) Kenneth Sharigian (ex officio) Neil Shubin Joy Bergelson, Ecology and Evolution Richard Fehon, Molecular Genetics and Cell Biology T. Conrad Gilliam, Human Genetics Anthony Kossiakoff, Biochemistry and Molecular Biology Vinay Kumar, UCMC Executive Office and Pathology Jan-Marino Ramirez, Organismal Biology and Anatomy Marsha Rosner, Ben May Department for Cancer Research Olaf Schneewind, Microbiology Eric Schwartz, Neurobiology, Pharmacology and Physiology Michele Seidl, UCMC Executive Office S. Murray Sherman, Neurobiology Neil Shubin, Organismal and Evolutionary Biology Ronald Thisted, Health Studies Matthew Bucksbaum Jordan J. Cohen Marvin Conney Mildred Conney Kim Duchossois Christopher S. Eklund James S. Frank L. Patrick Gage Ellen R. Gordon Robert G. Hershenhorn Hollye Harrington Jacobs David Kalt Attallah Kappas David Katz Kenneth L. Kummer Mitchell Lederer John D. Mabie Mary Ann MacLean Roland V. McPherson Rosemarie Mitchell Thomas L. Mitchell Steven Nakovich Timothy K. Ozark Charles Palmer Charles Polsky Thomas A. Reynolds III Theodore H. Roberts Paul G. Rogers John B. Snyder James A. Star James Stephen John Svoboda Paul Talalay Laura Thrall Daniel C. Tosteson Scott Wald Elizabeth White David Whitney Joan T. Zajtchuk Russ Zajtchuk Laurence Zung 34 UNIVERSITY OF CHICAGO MEDICAL CENTER 2007 ANNUAL REPORT 35

20 THE UNIVERSITY OF CHICAGO DIVISION OF THE BIOLOGICAL SCIENCES RECRUITMENT AND PROMOTIONS RECRUITMENT PROMOTIONS ANESTHESIA & CRITICAL CARE Frank Dupont, Assistant Professor Ori Gottlieb, Assistant Professor Michael Hernandez, Assistant Professor Igor Tkachenko, Assistant Professor BEN MAY DEPARTMENT FOR CANCER RESEARCH Richard Jones, Assistant Professor HEALTH STUDIES Habibul Ahsan, Professor Tyler Vanderweele, Assistant Professor HUMAN GENETICS Kevin White, Professor MEDICINE Steven Archer, Professor Sameer Badlani, Instructor George Bakris, Professor Nisha Bansal, Instructor George Bell, Instructor John Beshai, Assistant Professor Kristine Bordenave, Assistant Professor Rebecca Brown, Instructor Keme Carter, Assistant Professor Suma Dronavalli, Instructor Thomas Fisher, Instructor Caroline Harada, Instructor Keiki Hinami, Instructor James Holaska, Assistant Professor Haochu Huang, Assistant Professor Susan Kim, Assistant Professor Rick Kittles, Associate Professor Jerry Krishnan, Associate Professor Nanduri Prabhakar, Professor James Rhee, Assistant Professor Christopher Rhodes, Professor Rita Rossi-Foulkes, Assistant Professor Andrey Rzhetsky, Professor Aisha Sethi, Assistant Professor Patrick Singleton, Instructor Andrew Skol, Instructor Nilam Soni, Instructor Maria Tsoukas, Assistant Professor Kaveeta Vasisht, Instructor Roopa Vemulapalli, Instructor Victoria Villaflor, Assistant Professor Barton Wicksteed, Assistant Professor NEUROBIOLOGY Jason MacLean, Assistant Professor NEUROLOGY John Jacobsen, Assistant Professor Adil Javed, Assistant Professor Daniel Llano, Instructor OBSTETRICS & GYNECOLOGY Susan Fee, Associate Professor Sabrina Holmquist, Assistant Professor Natasha Jenkins, Instructor Sarah Temkin, Assistant Professor Mishka Terplan, Assistant Professor OPHTHALMOLOGY & VISUAL SCIENCE Michael Grassi, Assistant Professor Ana Loduca, Assistant Professor John Cunningham, Professor Ronald Espinal, Instructor Heather Fagan, Instructor Jeffrey Gossett, Instructor Daniel Johnson, Associate Professor Heather Johnston, Instructor Ivan Moskowitz, Assistant Professor Adriana Orozco-Kellermeier, Instructor Timothy Sentongo, Assistant Professor Mala Setty, Instructor Kelley Staley, Instructor Wim Van Drongelen, Assistant Professor Rachel Wolfson, Instructor Christine Yu, Instructor PSYCHIATRY Constance (Tina) Drossos, Instructor Peter Nierman, Assistant Professor Lisa Sanchez-Johnson, Assistant Professor Marie Tobin, Associate Professor Shona Vas, Assistant Professor RADIATION & CELLULAR ONCOLOGY Stanley Liauw, Instructor Bruce Minsky, Professor Joseph Salama, Instructor RADIOLOGY Paul Chang, Professor Aytekin Oto, Associate Professor Kenji Suzuki, Assistant Professor SURGERY Peter Angelos, Professor BEN MAY DEPARTMENT FOR CANCER RESEARCH Anning Lin, Professor BIOCHEMISTRY & MOLECULAR BIOLOGY Tobin Sosnick, Professor HUMAN GENETICS Bruce Lahn, Professor MEDICINE Marisa Alegre, Associate Professor Vineet Arora, Assistant Professor Anirban Basu, Assistant Professor Saima Chohan, Assistant Professor K. Douglas Hogarth, Assistant Professor Michelle Josephson, Professor Ann Mauer, Associate Professor Patrick Murray, Professor Elaine Petrof, Assistant Professor K. Gautham Reddy, Assistant Professor Daniel Spergel, Assistant Professor Walter Stadler, Professor Esra Tasali, Assistant Professor Janis Tupesis, Assistant Professor Tammy Utset, Associate Professor Monica Vela, Assistant Professor Chad Whelan, Associate Professor Amittha Wickrema, Associate Professor Tracie Wilcox, Assistant Professor Todd Zimmerman, Associate Professor MOLECULAR GENETICS & CELL BIOLOGY Jocelyn Malamy, Associate Professor ORGANISMAL BIOLOGY & ANATOMY Robert Ho, Professor PATHOLOGY Anthony Chang, Assistant Professor Anthony Montag, Professor PEDIATRICS Holly Benjamin, Associate Professor Maria Dowell, Assistant Professor Mark Hostetler, Associate Professor Peter Koenig, Associate Professor Tracy Koogler, Associate Professor Poj Lysouvakon, Assistant Professor Cathy Mavrolas, Associate Professor Swarupa Nimmagadda, Assistant Professor Tamara Nix, Assistant Professor Helaine Ross, Professor PSYCHIATRY Harriet de Wit, Professor RADIATION & CELLULAR ONCOLOGY Bulent Aydogan, Assistant Professor Steven Chmura, Assistant Professor RADIOLOGY Samuel Armato, Associate Professor Yulei Jiang, Associate Professor Gillian Newstead, Professor Mario Zaritzky, Assistant Professor SURGERY Tong-Chuan He, Associate Professor Ratneshwar Lal, Professor Gregory Lam, Instructor Tanguy Lim-Seiwert, Instructor Michael Maitland, Instructor Rupa Mehta, Assistant Professor Babak Mokhlesi, Assistant Professor Dan Nicolae, Associate Professor Anne O'Connor, Assistant Professor Monica Peek, Assistant Professor Minoli Perera, Instructor Blase Polite, Instructor PATHOLOGY Hikmat Al-Ahmadie, Assistant Professor Elizabeth Hyjek, Assistant Professor Jeffrey Mueller, Instructor Husain Sattar, Instructor PEDIATRICS Martin Bazi, Instructor Edith Chernoff, Assistant Professor Susan Cohn, Professor Rena Conti, Instructor Robert Bielski, Assistant Professor Kathleen Goss, Assistant Professor Mahesh Gupta, Associate Professor Ginard Henry, Assistant Professor Hue Luu, Assistant Professor Karl Matlin, Professor Jeffrey Matthews, Professor Russell Reid, Assistant Professor Martin ter Beest, Assistant Professor Mirjam Zegers, Assistant Professor NEUROLOGY Maria Baldwin, Assistant Professor OBSTETRICS & GYNECOLOGY Stuart Slaw, Assistant Professor S. Diane Yamada, Associate Professor Donald Liu, Professor Arieh Shalhav, Professor Mindy Statter, Associate Professor Dana Suskind, Associate Professor 36 UNIVERSITY OF CHICAGO MEDICAL CENTER 2007 ANNUAL REPORT 37

21 FEDERAL GRANTS Abe, Mark, Pediatrics Characterization of a ERK8, a New MAPK in Lung Abney, Mark A., Human Genetics National Center For Human Genome Research Methods for Complex Trait Mapping in Large Pedigrees Adams, Erin J., BMB Molecular Recognition of Ligand by the Gamma Delta T Cell Receptor Alegre, Maria-Luisa, Medicine Role of NF-kB Activation in Acute Allograft Rejection Alexander, Caleb, Medicine Agency for Healthcare Research and Quality A Randomized Controlled Trial (RCT) to Decrease Out-of-Pocket Prescription Costs Alexander, Kenneth, Pediatrics Anti-HPV RNA Interference Using Modified RNAs Alverdy, John, Surgery Pseudomonas Effects on the Gut Barrier from Surgery Anderson, Allen, Medicine Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist (TOPCAT) Armato, Samuel G., Radiology Computerized Analysis of Mesothelioma on Computed Tomography (CT) Scans Bakris, George, Medicine and Kidney Diseases AASK Cohort Study Bassiouny, Hisham, Surgery MR Determination of Carotid Atherosclerosis Progression Bell, Graeme, Medicine and Kidney Diseases Diabetes Research Training Center Bendelac, Albert, Pathology Glycolipid Presentation by CD1d Bendelac, Albert, Ben May Dept Can Res Interdisciplinary Training Program in Immunology Bergelson, Joy, E&E Forces Shaping Microbial Communities in the Phyllosphere of Arabidopsis thaliana Bergelson, Joy, E&E Evolutionary Genetics of R Loci in Arabidopsis Bergelson, Joy, E&E The Pattern of Polymorphism in Arabidopsis thaliana Beyer, Eric C., Pediatrics National Eye Institute Biology of Lens Intercellular Communication Beyer, Eric C., Pediatrics Connexons in Cardiovascular Cell Communication Bezanilla, Francisco, Pediatrics Electrophysiological Studies of Voltage Gated Channels Bezanilla, Francisco, Pediatrics Surface Plasmon-Coupled Flourescence Microscope to Study Ion Channel Dynamics Birukov, Konstantin, Medicine Mechanochemical Regulation of Endothelial Permeability Birukov, Konstantin, Medicine Control of Lung Permeability by Oxidized Phospholipids Bishop, Douglas K., Rad Onc Meiotic Interactions of the RecA Homologue Dmc1 Bishop, Douglas K., Rad Onc Genetic Dissection of BRCA1 s Recombination Function Bissonnette, Bruce, Medicine Roles of ErbB Signaling in Colonic Carcinogenesis Boone, David, Medicine and Kidney Diseases Regulation of TLR Signals and IBD by A20 Borevitz, Justin, E&E Genome Wide Association Mapping in Arabidopsis thaliana Brady, Matthew J., Medicine and Kidney Diseases Role of PTG in Adipocytic Glycogen Metabolism Bray, Elizabeth, MGCB Department of Energy Molecular-Genetic Analysis of Osmoregulation, Osmotic Adjustment and Growth in Arabidopsis Brorson, James, Neurology AMPA Receptor Expression and Selective Neuronal Death Burnet, Deborah, Medicine and Kidney Diseases Reach Out Chicago Children s Diabetes Prevention Project Burnet, Deborah, Pediatrics and Kidney Diseases Reducing Type-2 Diabetes Risk in African-American Youth Cagney, Kathleen A., Health Studies National Institute on Aging Neighborhood Context and the Health of Older Adults Cagney, Kathleen A., Health Studies Socioeconomic Status (SES) and Age-Related Disability in a Biracial Community Cai, Hua, Medicine Angiotensin II Uncoupling of enos in Hypertension Cai, Hua, Medicine Endocardial Dysfunction in Humans with Atrial Fibrillation Chang, Eugene B., Medicine and Kidney Diseases Inflammatory Bowel Disease (IBD) and Mucosal Inflammation, Immunology, and Microbiology of the GI Tract Chang, Eugene B., Medicine and Kidney Diseases Research Training in Digestive Diseases and Nutrition Chang, Eugene B., Medicine and Kidney Diseases Role and Regulation of Intestinal Na/H Exchangers Chang, Eugene B., Medicine and Kidney Diseases Cytoprotective Role of Heat Shock Proteins in IBD Chervonsky, Alexander V., Pathology and Kidney Diseases Genetic Control of Homing of Autoimmune T Cells Chervonsky, Alexander V., Pathology Infectious Diseases Fas in Host Defense and Autoimmune Diseases Cho, Judy, Medicine and Kidney Diseases IBD Genetics Consortium Data Coordinating Center Cho, Judy, Medicine and Kidney Diseases IBD Consortium Genetics Research Center Chong, Anita S., Surgery Infectious Diseases Graft Rejection and Accommodation by Anti-Gal mabs Chong, Anita S., Surgery and Kidney Diseases Spleen Regulation of Beta-Cell Regeneration Chong, Anita S., Surgery Stem Cells for Tolerance Induction Christian, Susan L., Human Genetics Genomic Imbalances in Autism Clark, Marcus Ramsay, Medicine B Cell Receptor Regulation of Antigen Processing Clark, Marcus Ramsay, Medicine Relationships Between B Cell Antigen Receptor Signaling and Endocytosis Claud, Erika C., Pediatrics National Institute of Child Health and Human Development Regulation of Inflammation in Immature Intestine Coates, Michael I., Evol Biology Environmental Protection Agency Loss, Generation and Maintenance of Ecomorphological Diversity in Marine Teleost Fishes: Deep Time Perspectives on Contemporary Biodiversity Basis Coccaro, Emil F., Psychiatry Impulsive Aggression: A Twin Study of Behavior and 5-HT Coccaro, Emil F., Psychiatry Fluoxetine and Divalproex: Treatment Correlates in Intermittent Explosive Disorder (IED) Coccaro, Emil F., Psychiatry Social Information Processing: Assessment Development Coe, Fredric L., Medicine and Kidney Diseases Pathogenesis of Calcium Nephrolithiasis Cohen, Ronald N., Medicine Recruitment of Corepressors in the Adipocyte Cohen, Ronald N., Medicine Role of SMRT and NCoR in Adipocyte Differentiation and Function Cohn, Susan, Pediatrics Children s Oncology Group Chair Award Cohn, Susan L., Pediatrics National Childhood Cancer Foundation for the Children s Oncology Group Cohn, Susan L., Pediatrics NANT (New Approaches to Neuroblastoma Therapy) Consortium Conzen, Suzanne D., Medicine Glucocorticoid Receptor-Mediated Survival Signaling in Breast Cancer Correa, Ana Maria, Pediatrics Voltage-Gating in Bacterial Ion Channels Cox, Nancy Jean, Medicine Genome-Wide Association for Asthma and Lung Function Cox, Nancy Jean, Medicine Genome-Wide Association Mapping of Metabolic, Lung and Cardiovascular Phenotypes Cox, Nancy Jean, Medicine and Kidney Diseases Copy-Number Polymorphism Analysis of the Type-2 Diabetes Gene Calpain 10 Cox, Nancy Jean, Medicine National Institute on Deafness and Other Communication Disorders Identification of Sex-Specific Genes for Stuttering Coyne, Jerry, E&E Genetic Basis of Species Differentiation in Drosophila Crispino, John D., Ben May Dept Can Res Mechanisms of Leukemogenesis in Down Syndrome Curlin, Farr A., Medicine National Center for Complementary and Alternative Medicine Religious Commitments and Clinical Engagements Dale, William, Medicine National Institute on Aging Emotions in Medical Decision-Making in Older Adults Dalvi, Arif, Neurology and Stroke POSTCEPT: A Longitudinal Observational Follow-up of the PRECEPT Study Cohort Dalvi, Arif, Neurology and Stroke PROGENI: Parkinson s Disease Collaborative Study of Genetic Linkage Daugherty, Christopher, Medicine Ethics and Clinical Trials in Advanced Cancer Care Daum, Robert S., Pediatrics Infectious Diseases Spread of Community-Acquired MRSA Among Household Contacts Daum, Robert S., Pediatrics Centers for Disease Control MRSA Colonization and Control in the Cook County Jail Dawson, Glyn, Pediatrics Glycosphingolipid Metabolism and Mental Retardation De Wit, Harriet, Psychiatry National Institute on Drug Abuse Drug Abuse and Impulsivity: Human Laboratory Models De Wit, Harriet, Psychiatry National Institute on Drug Abuse Craving During Smoking Abstinence: Does It Abate or Incubate? Deplewski, Dianne, Pediatrics and Kidney Diseases Role of PPAR Gamma Amino-Terminus in the Adipocyte Di Rienzo, Anna, Human Genetics and Kidney Diseases Evolutionary Genetics of the Metabolic Syndrome Di Rienzo, Anna, Human Genetics Local Adaptations in Humans Dignam, James J., Health Studies An Investigation of Approaches to Estimating Cause-Specific Survival After Early Stage Cancer Doi, Kunio, Radiology CAD for CT Nodules in Lung Cancer Detection Dolan, Mary Eileen, Medicine Role of DNA Repair in Protecting Against Secondary Leukemias 38 UNIVERSITY OF CHICAGO MEDICAL CENTER 2007 ANNUAL REPORT 39

