BIOLOGY 14: PHYSIOLOGY Fall 2015

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1 COURSE DESCRIPTION BIOLOGY 14: PHYSIOLOGY Fall 2015 This course examines the structure and function of cells, tissues, organs, and organ systems, and how combinations of these generate homeostatic mechanisms and adaptive responses that allow organisms to survive environmental changes. It will cover topics in human, animal, and plant physiology, often using a comparative approach, and will also include select examples of pathophysiology. The systems studied will also be considered on an integrative level, by analyzing how different organisms adapt to a variety of environmental demands and stresses (ion and water balance, temperature regulation, pressure) and move through their environment (navigation, locomotion, exercise). Lectures are supplemented by lab sessions that include dissection, experimentation, and discussion of primary research articles, and serve as an introduction to physiological techniques, animal models, and scientific investigation. CLASS MEETING TIME AND LOCATION Tuesday and Thursday from 10:00 11:50 am in room 201 of the Life Sciences Center (LSC). Lectures are also held during most of the X hours (Wednesday from 3:00 3:50 pm). Students are also required to attend a lab session once a week in LSC 204 during most weeks of the course. See the class schedule at the end of the syllabus for specific dates. INSTRUCTOR Hannah ter Hofstede, Ph.D. Assistant Professor Department of Biological Sciences Dartmouth College Hannah.ter.Hofstede@Dartmouth.edu Office Hours: Mon. 9:00-10:00 am, Wed. 2:00-3:00, Thu. 12:00-1:00 pm. All office hours are held in LSC 133. LAB DIRECTOR Cori A. Anderson, Ph.D. (Office: LSC 232) Cori.A.Anderson@Dartmouth.edu GRADUATE TEACHING ASSISTANTS Animakshi Bhushan Michael Butler Brown Ellie McNutt Andy Vacca Animakshi.N.Bhushan.GR@dartmouth.edu Michael.B.Brown.GR@dartmouth.edu Ellison.J.McNutt.GR@dartmouth.edu Andrew.J.Vacca.GR@dartmouth.edu Page 1 of 5

2 COURSE MATERIALS / RESOURCES Textbook: The recommended textbook for the course is Principles of Animal Physiology by Christopher D. Moyes and Patricia M. Schulte, Pearson Benjamin Cummings, 2 nd edition, Copies of the recommended text and other textbooks will be on reserve in Dana library (the new location is on the 3 rd floor of 37 Dewey Field Road). Students are responsible for all material covered in lectures and labs, and the textbook functions as an alternative source of information to understand lab and lecture material. On-line: Study aids (including practice quizzes) developed from the textbook are found at: Canvas Materials: The Canvas site for this course will include the Powerpoint slides of the lectures, as well as reading materials for the laboratory sessions and select research papers. EVALUATION Three in class, written exams will be given (the last exam is NOT cumulative), each worth 100 points, and together these account for 75% of the overall grade. The lab grade will determined by in-lab quizzes and short answer assignments worth 5-10 points per lab and a final independent lab report based on a group project worth 35 points. All together, the lab activities account for 25% of the final grade. Grades will be determined by the percentage of the total points possible (400), and not on a curve (the entire class could receive an A, an E, or anything in between). While 90% or above will definitely be an A and more than 60% will be required to pass the course, the grades associated with the remainder of the scores may be adjusted slightly depending upon the overall difficulty of the exams. Typical (but not necessarily final) percentages and corresponding grades are: 90 (A); (A-/B+); (B); (B-/C+); (C); (C-); (D); 60 (E). HONOR PRINCIPLE During this course it is expected that students will abide by the Honor Principle. The Dartmouth College Student Handbook (page iii) states "Fundamental to the principle of independent learning are the requirements of honesty and integrity in the performance of academic assignments, both in the classroom and outside. Dartmouth operates on the principle of academic honor, without proctoring of examinations. Students who submit work which is not their own or who commit other acts of academic dishonesty forfeit the opportunity to continue at Dartmouth." If you have any questions or concerns regarding the honor principle during the course, please contact Dr. ter Hofstede. STUDENTS WITH DISABILITIES Students with disabilities, including invisible disabilities such as chronic illnesses and learning disabilities, are encouraged to arrange for accommodations that might be helpful. Please meet with Dr. ter Hofstede as soon as possible, preferably during the first week of class, to discuss possible accommodations. All discussions will be confidential, although the Academic Skills Center may be consulted to verify any disability. STUDENTS RELIGIOUS OBSERVANCES Some students may wish to take part in religious observances that occur during the academic term. If you have a religious observance that conflicts with your participation in the course, please contact Dr. ter Hofstede as soon as possible to discuss appropriate accommodations. All discussions will be confidential. Page 2 of 5

