UNIVERSITY OF COLORADO AT BOULDER Department of Integrative Physiology. Spring 2013, MWF 3:00 3:50 pm, ATLAS 100

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1 UNIVERSITY OF COLORADO AT BOULDER Department of Integrative Physiology IPHY 4720: NEUROPHYSIOLOGY Spring 2013, MWF 3:00 3:50 pm, ATLAS 100 Instructor: TAs: Roger Enoka, Carlson 202E, Help session: Thu 12:30-3:00 pm in Clare 111 Brice Cleland Lead TA Matt Arnold T 10:00-11:50, T 12:00-1:50 David Caha (david.caha@colorado.edu) T 2:00-3:50, T 4:00-5:50 Ilana Peña-González (ilana.pena-gonzalez@colorado.edu) T 6:00 7:50 Prerequisites: IPHY 2800 Statistics IPHY 3410 Human Anatomy IPHY 3470 Human Physiology I Required Text: Enoka RM. Neuromechanics of Human Movement. Champaign, IL: Human Kinetics, In addition, the following optional text is on reserve in Norlin Library: Kandel ER, Schwartz JH, Jessel TM, Siegelbaum SA, Hudspeth JA. Principles of Neural Science, 5th edition. New York, NY: McGraw-Hill, Clickers: D2L: Grading: You are responsible for keeping your iclicker functional during the semester and are encouraged to bring a spare set of batteries (three AAA) to class. Material related to the course, including outlines of the lectures and information on your grade, is available at Desire2Learn (D2L). Your final grade will be based on your performance on the examination, quizzes, in-class questions, and assignments. 1. Exam (25%) The only exam for the course is scheduled for May 4 (4:30-7:00 pm). The exam will be cumulative and comprise ~10 short-answer questions. 2. Quizzes (50%) Most of your grade will be based on seven quizzes. Each quiz will comprise 10 multiple-choice questions on the material covered in class since the last quiz. The lowest quiz score will be dropped. The dates for the quizzes are: January 25 February 8, 22 March 8, 22 April 12, 26 There will be no make-up quizzes, but we will accommodate documented medical emergencies. 2. In-Class Questions (iclicker) (10%) The lectures will be interactive. The instructor will pose questions that you will answer after discussing the issue with other students. Points are awarded for participation with the three lowest scores (days) being dropped at the end of the term. Page 1

2 3. Assignments (15%) There will be one assignment each week. It will be posted on D2L on Monday and will be due by the start of class (3 pm) on the Friday of the same week. Late assignments will not be accepted or graded. With the exception of equations and drawings, assignments must be typed and printed. Handwritten or e- mailed assignments will not be accepted. 4. Grade distribution A A B B B C C C D D D F <50 Attendance: Consistent attendance is expected in both the lecture and recitations. Excessive (~8) absences from class are sufficient reason for the Instructor to award a failing grade. Honor Code: All students of the University of Colorado at Boulder are responsible for knowing and adhering to the academic integrity policy of this institution. Violations of this policy may include: cheating, plagiarism, aid of academic dishonesty, fabrication, lying, bribery, and threatening behavior. All incidents of academic misconduct shall be reported to the Honor Code Council (honor@colorado.edu; ). Students who are found to be in violation of the academic integrity policy will be subject to both academic sanctions from the faculty member and non-academic sanctions (including, but not limited to, university probation, suspension, or expulsion). Other information on the Honor Code can be found at and at It is a violation of the honor code to obtain copies of assignments, exams, or quizzes for this course from individuals or vendors who distribute such material. Religious Campus policy regarding religious observances requires that faculty make a reasonable Observances: effort to accommodate students who, because of religious obligations, have conflicts with scheduled exams, assignments, or required attendance. Please discuss your needs with the Instructor at least two weeks before the conflict will occur. Additional information can be found at: Disabilities: If you qualify for accommodations because of a disability, submit a letter to the Instructor from Disability Services no later than February 1, 2012 so that your needs may be addressed. Disability Services determines the necessary accommodations based on your documented disabilities. Contact: , Center for Community N200, and If you have a temporary medical condition or injury, see guidelines at Page 2