22 Dolan, Mary Eileen, Medicine Pharmacology of Cyclophosphamide and Other Alkylators Du, Wei, Ben May Dept Can Res Control of Cell Proliferation and Differentiation in the Developing Retina Dudek, Steven, Medicine Cortactin in Regulation of Pulmonary Vascular Permeability Dudek, Steven, Medicine Endothelial Cell Cytoskeletal Regulation by Cortactin Dulawa, Stephanie, Psychiatry Mechanisms for 5-HTT Control of PPI and Perseverative Behavior Using Mouse Models Dulawa, Stephanie, Psychiatry Mechanism of the Antidepressant Response in 5-Ht1Ar Mice Dulin, Nickolai, Medicine Activation of Protein Kinase A by Endothelin-1 Dwyer, Gregory, E&E Mechanisms of Disease Transmission Variability in Host Susceptibility and Forest Defoliator Outbreaks Ehrmann, David A., Medicine Sleep, Metabolic, and Cardiovascular Dysfunction in Polycystic Ovarian Syndrome (PCOS) Ehrmann, David A., Medicine Post-Diabetes Prevention Program Ewigman, Bernard G., Family Medicine Health Resources and Services Administration Faculty Development in Prime Care Feder, Martin, Organ Bio and Anatomy Ecological and Evolutionary Physiology of Stress Response and Stress Proteins Fehon, Richard G., MGCB Function of Merlin, a Drosophila NF2 Gene Homologue Fehon, Richard G., MGCB Functions of the Epithelial Septate Junction Ferguson, Edwin L., MGCB Establishment of DPP Activity Gradient in Drosophila Fichera, Alessandro, Surgery Timing of Rectal Cancer Response to Chemoradiation Fleming, Gini, Medicine Cancer and Leukemia Group B Fleming, Gini, Medicine Gynecologic Oncology Group Developmental Therapeutics Committee: Chair/Co-Chair Foster, Ian, Instr/Research Architecture Work Group Participation Foster, Ian, Instr/Research Architecture Work Group Participation Fozzard, Harry A., Medicine Structure-Function of the Cardiac Sodium Channel Franzoso, Guido, Ben May Dept Can Res The NF-kB Target Gadd45B in Lymphocytes and Liver Franzoso, Guido Ben May Dept Can Res Roles of Gadd45-beta in JNK Signaling, Apoptosis, and Cancer Frim, David M., Surgery Hydrocephalus, Intracranial Pressure, and Neurocognition Fu, Yang-Xin, Pathology The Development and Function of Lymphoid Tissues Fu, Yang-Xin, Pathology The Role of IgE in Airway Inflammation Fu, Yang-Xin, Pathology The Role of Lymphoid Microenvironment in Autoimmunity Fu, Yang-Xin, Pathology Enhanced Immunity Inside of Tumor Microenvironment Gajewski, Thomas F., Pathology Countering Immune Resistance in the Melanoma Tumor Microenvironment Gajewski, Thomas F., Pathology T Cell Responsiveness and Homeostasis in Anti-Tumor Gao, Jia-Hong, Radiology National Center for Research Resources 3T MRI Scanner for High Resolution MRI/MRIS Research Gao, Jia-Hong, Radiology National Institute of Biological Imaging and Bioengineering Development and Optimization of Magnetic Source MRI Gao, Jia-Hong, Radiology Office of Naval Research MRI of Current Density and Current Pathways Study Garcia, Joe G.N., Medicine Cytoskeletal Regulation of Lung Endothelial Pathobiology Garcia, Joe G.N., Medicine Ventilator-Associated Lung Injury: Molecular Approaches Garcia, Joe G.N., Medicine Environmental Protection Agency Particulate Matter Research Center (Toxicity Project) Garcia, Joe G.N., Medicine Pulmonary Hypertension and the Hypoxic Response in Sudden Cardiac Death (SCD) Garcia, Joe G.N., Medicine Endothelial Cell Phenotypes in Health and Disease Gershon, Elliot S., Psychiatry Fine Genomic Mapping of 13q32 in Bipolar Disorder Gershon, Elliot S., Psychiatry A Collaborative Genetic Study of Bipolar Disorder Gershon, Elliot S., Psychiatry Multidisciplinary Psychiatric Genetics Training Program Getz, Godfrey S., Pathology Lymphotoxin/LIGHT in Lipoprotein Metabolism and Atherosclerosis Getz, Godfrey S., Pathology ApoA1 Determining HDL Subclasses and Atherosclerosis Giger, Maryellen L., Radiology National Institute of Biological Imaging and Bioengineering Research Training in Medical Physics Giger, Maryellen L., Radiology National Institute of Arthritis and Musculoskeletal and Skin Diseases Computerized Radiographic Analysis of Bone Structure Giger, Maryellen L., Radiology Optimization of Computer-Aided Diagnosis (CAD) Output in Breast Imaging Giger, Maryellen L., Radiology Army Research Office Correlative Feature Analysis for Multi-Modality Breast CAD Gilad, Yoav, Human Genetics Natural Selection on Gene Regulation in Humans Gilliam, T. Conrad, Human Genetics Genetics of Common Heritable Disorders in Venezuela Gilliam, T. Conrad, Human Genetics National Center for the Study of Cellular Networks Glick, Benjamin, MGCB The Transitional ER-Golgi System in Budding Yeasts Glick, Susan, Medicine Cultural Competence Training for Resident Physicians Glotzer, Michael A., MGCB Molecular Dissection of Cytokinesis Glotzer, Michael A., MGCB Control of Central Spindle Assembly Goldberg, Jay M., NPP National Institute on Deafness and Other Communication Disorders Cellular Mechanisms of the Vestibular System Goldstein, Steve A.N., Pediatrics National Institute of Child Health and Human Development Research Career Training in Pediatrics Goldstein, Steve A.N., Pediatrics Cardiac K2P and Kv4 Potassium Channels Goldstein, Steve A.N., Pediatrics National Institute of Child Health and Human Development Investigation of the Role of Staphylococcus aureus Cytotoxins and Heme-Iron Uptake Pathways in a Murine Model of Pneumonia Golovkina, Tatyana, Microbiology Subversion of Innate Immune Response by Retroviruses Golovkina, Tatyana, Microbiology Novel Pathways in Retroviral Tumorigenesis Gomez, Christopher M., Neurology Acetylcholine Receptor Genes in Slow-Channel Syndrome Gornicki, Piotr, MGCB Department of Agriculture International Wheat Genome Sequencing Consortium: A Physical Map and Sample Sequencing of the Homoeologous Group-3 Chromosomes of Wheat Gray, Lawrence A., Pediatrics National Institute of Child Health and Human Development Mother s Soothing: Metabolic and Physiologic Advantages Grdina, David, Rad Onc Delayed Radioprotection by Thiols Grdina, David, Rad Onc Department of Energy Prevention of Low Dose Radiation-Induced Genomic Instability With Clinically Relevant Non-Protein Thiols and Vitamin E Grdina, David, Rad Onc D609 A Novel Cytoprotectant and Selective Antitumor Agent Green, William, Neurobiology National Inst. of Neurological Disorders The Neuronal a-bungarotoxin Binding Site Greenberg, Jean, MGCB Department of Agriculture Mechanism of ACD2 in Plant Cell Survival During Abiotic Stress Greenberg, Jean, MGCB Molecular Basis of Pathogen-Induced Cell Death in Plants Greenberg, Jean, MGCB Comparative Analyses of Resistance Gene Evolution Greenberg, Jean, MGCB ALD1-Dependent Signaling in the Plant Defense Response Greenberg, Jean, MGCB Effectors Required for Epiphytic Growth of P Syringae Greene, Geoffrey, Ben May Dept Can Res Graduate Training Program in Cancer Biology Grove, Elizabeth, Neurobiology The Role of the Cortical Hem in Patterning the Telencephalon Grove, Elizabeth, Neurobiology Molecular Mechanisms of Cerebral Cortical Patterning Grove, Elizabeth, Neurobiology The Specific Role of FGF8 and FGF17 in Cortical Patterning Gupta, Mahesh P., Surgery The Role of PARP-SIR2 Signalling in Heart Failure Hale, Melina E, Organ Bio and Anatomy Reticulospinal Control of Alternative Startle Behaviors Halpern, Howard, Rad Onc National Institute of Biological Imaging and Bioengineering Very Low Frequency EPR Imaging for in Vivo Physiology Halpern, Howard, Rad Onc National Institute of Biological Imaging and Bioengineering Magnitude Improvement of Molecular Signaling Imaging Hamann, Kimm Jon, Medicine Oxidants and Caspases: Initiation of Reperfusion Injury Hanck, Dorothy, Medicine Cardiac Channels: Targets of Drugs That Affect Kinetics Haraf, Daniel J., Rad Onc Oropharyngeal Function After Radiotherapy With Intensity Modulated Radiation Therapy (IMRT) Harvey, Ronald G., Ben May Dept Can Res Molecular Mechanisms of Multistage Carcinogenesis: Core 2 Harvey, Ronald G., Ben May Dept Can Res Molecular Mechanisms of Multistage Carcinogenesis: Project 2 Hatsopoulos, Nicholas G., Organ Bio and Anatomy Coding of Action by Motor and Premotor Cortical Ensembles Haydon, Rex C., Surgery National Institute of Arthritis and Musculoskeletal and Skin Diseases BMP6-Mediated Osteogenesis He, Tong-Chuan, Surgery Regulation of Beta-Catenin Signaling by Tyrosine Phosphorylation 40 UNIVERSITY OF CHICAGO MEDICAL CENTER 2007 ANNUAL REPORT 41

23 Herbst, Arthur L., Ob Gyn Continuation of Follow-Up of DES Exposed Cohorts Ho, Robert K. Organ Bio and Anatomy Specification of Blood Lineages in a Vertebrate Embryo Hoover, Robert, Medicine Regulation of the Sodium Chloride Cotransporter Huang, Elbert, Medicine National Institute on Aging Individualizing Diabetes Care for Older People Imamoto, Akira, Ben May Dept Can Res National Institute for Dental Research Developmental/Genetic Analysis of DiGeorge Models Jablonski, David, E&E Macroevolutionary Consequences of Abundance in Paleogene Bivalves Jabri, Bana, Pathology IEL and NKG2 Receptors in Celiac Disease Jabri, Bana, Pathology Regulation of Normal Human IEL By NKGD2D and IL-15 Jabri, Bana, Pathology Mechanism Underlying Immune-Modulatory Effects of LcrV Jacobson, Jeffrey, Medicine Endothelial Barrier Regulation by Simvastatin Jacobson, Kristen, Psychiatry The VETSA Longitudinal Study of Cortisol and Aging Josephs, Robert, MGCB Structure, Interaction, and Mechanism in Sickle Hemoglobin Kalinichenko, Vladimir, Medicine Fox Transcription Factors in Development of Pulmonary Capillaries Kang, Un Jung, Neurology The Neuroprotective Effect of Tetrahydrobiopterin Kang, Un Jung, Neurology The Neuroprotective Mechanism of DJ-1 in Parkinson s Disease Karczmar, Gregory, Radiology National Institute of Biological Imaging and Bioengineering High Spectral and Spatial Resolution Imaging of Breast Cancer Karczmar, Gregory, Radiology Fast Spectroscopic MR Imaging of Breast Cancer Karczmar, Gregory, Radiology Dynamic Spatial and Spectral Contrast Enhanced MRI of Breast Kee, Barbara Lynne, Pathology Regulation of Lymphocyte Development by Helix-Loop-Helix Proteins Keenan, Kathryn, Psychiatry Preadolescent Precursors to Depression in Girls Kent, Stephen Brian Henry, BMB A Systemic Approach to the Chemical Synthesis of G-Protein Coupled Receptors Kidwell, Susan M., Evol Biology Ecological Insight from Temperate Large-Mammal Death Assemblages in Yellowstone National Park Kindler, Hedy, Medicine Phase II Study of BAY for Patients with Imatinib-Resistant Gastrointestinal Stromal Tumors King, Andrea C., Psychiatry National Institute on Drug Abuse Efficacy of Naltrexone in Women s Smoking Cessation King, Andrea C. Psychiatry National Institute on Alcohol Abuse and Alcoholism Alcohol Stimulation and Sedation in Binge Drinkers King, Andrea C., Psychiatry National Institute on Alcohol Abuse and Alcoholism Alcohol Effects on Smoking Urge and Behavior Kittles, Rick, Medicine Department of Defense Admixture Mapping for Prostate Cancer Susceptibility Genes in African Americans Kittles, Rick, Medicine EphB2 as a Prostate Cancer Tumor Suppressor and Risk Factor in African Americans Kittles, Rick, Medicine Department of Health and Human Services Construction and Application of a US Admixture Map Konetzka, Rita Tamara, Health Studies Agency for Healthcare Research and Quality The Impact of Public Reporting on Nursing Home Quality of Care Kossiakoff, Anthony, BMB Integrated Centers for Structure and Function Innovation Kossiakoff, Anthony, BMB Chaperone Assisted Crystallography Kraig, Richard, Neurology Glial Reaction to Ischemic Brain Injury Kreitman, Martin, E&E Resolving Spatial Patterning and Egg Size in Drosophila Kron, Stephen J., MGCB National Center For Human Genome Research Molecular Library Screening By MALDI-TOF Scanning Of Functional Peptide Arrays Kron, Stephen J., MGCB BCR-ABL Kinase Assays for STI571 Sensitivity or Response Kron, Stephen J., MGCB and Kidney Diseases Undergraduate Training Program in Chemical and Physical Biology Kron, Stephen J., MGCB Radiation-Induced G1 Checkpoint Arres in Yeast Kron, Stephen J., MGCB Bcr-Abl Thiophosphorolation Profiling in Chronic Myelogenous Leukemia (CML) Using Matrix Assisted Laser Desorption Ionisation (MALDI) Kron, Stephen J., MGCB Role of the Lig3 BRCT Domains in DNA Repair Kron, Stephen J., MGCB Undergraduate Training Program in Chemical and Physical Biology Lahey, Benjamin, Health Studies Validity of DSM-IV Subtypes of Attention Deficit Hyperactivity Disorder (ADHD) for Young Children Lahey, Benjamin, Health Studies Genetic Epidemiology of Youth Conduct Problems Lahn, Bruce T., Human Genetics Paralleling Single-Cell Gene Expression Profiling Lal, Ratneshwar, Medicine Amyloid Ion Channels to Design Therapeutics for Neurodegenerative Diseases Lam, Ying-Wan, Neurobiology Circuit Basis of the Cortical Control of Sensory Information Flow in the Thalamus Lamppa, Gayle K., MGCB A Novel Genetic Strategy to Explore the Chloroplast Import Pathway Lauderdale, Diane S., Health Studies Time Allocated for Sleep: Sociodemographic Correlates and Secular Change Le Grange, P. Daniel F., Psychiatry Treatment for Adolescent Anorexia Nervosa Le Grange, P. Daniel F., Psychiatry Ecological Momentary Assessment of Anorexia Nervosa Le Beau, Michelle M., Medicine Etiology of Treatment Induced Secondary Leukemia Lee, Kwang-Sun, Pediatrics Competition, Volume, NICU Level and Outcome in California Lee, Raphael, Surgery Department of Defense Non-Ionizing Research: Electrical Stimulation of Biological Tissues Leff, Alan, Medicine Transcellular Communication in Airway Inflammation and Airway Hyperresponsiveness Lengyel, Ernst Robert, Ob Gyn Regulation of Adhesion and Proteolysis in Ovarian Cancer Lesniak, Maciej S., Surgery Targeted Adenoviral Gene Therapy for Malignant Glioma Li, Qiang, Radiology CAD for Lung Cancer Detection and Classifiction in CT Li, Wen-Hsiung, E&E Statistical Studies of DNA Evolution Li, Yanchun, Medicine Cardiovascular Effect of the Vitamin D Endocrine System Li, Yanchun, Medicine Vitamin D and Diabetic Nephropathy Li, Yanchun, Medicine Preventative Role of Vitamin D Receptor (VDR) in Colorectal Carcinogenesis Lin, Anning, Ben May Dept Can Res Integration of TNF Signaling in Apoptosis Lin, Anning, Ben May Dept Can Res Targeting BAD by c-jun N-terminal kinase (JNK) for Cell Survival Lingen, Mark W., Pathology National Institute for Dental Research Molecular Profiling of Premalignant Oral Lesions Lingen, Mark W., Pathology National Institute for Dental Research Oral Cancer, Chemoprevention, and Anti-Angiogenesis Lipton, Rebecca Bornstein, Pediatrics Chicago Childhood Diabetes Registry Llano, Daniel, Neurology National Institute on Deafness and Other Communication Disorders Functional Organization of Auditory Corticothalamic Projection Systems Long, Manyuan, E&E Detection of Distribution of New Genes in Drosphila Phylogeny Long, Manyuan, E&E Variation of D. melanogaster Chromosome 4 Long, Manyuan, E&E Genomic Analysis for Rates and Patterns of New Gene Originations in Drosophila Macleod, Kay, Ben May Dept Can Res Functions of prb in Stress Erythropoiesis Madara, James L., Pathology Functional Morphology of Intestinal Permeability Maki, Carl G., Rad Onc P53 Localization and Activity in Normal and Human Tumor Cells Maki, Carl G., Rad Onc Physical and Functional Interactions Between PML and MDM2 Makinen, Marvin W., BMB Predoctoral Training Program in Chemistry and Biology Malamy, Jocelyn, MGCB The Adaptation of Plant Development to Environmental Stress Margoliash, Daniel, Organ Bio and Anatomy National Institute on Deafness and Other Communication Disorders Characterization of Non-Linear Auditory Receptive Fields Margoliash, Daniel, Organ Bio and Anatomy Neurophysiology of Sensorimotor Learning Margoliash, Daniel, Organ Bio and Anatomy CRCNS: Statistics of Temporal Patterns in Sleep Mechanisms of Learning Margoliash, Daniel, Organ Bio and Anatomy National Institute on Deafness and Other Communication Disorders Cholinergic Regulation of a Sensorimotor Nucleus Marks, Jeremy, Pediatrics Mechanisms of Copolymer-Mediated Neuroprotection Marks, Jeremy, Pediatrics Department of Energy Imaging Polymer-Mediated Repair of the Neuronal Plasma Membrane at the Nanoscale Level Mason, Peggy, Neurobiology Training in Neural Systems Mason, Peggy, Neurobiology Pain Modulation and Visceral Stimulation Mason, Peggy, Neurobiology Roles for VMM Cells During Micturation and Continence Mastrianni, James A., Neurology The Role of the Lyosome in ER-Associated Degradation of Prp 42 UNIVERSITY OF CHICAGO MEDICAL CENTER 2007 ANNUAL REPORT 43

