MEDICAL CITY PARTNERS INFORMATION UNIVERSITY OF CENTRAL FLORIDA COLLEGE OF MEDICINE PAGE 10 SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE PAGE 13

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1 NEMOURS CHILDREN S HOSPITAL PAGE 2 ORLANDO VA MEDICAL CENTER PAGE 8 UNIVERSITY OF CENTRAL FLORIDA COLLEGE OF MEDICINE PAGE 10 SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE PAGE 13 UNIVERSITY OF FLORIDA RESEARCH & ACADEMIC CENTER...PAGE 15 1 Updated 2/2016

2 NEMOURS CHILDREN S HOSPITAL & THE NEMOURS FOUNDATION FUNDING * VISION, MISSION & VALUES Our Promise: To treat every child as if they were our own. Our Commitment: To do everything in our power to help children grow up healthy Mission: To provide leadership, institutions, and services to restore and improve the health of children through care and programs not readily available, with one high standard of quality and distinction, regardless of the recipient's financial status. Values: Excel ~ Respect ~ Serve ~ Honor ~ Learn We believe that our shared values inform and inspire our activities, helping us build and sustain a culture of trust. We are committed to doing whatever it takes to ensure our patients and families, visitors, colleagues, and business partners experience a uniquely satisfying experience each time they interact with Nemours. ABOUT NEMOURS The Nemours Foundation supports one of the largest integrated pediatric health systems in the U.S., including 50 pediatric subspecialty clinics, partner hospitals, and primary and urgent care clinics throughout Delaware, Pennsylvania, New Jersey and Florida, including two free-standing children s hospital in central Florida and Delaware. Nemours provides clinical care for more than 300,000 unique patients per year. Patient satisfaction scores for Nemours physician practices and hospitals are at or near the top 5 percent nationally. RESEARCH & EDUCATION HIGHLIGHTS Your Child Our Promise. Nemours Research delivers our promise by working every day to create a culture of inquiry, evidence, scholarship and integration between the bench and the bedside, and to the clinic and the community. Researchers at Nemours are tackling childhood cancers, medication safety, cardiac surgical outcomes, diabetes, asthma, genetic conditions, infant mortality and more. We are developing capacity in Health Care Delivery Science, to shed light on how we can improve the overall patient experience and the long-term well-being of the children we serve. In 2014, enterprise-wide Nemours had 388 federal, non-federal and industry-sponsored research grants and contracts with a combined total budget of $74 million; 236 ($40 million) in Florida overall; 67 ($4 million) at Nemours Children s Hospital in Orlando. Nemours has grown into one of the country s leading pediatric health networks, ranking 9 th in the nation for NIH research funding among free-standing children s hospitals. In addition, Nemours partnerships with the Community are fulfilling the NIH mandate for that highest level of Translational Research, dubbed T4, in which investigators study the factors and interventions that influence the health of populations, and ultimately result in improved global health. Dr. Terri H. Finkel, Chair of Pediatrics and Chief Scientific Officer, NCH $74 million to Nemours, $4 million to NCH from federal, nonfederal, and industry-sponsored grants and contracts * Updated 2/2016

