COURSE GUIDE BIOCHEMISTRY II

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1 1 PCA-27-F-01Ed00 COURSE GUIDE Universidad Católica de Valencia BIOCHEMISTRY II Year

2 2 Course guide BIOCHEMISTRY II COURSE GUIDE TO BIOCHEMISTRY II MODULE: Molecular biology and biochemistry 30 FIELD: Biochemistry 12 ECTS Subject: Biochemistry II 6 YEAR: 2º Type of learning: Semester: 1º Department: Mathematics and Teacher: Joaquin Carrasco Luna Experimental Sciences joaquin.carrasco@ucv.es MODULE ORGANIZATION MOLECULAR BIOLOGY AND BIOCHEMISTRY Nº ECTS: 30 Duration and temporal location within the curriculum: The Module is structurated in four fields and five subjects. Biochemistry I is found in 1ºst course. Enzymology in 3º and the other in 2º. Within this Module the student acquires the basic knowledge of biochemistry and molecular biology that will be useful as professional tool related to other areas of biotechnology. Subjects and Courses FIELD ECTS Courses ECTS Course/ semester Biochemistry I 6 2/1 Biochemistry 12 Biochemistry II 6 1/2 Molecular Genetics 6 Molecular Genetics 2/1 Enzimology 6 Enzimology 3/1 Molecular biology of microorganisms 6 Molecular biology of microorganisms 2/2

3 3 COURSE GUIDE TO THE SUBJECT: Biochemistry II Prerequisites: Passed or learning Biochemistry I. GENERAL GOALS Acquire a general idea about the basis of biochemistry Acquire a general idea about the principal routes and processes in bioenergetics and biocatalysis Comprehend the relationships among the different processes and elaborate conclusions Consolidate the necessary knowledge in chemistry and biochemistry for the elaboration of tasks related to biochemistry Acquire capacities to team working for the bibliographic research Develop capabilities for a laboratory of biochemistry COMPETENCES CG01 - Capacity to analyze and synthesize CB1 - Students acquire and understand knowledge in their field of study based on general secondary education but usually reaching a level that, although supported on advanced text books, also includes aspects involving state-of-the-art knowledge specific to their area. CB2 - Students are able to apply knowledge to their work in a professional way and have the competences enabling them to state and defend views and opinions as well as perform problem-solving tasks in their field of study CB3 - Students are able to collect and interpret relevant data (generally in their field of study) and give opinions that involve reflection on relevant social, scientific or ethical issues CB4 - Students can communicate information, ideas, problems and solutions to a specialized or non-specialized audience CB5 - Students develop the necessary learning skills to undertake further studies with a high level of autonomy. CT02 - Capacity to organize and plan CT03 - Mastering Spanish oral and written communication Competence measuring scale CT05 - Knowing and applying Basic ITC skills related to Biotechnology. CT06 - Capacity to manage information (capacity to look for and analyze information coming from different types of sources) CT07 - Problem solving

4 4 Course guide BIOCHEMISTRY II CT08 - Decision making CT09 - Capacity to work in interdisciplinary and multidisciplinary team CT10 - Interpersonal skills CT11 - Understanding multicultural and diverse environment CT12 - Critical and self-critical capacity CT13 - Ethics CT14 - Capacity to learn CT15 - Capacity to adapt to new situations CT16 - Capacity to produce new ideas (creativity) CT17 - Leadership abilities CT18 - Taking initiatives and enterprising spirit CT19 - Capacity to apply theoretical knowledge CT20 - Research skills CT21 - Sensitivity to environmental issues CE23 - Knowing how to use laboratory equipment and to carry out basic operations for each discipline including: safety measures, handling, waste disposal and activity register CE24 - Knowing basic and instrument laboratory techniques in the different areas of biotechnology CE25 - Knowing how to analyze and understand scientific data related to biotechnology CE29 - Contrasting and checking results of biotechnological experimentation CE32 - Knowing how to use different specific operating systems and software packages designed for Biotechnology LEARNING OUTCOMES R-1 Students have understood and acquired the subject s contents. COMPETENCES CG01, CB1, CB2, CB3, CB4, CB5, CT03, CT06, CT12, CT14, CT19, CT20, CE25