24 Matlin, Karl S., Surgery Cell-Matrix Interactions in Epithelial Polarization Matthews, Jeffrey B., Surgery Salt Transport in Surgical Diarrheal Disease Mc Gehee, Daniel S., Anesthesia & CC National Institute on Drug Abuse Nicotinic Modulation of the Mesoaccumbens DA System Mc Gehee, Daniel S., Anesthesia & CC National Institute on Drug Abuse The Processing of Tonic and Burst Activity Patterns in DA Terminals in the NAcc Mc Gehee, Daniel S., Anesthesia & CC National Institute on Drug Abuse Nicotinic and Dopamine Receptor Interactions in the Ventral Tegmental Area (VTA) Mc Gehee, Daniel S., Anesthesia & CC National Institute on Drug Abuse Adolescent Cocaine Abuse: Electrophysiology and Behavior McCloskey, Michael S., Psychiatry Individual Cognitive-Behavioral Psychotherapy for Intermittent Explosive Disorder (IED) McCrea, Robert A., Neurobiology National Eye Institute Physiology of Oculomotor Premotor Pathways McDade, William A., Anesthesia & CC The University of Chicago Young Scientist Program McKee, Mark D., Surgery CEA-Directed Cancer Treatment with Gene-Modified T Cells McLeod, Rima, Ophthalmology Innate Immune Receptors for Toxoplasma Gondii McNally, Elizabeth M., Medicine Cardiovascular Sciences Training Grant McNally, Elizabeth M., Medicine Sulfonylurea KATP Channels in Vascular Spasm McNally, Elizabeth M., Medicine Sarcoglycan in Myopathy and Muscle Membrane Stability McNally, Elizabeth M., Medicine Molecular Regulation of Cardiac KATP Channels in Ischemia Meltzer, David, Medicine Centers for Disease Control Chicago Center of Excellence in Health Promotion Economics Meltzer, David, Medicine Effectiveness of Training Early Achievers for Careers in Health (TEACH) Research Meltzer, David, Medicine National Institute on Aging MD/PhD Program in Medicine, Social Sciences, and Aging Meredith, Stephen C., Pathology National Inst. of Neurological Disorders N-Methyl and Other Peptide Inhibitors of Fibrillogenesis Millen, Kathleen J., Human Genetics Genetic Analysis of Roof Plate Function in the Central Nervous System (CNS) Millen, Kathleen J., Human Genetics National Institute of Child Health and Human Development Finding the Cause of Vertebrate Congenital Caudal Duplication Miller, Michael, Evol Biology Environmental Protection Agency Patterns and Processes of Diversity in Arbuscular Mycorrhizal Fungi (Glomeromycota) Moffat, John Keith, BMB Time-Resolved Macromolecular Crystallography Mueller, Gregory M., Evol Biology Department of Education Graduate Assistance in Areas of National Need: Evolutionary Environmental Biology Natarajan, Viswanathan, Medicine Nox4 in Endothelial Cell ROS Production, Signaling, and Motility Natarajan, Viswanathan, Medicine Intracellular S1P and Signaling in Lung Endothelial Cells Naureckas, Edward, Medicine Veterans' Administration Outcomes Associated With Salmetrol Use in Obstructive Lung Disease Nelson, Deborah, NPP Role of Ion Channels in Mononuclear Phagocyte Activation Newstead, Gillian, Radiology New Approaches to Sampling and Analyzing Contrast Media Nicosia, Antonia, Ob Gyn Agency for International Development A Multicenter, Open-Label Study on the Efficacy, Cycle Control and Safety of a Contraceptive Vaginal Ring Delivering a Daily Dose of 150mcg of Nestrorone and 15mcg of Ethinylestradiol (150/15 NES/EE CVR) Protocol 300 B Nishikawa, Robert, Radiology High-Performance Computer Cluster for Image Analysis Noth, Imre, Medicine Combination Therapy in Idiopathic Pulmonary Fibrosis Noth, Imre, Medicine IPFnet: Idiopathic Pulmonary Fibrosis Clinical Research Network Ober, Carole, Human Genetics Sex-Specific Genetic Architecture of Asthma-Associated Quantitative Traits Ober, Carole, Human Genetics Positional Cloning of a 6p-Linked Asthma Gene Ober, Carole, Human Genetics Gene-Environment Interactions and the Origins of Asthma Ober, Carole, Human Genetics HLA-G at the Maternal-Fetal Interface Ober, Carole, Human Genetics National Institute of Child Health and Human Development Molecular Genetic Studies of Fertility in the Hutterites Ober, Carole, Human Genetics Genetic and Mechanistic Determinants of Rhinovirus-Induced Asthma Odenike, Olatoyosi, Medicine Phase I Study of PXD101 in Combination with 5-Aza for Advanced Hematologic Malignacies Ojakangas, Catherine, Surgery Cerebral Mechanisms of Skill Learning in Humans Olopade, Olufunmilayo, Medicine Chicago Specialized Programs of Research Excellence (SPORE) in Breast Cancer Olopade, Olufunmilayo, Medicine Genetics of Breast Cancer in Blacks Olopade, Olufunmilayo, Medicine Basic Medical Research Training in Medical Oncology Palmer, Abraham A., Human Genetics National Institute on Drug Abuse Mouse QTL Translational Genetic Study of Methamphetamine Sensitivity Palmer, Abraham A., Human Genetics Translational Genetic Study of Fear and Anxiety Pan, Tao, BMB Kinetic/Thermodynamic/Structural Studies of RNA Folding Pan, Xiaochuan, Radiology National Institute of Biological Imaging and Bioengineering Targeted Imaging in Helical Cone Beam CT Pan, Xiaochuan, Radiology Department of Energy Phase-enhancement Micro-Computed Tomography Peek, Monica, Medicine The Impact of Shared Decision-Making Among African-Americans with Diabetes Pelizzari, Charles, Rad Onc Army Research Office Cone-Beam Computed Tomography for Image- Guided Radiation Therapy of Prostate Cancer Perozo, Eduardo, Pediatrics High Resolution Structural Dynamics of K Channels Perozo, Eduardo, Pediatrics Structural Dynamics of Mechanosensitive Channels Peter, Marcus E., Ben May Dept Can Res The Role of CD95 as a Tumor Promoter Peter, Marcus E., Ben May Dept Can Res Molecular Characterization of the Two CD95 Pathways Peter, Marcus E., Ben May Dept Can Res CD95 Signaling Mechanisms Petrof, Elaine, Medicine Probiotic Effects on Gut Epithelial HSPs and NF-kB Pfister, Catherine, E&E Department of Education Graduate Assistance in Areas of National Need: Ecology Phan, Kinh Luan D., Psychiatry Neuro-Genetic Markers of SSRI Treatment Response in Social Anxiety Disorder Philipson, Louis, Medicine Minority Predoctoral Fellowship Program Pilipenko, Evgeny, Microbiology Infectious Diseases The Role of Proteasomes in Viral RNA Translation Popko, Brian J., Neurology Genetic Analysis of Glycan Function in Myelinating Cells Popko, Brian J., Neurology National Center for Drug Discovery in Neurodegeneration Posner, Mitchell C., Surgery American College of Surgeons Oncology Group Chair, Gastrointestinal Committee Preuss, Daphne, MGCB Department of Energy Cell-Cell Interactions During Pollen Tube Guidance Preuss, Daphne, MGCB Dynamics of Centromere Evolution in the Brassicaceae Family Price, Trevor D., E&E Analysis of Regional Variation in Bird Species Diversity Along the Himalayas Prince, Victoria E., Organ Bio and Anatomy National Institute of Child Health and Human Development Role of cdx Genes and RA in Regionalizing the Endoderm Prince, Victoria E., Organ Bio and Anatomy and Kidney Diseases Early Development of the Zebrafish Pancreas Pritchard, Jonathan K., Human Genetics National Center For Human Genome Research Linkage Disequilibrium Methods for Complex Trait Mapping Pruett-Jones, Stephen, E&E Mechanisms of Sperm Competition in Fairy Wrens Przeworski, Molly, Human Genetics Identifying Human Adaptations: Theory and Applications Qin, Kenan, Pediatrics National Institute of Child Health and Human Development Regulation of Testosterone Synthesis in Theca Cells Quigg, Richard, Medicine Pathogenic Role of the Complement System in Murine Lupus Quigg, Richard, Medicine Nephrology Research Training Quigg, Richard, Medicine Targeting Complement Inhibitors to the Human Proximal Tubule Quinn, Michael T., Medicine Health Resources and Services Administration Increasing Organ and Tissue Donation in the Service Industry/Factory Workplace: A Peer Educator Approach Quintans, Jose, Pathology Medical Scientist National Research Service Award Ramirez, Jan-Marino, Organ Bio and Anatomy Substance P in the Central Respiratory Neural Network Ramirez, Jan-Marino, Organ Bio and Anatomy Hypoxic Effects on Mammalian Respiratory Neural Network Ratain, Mark J., Medicine Pharmacogenetics of Anticancer Agents Research Group Ratain, Mark J., Medicine Phase I Clinical Trials of Anticancer Agents Ratain, Mark J., Medicine Clinical Therapeutics Ratain, Mark J., Medicine Clinical Trials Working Group Rathouz, Paul, Health Studies Social-Emotional Contexts of Adolescent Smoking Patterns Rebay, Ilaria, Ben May Dept Can Res National Eye Institute Cell-Cell Signaling in Embryonic and Retinal Development Reder, Anthony T., Neurology National Center for Research Resources Treatment of Multiple Sclerosis 44 UNIVERSITY OF CHICAGO MEDICAL CENTER 2007 ANNUAL REPORT 45