3 NEMOURS CHILDREN S HOSPITAL & THE NEMOURS FOUNDATION FUNDING * RESEARCH & EDUCATION HIGHLIGHTS (CONT D) The Nemours Center for Endocrinology, Diabetes, and Metabolic Disorders has conducted numerous clinical trials, Phase II-IV, studying effects of hormones, growth, and metabolism on diabetes in children and young adults. Sponsors have included the NIH, JDRF, AstraZeneca, the Thrasher Research Fund, Genentech, Novartis, Pfizer, Novo Nordisk, Eli Lilly, Medtronic, Merck, and GlaxoSmithKline. In September 2014, the Center secured a 5-year $10 million multi-site grant from the National Institute of Child Health and Human Development for the project entitled, Type I diabetes and the brain in children: metabolic interventions. Included in the research team are collaborators from Nemours, Stanford, Yale, Washington University and University of Iowa. Dr. Nelly Mauras, Division Chief, Endocrinology Over $12 million from federal, nonfederal, and industry-sponsored grants and contracts The Nemours Oncology Research Laboratory develops novel treatment paradigms to promote healing and tissue regeneration in multiple tissues by modulating the inflammatory response, the composition of the extracellular matrix, and the progenitor cell content. This effort is supported by a joint Nemours/UCF research agreement with funding from the Florida High Tech Corridor Council. The Oncology lab is also engaged in a collaborative agreement with Sanford Burnham Prebys Medical Discovery Institute to support research on the regulation of the gene MYCN in MYCN-amplified advanced neuroblastomas. Dr. Tamarah Westmoreland, Surgeon, NCH $120,000 from FHTCC The Nemours Center for Pharmacogenomics and Translational Research includes the Asthma Clinical Research Center; Center for Pharmacogenetics; Core Clinical Research Program; and the Nemours Asthma Research Program (including Comparative Effectiveness and Outcomes Research, Sickle Cell Disease-Related Asthma and Lung Disease, Obesity-Related Asthma and Lung Disease, and the Impact of Nutrition on Asthma. The Nemours Center for Cancer and Blood Disorders (NCCBD) focuses on developmental therapeutics targeting the unique genetic events that result in pediatric cancers. The NCCBD recently secured a 5-year $10.2 million NIH Center of Biomedical Research Excellence grant to establish a Comprehensive Sickle Cell Research Center, and our HTS & Drug Discovery Lab was awarded a $1 million RO1 for assay development to discover new inhibitors of NSD1 methyltransferase for pediatric AML. Dr. John Lima, Associate Director of Clinical Research, Nemours Research Institute, NCH Dr. Jason Lang, Center Director, NCH Dr. E. Anders Kolb, Director, Blood and Bone Marrow Transplant Program Dr. Eric Sandler, Chief, Division of Hematology/Oncology $4,096,159 from ALA, NIH, NHLBI, FLDOH $16 million from NIH 3 Updated 2/2016

4 NEMOURS CHILDREN S HOSPITAL & THE NEMOURS FOUNDATION FUNDING * RESEARCH & EDUCATION HIGHLIGHTS (CONT D) The NCCBD strives to maximize our most precious resource: the clinical trial-eligible pediatric cancer patient. Nemours became a new Community Clinical Oncology Program (CCOP) just 18 months ago. The mission of the Nemours CCOP is to ensure that each child and young adolescent within our catchment areas has the opportunity to participate in national cancer prevention, control and treatment trials as appropriate to his/her background and need. The Nemours NCORP will continue the Nemours CCOP mission and success with further implementation of systems supportive of Cancer Care Delivery Research and robust quality management. Nemours recently secured a 5-year $4.65 million grant from NIH to support NCORP Dr. Andrew Napper, Director, HTS & Drug Development Lab Nemours is sharing in a $17 million dollar Patient-Centered Outcomes Research Institute (PCORI) grant, partnering with the leading and largest children s health systems in the nation to transform pediatric health care across the United States. Representing more than 5% of the U.S. pediatric population, the PCORI grant partners have created a secure electronic network, dubbed PEDSnet, allowing users to tap into a huge patient database of existing knowledge for clinical research. PEDSnet offers a platform for the evolution of the learning healthcare system to generate new insights that can be turned quickly to application on behalf of the health of America s children. PEDSnet was, in fact, born from the IOM Learning Health System Roundtable, when invited participants decided to collaborate. A PEDSnet-wide study on the effects of early childhood antibiotics on obesity is in progress. Dr. Tim Bunnell, Director of Bioinformatics Dr. Terri Finkel, Chief Scientific Officer, NCH $17 million over 5 years from PCORI to PEDSnet partners NemoursOne is a robust, comprehensive, fully integrated and operational electronic health record (EHR) system which has been recognized by Healthcare Information and Management Systems Society (HIMSS) Analytics with its Stage 7 Award. This highest stage represents an advanced patient record environment. Nemours is the first pediatric health institution in the U.S. to achieve HIMSS Stage 7. Dr. David Milov, Chief Medical Information Officer, NCH Both of our Hospitals have been named to the 16th annual Hospital and Health Networks magazine 2014 Most Wired list. Most Wired acknowledges excellence in the use of information technology in four key areas: infrastructure; business and administrative management; clinical quality and safety; and clinical integration. 4 Updated 2/2016