3 LAB EXERCISES LAB 1 ( 9/21) Anatomy and Function of the Central Nervous System. Students will 1) dissect and compare the central nervous systems of the sheep and leech, 2) visually compare brains of several species including pig, chicken, mouse, and frog to identify general structures of the brain, and 3) submit an assignment based on the lab activities (10 points). LAB 2 ( 9/28) Sensory Physiology: Visual System Anatomy and Function. Students will 1) participate in a quiz (5 points) and discussion based on reading an original research paper prior to lab, 2) dissect a cow eye and identify specific structures, 3) test their pupillary light reflex and learn about this neural circuit, 4) use specialized goggles to demonstrate aspects of visual system function, and 5) submit an assignment based on the lab activities (5 points). No Lab ( 10/5) LAB 3 ( 10/12) Comparative Cardiac Anatomy. Students will 1) complete a statistics module about data visualization prior to lab, 2) dissect a cow heart to identify structures and understand the flow of blood through the heart, 3) make observations of a dissected frog and frog heart, 4) conduct an experiment investigating the effects of different conditions on leech heart rate, 5) compare and contrast the hearts and circulatory systems in these three organisms, and 6) submit an assignment based on the lab activities (5 points). LAB 4 ( 10/19) Cardiopulmonary Anatomy. Students will 1) complete a statistics module about experimental design prior to lab, 2) submit a lab report at the start of lab on the leech heart experiment from lab 3 (10 points), 3) dissect a sheep pluck (heart, lungs, diaphragm, thyroid, trachea) to identify components of the cardiorespiratory system and learn about the flow of the blood through these structures, 4) learn to use blood pressure cuffs and heart rate monitors for their independent project, 5) form groups for the independent project and design an experiment that tests a hypothesis about blood pressure and heart rate in human volunteers (project outline due next week), and 6) submit an assignment based on the lab activities (5 points). LAB 5 ( 10/26) Independent Project. Students will 1) complete a statistics module about hypothesis testing prior to lab, 2) participate in a quiz (5 points) and discussion based on reading an original research paper prior to lab, and 3) submit their independent project outline for feedback and approval by their TA and Dr. Anderson. Starting on Friday of this week, groups can check out blood pressure cuffs and heart rate monitors for data collection for their independent projects. Data collection, analysis and writing of the independent report will be completed on the student's own time. Data collection for the projects should be done in groups, but each student must analyze the data independently of others, come up with their own conclusions, and write their own report. LAB 6 ( 11/2) GI Function: Digestion. Students will 1) use biochemical assays to measure nutrient (carbohydrate, protein) breakdown in segments of the gastrointestinal system isolated from cockroaches, and 2) submit an assignment based on the lab activities (10 points). LAB 7 ( 11/9) Integrative Physiology: Ion and Water Balance. Students will 1) dissect a pig kidney and identify structures related to its function, and 2) submit an assignment based on renal function case studies (10 points). No Lab ( 11/16) Lab Report (35 points): due by 10:00 am on 11/17/15. Students are required to submit a hard copy to Dr. Anderson before the deadline that meets all the requirements of the standard lab report format (detailed instructions to be provided). Lab exercises that are not handed in to your TA by the end of lab period will receive a grade of zero. Late penalty for the independent project: 7 points (20%) off for each 24 hr period after the deadline. Page 3 of 5