25 Reder, Anthony T., Neurology Quality of Life Outcomes in Neurological Disorders Refetoff, Samuel, Medicine Thyroid Physiology Studies of Inherited Disorders Refetoff, Samuel, Medicine Integrated Clinical and Basic Science Endocrinology Research Rezania, Kourosh, Neurology Clinical Trial of Ceftriaxone in Subjects with ALS Rhodes, Christopher J., Medicine Metabolic Control of Proinsulin Biosynthesis Translation Rhodes, Christopher J., Medicine Mitogenic Signal Transduction in Pancreatic Beta Cells Rice, Phoebe A., BMB Structure Biochemistry of Recombinase- DNA Complexes Rock, Ronald S., BMB Allostery in Myosins Studied at the Molecular Level Roe, Michael W., Medicine Calcium Signaling in Pancreatic Beta Cell Endoplasmic Reticulum Roizman, Bernard, Microbiology Functions of Herpes Simplex Virus ICP22 and US1.5 Roizman, Bernard, Microbiology Dissection of the Functions of Herpes Simplex Virus ICPO Roizman, Bernard, MGCB Selective Degradation of mrna by Herpes Simplex Virus 1 Roman, Brian B., Radiology NMR Detection of Gene Expression Roman, Brian B., Radiology National Institute of Biological Imaging and Bioengineering Imaging Pancreatic B-Cell Function by Magnetic Resonance Roos, Raymond P., Neurology Picornavirus - Host Cell Interactions and Disease Rosenfield, Robert L., Pediatrics Pediatric Endocrinology Research Training Grant Rosengart, Axel, Neurology Department of Energy Magnetically Targeted Thermal Cancer Therapy Using Designer Nanospheres Rosner, Marsha, Ben May Dept Can Res Signaling Pathways In Differentiating Neuronal Cells Rosner, Marsha, Ben May Dept Can Res Role of Raf Kinase Inhibitory Protein in Prostate Cancer Rosner, Marsha, Ben May Dept Can Res Modulation of Head and Neck Cancer by Protein Kinase C Ross, Helaine Friedman, Pediatrics Ethical Issues in Living Donor Transplantation Roth, Steven, Anesthesia & CC National Eye Institute The Role of Adenosine in Retinal Ischemia Rothman-Denes, Lucia, MGCB Genetics and Regulation (NRSA) Rothman-Denes, Lucia,MGCB Novel Transcribing Activities in N-4 Infected E. coli Roux, Benoit, Pediatrics Computational Studies of Ion Channels Roux, Benoit, Pediatrics Polarizable Force Field for Proteins and Lipids Roux, Benoit, Pediatrics Putting Molecular Dynamics to the Test: Ion Permeation Salgia, Ravi, Medicine Studies of a Novel Therapeutic Target in Non-Small Cell Lung Cancer (NSCLC) Salgia, Ravi, Medicine Role of c-met in Small Cell Lung Cancer (SCLC) and Potential for Novel Therapies Sanchez-Johnsen, Lisa A.P., Psychiatry Cultural Proficient Smoking and Weight Control Treatment Scanu, Angelo M., Medicine Biology of Proteolytic Derivatives of Lp(a) Schilsky, Richard, Medicine CALGB Human Specimen Repositories Schilsky, Richard, Medicine Quality of Life of African American Survivors of Cancer Schneewind, Olaf, Microbiology Bioterrorism: Molecular Analysis and Intervention Schneewind, Olaf, Microbiology LcrV Plague Vaccine with Altered Immune Modulatory Properties Schneewind, Olaf, Microbiology Surface Proteins and Sortases of Bacillus anthracis Schneewind, Olaf, Microbiology Surface Protein Anchoring in Gram Positive Bacteria Schneewind, Olaf, Microbiology Targeting Yop Proteins by Yersinia Enterocolitica Schneewind, Olaf, Microbiology Biodefense Training in Host-Pathogen Interactions Schreiber, Hans, Pathology CD8+ T Cells and Immunological Tumor Regression Schreiber, Hans, Pathology Manipulation of Tumor Specific Immunity Schreiber, Hans, Pathology Immunology of Unique Tumor Specific Antigens Schwartz, Nancy B., Pediatrics National Institute of Child Health and Human Development Biological Basis of Mental Retardation Schwartz, Nancy B., Pediatrics National Institute of Child Health and Human Development JP Kennedy Mental Retardation and Developmental Disabilities Research Center (MRDDRC) Schwartz, Nancy B., Pediatrics National Institute of Child Health and Human Development Graduate Training in Growth and Development Schwartz, Nancy B., Pediatrics National Institute of Child Health and Human Development Proteoglycan Synthesis in Mutant Mouse Systems Schwartz, Nancy B., Pediatrics Post Baccalaureate Research Education Program (PREP) Sherman, S. Murray, Neurobiology National Eye Institute Effects of Visual Deprivation on the Visual System Sherman, S. Murray, Neurobiology Information Processing in Sensory Systems Sherman, S. Murray, Neurobiology National Institute on Deafness and Other Communication Disorders Auditory Coticothalamic Projection Sytems Sherman, S. Murray, Neurobiology The Thalamocortical Synapse in Layers IV and VI Shilling, Rebecca, Medicine Infectious Diseases ICOS Expression Levels and Th Development Shubin, Neil H., Organ Bio and Anatomy Late Davonian Tetapodomorph Fishes and the Origin of Tetrapods Sidky, Emil, Radiology National Institute of Biological Imaging and Bioengineering Helical CT Reconstruction and Lung Cancer Screening Sipkins, Dorothy A., Medicine Imaging Cell Homing and Engraftment in the Bone Marrow Sisodia, Sangram S., Neurobiology Modulation of Beta Amyloid Peptide Deposition by Environmental Enrichment Sisodia, Sangram S., Neurobiology PKC Modulations for the Treatment of Alzheimers Disease Small, Stephen, Anesthesia & CC Agency for Healthcare Research and Quality Immersive Simulation Team Training Impact on Rescue, Recovery, and Safety Culture Small, Steven L., Neurology National Institute on Deafness and Other Communication Disorders Functional Neuroanatomy of Normal and Impaired Language Small, Steven L., Neurology National Institute on Deafness and Other Communication Disorders Neurophysiological Measurement in Aphasia Treatment Small, Steven L., Neurology National Institute on Deafness and Other Communication Disorders Bioinformatics Infrastructure for Large Scale Studies of Aphasia Recovery Smith, Peter J., Pediatrics Maternal and Child Health Bureau Illinois Medical Home Project Solway, Julian, Medicine National Institute of Allergy and Molecular Mechanisms of Asthma Solway, Julian, Medicine Research Training in Respiratory Biology Solway, Julian, Medicine Plasticity Regulation of Contracted Airway Smooth Muscle Solway, Julian, Medicine Imaging Airway Myocyte Ca2+ Signaling in Living Animals Sosnick, Tobin R., BMB Kinetic Studies of Protein Folding Sosnick, Tobin R. BMB Department of Energy The Protein Problem Spergel, Daniel J., Medicine National Institute of Child Health and Human Development Calcium Signaling in the Pubertal Activiation of the GnRH Pulse Generator Sperling, Anne I., Medicine CD43 Regulation of Immune Responses Sperling, Anne I., Medicine Mechanisms of Resolution in Experimental Asthma Stadler, Walter M., Medicine Dynamic Contrast-Enhanced MRI as a BAY Marker Stadler, Walter M., Medicine Phase II Study of AZD2171 in Pts with Advanced Refractory Renal Cell Carcinoma Staley, Jonathan P., MGCB Mechanisms for Rearranging RNA During Pre-mRNA Splicing Steinberg, Gary, Surgery Bladder Ca Microsatellite Analysis of Urinary Sediment Stephens, Matthew, Ben May Dept Can Res Genome Analysis: Data Accuracy, Haplotyping and Mapping Stephens, Matthew, Human Genetics Multipoint and Significance Methods for Genome-Wide Association Studies Storb, Ursula B., MGCB Mechanism of Immunoglobulin Hypermutation Storb, Ursula B., MGCB Immunoglobin Somatic Mutation Sun, Xiao Jian, Medicine Mechanism of Insulin-Induced Ubiquitination of IRS-1 Svensson, Eric C. Medicine Transcriptional Regulation of Cardiac Development Sweiss, Nadera, Medicine Infectious Diseases SCSSc-01: High-Dose Immunosuppressive Therapy Using Total Body Irrasiation, Cyclophosphamide, TGAM, and Autologous Transplantation with Auto-CD34+HPC vs Intravenous Pulse Cyclophosphamide for the Tx of Severe Systemic Sclerosis (SCOT) Tang, Wei-Jen, Ben May Dept Can Res Calmodulin-Activated Adenyl Cyclase Toxins Tang, Wei-Jen, Ben May Dept Can Res SK2-Associated Protein Kinase CK2: Molecular Basis and Physiological Roles Tasali, Esra Fatma, Medicine Pathways Linking Reduced Sleep Duration and Quality to Obesity Risk Thinakaran, Gopal, Neurobiology National Institute on Aging Amyloidogenic Processing of APP 46 UNIVERSITY OF CHICAGO MEDICAL CENTER 2007 ANNUAL REPORT 47

26 Thinakaran, Gopal, Neurobiology National Inst. of Neurological Disorders Mouse Model for Neuroprotection Thirman, Michael J., Medicine MLL Fusions and Cooperating Mutations in Acute Leukemia Thirman, Michael J., Medicine Molecular Genetics of MLL-Associated Leukemia Thistlethwaite, J. Richard, Surgery Immunosuppression Withdrawal in Liver Transplant Recipients Workscope: Planning Grant for Clinical Trial of Immunosuppression Withdrawal in Liver Transplant Recipients Tupesis, Janis, Medicine Health Resources and Services Administration Bioterrorism Training and Curriculum Development Program (BTCDP) Turkewitz, Aaron, MGCB Biogenesis of Dense Core Secretory Granules in Tetrahymena Turkewitz, Aaron, MGCB Characterization of a Dynamin-Related Protein Involved in Endocytosis in Tetrahymea thermophila Turner, Jerrold R., Pathology Regulation of Paracellular Permeability by IFNgamma and TNFalpha Turner, Jerrold R., Pathology Physiological Regulation of Intestinal Epithelial Transport and Barrier Function Turner, Jerrold R., Pathology Regulation of Intestinal Transport Ulinski, Philip S., Organ Bio and Anatomy Training in Computational Neuroscience Ulinski, Philip S., Organ Bio and Anatomy National Institute on Drug Abuse Undergraduate Training in Computational Neuroscience: From Biology to Model and Back Again Ulinski, Philip S., Organ Bio and Anatomy Computational Neuroscience Annual Meeting Van Besien, Koen, Medicine Busulfan Conditioning: Optimization, Kinetics, Genomics Van Cauter, Eve, Medicine National Institute on Aging Alterations of Circadian Timing in Sleep and Aging Van Cauter, Eve, Medicine Sleep Disturbance as a Non-Traditional Risk Factor in Chronic Kidney Disease (CKD) Van Cauter, Eve, Medicine Predictors of Adverse Metabolic Effects of Sleep Loss Van Voorhees, Benjamin, Medicine Primary Care-Based Depression Prevention for Adolescents Van Voorhees, Benjamin, Medicine Development of Internet Intervention for Depression Vanden Hoek, Terry L., Medicine Optimizing Heart and Brain Cooling During Cardiac Arrest Vanden Hoek, Terry L., Medicine Office of Naval Research Proteomic Development of Molecular Vital Signs: Mapping a Mitochondrial Injury Severity Score to Triage and Guide Resuscitation of Hemorrhagic Shock Verin, Alexander, Medicine Microtubules in Lung Endothelial Cell Barrier Regulation Verin, Alexander, Medicine ATP in Lung Endothelial Barrier Enhancement Vezina, Paul, Psychiatry Nicotine Exposure: Molecular to Behavioral Consequences Vezina, Paul, Psychiatry National Institute on Drug Abuse Neuropsychopharmacology Training in Drug Abuse Research Vezina, Paul, Psychiatry National Institute on Drug Abuse Sensitization and Stimulant Self-Administration Vokes, Everett E., Medicine Clinical Trials Working Group Vokes, Tamara, Medicine National Institute of Arthritis and Musculoskeletal and Skin Diseases Clinical Utility of Texture Analysis in Osteoporosis Wang, Chyung-Ru, Pathology Regulation and Function of Murine CD1 Molecules Wang, Chyung-Ru, Pathology Group 1 CD1 in Infectious Disease and T-Cell Development Wang, Eileen Y., Ob Gyn National Institute of Child Health and Human Development Placental Progesterone Biosynthesis in Preterm Pregnancy Wang, Zhenguo, Medicine Department of Defense Creating Oncolytic Adenovirus Targeting Tumor Lympahtics Webb, Gene C., Medicine Signal Transduction Leading to Insulin Synthesis Weichselbaum, Ralph R., Rad Onc Mechanisms of Resistance to Radio Inducible Gene Therapy Weichselbaum, Ralph R., Rad Onc DNA Damage Targeted Gene Therapy in Head and Neck Cancer Weigert, Martin, Pathology Genetics and Regulation of Autoantibodies Weiss, Roy, Emanuel, Medicine National Center for Research Resources Nuclear Cofactors in Human Thyroid Disease White, Kevin P., Human Genetics National Center For Human Genome Research A Cis Regulatory Map of the Drosophila Genome White, Kevin P., Human Genetics Comparative Studies of Gene Regulation in Drosophila White, Kevin P., Human Genetics Genomic Analyses of Drosophila Development White, Kevin P., Human Genetics The Mechanisms and Regulatory Networks of Alternative Splicing in Drosophila White, Kevin P., Human Genetics Molecular Genetics of Caloric Restriction in Aging Flies White, Steven, Medicine Regulation of Airway Epithelial Repair Wickrema, Amittha, Medicine Transcriptional Regulation of Myeloma Cell Growth Wicksteed, Barton, Medicine Does Insulin or Glucose Regulate Alpha-Cell Function? Wolfe, Andrew, Pediatrics National Institute of Child Health and Human Development Growth Factor Regulation of the GnRH Neuron Wootton, John Timothy, E&E Department of Agriculture River Food Web Response to Riparian Zone Management Wootton, John Timothy, E&E Quantitative Interaction Strengths in Omnivorous Food Webs Across a Gradient in Primary Productivity Wu, Chung-I, E&E Transcriptional and Genic Basis of Incipient Speciation Xu, Ming, Anesthesia & CC National Institute on Drug Abuse Molecular Determinants of Compulsive Cocaine-Taking Xu, Ming, Anesthesia & CC National Institute on Drug Abuse Role of C-Fos In Cocaine Actions Yu, Ping, Pathology Generation and Analysis of Immunity Inside Tumor Tissues Yuan, Chun-Su, Anesthesia & CC National Center for Complementary and Alternative Medicine Herbal Effects on Oxidant Dynamics of Cardiomyocytes Zacny, James P., Anesthesia & CC National Institute on Drug Abuse Behavioral Effects of Opioids in Volunteers Zacny, James P., Anesthesia & CC National Institute on Drug Abuse A Model of Inhalant Abuse Using Inhalant Responders Zhang, Jian, Medicine National Institute of Arthritis and Musculoskeletal and Skin Diseases Cbl-b in T Cell Activation and Autoimmunity Zhang, Jian, Medicine National Institute of Arthritis and Musculoskeletal and Skin Diseases IL-4 Potentiates T Cell Death in Autoimmune Arthritis Zhuang, Xiaoxi, Neurobiology Genetic and Behavioral Dissection of Inhibitory Control Zhuang, Xiaoxi, Neurobiology National Institute on Drug Abuse Epigenetic Mechanisms in Motor Habits Stability Zhuang, Xiaoxi, Neurobiology National Institute on Drug Abuse Genetic Manipulation of Phasic Dopaminergic Activity 48 UNIVERSITY OF CHICAGO MEDICAL CENTER 2007 ANNUAL REPORT 49