5 NEMOURS CHILDREN S HOSPITAL & THE NEMOURS FOUNDATION FUNDING * RESEARCH & EDUCATION HIGHLIGHTS (CONT D) In light of studies indicating that returning military physicians may show a loss of certain clinical skills, the Department of Defense awarded Nemours a $3.9 million grant to evaluate how physicians can maintain these skills. Using Nemours comprehensive electronic medical record system, researchers will compare best practices to actual care decisions based upon how often a condition is seen. Ultimately, the study will test decision support interventions, such as feedback alerts in the electronic medical records, benefiting military and civilian physicians alike. Dr. Tim Wysocki, Director, CHDS $3.9 million from DoD Healthcare delivery science (HDS) examines the variables that influence how the right care is delivered to the right patient at the right time. Embracing this concept for a rapidly changing and value-driven health care economy, Nemours has expanded its Center for Healthcare Delivery Science by bringing aboard a new codirector, forming a 13-member scientific advisory board, and adding to its research staff. The Center s vision is to be recognized as one of the nation s premier models of integration of HDS research, training, clinical application, mentoring and external collaboration. Dr. Anne Kazak & Dr. Tim Wysocki, Directors, CHDS $1 million from federal grants Nemours investment in education and training of health professionals makes it one of the largest virtual classrooms in the nation. In 2014, Nemours invested $4.5 million to support education and training for 503 medical students, 717 residents, 87 fellows and 1,200 nursing students. Nemours has affiliations with Jefferson Medical College, Mayo Medical School, and the Colleges of Medicine at the University of Florida, Florida State University and the University of Central Florida. Dr. Heather Fagan, Vice-Chair of Education, NCH, Assistant Dean for UME, UCF COM Nemours offers Continuing Medical Education (CME) for physicians, nurses and health professionals both inside and outside of the Nemours system, including national and regional conferences, regularly scheduled activities and physician outreach. NemoursEducation.org, Nemours free online continuing medical education, continues to grow. The number of total registered users across the U.S. is more than 76,000. Dr. Pamela Arn, Director of Medical Education 5 Updated 2/2016

6 NEMOURS CHILDREN S HOSPITAL & THE NEMOURS FOUNDATION FUNDING * SPACE & FACILITIES Nemours Children s Hospital (NCH) has access to excellent laboratory space and core resources both within NCH and within the outstanding research facilities of its Medical City Partners: Cyril Doucet Director of Research DEVOTED TO RESEARCH NCH has a fully equipped General Clinical Research Center (GCRC) on the 4 th floor of NCH, supported by dedicated clinic rooms and inpatient rooms as required for research studies, and with additional space for equipment, supplies, staff and other resources. (In addition, NCH also maintains a General Clinical Research Center (GCRC) at NCH s Clinic at 1717 Orange Avenue in Orlando for patients visits at that Clinic.) The research effort is supported by the Pathology Department, whose resources include state-of-the-art testing facilities and the recently established Nemours-UCF COM Roche Molecular Center of Excellence, designed to accelerate and expand molecular diagnostics testing. Operations Nemours Research Institute, NCH Dr. Kamran Badizadegan, Chair of Pathology, NCH NCH leases over 3,000 sq. ft. of laboratory and office space for its biomedical research projects located at the Sanford Burnham Medical Research Institute. Our research efforts are enhanced by Sanford-Burnham s advanced technology platforms, including ultra-high-throughput small-molecule screening, disease model phenotyping, metabolomics, genomics, medicinal chemistry and pharmacology. NCH also leases over 4,000 sq. ft. of laboratory and office space at the UCF College of Medicine s Burnett School of Biomedical Sciences. With ample room to expand its activities as necessary, NCH houses its Offices of Clinical Research and Sponsored Projects. Nemours efforts are also augmented by UCF s strengths in nanotechnology, simulation, chemistry, engineering, optics and photonics. The NCH research effort is fully integrated as part of the Nemours Research Institute, with activities at its four locations: Orlando, Jacksonville, Pensacola and Wilmington (Delaware). This provides NCH with direct access to outstanding services, facilities, faculty and staff located throughout the Nemours Children s Health System. 6 Updated 2/2016