5 5 R-2: Students are able to solve problems or cases related to those contents by using various resources (literature, computer-based, etc.) R-3: Students are able to work and correctly perform basic activities in a lab in compliance with the relevant safety requirements. They can plan, develop and understand the purpose for the experience as well as contrast and validate the results obtained. R-4: Students are able to write a clear and well-organized text on diverse aspects of the subject R-5: Students are able to adequately present and defend their work R-6: Students seek bibliographic information from several sources and can analyse it with a critical, constructive attitude. R-7: Students cooperate with the teacher and peers throughout the learning process. They can work as members of a team. They are respectful, proactive and comply with the subject s organizational rules. CG01, CB2, CB3, CB4, CT02, CT03, CT05, CT06, CT07, CT08, CT12, CT14, CT16, CT19, CT20, CT21, CE25, CE32 CG01, CB5, CT02, CT05, CT07, CT08, CT09, CT10, CT12, CT13, CT14, CT15, CT16, CT19, CT20, CT21, CE23, CE24, CE25, CE29, CE32 CG01, CB1, CB2, CB3, CB4, CB5, CT02, CT03, CT05, CT06, CT09, CT12, CT14, CT15, CT16, CT18, CT20, CE25 CG01, CB1, CB2, CB3, CB4, CB5, CT02, CT03, CT05, CT06, CT09, CT12, CT14, CT15, CT16, CT18, CT20, CE25 CG01, CB1, CB2, CB3, CB5, CT02, CT05, CT06, CT07, CT08, CT12, CT14, CT15, CT16, CT18, CT20, CE25, CE32 CT09, CT10, CT11, CT12, CT13, CT15, CT16, CT17, CT18 ON-CAMPUS EDUCATIONAL ACTIVITIES ACTIVITY Teaching-Learning Methodology Relationship With Learning Outcomes for the subject ECTS 5 ON-CAMPUS CLASS Teacher presentation of contents, analysis of competences, explanation and in-class display of skills, R-1, R-2, R-5, R-6, R

6 6 Course guide BIOCHEMISTRY II abilities and knowledge. PRACTICAL CLASSES Group work sessions supervised by the professor. Case studies, diagnostic tests, problems, field work, computer room, visits, data search, libraries, on-line, Internet, etc. Meaningful construction of knowledge through interaction and student activity. R-1, R-2, R-3,R-4, R- 5, R-6, 0.2 LABORATORY Activities carried out in spaces with specialized equipment. R-4, R-5, R SEMINAR Supervised monographic sessions with shared participation R-2, R-3, R-5, R GROUP PRESENTATION OF PAPERS Application of multidisciplinary knowledge R-1, R-2, R-3, R-5, R- 6, R OFFICE ASSISTANCE Personalized and small group attention. Period of instruction and/or orientation carried out by a tutor to review and discuss materials and topics presented in classes, seminars, readings, papers, etc. R-2, R-3, R-5, R ASSESSMENT Set of oral and/or written tests used in initial, formative or additive assessment of the student R-1, R-2, R-3, R-5, R- 6, R Total The subject and / or material is organized in ON-CAMPUS EDUCATIONAL ACTIVITIES and INDEPENDENT WORK ACTIVITIES, with an estimated percentage ECTS. Proper distribution is as follows: 35-40% for Classroom Training Activities and 65-60% for independent work activities. (For 6 ECTS subject : 2.4 and 3.6 respectively). The teaching-learning methodology described in this guide in a generic way, shape in the teaching units in which the subject/ or material is organized.