27 SPARK DISCOVERY, ILLUMINATE LIFE CAMPAIGN HONOR ROLL A PHILANTHROPIC MARK OF DISTINCTION Once again, the University of Chicago Medical Center has not only met but also exceeded its fundraising goals. In 2007, gifts to the Medical Center totaled $117.5 million, marking the second year in a row with contributions in excess of $100 million. Notably, the Daniel K. Ludwig Fund made a commitment of $50 million for cancer research. With Ludwig Fund support, the University of Chicago will be one of six prestigious Ludwig Centers in the United States. Chicago s Ludwig Center will focus on the study of metastasis. Since 2000, more than $700 million has been contributed to the Spark Discovery, Illuminate Life campaign, enabling a dynamic group of faculty leaders to launch new programs and make important breakthroughs in many areas of science and medicine. More than $150 million has helped the Medical Center create a new biomedical campus, beginning with the Comer Children s Hospital and extending to state-of-the-art research facilities, which include the Ellen and Melvin Gordon Center for Integrative Science and the Gwen and Jules Knapp Center for Biomedical Discovery. Campaign philanthropy also supports our distinguished faculty. Campaign donors have funded 14 new named, endowed professorships. With 73 positions now in place, the Medical Center aspires to ultimately fund 100 such professorships. More than $40 million has been contributed for graduate or medical student aid, making it possible for more of the nation s most talented young people to study at Chicago. Thirty thousand campaign donors have, through their philanthropy, transformed the landscape at the University of Chicago Medical Center. $25,000,000 AND ABOVE Comer Science & Education Foundation Fund of The Chicago Community Foundation Frances and Gary + Comer Virginia & D.K. Ludwig Fund for Cancer Research The Pritzker Foundation $10,000,000 TO 24,999,999 Brain Research Foundation Craig and Janet Duchossois Elaine Frank Jim and Karen Frank Ellen and Melvin Gordon Howard Hughes Medical Institute Gwen and Jules F. Knapp Trust Estate of Ben May Jr. University of Chicago Cancer Research Foundation $5,000,000 TO 9,999,999 American Cancer Society, Inc. American Heart Association The Arthur Foundation Cancer Research Foundation The Duchossois Family Foundation Dick and Judi Duchossois Dr. Ralph and Marian Falk Medical Trust Gastro-Intestinal Research Foundation Juvenile Diabetes Research Foundation Leukemia & Lymphoma Society Mary Ann and Barry MacLean Jack and Goldie Wolfe Miller Tang Foundation for the Research of Traditional Chinese Medicine Over 30,000 donors have contributed more than $700 million to the Spark Discovery, Illuminate Life Medical Center campaign since it began in Here, we recognize those generous friends who have contributed $1million or more to this effort. This campaign has transformed the Medical Center in many ways we invite you to campus to see the new buildings, meet our dynamic faculty, and learn more about our ongoing efforts to translate scientific breakthroughs to improved patient care. $1,000,000 TO 4,999,999 Alzheimer's Disease and Related Disorders Association, Inc. American Cancer Society Illinois Division, Inc. American Diabetes Association American Health Assistance Foundation Amyotrophic Lateral Sclerosis Association The Atlantic Philanthropies The Earl M. Bane Charitable Trust Mr. + and Mrs. Martin Boyer The Breast Cancer Research Foundation Deborah A. Bricker Neville F. Bryan and John H. Bryan Mr. and Mrs. Matthew Bucksbaum David and Denise Bunning Burroughs Wellcome Fund Cancer Research Institute The Chicago Home for Incurables Dr. Joseph C.F. Chow + Zylpha, Martha, and Bruce Clinton Mildred and Marv Conney P Cornelius Crane Trust Crohns and Colitis Foundation Annette Dubner Thomas J. Duckworth and Connie Duckworth Fritz L. and Mary Lee Duda Family Foundation Doris Duke Charitable Foundation Mrs. Arthur Edelstein The George M. Eisenberg Foundation for Charities Christopher S. Eklund Dr. and Mrs. Murray Engel P EIF Entertainment Industry Foundation Rabbi Morris Esformes Julius N. Frankel Foundation Adolph Frederick Lange Fund Estate of Frank H. Gabriel Geraldi Norton Foundation GlaxoSmithKline Drs. Gretchen B.H. & Allan M. Goldberg Stanford and Ann Dudley Goldblatt Grant Healthcare Foundation Terence and Susan Graunke Estate of Livia E. Groth Joan and Irving Harris Trust Estate of Therese M. Hasterlik Trust Estate of Bernard I. Hasterlik Housewares Charity Foundation Dr. and Mrs. Paul H. Jordan, Jr. Susan Simon Kalt and David S. Kalt Constance T. and Dennis J. Keller Susan G. Komen Breast Cancer Foundation Kovler Family Foundation Trust Estate of Richard G. Lambert Dr. Lester + & Dorothy Page Lebo + The Francis L. Lederer Foundation Mrs. Adrienne Lederer Lupus Research Institute Mr. and Mrs. John D. Mabie P Trust Estate of Dorothy Jean MacLean March of Dimes Birth Defects Foundation Charles E. Marshall, MD, and Mary Q. Marshall G. Harold and Leila Mathers Charitable Foundation The Willey S. McCrea Trust Bernice + and Earl Meltzer Muscular Dystrophy Association, Inc. NARSAD Research Institute, Inc. National Geographic Society National Multiple Sclerosis Society The David and Lucile Packard Foundation 50 UNIVERSITY OF CHICAGO MEDICAL CENTER 2007 ANNUAL REPORT 51

28 The Charles W. Palmer Family Richard P. Parillo Pfizer, Inc. Philip Morris U.S.A., Inc. Pulmonary Fibrosis Foundation R2 Technology, Inc. Camille Lange Rathbun Fund Research to Prevent Blindness, Inc. Donald W. Reynolds Foundation The Sandler Family Supporting Foundation Sara Lee Corporation Trust Estate of Marion H. Schenk Mr. Charles G. Schultz P $10,000,000 AND ABOVE Virginia & D.K. Ludwig Fund for Cancer Research $5,000,000 TO 9,999,999 Leukemia & Lymphoma Society University of Chicago Cancer Research Foundation $1,000,000 TO 4,999,999 American Cancer Society Illinois Division, Inc. American Cancer Society, Inc. American Heart Association Deborah A. Bricker Zylpha, Martha, and Bruce Clinton Crohns and Colitis Foundation Doris Duke Charitable Foundation Mrs. Arthur Edelstein Estate of Frank H. Gabriel The Schweppe Foundation The Searle Funds at The Chicago Community Trust Coleman R. Seskind, MD P The Walden W. and Jean Young Shaw Foundation Barbara and Michael Simon Smart Family Foundation Donald F. Steiner, MD P The Stephen Family Ms. Norma Stone Gwendolen Stoughton P Sun Microsystems, Inc. Trust Estate of Albina Y. Surbis 2007 HONOR ROLL OF CONTRIBUTORS Housewares Charity Foundation Kovler Family Foundation Mr. and Mrs. Peter B. Kovler Mrs. Adrienne Lederer The Francis L. Lederer Foundation Mary Ann and Barry MacLean Bernice + and Earl Meltzer Pulmonary Fibrosis Foundation Mr. Charles G. Schultz The Searle Funds at The Chicago Community Trust Donald F. Steiner, MD $500,000 TO 999,999 Alliance for Cancer Gene Therapy, Inc. Alzheimer's Disease and Related Disorders Association, Inc. United States Surgical Corporation University of Chicago Cancer Research Foundation Women s Board Louise H. Benton Wagner Trust Mr. and Mrs. Dean V. White Paula Wolff and Wayne Whalen Drs. Rostik and Joan Zajtchuk P Dr. and Mrs. Laurence Zung Ronald Zung P Denotes planned gift: these partners have included the Medical Center in their estate plans + Deceased The Medical Center gratefully acknowledges all of our donors for their extraordinary commitment to and support of patient care, teaching and research. The following individuals, corporations and foundations made new pledges over $1,000 from July 1, 2006 to June 30, Brain Research Foundation The Breast Cancer Research Foundation The Chicago Home for Incurables Thomas J. Duckworth and Connie Duckworth Estate of Edna L. Dunning Gastro-Intestinal Research Foundation GlaxoSmithKline Juvenile Diabetes Research Foundation Lupus Research Institute March of Dimes Birth Defects Foundation National Multiple Sclerosis Society Sandler Program for Asthma Research University of Chicago Cancer Research Foundation Women's Board $250,000 TO 499,999 The Alafi Family American Diabetes Association Anagen Therapeutics, Inc. Arnold and Mabel Beckman Foundation Cancer Research Foundation Mr. and Mrs. Michael Cogan Cystic Fibrosis Foundation EIF Entertainment Industry Foundation The Gruss-Lipper Family Foundation, Greg and Daniella Lipper Coules Michael and Rosalind Keiser Susan G. Komen Breast Cancer Foundation Genevieve Marion James McHugh Jack and Goldie Wolfe Miller Muscular Dystrophy Association, Inc. NARSAD Research Institute, Inc. R2 Technology, Inc. Seoul National University Ms. Norma Stone $100,000 TO 249,999 Ajinomoto Company Inc. Mr. Tariq M. Almutlaq American College of Medical Genetics American College of Surgeons American Geriatrics Society, Inc. American Health Assistance Foundation American Heart Association of Metropolitan Chicago American Liver Foundation American Lung Association American Lung Association of Metropolitan Chicago American Sleep Medicine Foundation American Society for Therapeutic Radiology and Oncology American Society of Nephrology Amyotrophic Lateral Sclerosis Association Arthritis Foundation Ms. Diane Patricia Atwood and Mr. Paul J. Reilly, Jr. Mr. and Mrs. Joel Barnett The Blowitz-Ridgeway Foundation Mr. + and Mrs. Martin Boyer The Brinson Foundation Cabot Microelectronics Corporation Cancer & Leukemia Group B Foundation Chicago Children's Advocacy Center Bruce Cohan Cure Alzheimers Fund The Diamond Family Foundation Mr. and Mrs. Terry D. Diamond Robert and Joan Feitler Douglass and Kim Given Mr. and Mrs. George A. Gould Grant Healthcare Foundation Guidant Foundation, Inc. The John A. Hartford Foundation, Inc. Trust Estate of Therese M. Hasterlik The Hilibrand Foundation International Conference Services, Ltd. Mr. Kenneth R. Jensen Richard and Victoria Kohn Leukemia Research Foundation, Inc. Shutsung Liao, PhD Lymphoma Research Foundation Edward Mallinckrodt, Jr. Foundation Ben May Charitable Trust Merck & Co., Inc. Mary Louise and Dane Miller The Bernard A. and Marjorie I. Mitchell Family Foundation, Marjorie I. Mitchell and Lee H. Mitchell National Geographic Society National Opinion Research Center The New York Community Trust Kenneth Niemeyer William F. O'Connor Foundation Ms. Mary Jane O'Connor Orthopaedic Research and Education Foundation Elsa U. Pardee Foundation PDL BioPharma Inc. Pfizer Inc. PVA Spinal Cord Research Foundation RAS Therapeutics, Inc. Roche Organ Transplantation Research Foundation sanofi pasteur US The Schweppe Foundation Siemens Medical Solutions USA, Inc. Smart Family Foundation Dr. and Mrs. George A. Spikes Elmer and Sylvia Sramek Charitable Foundation Trust Estate of Albina Y. Surbis Takeda Pharmaceuticals Camille Canzone and Ronald Tarrson The Thrall Family Mr. and Mrs. Jerome A. Thrall Mr. and Mrs. J. Jeffrey Thrall Mr. J. Randall Thrall Ms. Brooke Thrall and Mr. Richard Weinberger Mr. and Mrs. A. Jay Thrall Mr. and Mrs. J. Christopher Thrall Mr. and Mrs. Michael Mazza Heather Margaret Bligh Springer Trust Fund Jim and Eve Tyree University of Chicago Cancer Research Foundation Auxiliary Board The V Foundation for Cancer Research $50,000 TO 99,999 ARCS Foundation - Achievement Rewards for College Scientists - Chicago Chapter Adler Foundation, Inc. Fred and Jean Allegretti Foundation American Foundation for Suicide Prevention American Gastroenterological Association American Society of Clinical Oncology American Society of Transplantation (AST) Gilbert F. and Judith S. Asher Astellas Pharma, Inc. AstraZeneca LP Berlex Laboratories, Inc. Mr. and Mrs. Keith F. Bradley Anthony F. & Helen J. Castle Scholarship Foundation Dean and Mrs. Joseph J. Ceithaml Celgene Corporation The Children's Health Fund The Clorox Company Foundation Coalition for Pulmonary Fibrosis Concern Foundation Cordis Corporation Mr. and Mrs. Jeffrey Diermeier Craig and Janet Duchossois Trust Estate of Annie W. Durand Dystonia Medical Research Foundation William Elias Embryon, Inc. Forest Pharmaceuticals, Inc. Jim and Karen Frank Lloyd A. Fry Foundation Mr. and Mrs. Robert B. Gelbort The Genetic Research Fund Gilead Sciences The Milo Gladstein Foundation Mr. and Mrs. Richard Gonzalez Kenneth and Anne Griffin Group Healthcare Cooperative The Gynecologic Cancer Foundation Mr. and Mrs. Charles P. Hammersmith Heart Failure Society of America, Inc. Ms. Mary Joanne Henry and Mr. Richard K. Mullin International Retinal Research Foundation, Inc. Jain Foundation, Inc. Mr. and Mrs. Eric Jensen 52 UNIVERSITY OF CHICAGO MEDICAL CENTER 2007 ANNUAL REPORT 53