7 NEMOURS CHILDREN S HOSPITAL & THE NEMOURS FOUNDATION FUNDING * HEALTHY LIVING RESOURCES Nemours Health and Prevention Services (NHPS) vision is optimal health and development for all children. We take a population-oriented, multi-sector approach in Delaware, and build on community strengths and resources, to make policy, system and environmental changes where children and families live, learn, play, worship and seek healthcare. We are committed to working with our partners to transform communities and health care delivery systems that will improve population health. Mary Kate Mouser, M. Ed., Operational Vice President, Nemours Health & Prevention Services Nemours Center for Children s Health Media (KidsHealth) is a national leader in the creation of engaging, family-friendly health media and tools that educate and motivate families while helping care-providers to be more efficient and effective. Among its many widely-known products is KidsHealth.org, the #1 most-visited site devoted to children s health and parenting in both English and Spanish. On a typical weekday, about one million parents, kids, and teens turn to KidsHealth.org for expert advice and answers. KidsHealth s physician-led staff consists of clinician-educators, health and science editors, graphic and web designers, Dr. Neil Izenberg, Operational Vice President, NCCHM; Madeleine Boyer, Chief Marketing Officer, NCCHM video producers, business developers, and technologists. The Center works with, and licenses private-labeled educational products (including online content, patient instructions, educational videos, text and newsletter series, and other communication tools) to 80 of the nation s children s hospitals and hundreds of media, governmental, educational, and consumer product companies. KidsHealth also creates KidsHealth in the Classroom, a free website for educators featuring standards-based health curricula, activities, and handouts. The Nemours Florida Prevention Initiative works with the community to share healthy lifestyle messages with children and families. Targeted health promotion and disease prevention programs help child care providers, educators, health professionals, and community advocates teach children and their families positive health habits that can last a lifetime. Dr. Lloyd N. Werk, MPH, Division Chief, General Pediatrics, NCH Established in 2008, Nemours National Office of Policy and Prevention promotes optimal health and wellbeing for all children, not only children served within the Nemours health system. To do this, we work with stakeholders across Nemours and the country to advocate for federal policy change and identify, promote and Debbie I. Chang, MPH, Vice President of Policy & Prevention grow innovative practice and population-level solutions within and outside Nemours, advancing clinical care and community-based prevention efforts. The Nemours Health System also provides us with a laboratory in which to test new and innovative models, which informs our national policy and practice work. Through this work, we serve as a trusted resource and voice for children nationally. Nemours BrightStart! researches, develops and offers evidence-based tools targeting young children at risk for reading failure, which affects 30 percent or more of our nation s children. Since BrightStart! began in 2005, tens of thousands of prekindergarteners have been screened on early literacy skills, with thousands of at-risk children receiving Nemours BrightStart! intensive educational instruction. Dr. Laura Bailet, Operational Vice President of Nemours BrightStart! 7 Updated 2/2016

8 ORLANDO VA MEDICAL CENTER VISION SUMMARY EMERGING CENTER OF INNOVATION COMPREHENSIVE MEDICAL SERVICES TELEHEALTH We are committed to being a patient-centered integrated health care organization that provides Veterans excellent health care, research, and education. We strive to be an organization where people choose to work and an active community partner. We stand as a back-up in responding to national emergencies. The Orlando VA currently employs approximately 3,400 staff at 12 Points of Patient Care across Central Florida, who managed more than 1.3 million visits last year. The organization experienced 3% growth in enrolled patients in the last year. The Orlando VA Medical Center was designated an Emerging Center of Innovation by the VA Office of Patient Centered Care and Cultural Transformation. Some transformational activities currently underway at the medical center include PACT Team Motivational Interviewing, Complimentary (Alternative) Medicine, Patient Centered Care Hiring, Cooking Demonstrations and Farmers Markets, Patient Interactive System, Patient Centered Care Concierge Concepts, Real Time Customer Service Data Collection and Integrated Data Base Construction, Innovative Complaints Management and Service Recovery Systems, and the Faces of Freedom -- Patient Centered Care Video Project. In addition to services provided through 11 other sites, the new Orlando VA Medical Center in Lake Nona has a large multispecialty outpatient clinic, 134-inpatient beds, 120-community living center beds, a 60 - bed Domiciliary and Mental Health Residential Rehabilitation Program, and administrative and support services. The first primary care team began seeing patients at the new facility on Feb. 24. Additional services, including audiology, surgery, interim care, dental care, eye clinic and primary care physicians have been activated and will continue to roll out in The new Lake Nona medical campus is a stateof-the-art facility, and has increased accessibility to health care for more than 400,000 Central Florida veterans. The Orlando VA Medical Center uses communication and information technologies to provide health care delivery to Veterans. The term Virtual Care means using modern technology to provide clinical care and patient education when the patient and provider are in separate locations. The Orlando VA Medical Center uses these technologies to improve Veterans access to specialty care and services in VA clinics that are located closest to their homes. 55,655 Veterans in the Corporate Orlando system were actively involved in one or more of the five Virtual Care modalities in Fiscal Year Heather Frebe, Orlando VA Medical Center Public Affairs Officer 8 Updated 2/2016