7 7 INDEPENDENT WORK ACTIVITIES ACTIVITY GROUP WORK Teaching-Learning Methodology Group preparation of readings, essays, problem solving, seminars, papers, reports, etc. to be presented or submitted in theoretical lectures, practical and/or small-group tutoring sessions. Relationship of Course with Learning Outcomes R-1, R-2, R-3, R-4, R-5, R-6, R-7 ECTS 0.72 Work done on the university e-learning platform ( ) INDEPENDENT WORK Student study: Group Individual preparation of readings, essays, problem solving, seminars, papers, reports, etc. to be presented or submitted in theoretical lectures, practical and/or small-group tutoring sessions. R-1, R-2, R-3, R-4, R-5, R-6, R Work done on the university e-learning platform ( ) Total 3.6 SYSTEM FOR ASSESSING THE ACQUISITION OF THE COMPETENCES AND ASSESSMENT SYSTEM Assessment Tool LEARNING OUTCOMES ASSESSED Allocated Percentage

8 8 Course guide BIOCHEMISTRY II Written exam Practical laboratory Written lab exam Attendance to practice sessions R1= CG01, CB1, CB2, CB3, CB4, CB5, CT03, CT06, CT12, CT14, CT19, CT20, CE25 R2= CG01, CB2, CB3, CB4, CT02, CT03, CT05, CT06, CT07, CT08, CT12, CT14, CT16, CT19, CT20, CT21, CE25, CE32 R6= CG01, CB1, CB2, CB3, CB5, CT02, CT05, CT06, CT07, CT08, CT12, CT14, CT15, CT16, CT18, CT20, CE25, CE32 R7= CT09, CT10, CT11, CT12, CT13, CT15, CT16, CT17, CT18 R1= CG01, CB1, CB2, CB3, CB4, CB5, CT03, CT06, CT12, CT14, CT19, CT20, CE25 R2= CG01, CB2, CB3, CB4, CT02, CT03, CT05, CT06, CT07, CT08, CT12, CT14, CT16, CT19, CT20, CT21, CE25, CE32 R3= CG01, CB5, CT02, CT05, CT07, CT08, CT09, CT10, CT12, CT13, CT14, CT15, CT16, CT19, CT20, CT21, CE23, CE24, CE25, CE29, CE32 R4= CG01, CB1, CB2, CB3, CB4, CB5, CT02, CT03, CT05, CT06, CT09, CT12, CT14, CT15, CT16, CT18, CT20, CE25 R5= CG01, CB1, CB2, CB3, CB4, CB5, CT02, CT03, CT05, CT06, CT09, CT12, CT14, CT15, CT16, CT18, CT20, CE25 R6= CG01, CB1, CB2, CB3, CB5, CT02, CT05, CT06, CT07, CT08, CT12, CT14, CT15, CT16, CT18, CT20, CE25, CE32 R1= CG01, CB1, CB2, CB3, CB4, CB5, CT03, CT06, CT12, CT14, CT19, CT20, CE25 R4= CG01, CB1, CB2, CB3, CB4, CB5, CT02, CT03, CT05, CT06, CT09, CT12, CT14, CT15, CT16, CT18, CT20, CE25 R6= CG01, CB1, CB2, CB3, CB5, CT02, CT05, CT06, CT07, CT08, CT12, CT14, CT15, CT16, CT18, CT20, CE25, CE32 R1= CG01, CB1, CB2, CB3, CB4, CB5, CT03, CT06, CT12, CT14, CT19, CT20, CE25 R2= CG01, CB2, CB3, CB4, CT02, CT03, CT05, CT06, CT07, CT08, CT12, CT14, CT16, CT19, CT20, CT21, CE25, CE32 R3= CG01, CB5, CT02, CT05, CT07, CT08, CT09, CT10, CT12, CT13, CT14, CT15, CT16, CT19, CT20, CT21, CE23, CE24, CE25, CE29, CE32 R5= CG01, CB1, CB2, CB3, CB4, CB5, CT02, CT03, CT05, CT06, CT09, CT12, CT14, CT15, CT16, CT18, CT20, CE25 R6= CG01, CB1, CB2, CB3, CB5, CT02, CT05, CT06, CT07, CT08, CT12, CT14, CT15, CT16, CT18, CT20, CE25, CE32 R7= CT09, CT10, CT11, CT12, CT13, CT15, CT16, CT17, CT * In order to calculate the final grade, a minimum of 5/10 is required in all assessment tools Each part mark (only if above or equal to 5) will apply the appropriate correction for the allocated percentage. Attendance at practices is mandatory to assess the practical part of the subject.. DESCRIPTION OF CONTENTS COMPETENCES DIDACTIC UNIT I: BIOENERGETICS GENERALITIES 1. Transport and Membrane Potential 2. Introduction and Metabolic organization 3. Electron transport chains and synthesis of ATP 4. Photosynthesis CG01, CB1, CB2, CB3, CB4, CB5, CT02, CT03, CT05, CT06, CT07, CT08, CT09, CT10, CT11, CT12, CT13, CT14, CT15, CT16,