29 Walter S. Johnson Foundation Mr. and Mrs. James Bozik Foundation for the National Institute of Health Bowman C. Lingle Trust Irving and Carol Slott Mr. and Mrs. William Adams IV Ms. Josephine M. Krug and Mr. Gerard Schulte Bristol-Myers Squibb Company Mr. L. James Lawson III and Mrs. Wende L. Fox Mr. and Mrs. Robert Linn Social Science Research Council Dr. Mary Abby Adams McCormick Tribune Foundation John and Jacolyn Bucksbaum Elaine Frank Mr. and Mrs. John D. Mabie Janice Nolan and Leif Sorensen Dr. and Mrs. Robert K. Adamson Medtronic, Inc. Angelo and Mary Cappas Norman Frankel, PhD Robert H. Malott Spine Research and Education, Inc. Mr. and Mrs. David H. Addis Margaret and Richard Merrell Foundation Centocor Incorporated Drs. Sheila F. and Martin Friedlander Amy Mazzolin James Reynolds/Loop Capital Markets Adirondack Community Trust Michael Reese Health Trust Ms. Kathleen E. Chapski Friends Against AIDS Ronald McDonald House Charities Mr. and Mrs. Thomas A. Reynolds III The Doctors Jack and Judith Adler Michael Rolfe Pancreatic Cancer Foundation Mr. and Mrs. Benjamin Chereskin Genentech, Inc. Mr. John McDonald James Adam Stankiewicz, MD Affiliated Engineers, Inc. Adolph R. Nachman, MD National Kidney Foundation of Illinois Neuroblastoma Children's Cancer Society Judy Paik and Kang-Ihnn Paik Gustavus & Louise Pfeiffer Research Foundation Lisa and Mark Pinsky Ms. Ann Portes + Procter and Gamble Pharmaceuticals The Rett Syndrome Research Foundation Riverain Medical Group Mr. and Mrs. Earl W. Shapiro Susan and David Sherman John B. and Ann B. Snyder Society of Hospital Medicine St. Jude Medical, Inc. Raymond W. Steblay, MD Ms. Marie Wilkinson $10,000 TO 49,999 Abbott Mr. and Mrs. James D. Abrams Alex's Lemonade Stand Foundation Alsius Corporation American Society for Gastrointestinal Endoscopy American Association of Neurosurgeons American-Italian Cancer Foundation American Psychiatric Association American Skin Association, Inc. Amgen, Inc. John W. Anderson Foundation Paul and Mary Anderson Mildred P. Andrews Charitable Remainder Unitrust Daniel and Susan Asher Family Foundation Mr. and Mrs. J. Douglas Bacon The Harold and Roberta Barron Charitable Foundation Mr. and Mrs. Douglas S. Basler Mr. and Mrs. James Bay Bear Necessities Pediatric Cancer Foundation Kenneth M. Begelman, MD Sarah and Blake Berg Marie Krane Bergman and Robert H. Bergman Bisense Webster, Inc. William Blair & Company Boehringer Ingelheim Ltd. The Chester Foundation Chicago Blackhawk Charities, a fund of the McCormick Tribune Foundation The Chicago Community Trust Chicago Dermatological Society, Inc. Chicago Health Connection Chicago White Sox Charities, Inc. Children's Brain Disease Foundation The Children's Initiative, a project of the J.B. and M.K. Pritzker Foundation Children's Neuroblastoma Cancer Foundation Children's Research Foundation, Inc. Chronic Hepatitis Foundation Citigroup Business Services Clonick Family Foundation Mr. and Mrs. Michael Cogan Dr. and Mrs. Louis Cohen Community Foundation for Southeastern Michigan Condell Medical Center Auxiliary Mr. Louis Gold Conforti and Ms. Laura Van Peenan Carey Cooper Mr. and Mrs. J. Michael Crouch Mr. and Mrs. James S. Crown Mrs. Rebecca E. Crown Mr. and Mrs. Rod Dammeyer Jordan L. Daniels, MD, and Barbara L. Daniels Mr. Lambertus M. De Kool Mr. and Mrs. John Dearie Dermatology Foundation The Dominick's Foundation The Duchossois Family Foundation Dick and Judi Duchossois Fritz L. and Mary Lee Duda Family Foundation The George M. Eisenberg Foundation for Charities Eli Lilly and Company EMD Biosciences, Inc. Encysive Pharmaceuticals, Inc. Sidney and Sondra Berman Epstein Esmark, Inc. Exelon Corporation Mrs. Leonard S. Florsheim, Jr. Mr. and Mrs. James Foley Foundation for Informed Medical Decision Making General Constructors, Inc. of The Quad Cities Stanford and Ann Dudley Goldblatt Max Goldenberg Foundation Mr. and Mrs. Rodney L. Goldstein Ellen and Melvin Gordon Grant Community High School District 124 Sue and Melvin Gray Jules R. and Eleanor B. Green Charitable Trust The Greenwall Foundation Richard Hanrahan Mr. and Mrs. Charles C. Harrold III Myhrvold Family Charitable Fund Linda and Tom Heagy Mr. and Mrs. Robert G. Hershenhorn Mr. William J. Hunckler and Diane Goldberg Illinois Neurofibromatosis, Inc. Influmedix, Inc. International Brain Research Organization International Organization of Inflammatory Bowel Disease Investment Professionals for Childern's Charities Valerie B. Jarrett Johnson Foundation, Inc. JP Morgan Chase Junior Cancer League Mr. and Mrs. David Katz KCI Kidneeds Mr. and Mrs. Donald A. King, Jr. Dr. Mary E. King Kirin Brewery Co., Ltd. Howard and Stephanie Kirz Knights Templar Eye Foundation, Inc. Mr. William J. Krug and Ms. Marta Ramirez Krug Laerdal Medical Ltd. Paul Kai Bor Lam, MD Mr. and Mrs. William M. Landes Trust Estate of Susanne E. Larsh Mrs. Barbara Lazerwitz Dr. and Mrs. Norman Leaf The Lehman Brothers Foundation Leopardo Construction, Inc. Andrea and Benjamin Leshem The Libra Foundation Mr. and Mrs. Michael J. McGuinnis Ms. Noreen McGuire The Medicines Company Mr. and Mrs. Richard Melman MGI Pharma, Inc. Midway Pharmaceuticals, Inc. Harvey L. Miller Family Foundation Mr. and Mrs. Joshua W. Miller Mr. and Mrs. Jon Mills Mr. and Mrs. John A. Morris Motorola, Inc. Ralph and Susan Muller Myogen, Inc. National Ataxia Foundation National Organization for Rare Disorders National Sleep Foundation Mr. and Mrs. Brien O'Brien Mr. and Mrs. Timothy K. Ozark Pacific Northwest Research Institute Gladys Pancoe and Arthur Pancoe Pharma Mar Pharmion Corporation Polk Bros. Foundation, Inc. Radiological Society of North America Cheryl Ragusa John and Mary Rayis RBC Dain Rauscher Foundation ResMed Foundation Ms. Cynthia M. Reusche Ride For Life Riding For a Cure Rafael Rivera III Asthma Research Fund Mr. and Mrs. Theodore H. Roberts Mr. Peter N. Rogers Dr. and Mrs. Kris and Trisha Rooney Alden Hulda B. and Maurice L. Rothschild Foundation Dr. + and Mrs. Louis Rubin Paul and Joan Rubschlager Foundation The Ryan Licht Sang Bipolar Foundation Mr. Anthony Santacroce Sara Lee Foundation Coleman R. Seskind, MD Mr. and Mrs. Chris Seth Alfred P. Sloan Foundation Mr. and Mrs. James Star Starlight Starbright Children's Foundation/Toys "R" Us, Inc. The Steans Family Foundation Ms. Robin M. Steans and Mr. Leonard A. Gail Dr. Alexis C. Strongin and Mr. Steven H. Strongin Mr. Randall Svendsen Mr. and Mrs. John Svoboda Dr. and Mrs. Robert G. Tardiff Totoku Electric Co. Ltd. Tourette Syndrome Association U.S. Equities Realty Inc. United Conveyor Corporation United States-Israel Binational Science Foundation University of Chicago Cancer Research Foundation Associates Board The University of Chicago Comer Children's Hospital Service Committee Mr. Joseph Valenti Eugene and Mary Van Scott Vioptix, Inc. Matthew Walsh Mrs. Roy I. Warshawsky Trust Estate of William J. Watson Mr. James M. Weichselbaum and Ms. Susan L. Weichselbaum Mr. and Mrs. Robert G. Weiss Ellen S. Alberding and Kelly R. Welsh Wenner-Gren Foundation for Anthropological Research White Lodging Services Corporation Bruce and Beth White Mr. Mark Wight Mrs. Harry Woldenberg Mr. and Mrs. Richard M. Woldenberg Paula Wolff and Wayne Whalen Wyeth-Ayerst Pharmaceuticals Holland/Yates Family Harry D. Zale Fund, Inc. $1,000 TO 9,999 Mr. Gustavo Abello and Ms. Isabell Siegel Stuart & Jesse Abelson Foundation Dr. and Mrs. Herbert T. Abelson The Absolute Spirits Company AGE Medical Corporation Dr. George Alavanja + Drs. Laurie and John Albertini Alberto-Culver Company Albourne America, LLC Charles M. Alexander, MD Dr. Kenneth A. Alexander Dr. Ellen S. Alkon Alliances for Quality Education, Inc. Alpha Omega Alpha Honor Medical Society Mr. Murray J. Alscher American Society of Cataract & Refractive Surgery Foundation American Girl American Ornithologists' Union American Society of Maxillofacial Surgeons AMS Mechanical Systems, Inc. Amylin Pharmaceuticals Analytica International Animal Behavior Society Dr. and Mrs. Jeffrey L. Apfelbaum J. Steven Arnold, MD Thomas B. Arnold, MD Drs. Andrew and Iris Aronson Mr. and Mrs. Robert Arquilla Arup Laboratories Association for Vascular Access Mr. and Mrs. Anthony J. Augustine B. Braun Medical, Inc. Baer Family Foundation Dr. Donald G. Ball Bank of America Bank of America Foundation Dr. Sirirat R. Banuchi Mr. and Mrs. Thomas Barad Drs. David and Nancy Barber Dr. Richard L. Baron Mr. and Mrs. Shale D. Baskin Mr. Mark Bass Modestus Bauer Foundation Baxter Healthcare Corporation Baxter International Foundation Bruce and Madeline Becker Mr. and Mrs. R. William Becker Beckman Coulter, Inc. 54 UNIVERSITY OF CHICAGO MEDICAL CENTER 2007 ANNUAL REPORT 55

30 Donald Beemer Mrs. William Belman Dr. and Mrs. John R. Benfield Mr. and Mrs. Lawrence Benjamin Arlene and Marshall Bennett Dr. and Mrs. James L. Bennington Erica Benton, PhD, and Timothy Benton Law Offices of John T. Benz Mr. and Mrs. D. Theodore Berghorst Fred Berglund & Sons, Inc. Dr. and Mrs. Sam Berkman Mr. Alan G. Berkshire Mr. Robert Berman Mr. and Mrs. Maurice J. Beznos Biostrategics Consulting Ltd. Mitchell A. Bitter, MD Dr. and Mrs. Eugene H. Blackstone William Blair & Company Foundation Mr. and Mrs. Edward McCormick Blair, Jr. Richard K. Blaisdell, MD Blinderman Construction Company, Inc. Mrs. Tybe Blink Block Electric Company Mr. and Mrs. Andrew K. Block Ellen Block Dr. J. Robert Bloomfield Charles R. Boardman, MD Mr. and Mrs. Norman R. Bobins Bollinger, Ruberry & Garvey Mr. and Mrs. Darcy R. Bonner Mr. Dennis Bookshester Mr. Stephen K. Bossu Bovis Lend Lease, Inc. Dr. and Mrs. James E. Bowman, Jr. Mrs. Saramae Braun Allan Michael Brecher, MD and Janice W. Lyon, MD Arnold K. Brenman, MD Mrs. Mary Brennan Mr. Eugene A. Breslow Mr. and Mrs. Marc J. Breslow Mrs. Monica J. Breslow Donna Bricker Mr. and Mrs. Renton K. Brodie Estate of Lillian Z. Bronkhurst Dr. Jerome J. Brosnan Kevin and Kristi Brown Ms. Katherine M. Brown Mr. Marc A. Brown Mr. and Mrs. Frank S. Brumfield Mr. and Mrs. Hardy Brumfield Mr. and Mrs. Harris Brumfield Gilda Buchbinder and Henry Buchbinder John and Kathleen Buck Dr. Kenneth Buckwalter Paul L. Bunce, MD Ms. Pauline Burelli Melissa and John Burnstine Dr. Shail Busbey and Mr. Kent Douglas Daniel Mr. and Mrs. Michael J. Busch Reilly C. Bush Foundation Norman T. Byers, MD Caitlin's Cause, Inc. Diana and Arnie Calica Mr. Calvin C. Campbell Cannon Design Donald L. Cantway, MD CardiacAssist, Inc. Caremark RX, Inc. Carleton College Mr. and Mrs. Richard C. Carr Mr. and Mrs. J. Rowan Carroll Dr. Carmen Casas The Celiac Sprue Association of Greater Chicago Central Indiana Community Foundation Cephalon, Inc. Dr. Wing C. Chan and Ms. Angelina Hoo-Yee Li Kee N. Chan, MD Chapin-May Foundation of Illinois Chartwell Insurance Services Mr. Edward B. Chez and Ms. Camille DeFrank Chicago Board of Trade Foundation Chicago Lying-In Hospital Board of Directors Chromosome 9P-Network Chubb Corporation Diana Chung, MD Frank and Vera Clark Mr. and Mrs. Henrik Clausen Mr. and Mrs. Harry Cody Merle and Seymour A. Cohen Dr. and Mrs. Mimis Cohen Dr. and Mrs. Jordan Cohen Mr. and Mrs. Neil Coleman Mr. Lewis M. Collens Ms. Michelle Collins The Comcast Foundation Comer Science & Education Foundation Fund of The Chicago Community Foundation Frances and Gary + Comer Congregation Beth Shalom Youth Mr. Jeffrey C. Conklin Mr. and Mrs. Kevin A. Connellan Mildred and Marv Conney ContiGroup Companies Foundation William F. Conway, MD Corboy & Demetrio, P.C. Robert J. Costarella, MD Mr. Michael Coughlin Patricia Cox Mr. and Mrs. Thomas L. Cox Cornelius Crane Trust Mr. and Mrs. Michael E. Crane Mr. Chris Crowley Jodi and Gary Cullen Roy Curtiss III, PhD Mr. and Mrs. Andrew Da Miano James E. Dahlberg, PhD Ms. Helen B. Daigle Mr. and Mrs. James P. Daley Damer & Cartwright, Inc. Danze, Inc. Mr. and Mrs. Thomas C. D'Aprile Mr. John R. Daquilante Mr. Keith L. Davidson Paul T. and Janet M. Davidson Mr. Robert Davis Leslie P. Dean, MD Brian Delanty Invitational Mr. William G. Dempsey Thomas S. DeNapoli, MD Mr. and Mrs. Robert Dennis Charles Denny Sandra Deromedi and Roger Deromedi Mr. and Mrs. David W. Devonshire Dr. Rajiv Dhand Diemand Printing Co., Inc. Ms. Janet Dobbertin Estate of Frances J. Donnelly Shawn M. Donnelley Fund Mrs. Nancy S. Donovan Mr. and Mrs. Nicholas Dopuch Dr. Erl Dordal and Ms. Dorothy K. Powers Dr. Peter E. Doris Dr. R. M. Doroghazi and C. S. Doroghazi Ms. Claire Ducey-Bach Mr. and Mrs. Mitchell Dudnikov Mr. and Mrs. Richard F. Duffy Ms. Carol K. Dugan Mr. and Mrs. Ronald L. Duitsman Duk Young Foundation Eileen Hastings Duncan Eastco International Corporation Edwards Lifesciences, LLC Drs. Douglas F. and Kathleen D. Eggli Charles Eil, MD, PhD Mr. Gerald M. Eisenberg Christopher S. Eklund EMC Corporation Endoscopic Technologies, Inc. Enright Foundation, Inc. Epic Systems Corporation C.J. Erickson Plumbing Co. Ms. Susan F. Erler Milton N. Estes, MD Ethicon, Inc. James Ethington Carole and Richard Ettelson Richard and Roberta Evans Dr. Bernard Ewigman Heidi Farrell Dr. Ahmad Fathizadeh Mr. and Mrs. Fred Feinstein Barbara Feldman Dr. and Mrs. Ira E. Felman Ms. Penny Fenerstein Bruce and Annie Fenster Ferro-Di Piazza, Inc. Mr. and Mrs. Eric Fess Jose A. Filos Diaz, MD Dr. and Mrs. Laurence Finberg Jeffrey and Karen Finesilver Fireco, Inc. First Colony Capital, LLC Firstgiving, Inc. Dr. and Mrs. Frank W. Fitch Mr. William Fizzell Dr. and Mrs. Timothy Flood Ms. Kathie Florsheim Fogelson Foundation Danny Foley Christopher E. Foreman and Mrs. Laura E. McClain-Foreman Foundation for Anesthesia Education and Research Mr. and Mrs. David W. Fox, Jr. David S. Fox, MD Mr. and Mrs. Stanley M. Freehling Mr. Maynard Freeman Mr. John E. Freund Dr. and Mrs. Ralph Friedlander Mayumi Fukui Lawrence J. Furnstahl Dr. and Mrs. Damien A. Gabis The Galter Foundation Joe G.N. Garcia, MD, Sue Garcia Mr. and Mrs. Gary Gardner Garland Law P.C. Mr. Richard J. Geddes and Ms. Rebecca Davidson Mr. James I. Gelbort Geraldi Norton Foundation Dr. Anthony J. Geroulis Diane Gershowitz and Harold Gershowitz Mr. Bert A. Getz Drs. Godfrey and Lorraine Getz John Giampoli Dr. Robert M. Gifford Gift of Hope Organ & Tissue Donor Network Miles Gilburne and Nina Zolt The Gillette Foundation Dr. and Mrs. Michael Ginsburg Maurice H. Givens Charitable Trust Dr. Mitchell Glass Dr. Harvey W. Glasser Mr. Kenneth Glick Dr. Paul B. Glickman Dr. and Mrs. Donald J. Glotzer GMAC Insurance Michael F. Golden, MD Deborah Goldfine and Reva Smilgoff Memorial Club for Cancer Research Goldman Sachs & Company Mr. Steven Robert Goldman and Ms. Lesli K. Henderson James A. Goldstein, MD Dr. Steve A.N. Goldstein and Ms. Emily Novick Mr. and Mrs. Freeman F. Gosden, Jr. Lawrence I. Gottlieb, MD Mr. and Mrs. Donald P. Grasso D. Allan Gray Mrs. Lorraine Greeberg Dr. Mark J. Greenwald David S. Greer, MD Dr. James B. Grossweiner Dr. and Mrs. Raj P. Gupta Clifford and Doris Gurney William Hackett Mr. and Mrs. Brian Hahn Mr. Martin Halfman Hall, Booth, Smith & Slover PC Mr. and Mrs. Jeffrey A. Hall Jesse Hall and Barbara Engel Ernest Hamel, MD, PhD Mr. and Mrs. R. Dickey Hamilton Mrs. Linda Hanan Dr. and Mrs. James E. Hannigan, Jr. David L. Hansen, MD Martin E. Hanson, MD Ms. Carol Ann Harbert Harley Ellis Devereaux Mr. and Mrs. John T. Harris Hattie A. Harris Fund Joan and Irving + Harris Mrs. Sheldon Harris Mr. John H. Hart and Ms. Carol Prins Mr. and Mrs. Robert S. Hartman Mr. W. H. Hartz, Jr. + Dr. Joseph K. Hassoun Stephen Crane Hauser, MD Mr. Martin Hayden Kenneth and Janet Gray Hayes Joan Hefner and David Hefner Mr. and Mrs. Steven J. Hefter Jane Heinrikson and Robert Heinrikson, PhD Dr. and Mrs. Samuel Hellman Mr. and Mrs. Robert A. Helman Mr. and Mrs. Steven S. Helms Mr. Seth Joseph Hewitt Ruth M. Heyn, MD Dr. and Mrs. Ziyad M. Hijazi Mr. and Mrs. James W. Hinderaker John J. Hinz + Mr. Austin L. Hirsch and Ms. Beth Gomberg-Hirsch Mr. and Mrs. David Ho Glenn Ross Hodges, MD Mr. William Hoffman Mr. and Mrs. William J. Hokin Dr. William F. Hopkins and Mrs. Florence Hopkins The Horner Foundation Mr. and Mrs. Thomas Horwich David L. Horwitz, MD, PhD Mr. Gregory C. Hosbein Mr. Frank B. Hubachek, Jr. Jill Hulten Drs. Holly Humphrey and Duane Follman Victoria L. Humphrey HWOA LLC Hyatt Corporation Ms. Susan Ifergan Illinois Society for the Prevention of Blindness Illinois Tool Works Foundation Imclone Systems Incorporated The Impact Group Innercool Therapies, Inc. InnerWireless, Inc. INO Therapeutics Interstate Electronics Company International Human Frontier Science Program Ellen J. Irwin Dr. Mahmoud A. Ismail Ismie Mutual Insurance Company ITG Solutions Thomas Yutaka Ito, MD 56 UNIVERSITY OF CHICAGO MEDICAL CENTER 2007 ANNUAL REPORT 57

