February 3 4, Hollywood, Florida USA. IN PARTNERSHIP WITH TheIOMeeting.com

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1 February 3 4, 2018 IN PARTNERSHIP WITH TheIOMeeting.com S Y M P O S I U M O N C L I N I C A L I N T E R V E N T I O N A L O N C O L O G Y

2 THE IO MEETING OF THE YEAR FOR INTERVENTIONAL RADIOLOGISTS Why CIO? For 10 years, CIO has served as the premier arena for practical education in the expanding field of interventional oncology. There simply is no comparison. Unconventional and unexpected, this is where leading minds gather, where breakthroughs are shared and boundaries are pushed. There is an IO Aha in every session, at every turn. CIO is a concentrated two-day program designed with you in mind. Renowned for its originality, practicality, and focus on improving patient care, CIO highlights the most viable and sought-after treatments in this rapidly growing practice area. CIO is the must-attend symposium for those looking to learn concise, efficient applications from the experts at a low cost. Don t miss a day at the office. Spend the weekend expanding your knowledge of interventional oncology while enjoying the iconic backdrop of Hollywood, Florida, and the Diplomat Hotel. CIO represents an unprecedented opportunity to learn about practical and innovative applications in clinical interventional oncology that have the potential to significantly change the management of patients with cancer. INTENSIVE 2 Days of Practical IO Education COMPREHENSIVE 50+ Presentations 30 Faculty PRACTICAL Apply What You Learned at the Office on Monday GREAT VALUE The Best IO Education at the Lowest Cost ICONIC LOCATION Spend February in Florida at the Beautiful Diplomat Hotel IN PARTNERSHIP WITH The Official News Source for the Symposium on Clinical 2 3

3 THE FACULTY Pioneers of the Possible s CIO Faculty Daniel Brown, MD Vanderbilt University School of Medicine Nashville, Tennessee Minesh Mehta, MD Miami Cancer Institute, Baptist Health South Florida 2 Days 50+ Presentations 30 Faculty 12 CME/CNE Credits THE HIGHLIGHTS Be a Pioneer of the Possible The Year in Review in IO Liver-Directed Therapy The Role of Y90 Renal Cell Carcinoma Lung Ablation Musculoskeletal Interventions Interventions for Prostate and Pancreatic Cancer Thyroid and Lymph Node Ablation Building an IO Practice Understanding IO Trial Data Constantino S. Peña, MD, Karen Brown, MD, Memorial Sloan Kettering Cancer Center New York, New York Matthew Callstrom, MD, PhD Mayo Clinic Rochester, Minnesota Timothy Clark, MD University of Pennsylvania Penn Presbyterian Philadelphia, Pennsylvania Thierry de Baere, MD Institut Gustave Roussy Villejuif, France Yuman Fong, MD Surgery City of Hope Medical Center Duarte, California Debra Gervais, MD Abdominal Imaging Massachusetts General Hospital Boston, Massachusetts Alice Gillams, MB, ChB, MRCP, FRCR London Clinic Marylebone, London, England Leonard Kalman, MD Oncology Miami Cancer Institute, Baptist Health South Florida Riccardo Lencioni, MD University of Miami Miller Robert Lewandowski, MD, Northwestern University Feinberg Chicago, Illinois Peter Littrup, MD Barbara Ann Karmanos Cancer Institute, Wayne State University Detroit, Michigan Govindarajan Narayanan, MD University of Miami Miller William S. Rilling, MD, Medical College of Wisconsin Milwaukee, Wisconsin Riad Salem, MD, MBA Northwestern University Feinberg Chicago, Illinois Stephen Solomon, MD Memorial Sloan Kettering Cancer Center New York, New York Daniel Sze, MD, PhD Stanford University Medical Center Stanford, California Alda Tam, MD The University of Texas M.D. Anderson Cancer Center Houston, Texas Gao-Jun Teng, MD, Radiology Zhongda Hospital, Southeast University