9 ORLANDO VA MEDICAL CENTER RESEARCH HIGHLIGHTS In 2015, the Orlando VA Medical Center s research program continued to grow with 53 research projects, THE SIMULATION LEARNING, EDUCATION AND RESEARCH NETWORK (SimLEARN) 18 are ongoing and the remaining are in various preparation stages. We have established collaborations with the DoD, NIH/NIDDK, academic research institutions including several colleges within UCF, University of Florida, Tuft University, Vanderbilt Univ., Duke Univ., MD Anderson Cancer Center, Southwest Oncology Group Consortium, and industry partners. Projects include the VA s Million Veteran Program, CONFIRM testing, Lithium treatment in depression, hormone replacement, study of Vitamin D and Type 2 diabetes, screening and treatment of anal cancer, treatment of plantar fasciitis and many other disease entities. The Veterans Health Administration (VHA) SimLEARN National Simulation Center is currently under construction and will open in Lake Nona in spring This will be a high-technology, immersive environment for train-the-trainer activities and the operational hub for coordinating national VHA clinical simulation activities to meet the local simulation-based training needs of VA medical centers across the country. The facility will provide a high-fidelity training environment by replicating actual patient treatment areas in outpatient clinic setting, and inpatient/hospital settings including an intensive care unit, an operating room and more. HEALTH CARE FOR HOMELESS VETERANS The Orlando VAMC currently has 316 Grant and Per Diem transitional housing beds in its catchment areas, which includes Brevard, Orange, Volusia, and Osceola counties. Additionally, the OVAMC has more than 1,000 Veterans currently housed through the U.S. Housing and Urban Development Veterans Affairs Supportive Housing Program (HUD-VASH), a majority of which live in the greater Orlando area and lesser amounts in Titusville, Daytona, and within the Seminole County housing authority. These services provide permanent supported housing to Veterans and their families. There are 1,200 HUD- VASH vouchers allocated to the Orlando catchment area. Orlando is participating in the 25 Priority Cities Initiatives. As part of this initiative, Orlando VA Leadership is working closely with community partners to develop a collaborative coordinated assessment. The goal is aimed at better identifying and matching the best-fit housing resources to homeless Veterans. RESIDENCY PROGRAMS In 2015 the Orlando VAMC welcomed 16 residents as part of the new internal medical residency training program. The program is in collaboration with the University of Central Florida Medical School and Osceola Regional Medical Center, and can accommodate up to 20 residents per year. 9 Updated 2/2016