31 ITW Industrial Finishing J.P. Morgan Chase & Co. Hollye and Jeff Jacobs Mr. Harvey Jacobson Mr. Martin Jacobson Mr. and Mrs. Elliot S. Jaffe Mr. Robert D. Jaffee Deborah R. and Edgar D. Jannotta Ms. Meghan Jannotta Japanese Society of Radiological Technology Mr. Sidney F. Jarrow Mr. Howard E. Jessen JMR Charities Mr. Saul Jodel Johnson & Bell, Ltd. Johnson & Johnson Family of Companies Johnson Controls, Inc. Charles R. Johnson, MD Ms. Lorraine Johnson Elizabeth Jones and Everett Jones Dr. Harold Irwin Juran K.R. Miller Contractors, Inc. Ms. Julie Kahan Bonnie L. Kaiser, PhD Susan Simon Kalt and David S. Kalt Jonathan Anthony Kans, PhD Karen L. Kaplan, MD, PhD, and Jonathan S. Kaplan, MD, PhD Attallah Kappas, MD John W. Karesh, MD Alice Karl and Barry Karl Leon R. Kass, MD Herman and Rose Weiner Kattlove Drs. Julian and Sheila M. Katz Mr. Ronald C. Katz Michael W. Kaufman, MD Mr. Ronald Kaufman Mr. Thomas Kehoe Cary S. Keller, MD Laurie Kentor and Paul Kentor Mr. D. Roderick Kiewiet Mr. and Mrs. Thomas E. Kilcollin Edwin Hyun-Jin Kim, MD Sunny S. Kim, MD Dr. Young P. Kim Douglas M. Kinney Kirby Sheet Metal Works, Inc. Dr. Joseph B. Kirsner Mr. and Mrs. Hersch Klaff Klein Tools, Inc. Mr. and Mrs. Thomas R. Klein Drs. Joel E. and Dushanka V. Kleinman Gwen and Jules F. Knapp Michael Koetting and Barbara Shaw Kohler Interiors Rachel Kohler and Mark Hoplamazian Mr. Bradley Kolar Catharine + and Jerry + Kollros Mr. Edwin B. Kooperman Richard Koretz Jennifer Kotler and Brad Kotler Mr. Neal Kottke John and Lorraine Kottra Mr. and Mrs. Mark Koulogeorge Kraft Foods Global, Inc. Krahl Associates Inc Jeffrey Kramer The Kreilick Family Foundation Inc. Mrs. Sammie Krepp Mr. Larry Krueger Jill Kummer and Kenneth Kummer Ms. Maia Labow Si-Hoi Lam, MD Mr. and Mrs. Lester Lampert Dr. Richard Landau Mrs. Lois A. Lapper Mr. Kevin D. Larson LaSalle Bank Corporation Latham & Watkins LLP Mr. and Mrs. Leonard H. Lavin Law Offices of Amari & Locallo Mr. Alan A. Lazzara Dr. Thuy B. Ledesai The Lee Institute of Skin & Laser The Lefkofsky Family Foundation Ken and Lucy Lehman Otto W. Lehmann Foundation Thomas John Leipzig, MD Mr. and Mrs. Ira Levin Linda Levine and Laurence Levine Barry S. Levine, MD Darlene Lewis Mr. Laurence Lewis Mr. and Mrs. Paul D. Lieberman Mr. Martin Liebman LifeCell Lucius N. Littauer Foundation Lowis & Gellen Loyola University Health System Dr. Barbara Lukash Dr. and Mrs. Cole Lundquist Ms. Lisa Gay Lundstrom Marshall G. Lutz Foundation Janice W. Lyon, MD, and Allan Michael Brecher, MD Dr. Anna M. Lysakowski Vicki M. and James L. Madara Henry C. Maguire, Jr., MD Robert C. Mahler Memorial Fund Mary and Anthony Mahowald Hiro Makino, MD Mr. and Mrs. Jahangir Malik Dr. Eugene Mandrea Mr. and Mrs. Tony Manzari Thomas Markland Dr. and Mrs. James E. Marks Marsh USA Inc. Ms. Arona Martin Ms. Elizabeth J. Martin Mr. and Mrs. Thomas Marziani G. Robert Mason, MD, PhD Daniel P. Mass, MD, and Lenore E. Mass Emil Mastandrea Architect, Inc. Joan Matthews and Jeffrey Matthews The May Department Stores Company Foundation The Dick and Diane May Foundation, Inc. Mitzi Mayer Mr. Donald J. McCullough William A. McDade, MD, PhD Nancy Lauter McDougal and Alfred L. McDougal Mr. and Mrs. Andrew L. McGaan Mr. and Mrs. Patrick McGarvey Thomas J. McKearn, MD, PhD Mr. Andrew J. McKenna Mr. and Mrs. J. Neil McLoughlin Medpoint Communications, Inc. Kelly Mehrholz and Robbie Mehrholz The Melrene Fund David Owen Meltzer, MD, PhD Mentor Corporation Merchandise Mart Properties Merrill Lynch and Co. Foundation, Inc. Mr. and Mrs. Stephen Meskan Metro Analytical Consultants L.L.C. Metz Foundation Dr. and Mrs. Ernest E. Mhoon, Jr. Michigan Association of Nurse Anesthetists Microsoft Giving Campaign Midwest Interstate Technologies Mr. and Mrs. Edward J. Miller Dr. Martin Brier Miller Kristen and Charlie Mills Milwaukee Neurological Institute Ms. Eleanor Mirich Tom and Rosemarie Mitchell Dr. Charles Mittman Jean and Dan Mohan Karol J. Moller Moneris Solutions, Inc. Ralph G. Moore and Associates Mr. J. Clifford Moos Adeline Morrison Mr. Harold Morrison Mr. and Mrs. Robert S. Morrison Mothers' Aid of the Chicago Lying-In Hospital Mount Sinai Hospital Medical Center Dick Moy MSI General Corporation Mr. and Mrs. Robert L. Mueller Mary Mullin Trust Mr. William E. Mullin Stephanie Munger Carmi and Chris Murphy Ronald E. Myers, MD, PhD Mr. and Mrs. Steven B. Nakovich, Jr. James E. Nall and Ann Nall Claire and Dennis Nardoni National Childhood Cancer Foundation Robert M. Nauman Trust Mr. Stephen D. Nechtow Mr. R. Gregory Neidballa Ms. Cynthia Neiman Phillip G. Nelson, MD, PhD Neph Rx Corporation Dr. Roland and Mrs. Vivian Ng Wayne M. Nichols, MD North Central Section American Urological Association The Northern Trust Company Novo Nordisk Pharmaceuticals, Inc. Novy Family Foundation Mr. and Mrs. Nicholas Noyes Mr. and Mrs. David Nuelle Dr. Carole Ober The M.J. O'Brien Family Foundation Jack David Ohringer, MD Carol A. Olson, MD, PhD Kim Marie Olthoff, MD, and David Jon Van Houten, PhD Jamie M. O'Malley Mr. Michael F. O'Malley Mr. and Mrs. Daniel E. O'Neil James A. O'Neill, MD Dr. Daniel Orozco James E. Orr, MD, PhD Bruce and Lori Ovitz Lauren M. Pachman and Mark M. Satterthwaite Mr. and Mrs. Lyle E. Packard George Yusun Paik, MD Charles Y. Pak, MD Mrs. Kathleen Palla Ms. Elitsa Papadopoulos Parents Activating Love, Support and Research Park National Bank F. H. Paschen, S.N. Nielsen & Associates, LLC Pasquinelli Family Foundation Patient Mentor Foundation Mrs. Nancy H. Peck and Mr. Emmett Peck Donald H. Pellar, MD Ms. Susan Peloza Mr. William Peluchiwski Catherine Pena and John Pena Performance Physical Therapy of Bridgeview Eugene N. Pergament, MD Lloyd E. Perino, MD Mr. and Mrs. Vic Peterson Mr. Miles Peterson Phoebe and John D. Lewis Foundation Mr. Mark R. Pierce Planet Honda Mr. and Mrs. Harvey B. Plotnick Mr. and Mrs. Larry Plunkett PMA Consultants LLC Mrs. Colette O. Pollock Mr. and Mrs. Gordon Lee Pollock Porter Foundation Barbara Portes Mr. Thomas Postek The Isaac & Leah Potts Foundation, Inc. Power Rogers & Smith PC Mr. Edward J. Powers Proteus Group LLC Ms. Jane Pugh Mr. Charles Queenan Mr. Richard Quigley Jean and Bill Quinlan Radiant Research Dr. Brian Randall and Dr. Mary C. Kemen Reed Illinois Corporation Mr. Gus N. Rentas Dr. Robert Replogle Dr. Paul D. Revis and Family Trust Estate of Agnes G. Rezler Mr. and Mrs. James T. Rhind Marilyn and John Richards Robert W. Ridley, MD The Riley Family Foundation David P. and Linda M. Riley Arthur G. Robins, MD Roche Diagnostics Corporation Mr. Richard Roeper The Honorable Paul G. Rogers Mr. Alan Rose Madeline and Michael Rosenberg Betsy and Andrew Rosenfield Dr. and Mrs. Robert L. Rosenfield Mr. Joshua Rosenstein Mr. Donald Rosenwinkel RST Memorial Cancer Foundation Mr. and Mrs. Scott Ruckebeil William Steven Rudd, MD Dr. and Mrs. Paul S. Russell Donna Sagami Mark Sajjadi, MD David Saloom Salvi, Schostok & Pritchard P.C. Mrs. Elinor Salvino Dr. and Mrs. Martin E. Sanders Mr. Scott Sauer Schain, Burney, Ross & Citron Ltd. Mr. and Mrs. Frank Charles Schell III Michele Schiele and Chris Iannuccilli Mrs. Louise L. Schiff Mr. and Mrs. James Schink Mr. and Mrs. Robert G. Schloerb Phillip G. Schmid, Jr., MD Mr. Thomas B. Schoder Dr. and Mrs. Joseph C. Schoolar Schreiber Foundation for Cancer Research Andrew Oscar Schreiber, MD James A. Schulak, MD Mr. David Schuster Mr. Theodore R. Schwandt Mr. and Mrs. David R. Schwartz M. Roy Schwarz, MD Mr. Richard J. Schweickert Mr. Manuel Vivas and Ms. Ann Schwind Mr. and Mrs. Richard P. Scully Mr. and Mrs. Gordon I. Segal Morris J. Seide, MD Mr. and Mrs. Rex Sessions Shamrock Sales, Inc. Bennett and Anna Shatkin Dr. Christopher R. Shea Hope and Jeffrey Sheffield Drs. Michael L. and Vivien B. Shelanski Mr. Ron Sheldon Susan S. Sher Ms. Jean E. Sheridan Mr. Mark Sherman Shionogi Pharmaceutical Institute Co., Ltd. 58 UNIVERSITY OF CHICAGO MEDICAL CENTER 2007 ANNUAL REPORT 59