Nanjing, China Sean M. Tutton, MD, Medical College of Wisconsin Milwaukee, Wisconsin Antonio Ucar, MD Oncology Miami Cancer Institute, Baptist Health South Florida Sarah White, MD, MS, Medical College of Wisconsin Milwaukee, Wisconsin Bradford Wood, MD NIH Center for Interventional Oncology Bethesda, Maryland Fellowship Director, Interventional David Liu, MD,, Radiology, University of Virginia School FRCPC of Medicine Charlottesville, Virginia University of British Columbia Vancouver, British Columbia, Canada 4 5 Medical Director of Vascular Imaging Ripal T. Gandhi, MD, FSVM Barry T. Katzen, MD, FACC, FACR, Founder and Chief Medical Executive Adam Geronemus, MD South Miami Heart Center Guest s Ziv J. Haskal, MD,, FAHA, FACR, FCIRSE Guest Shaun Samuels, MD, James F. Benenati, MD, Medical Director Noninvasive Vascular Laboratory Fellowship Program Director Alex Powell, MD, Medical Director Charles Ray, MD, PhD, MS Guest University of Illinois Hospital Chicago, Illinois

4 2018 Program Saturday, February 3 7:00 AM 7:50 AM Industry Sessions (non-accredited) Complimentary Breakfast, Seating is Limited COMPLIMENTARY BREAKFAST FOR ALL ATTENDEES SESSION 2 CIO Townhall 11:15 AM 12:25 PM MODERATORS: CONSTANTINO PEÑA, MD; RIPAL GANDHI, MD, FSVM The Big Picture: The Value of IO in a Major Cancer Center LEONARD KALMAN, MD SESSION 4 3:00 PM 3:30 PM RadioHead Revisited: All That s Happening in Y90 MODERATOR: RIPAL GANDHI, MD, FSVM Weekend Update: Y90 Year in Review DAVID LIU, MD,, FRCPC 8:00 AM 8:10 AM Opening Remarks CONSTANTINO PEÑA MD, ; RIPAL GANDHI, MD, FSVM; SHAUN SAMUELS, MD, SESSION 1 I Love the Liver 8:10 AM 10:10 AM Weekend Update: HCC Year in Review RICCARDO LENCIONI, MD HCC Panel: What Riccardo Lencioni Missed PANELISTS: YUMAN FONG, MD; DAVID LIU, MD,, FRCPC; PETER LITTRUP, MD; SARAH WHITE, MD, MS, Declaring Mistrials: What to Make of the Negative IO Studies and Other Literature Conundrums MODERATOR: ZIV HASKAL, MD PANELISTS: RIAD SALEM, MD, MBA; KAREN BROWN, MD, ; DAVID LIU, MD,, FRCPC; WILLIAM RILLING, MD, ; CHARLES RAY, MD, PHD; DANIEL SZE, MD, PHD; DANIEL BROWN, MD Within the last year, a number of trials focused on a variety of IO procedures have been published with mixed and sometimes confusing results. Other studies that have been published in radiation oncology have led to an accelerated integration into NCCN guidelines. As a busy practitioner, it can be hard to keep track of all the updates. This session will identify the most important recent trials, boil them down, and provide the essentials you need to discuss with your colleagues and apply to your practice and tumor board. SESSION 3 1:35 PM 3:00 PM Craftsmen's Corner: Techniques in Liver-Directed Therapy Conventional TACE TIMOTHY CLARK, MD Drug-Eluting Embolics GOVINDARAJAN NARAYANAN, MD Liver Ablation The Big Picture: The Many Uses of Y90 in the Liver (and Beyond?) DANIEL BROWN, MD 3:30 PM 3:45 PM REFRESHMENT BREAK SESSION 4 (CONT D) RadioHead Revisited: All That s Happening in Y90 MODERATOR: RIPAL GANDHI, MD, FSVM 3:50 PM 5:15 PM Special Considerations in Y90: Shunts, PVT, and Non-Target Embolization Protection RIAD SALEM, MD, MBA Weekend Update: Liver Metastatic Disease Year in Review DANIEL SZE, MD, PHD Mets Panel: What Dan Sze Missed PANELISTS: ROBERT LEWANDOWSKI, MD, ; TIMOTHY CLARK, MD; THIERRY DE BAERE, MD; ALICE GILLAMS, MB, CHB, MRCP, FRCR What IO Missed: A Medical Oncologist s View ANTONIO UCAR, MD What Everyone, Including the Medical Oncologist, Missed: A Surgeon s View YUMAN FONG, MD Set Proton Beam on Stun: Radiation Oncology in the Liver MINESH MEHTA, MD Current State of the Art in Liver Tumor Detection and Treatment Planning Buzzkill Corner: The Existential Threats to and the Possible Solutions MODERATOR: CHARLES RAY, MD, PHD PANELISTS: STEPHEN SOLOMON, MD; ALDA TAM, MD; TIMOTHY CLARK, MD; PETER LITTRUP, MD; SARAH WHITE, MD, MS, Join the discussion that will explore how the advent of immunotherapy, biologics, and genomics affects. This session will take a deeper dive into some of the data that is driving the enthusiasm for these newer approaches and analyze how this is affecting treatment decisions and patient care in an IO practice. 