3 Classroom Behavior: Students and faculty each have responsibility for maintaining an appropriate learning environment. Those who fail to adhere to behavioral standards may be subject to discipline. Professional courtesy and sensitivity are especially important with respect to individuals and topics dealing with differences in race, color, culture, religion, creed, politics, veteran s status, sexual orientation, gender, gender identity and gender expression, age, disability, and nationalities. Class rosters are provided to the instructor with the student s legal name. I will gladly honor your request to address you by an alternate name or gender pronoun. Please advise me of this preference early in the semester so that I may make appropriate changes to my records. See policies at and at Discrimination The University of Colorado at Boulder Discrimination and Harassment Policy and and Procedures, the University of Colorado Sexual Harassment Policy and Procedures, and Harassment: University of Colorado Conflict of Interest in Cases of Amorous Relationships policy apply to all students, staff, and faculty. Any student, staff, or faculty member who believes s/he has been the subject of discrimination or harassment based upon race, color, national origin, sex, age, disability, religion, sexual orientation, or veteran status should contact the Office of Discrimination and Harassment (ODH) at or the Office of Student Conduct (OSC) at Information about the ODH, the above-referenced policies, and the campus resources available to assist individuals who believe they have been sexually harassed can be obtained at: Learning tips: To do well in this course, we recommend the following: 1. Get to know your TA 2. Never miss class 3. Establish a peer group for in-class discussions, working on assignments, and studying 4. Download and read the lecture notes as soon as they are available 5 Read the relevant textbook material at least one day BEFORE every class and learn the vocabulary. Make a note of concepts that you are not sure you understand. Have one night s sleep between reading the material and the class period when the material is discussed. 6. Ask questions in class 7. Understand the diagrams and graphs discussed 8. Meet with your study group once a week to review the material covered in class 9. Use the book on reserve in Norlin; you will need it for some assignments 10. Be an active participant in class and in lab 11. Attend Help sessions (Clare 111) and office hours to discuss terms and concepts you do not understand 12. Use the questions asked in class as a study guide 13. Read the quiz and exam questions carefully Page 3

4 Learning Goals: Course Outline: The learning goal for this course is to enable you to integrate knowledge on the structure and function of the nervous system to how it controls human movement. There is one overall learning goal for each of the five topics: 1. To define the processes involved in transmitting electrical signals between neurons and muscle fibers 2. To list the properties of the basic functional unit that connects the nervous system to muscle and to explain how it produces muscle force 3. To diagram the reflex pathways and to describe their modulation during movement 4. To define the properties of neurons and to diagram the neural circuits that can produce automatic behaviors 5. To deduce the interactions that must occur within the nervous system to perform purposeful actions To realize the learning goals, the course will cover the following five topics at a rate that will be determined by the discussions in the interactive class sessions. The topics are organized so that we proceed from the properties of excitable membranes to the activation of muscle during reaching: 1. Action Potentials and Signaling rapid signal transmission a. Fundamentals of electrical circuits b. Current around a circuit c. Cell membrane circuit d. Equivalent neuron properties e. Resting membrane potential f. Membrane currents g. Passive properties of neurons h. Action potential i. Action potentials in muscle j. Chemical and electrical synapses k. Nerve-muscle synapse l. Post-synaptic potentials m. Ionotropic and metabotropic receptors 2. Motor Unit and Muscle Action the neuromuscular system a. Final common pathway b. Motor unit types c. Motor unit recruitment and rate coding d. Muscle fatigue e. Physical training f. Aging 3. Spinal Reflexes basic neural circuits a. Control strategies b. Tendon organs and muscle spindles c. Ia afferent reflexes d. Modulation of spinal reflexes e. Reflexes and muscle fatigue f. Reflexes and spinal cord injury Page 4

5 4. Automatic behaviors actions that do not involve the motor cortex a. Biomechanics of locomotion b. Neural control of locomotion c. Central pattern generators d. Sensory input e. Cortical control of the spinal locomotor system 5. Voluntary Actions generating the motor commands a. Motor system b. Reaching and pointing c. Neuroplasticity Lab: The purpose of the lab is: 1. To review in-class questions, key vocabulary, and important concepts 2. To participate in learning experiences that enhance the lecture material 3. To prepare for and review the quizzes. 1/15 Introductions Contact information and office hours Orientation to course 1/22 Units of measurement (pp. 3-5 and Appendix A in Enoka) Building circuits 1/29 Review Quiz 1 Equilibrium potentials and resting membrane potential 2/5 Action potentials 2/12 Review Quiz 2 Evoked contractions 2/19 Electromyography 2/26 Review Quiz 3 Research paper 1 3/5 Motor unit demonstration (Neurophysiology of Movement Laboratory) 3/12 Review Quiz 4 Research paper 2 3/19 H-reflex demonstration (Neurophysiology of Movement Laboratory) 4/2 Review Quiz 5 Research paper 3 4/9 Reflexes and stretching exercises 4/16 Review Quiz 6 Locomotion 4/23 Research paper 4 4/30 Review Quiz 7 Prepare for Exam Page 5

IPHY 3410 Section 1 - Introduction to Human Anatomy Lecture Syllabus (Spring, 2017)

IPHY 3410 Section 1 - Introduction to Human Anatomy Lecture Syllabus (Spring, 2017) INSTRUCTOR: Dr. Leif Saul Office: TB01-108 (Temporary Bldg. 01 is attached to the West end of Clare Small) Phone: (303)