32 Rahmawati Sih, MD Dr. and Mrs. + Bernard Silber Mr. Rouben Terzian Charles E. Test, MD Mr. and Mrs. William S. Wardrop, Jr. Jonathan Warren, MD ANNUAL FUNDS Michael H. Silverman, MD David M. Silverstein, MD Dr. Patricia Simmons and Dr. Lester Wold Barbara and Michael Simon Mr. and Mrs. Frank M. Sims Colin G. Thomas, Jr., MD The Three Ninety Fund Mr. Norris L. Tibbetts Mr. and Mrs. Richard W. Tinberg Stephanie Todak Washington Mutual Bank Ms. Lynne Watka Mr. Stan Watt The Weese Foundation by William C. Weese Mr. Roman L. Weil Every year alumni, patients and friends invest in the Forefront of science and medicine through unrestricted gifts to the annual funds, including the Forefront Fund and the Medical & Biological Sciences Annual Funds. Dale Siswick Mr. Scott Six Drs. Joseph and Edith Skom Smith Nephew Wound Management Ralph Smykal John B. and Ann B. Snyder Jorge Solis Norman H. Solliday, MD Dr. Keyoumars Soltani Mr. Hugo F. and Mrs. Elizabeth Sonnenschein SpaceTime, Inc. Spectrum Family Medicine S.C. Donna Speigel Ms. Roslyn Spellman Loreatta Spesia and Douglas Spesia Mrs. Ann Thirolf Spieth Mr. Jonathan Splitt Estate of Ky-Ann Sponberg Philip Stahl Gay K. Stanek and John R. Stanek Mr. Ron Zvi Stav Ms. Jennifer W. Steans and Mr. Jim Kastenholz Lois M. Steans and Harrison I. Steans Mr. and Mrs. Avy H. Stein The Stephen Family Marvin J. Stone, MD Dr. Sarah E. Strandjord Christopher M. Straus, MD Frances E. Streit Foundation Trust Mr. John L. Stringer Stuart-Rodgers Ltd. Jeffrey T. Sugimoto, MD Drs. John and Susan Sultan Stephen and Deborah Suzuki Mr. and Mrs. Lloyd Swanson William L. Sweet, MD Philip Sylvester Takeda Pharmaceuticals North America, Inc. Paul and Pamela Talalay Cheryl and Alan Talpalar Edward Tarlov, MD Christina M. Tchen Tellabs Donald E. Temple, MD Louann Temple and Larry Temple Mr. Stephen G. Tomlinson and Ms. Margaret A. Shanahan Dr. James H. Tonsgard Treasurer of Lake County, Indiana Mr. and Mrs. Barton G. Tretheway Mr. and Mrs. Matt Tretter Ms. Paulette Ann Triplett Trustmark Recovery Services Turner Construction Mr. and Mrs. Howard H. Turner Mr. and Mrs. Timothy H. Ubben UBS Foundation USA Peter Ungerer-Benz United States & Canadian Academy of Pathology, Inc. University Health Network University of Florida Jacksonville Physicians, Inc. University of Nebraska Medical Center University of Texas Medical Branch at Galveston Dr. and Mrs. + Robert B. Uretz Mark and Carmel Urquhart Stephen G. Vaccarezza, MD Mr. David Paul Van Dam Mr. Mark Van Denend Terry and Linda Van Der Aa Karla Van Drunen Littooy Drs. Todd and Tien Vanden Hoek Mr. Michael Vannier Joey Vartanian Mr. Brad Vazales Jose Luis Velazquez, MD Dr. Jacob Verghese Todd E. Vermeer, MD, and Mrs. Samantha A. Hodgkins Mrs. Mimi Mullin Villaume and Mr. John Harrigan Ms. Rebekah Wagenbach Louise H. Benton Wagner Trust Jay E. Wagner, MD Mr. and Mrs. Gary D. Waldman Walgreen Co. Mr. and Mrs. Charles R. Walgreen III Kay Walgren and Kenneth Walgren Robert Wall Dr. Christine M. Walter Anne Bouise Ward, MD Charlotte Weiler and Roger Weiler Mr. and Mrs. Norman R. Weinberg Mr. Elliot M. Weiner Mary and Stephen Weinstein Charles Eric Welander, MD Thomas E. Wellems, MD, PhD Herbert C. Wenske Foundation Mrs. Florence Werner Mr. and Mrs. Michael Werner Mr. and Mrs. Richard L. Werner West Business Services, L.P. Mrs. Maria G. Westropp Dr. Elizabeth A. Whalen and Dr. Terrence W. Ryan Mr. Duncan M. White Dr. David H. Whitney and Dr. Juliana Chyu Mrs. Charlotte H. Williams Juliann K. Williams, MD Ms. Mary Beth Williams Mr. and Mrs. James R. Woldenberg Mr. and Mrs. Allen E. Wolf Mr. and Mrs. Arnold R. Wolff Mr. and Mrs. Lawrence D. Wolin Harvey Wolinsky, MD, PhD Felicia and William Wong Maryelen Zagotta, Words&Pictures, Inc. George Wu, MD Eric Yablonka Nancy Wee Young Christopher J. Young, MD Dr. David Yousefzadeh Ms. Geralyn Annette Yoza and Dr. Miguel Agustin Arias Drs. Rostik and Joan Zajtchuk Mary T. Zech Tita Zeffren and Gene Zeffren, PhD Ronna Rubinoff and Steven Zoll Mr. and Mrs. Steven E. Zuccarini Jacob J. Zuidema, MD John Zwaanstra, MD + Deceased $25,000 AND ABOVE Forefront Fund Distinguished Benefactors The Leon O. Jacobson Society Dean and Mrs. Joseph J. Ceithaml Mr. and Mrs. James S. Crown Craig and Janet Duchossois Jim and Karen Frank Douglass and Kim Given Mr. William J. Hunckler and Diane Goldberg Mary Louise and Dane Miller Mr. and Mrs. Brien O'Brien Camille Canzone and Ronald Tarrson Bruce and Beth White $10,000 TO 24,999 Forefront Fund Benefactors The Leon O. Jacobson Society ARCS Foundation, Inc., Chicago Chapter Paul and Mary Anderson Arie and Ida Crown Memorial Kenneth M. Begelman, MD Marie Krane Bergman and Robert H. Bergman Deborah A. Bricker John and Jacolyn Bucksbaum Sidney and Sondra Berman Epstein Robert and Joan Feitler Elaine Frank Stanford and Ann Dudley Goldblatt Mr. and Mrs. Rodney L. Goldstein Ellen and Melvin Gordon Sue and Melvin Gray Linda and Tom Heagy Mr. and Mrs. Robert G. Hershenhorn Valerie B. Jarrett Johnson Foundation, Inc. Howard and Stephanie Kirz Paul Kai Bor Lam, MD Dr. and Mrs. Norman Leaf Mr. and Mrs. John D. Mabie Mr. and Mrs. Timothy K. Ozark John and Mary Rayis James Reynolds/Loop Capital Markets Mr. and Mrs. Thomas A. Reynolds III Dr. + and Mrs. Louis Rubin Sara Lee Foundation Smart Family Foundation Mr. and Mrs. James Star Dr. Alexis C. Strongin and Mr. Steven H. Strongin Mr. and Mrs. John Svoboda Michael and Diane Tang Dr. and Mrs. Robert G. Tardiff Townsend Family Foundation Jim and Eve Tyree Eugene and Mary Van Scott Mr. and Mrs. Robert G. Weiss Ellen S. Alberding and Kelly R. Welsh Paula Wolff and Wayne Whalen $5,000 TO 9,999 Forefront Fund Fellows The Charles B. Huggins Society Mr. and Mrs. Robert Arquilla Ms. Diane Patricia Atwood and Mr. Paul J. Reilly, Jr. Ellen Block Mr. and Mrs. Norman R. Bobins Mrs. Mary Brennan Kevin and Kristi Brown Pauline M. Burelli Dr. Wing C. Chan and Ms. Angelina Hoo-Yee Li Diana Chung, MD Frank and Vera Clark Mr. Keith W. Colburn Mildred and Marv Conney Robert J. Costarella, MD Sandra Deromedi and Roger Deromedi Shawn M. Donnelley Fund Mr. and Mrs. Eric Fess Lawrence J. Furnstahl Mr. and Mrs. Gary Gardner Mr. Bert A. Getz Miles Gilburne and Nina Zolt Dr. Harvey W. Glasser Goldman Sachs & Company Jesse Hall and Barbara Engel Kenneth and Janet Gray Hayes Mr. and Mrs. Thomas Horwich Patricia Cox Drs. Julian and Sheila M. Katz Jill Kummer and Kenneth Kummer LaSalle Bank Ken and Lucy Lehman Mr. and Mrs. Robert Linn Mary Ann and Barry MacLean Vicki M. and James L. Madara Nancy Lauter McDougal and Alfred L. McDougal Metz Foundation Ralph G. Moore and Associates Carmi and Chris Murphy Dr. Roland and Mrs. Vivian Ng Catherine Pena and John Pena Lloyd E. Perino, MD Polk Bros. Foundation, Inc. David P. and Linda M. Riley Dr. and Mrs. Kris and Trisha Rooney Alden Madeline and Michael Rosenberg Paul Rubschlager and Joan Rubschlager Dr. and Mrs. Martin E. Sanders Mr. and Mrs. Robert G. Schloerb Dr. and Mrs. Joseph C. Schoolar M. Roy Schwarz, MD Hope and Jeffrey Sheffield Dr. and Mrs. + Bernard Silber Jorge Solis Mr. and Mrs. Avy H. Stein Christina M. Tchen Terry and Linda Van Der Aa Dr. David H. Whitney and Dr. Juliana Chyu Mr. and Mrs. Allen E. Wolf Drs. Rostik and Joan Zajtchuk $2,500 TO 4,999 Forefront Fund Ambassadors The Helen Culver Society Arlene and Marshall Bennett Mr. and Mrs. Maurice J. Beznos Dr. and Mrs. Eugene H. Blackstone Mr. and Mrs. Edward McCormick Blair, Jr. Donna Bricker Kee N. Chan, MD Chicago Community Trust Jodi and Gary Cullen 60 UNIVERSITY OF CHICAGO MEDICAL CENTER 2007 ANNUAL REPORT 61

33 Charles Denny Christopher S. Eklund Dr. Bernard Ewigman Exelon Corporation Joe G.N. Garcia, MD, Sue Garcia Diane Gershowitz and Harold Gershowitz Mr. and Mrs. Richard Gonzalez Mr. and Mrs. John T. Harris Mr. John H. Hart and Ms. Carol Prins Joan Hefner and David Hefner Robert and Jane Heinrikson Johnson & Johnson Family of Companies Susan Simon Kalt and David S. Kalt Karen L. Kaplan, MD, PhD and Jonathan S. Kaplan, MD, PhD John W. Karesh, MD The Kreilick Family Foundation Inc. Dr. and Mrs. Cole Lundquist William A. McDade, MD, PhD Thomas J. McKearn, MD, PhD Tom and Rosemarie Mitchell Geraldi Norton Foundation Donald H. Pellar, MD Mr. and Mrs. James T. Rhind The Riley Family Foundation Mr. and Mrs. Gordon I. Segal Bennett and Anna Shatkin Rahmawati Sih, MD John B. and Ann B. Snyder Philip Stahl The Stephen Family Charles E. Test, MD The Three Ninety Fund Mark and Carmel Urquhart Robert Wall The Weese Foundation by William C. Weese Mr. Roman L. Weil Dr. and Mrs. Jeffrey L. Apfelbaum J. Steven Arnold, MD Thomas B. Arnold, MD AT&T Foundation Drs. David and Nancy Barber Bruce and Madeline Becker Dr. and Mrs. James L. Bennington Biostrategics Consulting Ltd. Mitchell A. Bitter, MD Richard K. Blaisdell, MD Mr. and Mrs. Andrew K. Block Dr. J. Robert Bloomfield Charles R. Boardman, MD Mr. Dennis Bookshester Mr. + and Mrs. Martin Boyer Mrs. Saramae Braun Allan Michael Brecher, MD, and Janice W. Lyon, MD Arnold K. Brenman, MD Paul L. Bunce, MD Norman T. Byers, MD Diana and Arnie Calica Donald L. Cantway, MD Mr. Edward B. Chez and Ms. Camille DeFrank Seymour A. Cohen Family Foundation Dr. and Mrs. Jordan Cohen Merle and Seymour A. Cohen Mr. Lewis M. Collens Ms. Michelle Collins William F. Conway, MD Roy Curtiss III, PhD James E. Dahlberg, PhD Paul T. and Janet M. Davidson Leslie P. Dean, MD Thomas S. DeNapoli, MD Dr. Erl Dordal and Ms. Dorothy K. Powers Dr. R. M. Doroghazi and C. S. Doroghazi Drs. Godfrey and Lorraine Getz Dr. and Mrs. Michael Ginsburg Dr. Mitchell Glass Dr. Paul B. Glickman Dr. and Mrs. Donald J. Glotzer Michael F. Golden, MD James A. Goldstein, MD D. Allan Gray David S. Greer, MD Clifford and Doris Gurney Ernest Hamel, MD, PhD Mr. and Mrs. R. Dickey Hamilton Dr. and Mrs. James E. Hannigan, Jr. David L. Hansen, MD Martin E. Hanson, MD Joan and Irving + Harris Dr. Joseph K. Hassoun Stephen Crane Hauser, MD Dr. and Mrs. Samuel Hellman Mr. and Mrs. Robert A. Helman Ruth M. Heyn, MD Mr. and Mrs. David Ho Glenn Ross Hodges, MD Dr. William F. Hopkins and Mrs. Florence Hopkins David L. Horwitz, MD, PhD Jill Hulten Victoria L. Humphrey Dr. Mahmoud A. Ismail Thomas Yutaka Ito, MD Hollye and Jeff Jacobs Charles R. Johnson, MD Bonnie L. Kaiser, PhD Jonathan Anthony Kans, PhD Attallah Kappas, MD Leon R. Kass, MD Herman and Rose Weiner Kattlove Mr. and Mrs. Leonard H. Lavin Dr. Thuy B. Ledesai Thomas John Leipzig, MD Barry S. Levine, MD Darlene Lewis Mr. and Mrs. Paul D. Lieberman Janice W. Lyon, MD and Allan Michael Brecher, MD Henry C. Maguire, Jr., MD Hiro Makino, MD G. Robert Mason, MD, PhD Joan Matthews and Jeffrey Matthews Mr. and Mrs. J. Neil McLoughlin Dr. and Mrs. Ernest E. Mhoon, Jr. The Bernard A. and Marjorie I. Mitchell Family Foundation, Marjorie I. Mitchell and Lee H. Mitchell Dr. Charles Mittman Dick Moy Ronald E. Myers, MD, PhD Mr. and Mrs. Steven B. Nakovich, Jr. Phillip G. Nelson, MD, PhD Jack David Ohringer, MD Carol A. Olson, MD, PhD Kim Marie Olthoff, MD, and David Jon Van Houten, PhD Jamie M. O'Malley James A. O'Neill, MD James E. Orr, MD, PhD Lauren M. Pachman and Mark M. Satterthwaite George Yusun Paik, MD Charles Y. Pak, MD Jean and Bill Quinlan Marilyn and John Richards Robert W. Ridley, MD Arthur G. Robins, MD The Honorable Paul G. Rogers Mr. and Mrs. Scott Ruckebeil William Steven Rudd, MD Mark Sajjadi, MD Michele Schiele and Chris Iannuccilli Mrs. Louise L. Schiff Phillip G. Schmid, Jr., MD Andrew Oscar Schreiber, MD James A. Schulak, MD Mr. Theodore R. Schwandt Mr. and Mrs. David R. Schwartz Mr. Richard J. Schweickert Mr. Manuel Vivas and Ms. Ann Schwind Morris J. Seide, MD Drs. Michael L. and Vivien B. Shelanski Susan S. Sher Mark and Anna Siegler Michael H. Silverman, MD David M. Silverstein, MD Dr. Patricia Simmons and Dr. Lester Wold Barbara and Michael Simon Drs. Joseph and Edith Skom Norman H. Solliday, MD Donald F. Steiner, MD Dr. Sarah E. Strandjord Jeffrey T. Sugimoto, MD Drs. John and Susan Sultan Stephen and Deborah Suzuki Mr. and Mrs. Lloyd Swanson William L. Sweet, MD Edward Tarlov, MD Ronald A. Thisted Colin G. Thomas, Jr., MD Dr. and Mrs. + Robert B. Uretz Stephen G. Vaccarezza, MD Karla Van Drunen Littooy Drs. Todd and Tien Vanden Hoek Jose Luis Velazquez, MD Todd E. Vermeer, MD, and Mrs. Samantha A. Hodgkins Jay E. Wagner, MD Mr. and Mrs. Gary D. Waldman Dr. Christine M. Walter Anne Bouise Ward, MD Jonathan Warren, MD Mary and Stephen Weinstein Charles Eric Welander, MD Dr. Elizabeth A. Whalen and Dr. Terrence W. Ryan Juliann K. Williams, MD Harvey Wolinsky, MD, PhD Felicia and William Wong George Wu, MD Eric Yablonka Christopher J. Young, MD Dr. David Yousefzadeh Mary T. Zech Jacob J. Zuidema, MD John Zwaanstra, MD Donors to the Forefront Fund are recognized as: Distinguished Benefactors ($25,000 and above) Benefactors ($10,000 24,999) Fellows ($5,000 9,999) Ambassadors ($2,500 4,999) Sponsors ($1,000 2,499) Donors to the Alumni Annual Funds are recognized by membership in: The Leon O. Jacobson Society ($10,000 and above) The Charles B. Huggins Society ($5,000 9,999) The Helen Culver Society ($1,000 4,999) + Deceased Thomas E. Wellems, MD, PhD Mr. and Mrs. Mitchell Dudnikov Michael W. Kaufman, MD Maryelen Zagotta, Words&Pictures, Inc. Eileen Hastings Duncan Mr. Thomas Kehoe Nancy Wee Young Drs. Douglas F. and Kathleen D. Eggli Cary S. Keller, MD Ms. Geralyn Annette Yoza and Dr. Miguel Agustin Arias Tita Zeffren and Gene Zeffren, PhD Charles Eil, MD, PhD Ellen J. Irwin Milton N. Estes, MD Edwin Hyun-Jin Kim, MD Sunny S. Kim, MD Dr. Joseph B. Kirsner $1,000 TO 2,499 Forefront Fund Sponsors The Helen Culver Society Abbott Laboratories Employee Giving Campaign Dr. and Mrs. Herbert T. Abelson Dr. and Mrs. Robert K. Adamson The Doctors Jack and Judith Adler Drs. Laurie and John Albertini Charles M. Alexander, MD Richard and Roberta Evans Dr. and Mrs. Ira E. Felman Bruce and Annie Fenster Jose A. Filos Diaz, MD Jeffrey and Karen Finesilver Mr. William Fizzell David S. Fox, MD Dr. and Mrs. Ralph Friedlander Mayumi Fukui Drs. Joel E. and Dushanka V. Kleinman Michael Koetting and Barbara Shaw Richard and Victoria Mitchell Kohn Mr. Bradley Kolar Catharine + and Jerry + Kollros Mr. Edwin B. Kooperman Kovler Family Foundation Mr. and Mrs. Peter B. Kovler Mr. Kevin D. Larson 62 UNIVERSITY OF CHICAGO MEDICAL CENTER 2007 ANNUAL REPORT 63

34 PRODUCED BY THE UNIVERSITY OF CHICAGO MEDICAL CENTER COMMUNICATIONS OFFICE DESIGN BY WORDS&PICTURES, INC. PRINCIPAL PHOTOGRAPHY BY DAN DRY ADDITIONAL CREDITS: PAGE 5: BOTTOM PHOTO BY DAVID CHRISTOPHER PAGE 8: PHOTO BY LARA KASTNER PAGE 9: BOTTOM PHOTO BY BART HARRIS PAGE 13: ARTIST RENDERING OF RICKETTS LAB BY FLAD & ASSOCIATES PAGE 14: PHOTO BY YVETTE DOSTATNI PAGE 15: TOP PHOTO BY PETER THOMPSON/THE NEW YORK TIMES PAGE 17: SCANS COURTESY OF MICHAEL VANNIER; BOTTOM PHOTO BY DAVID CHRISTOPHER, MODEL BY RAFAEL VINOLY ARCHITECTS PAGE 18: DIGITAL ART COURTESY OF BENOIT ROUX PAGE 21: PHOTO BY ROARK JOHNSON PHOTOGRAPHY PAGE 23: PHOTO BY ERIC HERZOG PAGE 25: TOP PHOTO COURTESY OF JANELIA FARM; BOTTOM PHOTO BY MICHAEL LABARBERA PAGE 27: TOP PHOTO BY 20/20 COMMUNICATIONS INC. 64 UNIVERSITY OF CHICAGO MEDICAL CENTER