12:30 PM 1:30 PM Industry Sessions (non-accredited) Complimentary Lunch, Seating is Limited COMPLIMENTARY LUNCH IN THE EXHIBIT HALL ALICE GILLAMS, MB, CHB, MRCP, FRCR Radial Access in IO CONSTANTINO PEÑA, MD Y-90 ROBERT LEWANDOWSKI, MD, Bland Embolization KAREN BROWN, MD The Fun Part: Operator s Session in Liver-Directed Therapy PANELISTS: ALICE GILLAMS, MB, CHB, MRCP, FRCR; KAREN BROWN, MD, ; ROBERT LEWANDOWSKI, MD, ; RIPAL GANDHI, MD, FSVM; GOVINDARAJAN NARAYANAN, MD; TIMOTHY CLARK, MD Dosimetry Review for the Impatient IO CHARLES RAY, MD, PHD Heads Up: Red Flags and Cautions in Y90 RIPAL GANDHI, MD, FSVM Workout at the Y: Operator s Session on Radioembolization Cases MODERATOR: RIPAL GANDHI, MD, FSVM PANELISTS: RIAD SALEM, MD, MBA; ROBERT LEWANDOWSKI, MD, ; DAVID LIU, MD,, FRCPC; DANIEL SZE, MD, PHD; CHARLES RAY, MD, PHD; DANIEL BROWN, MD Day 1 Roundup: What I Learned and Audience Q&A RIPAL GANDHI, MD, FSVM; CONSTANTINO PEÑA, MD; SHAUN SAMUELS, MD, ; CHARLES RAY, MD, PHD 5:15 PM 6:45 PM CIO Exhibit Hall Reception Complimentary hors d'oeuvres and cocktails for all attendeess BRADFORD WOOD, MD 6 Curbside Corner: Liver Case Review PANELISTS: YUMAN FONG, MD; MINESH MEHTA, MD; ANTONIO UCAR, MD; GOVINDARAJAN NARAYANAN, MD; DAVID LIU, MD,, FRCPC 10:15 AM 11:00 AM REFRESHMENT BREAK IN THE EXHIBIT HALL 11:05 AM 11:15 AM Treatment of HCC in China with Emphasis on Portal Vein Thrombosis GAO JUN TENG, MD *Program and faculty subject to change. REGISTER TODAY AT THEIOMEETING.COM OR CALL E X P E R I E N C E THE EXHIBIT HALL Engage with the world's leading companies showcasing the latest devices and tools being used in the cutting-edge field of interventional oncology. 7

5 2018 Program Sunday, February 4 7:00 AM 7:50 AM Industry-Supported CME Symposia Complimentary Breakfast, Seating is Limited COMPLIMENTARY BREAKFAST FOR ALL ATTENDEES 8 SESSION 5 8:00 AM 9:10 AM Lung Ablation: Breathing New Life or Last Gasp? The Case for Lung Ablation: Why You Should Be Doing It ALICE GILLAMS, MB, CHB, MRCP, FRCR Weekend Update: Lung Ablation Year in Review STEPHEN SOLOMON, MD Lung Cryo: Ready for Prime Time? PETER LITTRUP, MD Cases You Should Be Doing: Operator s Session on Lung Ablation PANELISTS: ALICE GILLAMS, MB, CHB, MRCP, FRCR; STEPHEN SOLOMON, MD; THIERRY DE BAERE, MD; PETER LITTRUP, MD; ALDA TAM, MD SESSION 6 9:10 AM 10:15 AM Far Afield: Far-Flung Applications in IO MODERATOR: ZIV HASKAL, MD Thyroid Ablation ZIV HASKAL, MD Lymph Node Ablation and Other Interventions SARAH WHITE, MD, MS, Interventions for Adrenal Malignancy DEBRA GERVAIS, MD Interventions for Prostate Cancer BRADFORD WOOD, MD Interventions for Pancreatic Cancer GOVINDARAJAN NARAYANAN, MD CIO s Best Abstract and Runner-Up PRESENTERS TBD Dashcam Video from MCVI PANELISTS: ROBERT LEWANDOWSKI, MD; WILLIAM RILLING, MD, ; CHARLES RAY, MD, PHD; ZIV HASKAL, MD; STEPHEN SOLOMON, MD Here s a chance to find out if the CIO presenters walk the walk during their procedures. Several pre-recorded IO cases edited to the essentials will be presented, discussed, and critiqued by a panel. Gain additional insights by seeing the application of the techniques discussed. 