9 9 CT17, CT18, CT19, CT20, CE25, CE32 DIDACTIC UNIT II: CELLULAR METABOLISM 5. The acetyl-coa and the citric acid cycle. 6. Metabolism of carbohydrates. 7. Lipid metabolism. 8. Metabolism of nitrogen compounds DIDACTIC UNIT III: COORDINATION AND METABOLISM INTEGRATION 9. Hormonal regulation. 10. Biochemistry tissue. 11. Metabolic adaptations. 12. Molecular Bases inherited metabolic diseases.nutrigenomic. DIDACTIC UNIT IV - BLOCK PRACTICAL. Membrane Potential. Light reactions of photosynthesis Metabolism of carbohydrates Lipase Activity type II CG01, CB1, CB2, CB3, CB4, CB5, CT02, CT03, CT05, CT06, CT07, CT08, CT09, CT10, CT11, CT12, CT13, CT14, CT15, CT16, CT17, CT18, CT19, CT20, CE25, CE32 CG01, CB1, CB2, CB3, CB4, CB5, CT02, CT03, CT05, CT06, CT07, CT08, CT09, CT10, CT11, CT12, CT13, CT14, CT15, CT16, CT17, CT18, CT19, CT20, CE25, CE32 CG01, CB1, CB2, CB3, CB4, CB5, CT02, CT03, CT05, CT06, CT07, CT08, CT09, CT10, CT11, CT12, CT13, CT14, CT15, CT16, CT17, CT18, CT19, CT20, CT21, CE23, CE24, CE25,CE29, CE32

10 10 Course guide BIOCHEMISTRY II TEMPORAL ORGANIZATION OF LEARNING: CONTENT/TEACHING UNIT # OF MEETINGS DIDACTIC UNIT I: BIOENERGETICS GENERALITIES 1 Transport and Membrane Potential 2 2 Introduction and Metabolic organization 3 3 Electron transport chains and synthesis of ATP 3 4 Photosynthesis 2 DIDACTIC UNIT II: CELLULAR METABOLISM 5 The acetyl-coa and the citric acid cycle 3 6 Metabolism of carbohydrates 3 7 Lipid metabolism 3 8 Metabolism of nitrogen compounds 3 DIDACTIC UNIT III: COORDINATION AND METABOLISM INTEGRATION 9 Hormonal regulation 2 10 Biochemistry tissue 2 11 Metabolic adaptations 2 12 Molecular Bases inherited metabolic diseases 2 Practical block 10 REFERENCES

11 11 Stryer L. et al. Bioquímica. (Traducción de la 7ª edición, 2012). Editorial Reverté, S.A. Barcelona. Lehninger, A., Nelson, D. y Cox, M. Principios de Bioquímica. Editorial Omega, 6º edición Alberts, B., et al. Biología Molecular de la Célula. (Traducción de Molecular Biology of the Cell). Editorial Omega,6º Edición Matthews, C.K., et al. Bioquímica. (4ª edición, 2013). Editorial Addison-Wesley. Devlin, T.M. Bioquímica.. México, DF. 4a ed. Reverté S.A Lehninger, Albert L. Bioquímica: Las bases moleculares de la estructura y función celular. Barcelona, España. 2a ed. Omega, Metzler Biochemistry 3 ed Elsevier Harper, Bioquímica Ilustrada 28 ed Ed Mc Graw Hill Lange. MENTION OF DISTINCTION: The mention of Distinction will be awarded to students who have achieved a score equal to or greater than 9.0. The number of Distinctions granted will not exceed 5% of students enrolled in a subject in the corresponding academic year unless enrollment is under 20, in which case only one Distinction may be granted. (Royal Decree 1125/2003).

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