10 UNIVERSITY OF CENTRAL FLORIDA COLLEGE OF MEDICINE VISION The University of Central Florida College of Medicine aspires to be the nation s premier 21st century college of medicine. Deborah C. German, MD, Vice President for Medical Affairs and Dean The UCF College of Medicine will be a national leader in education, research, and patient care, recognized for supporting and empowering its students and faculty to realize their passion for discovery, healing, health, and life, and for its ability to create partnerships to transform medical education, health care, and research. EDUCATION Provides biomedical and M.D. educational programs for UCF, the nation s second largest university. Over 3,000 undergraduate students studying biomedical sciences, including a new biomedical engineering program. Graduate Program consisting of Ph.D. and M.S. students in biomedical sciences First M.D. class graduated in May In , the M.D. program will be at full enrollment, training 480 medical students per year. 97 percent of medical students who graduated in the past three years matched into top residency programs across the state and country. Combined MD-PhD program trains physician scientists in a multidisciplinary setting. ACGME-accredited Internal Medicine residency program developed in collaboration with Orlando VA Medical Center and Osceola Regional Medical Center which currently has 34 trainees. New partnership with Hospital Corporation of America will add 550-plus residency slots in Florida. Health Explorers and Leaders (HEAL) pipeline program helps prepare underserved middle and high school students for future health careers. More than 2,200 volunteer and affiliated faculty physicians. Global health initiatives include an annual Global Healthcare Forum, and interdisciplinary teams perform medical mission trips to the Dominican Republic annually. The student-run KNIGHTS (Keeping Neighbors in Good Health Through Service) in collaboration with Grace Medical Home provides clinical care to Orlando s underserved. The Clinical Skills and Simulation Center uses simulation as a clinical education and treatment tool, partnering with the Orlando VA Medical Center and others and leveraging the region s $3 billion modeling and simulation industry resources. The college s simulation resources model new approaches to health care delivery and patient engagement. The state-of-the-art Anatomy Lab includes larger-than-life medical imaging of hearts, livers and kidneys, touch-screen HD monitors and a table that displays a high-definition virtual cadaver that can show every anatomical system from a full body to individual nerves. Richard Peppler, Ph.D., Associate Dean, Faculty and Academic Affairs Griffith Parks, Ph.D., Director, Burnett School of Biomedical Sciences Diane Davey, M.D., Assistant Dean, Graduate Medical Education Juan Cendan, M.D., Chair, Medical Education, Assistant Dean of Simulation 10 Updated 2/2016

11 UNIVERSITY OF CENTRAL FLORIDA COLLEGE OF MEDICINE PATIENT CARE UCF Health, the College s multispecialty physician practice began treating patients in November 2011 at a facility blocks from the main UCF campus. The practice opened its second location in Medical City in March 2015 and in spring 2016 will open an on-site clinic for employees of the Osceola County Sheriff s Office and their dependents. All UCF Health physicians are faculty at the medical school. Edward Ross, M.D., Chair, Department of Internal Medicine, and Interim Associate Dean for Clinical Affairs Members of the Departments of Medical Education, Internal Medicine and Clinical Sciences practice medicine in a variety of clinical settings across the community. Diane Davey, M.D., Interim Chair, Clinical Sciences RESEARCH Clinical Directions: Be a catalyst for transforming healthcare in collaboration with local and national partners; develop, test and implement new approaches to delivering efficient, effective high quality care and improving population health. Establish innovative, patient-centered, technology-rich clinical education and research programs and facilities at the UCF Health Sciences campus at Lake Nona. Partner with others across Central Florida to address fragmentation and enable coordinated, seamless care. The College s Burnett School of Biomedical Sciences (BSBS) focuses its research on: Cancer faculty are creating innovative models for studying tumor growth, metastasis of human cancers, and anticancer therapeutic agents that target DNA and kill tumor cells Cardiovascular Disease Areas of focus include topics such as elucidation of molecular/cellular signaling events that control heart development and the application of stem cell therapies for treatment of ischemic heart disease Neurodegenerative Disease Research includes biology of demyelination and potential treatment options for Parkinson s disease and neurological disorders including ALS (Lou Gehrig s disease) and Alzheimer s disease. Infectious Disease Novel therapies are being developed at BSBS to understand, diagnose, and treat diseases such as Lyme disease, malaria, and tuberculosis, as well as the immune response to microbial infections. Sampath Parthasarathy, Ph.D., Associate Dean for Research Griffith Parks, Ph.D., Director, Burnett School of Biomedical Sciences 11 Updated 2/2016

12 UNIVERSITY OF CENTRAL FLORIDA COLLEGE OF MEDICINE RESEARCH (CONT D) Medical school has more than 200 research partnerships across the globe. Medical education research programs focus on medical simulation, assessment, professionalism, humanism and interprofessional education. 100 percent of M.D. students conduct research as part of the curriculum s two-year FIRE (Focused Inquiry and Research Experience) module. FIRE mentors include many community physicians and scientists. An NIH-sponsored team across three research institutions develops and studies interactive avatars that simulate physician-patient interactions and present pathology to the learner. The Office of the Associate Dean for Research spearheads new research programs, initiatives, and avenues for the college and fosters interdisciplinary collaboration within the College of Medicine, other UCF colleges, and external partners. UCF REGIONAL EXTENSION CENTER FOR HEALTH IT (REC) With an $8.6 million federal grant, the College helped more than 2,800 Central Florida physicians implement electronic health records to improve patient care quality and support transformational new models of health care. The College s Regional Extension Center has expanded its services to support patient-centered medical homes, ICD-10 training, health analytics and data, clinical decision support, advanced meaningful use, and other initiatives to achieve the triple aim of better quality care, greater population health, and more affordable healthcare. Jeanette Schreiber, JD, MSW, AVP for Medical Affairs, CLO 12 Updated 2/2016