10:15 AM 11:00 AM REFRESHMENT BREAK IN EXHIBIT HALL SESSION 7 11:05 AM 11:45 AM Interventions in Renal Cell Carcinoma Weekend Update: Renal Cell Carcinoma Year in Review DEBRA GERVAIS, MD Craftsman s Corner: Operator s Session in Renal Ablation/Intervention PANEL: PETER LITTRUP, MD; DEBRA GERVAIS, MD; MATTHEW CALLSTROM, MD, PHD SESSION 8 11:45 AM 12:25 PM Musculoskeletal Interventions Weekend Update: MSK Year in Review SEAN TUTTON, MD, Craftsman s Corner: Operator s Session in MSK Interventions PANELISTS: ALDA TAM, MD; SEAN TUTTON, MD, ; MATTHEW CALLSTROM, MD, PHD 12:30 PM 1:30 PM Industry Sessions (non-accredited) Complimentary Lunch, Seating is Limited COMPLIMENTARY LUNCH IN THE EXHIBIT HALL SESSION 9 Practice Building Tips 1:35 PM 2:15 PM Value Proposition in IO: Selling It to the Hospital and Oncologists SARAH WHITE, MD, MS, Mini Debate Private Practice IO: Patients Prefer the Private Touch CONSTANTINO PEÑA, MD Academic Center IO: There is No Substitute for a Transplant Center RIAD SALEM, MD, MBA Role of the Society of for the IO CHARLES RAY, MD, PHD Role of the Society of STEPHEN SOLOMON, MD *Program and faculty subject to change. REGISTER TODAY AT THEIOMEETING.COM OR CALL SESSION 10 2:15 PM 2:45 PM Ancillary Procedures in IO Importance of Biopsy in the Era of Personalized Medicine ALDA TAM, MD Biliary Interventions in Hepatic Malignancies KAREN BROWN, MD, Mini Debate Immunotherapy in IO: Do Not Miss the Wave DANIEL SZE, MD, PHD Immunotherapy in IO: Don't Quit Your Day Job WILLIAM RILLING, MD, SESSION 11 2:45 PM 3:30 PM M and M: Hard Lessons from the World of IO MODERATORS: CONSTANTINO PEÑA, MD; CHARLES RAY, MD, PHD Case Review: Bad Outcomes and Whether They Could Have Been Avoided PANELISTS: SARAH WHITE, MD, MS, ; SEAN TUTTON, MD, ; ALICE GILLAMS, MB, CHB, MRCP, FRCR; DANIEL SZE, MD, PHD; ALDA TAM, MD SESSION 12 Extreme IO MODERATOR: ZIV HASKAL, MD 3:30 PM 4:00 PM Insanely Great Cases in IO CASE PRESENTERS: RIAD SALEM, MD, MBA; BRADFORD WOOD, MD; ALDA TAM, MD 4:00 PM CIO Roundup and Closing Comments CONSTANTINO PEÑA, MD; RIPAL GANDHI, MD, FSVM; SHAUN SAMUELS, MD, 6:00 PM 10:00 PM Ultimate Tailgate and Super Bowl Party Clear the general session and put on your game face. We are proud to present the big game on our ultra high-definition cinematic widescreen, making for one of the best viewing opportunities in the nation. As an attendee, you will be able to enjoy complimentary drinks and exceptional game fare at this can t-miss event. New for 2018! Resident/Fellow/Recent Fellow Activity Scholarship New this year, CIO welcomes recent fellows, current fellows-in-training, and residents for an opportunity to participate in the Resident/Fellow Activity Scholarship, which includes tuition reimbursement to attend the meeting. Scholarships are limited, so visit residentsfellows for application details. CIO also offers discounted tuition rates for Residents/Fellows. To learn more, visit Do you have cutting-edge research in interventional oncology? This is your opportunity to share your research with the best in the field. All submitted abstracts will undergo a blind peer review and for quality of research, educational or scientific content, logical presentation, and impact on healthcare. Accepted abstracts will be eligible for one or more of the following: PRESENTATION Oral Presentation (Select abstracts only) Poster Display (All accepted abstracts) AWARDS Best Poster and Young Investigator Awards (One selected abstract for each award). All displayed posters will be eligible. IMPORTANT DEADLINES Abstract Submissions Site Closed: Sunday, October 8, 2017, 11:59 p.m. Acceptance/Waitlist Notifications: Week of October 31, 2017 Withdrawal Deadline: Monday, November 5, 2017 Registration/Intent to Present Due: Wednesday, November 15, 2017 PUBLICATION Online Publication in the digital version of the Journal of Vascular and (JVIR) TUITION SUPPORT Complimentary Registration (abstracts selected for Oral Presentation only) or Discounted Registration (all accepted abstracts). Abstract authors who are accepted for poster display will receive a 50% tuition discount on registration for the first author and 25% off for the second author. To view submission categories and learn more, visit abstracts. 9

6 Legendary Meeting. Iconic Location. Stay for unequaled endovascular education. The Diplomat 3555 S. Ocean Drive Hollywood, FL Ways REGISTRATION Spend February in Florida at the beautiful Diplomat Hotel, a legendary resort on Florida s glamorous Gold Coast. This vibrant Hollywood, Florida destination offers endless ways to connect, recharge, and recreate. Voted one of the best hotels in Florida by Condé Nast Traveler. To make hotel reservations and for travel information, please visit TheIOMeeting.com/hotel-and-travel. The deadline to reserve a room at the discounted rate is January 4, SPECIAL CONFERENCE HOTEL ROOM RATE $355 to 1 ONLINE: TheIOMeeting.com/register Register 2 BY PHONE: Early Bird 6/15/17 10/27/17 Advance 10/28/17 1/19/18 Regular/Onsite 1/20/18 2/7/18 February 3 7, 2018 The Diplomat MASTER YOUR FIELD AND YOUR FUTURE. For 30 years, ISET has served as the premier arena for pioneering and practical endovascular education. Alumni have gone on to transform the fields of interventional radiology, interventional cardiology, vascular surgery, and more. There simply is no comparison. ISET is where legends current and future come together to explore groundbreaking techniques, technologies, and procedures while exchanging discussion and debate that ultimately drive patient care forward. Come to ISET for unequaled endovascular education. PROGRAM HIGHLIGHTS* Critical Limb Ischemia Advanced Venous Intervention Peripheral Artery Disease Arterial Access and Closure Techniques DVT and PE Interventions Aortic Dissection Techniques Hands-On Stroke Management Non-Invasive Diagnosis Intervention Embolization: Old and New Applications Aortic and Peripheral Aneurysms Dialysis Access Intervention Wound Care for the Interventionalist *To view the full ISET program, visit PHYSICIAN MVP: CIO & ISET $1,499 $1,699 $1,749 CIO Only $549 $749 $799 NURSE/ALLIED HEALTH PROFESSIONAL MVP: CIO & ISET $599 $599 $599 CIO Only $249 $249 $299 FELLOW/RESIDENT/STUDENT MVP: CIO & ISET $699 $699 $749 CIO Only $199 $249 $299 INDUSTRY/NON-CLINICAL (Please note that if you are employed by industry, you MUST register as Industry/Non-Clinical.) MVP: CIO & ISET $1,699 $1,799 $1,799 CIO Only $649 $849 $949 MILITARY/VA MVP: CIO & ISET $699 $699 $749 CIO Only $199 $249 $299 CIO Accreditation Intended Learners The Symposium on Clinical Interventional Oncology (CIO) is designed for interventional radiologists, surgeons, oncologists, and other healthcare professionals involved in the treatment of cancer or looking to expand into this arena. Learning Objectives After attending the Symposium on Clinical (CIO), participants should be able to: Perform catheter-based procedures to treat solid tumors, using the latest techniques and technologies. Assess the most appropriate therapeutic agent in catheter-directed therapy for hepatic malignancies. Demonstrate appropriate decision-making skills and techniques in ablation involving tumors of the kidney, bone, liver, and lung. Determine the most appropriate imaging modalities during assessment, treatment, and follow-up of patients. Provide improved patient care by applying the knowledge and experience of experts in the field of interventional oncology. Analyze the evidence behind the various modalities utilized in interventional oncology. Accreditation In support of improving patient care, North American Center for Continuing Medical Education (NACCME) is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC) to provide continuing education for the healthcare team. CME NACCME designates this live activity for a maximum of 12.0 AMA PRA Category 1 Credits.