13 SANFORD-BURNHAM-PREBYS MEDICAL DISCOVERY INSTITUTE AT LAKE NONA VISION Scientists at Sanford Burnham Prebys are committed to translating basic research discoveries into innovative therapeutics that have a tangible impact on human health. CENTER FOR METABOLIC ORIGINS OF DISEASE (CMOD) Scientists in the CMOD are studying the metabolic origins of obesity-related diabetes and its cardiovascular complications. The Center is supported by extensive shared resources, including the Conrad Prebys Center for Chemical Genomics, cardiometabolic phenotyping, metabolomics, analytical and functional genomics, medicinal chemistry, and pharmacology. Through partnerships with clinical and commercial organizations, Center scientists advance laboratory breakthroughs to provide clinical benefit for those suffering from disease. Daniel Kelly, M.D., scientific director INTEGRATIVE METABOLISM PROGRAM Researchers study how organs and cells work together to respond to biological and environmental challenges that lead to the development of metabolic diseases. The program brings together investigators with complementary expertise in cell and molecular biology, chemistry, and physiology. Since metabolic changes are also fundamental to many other pathological conditions, the basic principles of the research also provide insight and therapeutic avenues for combating other human diseases. Timothy Osborne, Ph.D., program director CARDIOVASCULAR METABOLISM PROGRAM Scientists conduct research into fundamental and early translational aspects of cardiovascular biology, physiology, and disease. This research focuses on the intersections of metabolic and cardiovascular diseases, including the interrelated effects of heart and vasculature disease. For example, hypertension, ischemic injury, and diabetes all lead to pathologic cardiac remodeling that involves myocyte hypertrophy, fibrosis and progressive ventricular dilatation. Similarly, hypertension, smoking, hypercholesterolemia, and diabetes lead to atherosclerosis. This is especially true in the obese or diabetic patient, given that hypertension and ischemic heart disease often coexist with inciting metabolic disturbances. Peter Crawford, M.D., Ph.D., program director GENOMIC CONTROL OF METABOLISM PROGRAM The focus of the Genomic Control of Metabolism program is to dissect and understand the genomic and epigenetic regulatory mechanisms responsible for proper metabolic control to maintain homeostasis. Institute scientists primarily study diseases in adipose tissue, liver, muscle, and immune cells. Particular emphasis is put on defining the role of key transcriptional regulatory proteins and nuclear hormone receptors in metabolic processes at the cellular level, in animal models, and in human disease. Another theme of the program s research is the systems-level analysis of metabolic processes using integrated experimental and bioinformatics approaches. Laszlo Nagy, M.D., Ph.D., program director 13 Updated 2/2016

14 SANFORD-BURNHAM-PREBYS MEDICAL DISCOVERY INSTITUTE AT LAKE NONA CONRAD PREBYS CENTER FOR CHEMICAL GENOMICS The Conrad Prebys Center for Chemical Genomics is Sanford Burnham Prebys Institute s robotic ultra-highthroughput and high-content screening center for testing large collections of small chemical structures to find promising drug leads. It is equipped with the most advanced drug discovery technologies in the nonprofit world and staffed with highly trained scientists, many with years of experience in the pharmaceutical industry. Layton Smith, Ph.D., director, Drug Discovery Florida FLORIDA TRANSLATIONAL RESEARCH PROGRAM (FTRP) The FTRP is a unique research-collaboration program open to Florida-based scientists. Funded by the Florida Department of Health, the FTRP strives to produce a pipeline of potential new medicines based on laboratoryresearch discoveries. Layton Smith, Ph.D., director, Drug Discovery Florida BUSINESS DEVELOPMENT The business development office manages the commercialization of discoveries that result from Sanford Burnham Prebys research. The business development team is actively engaged in developing relationships with potential partners and funding organizations for the advancement of shared research initiatives. The Intellectual Property team manages the licensing of technology and material transfers. Our multidisciplinary approach provides partners with access to custom-designed teams that include academic investigators, clinical researchers, and inhouse scientists with extensive pharmaceutical and biotechnology industry experience. Leslie Molony, Ph.D., senior director, Business Development 14 Updated 2/2016