* Physicians should claim only the credit commensurate with the extent of their participation in the activity. The National Commission on Certification of Physician Assistants accepts AMA PRA Category 1 Credits from organizations accredited by the ACCME. CNE This continuing nursing education activity awards 12.0 contact hours. Provider approved by the California Board of Registered Nursing, Provider #13255 for 12.0 contact hours. Nurse practitioners may participate in this educational activity and earn a certificate of completion as AANP accepts AMA PRA Category 1 Credits through its reciprocity agreements. UEMS/EACCME CME Credit Recognition The American Medical Association (AMA) has an agreement of mutual recognition of CME credit with the UEMS. Under the terms of this agreement, the European Accreditation Council for Continuing Medical Education (EACCME), the accrediting arm of the UEMS, will convert CME credit for live activities certified by the AMA. Hardware/Software Requirements All educational activities are accessible via a PC (Windows Vista 7, 8, 10) or Mac (Mac OS 10.x or later) computer with current versions of the following browsers: Internet Explorer, Mozilla Firefox, Google Chrome, or Safari. Windows Media Player or compatible alternative, sound card, and speakers are required for streamed audio. The latest version of the Adobe Flash Player is suggested for video programs. A PDF reader is required for print publications. Please direct technical questions to webmaster@ naccme.com. Requirements for Credit To be eligible for documentation of credit for each session attended, attendees must participate in the full activity and complete the online evaluation form for each session. For questions regarding this educational activity, please call Privacy Policy NACCME protects the privacy of personal and other information regarding participants, educational partners, and joint sponsors. NA- CCME and our joint sponsors will not release personally identifiable information to a third party without the individual s consent, except such information as is required for reporting purposes to the appropriate accrediting agency. NACCME maintains physical, electronic, and procedural safeguards that comply with federal regulations to guard your nonpublic personal information. Copyright 2017 by North American Center for Continuing Medical Education, LLC. All rights reserved. No part of this accredited continuing education activity may be reproduced or transmitted in any form or by any means, electronic or mechanical, without first obtaining permission from North American Center for Continuing Medical Education. ADA Statement North American Center for Continuing Medical Education complies with the legal requirements of the Americans with Disabilities Act and the rules and regulations thereof. If any participant in this educational activity is in need of accommodations, please call Note: Information contained herein is subject to change without notice

7 70 E. Swedesford Road Suite 100 Malvern, PA February 3 4, 2018 The Diplomat BE A PIONEER OF THE POSSIBLE TheIOMeeting.com Register by October 27 for the best rates. Plus! Don t miss the 30th International Symposium on Endovascular Therapy S Y M P O S I U M O N C L I N I C A L I N T E R V E N T I O N A L O N C O L O G Y TheIOMeeting.com 12 IN PARTNERSHIP WITH February 3 4, 2018