15 UNIVERSITY OF FLORIDA RESEARCH AND ACADEMIC CENTER VISION Foster collaboration that stimulates innovative approaches to research and patient care, particularly in the areas of cancer, cardiovascular disease, diabetes and brain disorders ORLANDO COLLEGE OF PHARMACY The Helen and David Bean Campus of the University of Florida, College of Pharmacy in Orlando is located at the UF Research and Academic Center in Lake Nona. The facility houses a four-year Doctor of Pharmacy (Pharm.D.) Program. About 70 new students are accepted each year, with a total of 280 students working to become licensed pharmacists. Erin St.Onge, Pharm.D., Assistant Dean and Campus Director CENTER FOR PHARMACOMETRICS AND SYSTEMS PHARMACOLOGY The Center conducts applied research proximal to clinical trials and/or clinical practice oriented toward problem solving through quantitative analysis, drug-disease modeling/simulation, and clinical trial design. Research interests include Cancer, Cardiovascular diseases, Diabetes & Obesity, Orphan drugs, and special patient populations, such as pediatric rare diseases. Larry Lesko, PhD., Center Director and Clinical Professor CENTER FOR PHARMACOGENOMICS Housed within the UF College of Pharmacy, the Center is one of the leading educational institutions in pharmacogenomics research and training of future scientists. Investigations include the study of disease-gene associations and relevance to pharmacogenomics. Larisa H. Cavallari, Pharm.D., BCPS, Director INSTITUTE FOR THERAPEUTIC INNOVATION (ITT) ITT focuses on developing and testing new drugs to treat and cure a variety of infectious diseases caused by drug-resistant pathogens such as TB and MRSA commonly linked to hospital-acquired infections. George Drusano, MD Institute Director INSTITUTE ON AGING (IOA) Housed within the UF College of Medicine, the Institute on Aging conducts leads the aging and geriatric research department clinical research unit which will allow thousands to participate in clinical and translational research studies aimed at improving the health and independence of older adults. Research focuses on mechanisms, etiology, prevention and rehabilitation of cognitive and physical disability. Among several projects, UF is leading the largest NIH funded study of physical activity lifestyle interventions to prevent disability in older adults ($86,000,000 project involving over 1,600 older adults throughout the U.S.). Marco Pahor, MD, Director; Professor and Chair, Department of Aging and Geriatric Research 15 Updated 2/2016

16 UNIVERSITY OF FLORIDA RESEARCH AND ACADEMIC CENTER CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTE (CTSI) The mission of the CTSI is to improve human health by accelerating the translation of scientific discoveries into practical applications and practices for the diagnosis, treatment, prevention and cure of human diseases. As a catalyst and hub connecting resources, people and ideas, the CTSI expands collaboration and advances science across UF s 16 colleges, the state of Florida and the national Clinical and Translational Science Award consortium. Dr. David Nelson, Director, UF CTSI MEDICATION THERAPY MANAGEMENT COMMUNICATION AND CARE CENTER (MTMCCC) The center provides an experiential practice site for fourth-year student pharmacists, allowing them to perform comprehensive medication reviews via the telephone, complete patient chart quarterly reviews, and speak to patients regarding adherence issues. Anna Marie Hall, Pharm.D., BCACP, Assistant Director, MTMCCC THE FLORIDA MINORITY CANCER RESEARCH AND TRAINING CENTER (MiCaRT) The Florida Minority Cancer Research and Training Center (MiCaRT) is a partnership between UF and Florida A&M University with funding from the National Cancer Institute. The partnership is the only federally-funded minority partnership focused on cancer research and training for African Americans. The center launched a Minority Health Behavioral Research Core, which has a lab in Lake Nona, including a private waiting room, community resource center, focus group room, computer room for surveys, and for preparing and processing mail surveys. The goal is to train black researchers and support more studies focused on minority health. 16 Updated 2/2016