4 CLASS SCHEDULE DATE TOPIC TEXT READINGS Thu 9/17 Lecture 1: Course Introduction / Molecules and Cells p , 22-78, Lab 1: Central Nervous System Anatomy and Function Tue 9/22 Lecture 2: Nervous System: Functional Organization p Wed 9/23 Lecture 3: Nervous System: Cell Structure and Function I p Thu 9/24 Lecture 4: Nervous System: Cell Structure and Function II p Lab 2: Visual System Anatomy and Function Tue 9/29 Lecture 5: Nervous System: Sensory Systems I p , Wed 9/30 Lecture 6: Nervous System: Sensory Systems II p Thu 10/1 Lecture 7: Endocrine System p Tue 10/6 NO LAB EXAM I Wed 10/7 Lecture 8: Muscle I p Thu 10/8 Lecture 9: Muscle II p Lab 3: Comparative Cardiovascular Anatomy and Function Tue 10/13 Lecture 10: Cardiovascular Physiology I p Wed 10/14 Lecture 11: Cardiovascular Physiology II same as above Thu 10/15 Lecture 12: Respiratory Physiology: Gas exchange p Lab 4: Cardiopulmonary Anatomy and Function Tue 10/20 Lecture 13: Reproductive Physiology p Wed 10/21 Thu 10/22 Tue 10/27 Lecture 14: Immune System Lecture 15: Plant Physiology Lab 5: Independent Project EXAM II Wed 10/28 Lecture 16: GI System: Anatomy and Feeding p Thu 10/29 Lecture 17: GI System: Digestion and Metabolism p , Tue 11/3 Wed 11/4 Thu 11/5 Lab 6: Metabolism and GI Function Lecture 18: Integrative Physiology - Exercise / Locomotion X-Hour: no lecture Lecture 19: Integrative Physiology - Low O 2 Environments Page 4 of 5

5 Lab 7: Integrative Physiology - Ion and Water Balance Tue 11/10 Lecture 20: Integrative Physiology - Ion and Water Balance p Wed 11/11 X-Hour: no lecture Thu 11/12 Lecture 21: Integrative Physiology - Thermoregulation p Tue 11/17 Mon 11/23 NO LAB Lecture 22: Ecological Physiology - Phenology, Migration, and Navigation (Guest lecturer: Prof. Matt Ayres). *Independent Lab Project Reports Due by 10:00 a.m.* EXAM III: 11:30 a.m. - 2:30 p.m. Page 5 of 5

6 BIO14 - PHYSIOLOGY LABORATORY SYLLABUS FALL 2015 Welcome to the laboratory of Bio14! This portion of the course will complement the lecture by offering you the opportunity to engage in the scientific process within the field of physiology. The specific laboratory objectives for Bio14 are as follows: 1) Using both live and fixed animal tissues, students will be challenged to carefully dissect and critically observe specimens to understand how structure underlies function in several different physiological systems. 2) Students will learn the process of scientific inquiry by generating hypotheses, developing study designs, collecting data, and interpreting their results. Written laboratory reports will be culminating assignments for students to display proficiency in communicating their scientific ideas and findings. 3) Additional laboratory assignments, including in- lab questions and research paper discussions will assess how well students have learned the laboratory material. 4) Students will be responsible for laboratory materials on examinations. This syllabus will outline the material that will be covered this term, important dates, and laboratory policies. We will review this syllabus during your first laboratory session. However, it is your responsibility to be familiar with all parts of this syllabus and to follow them closely. Please refer back to this document throughout the term. Laboratory Personnel Laboratory Director: Dr. Cori Anderson Cori.A.Anderson@dartmouth.edu Graduate Teaching Assistants: Animakshi Bhushan Animakshi.N.Bhushan.GR@dartmouth.edu Michael Butler Brown Michael.B.Brown.GR@dartmouth.edu Ellie McNutt Ellison.J.McNutt.GR@dartmouth.edu Andy Vacca Andrew.J.Vacca.GR@dartmouth.edu 1

7 Laboratory Section Assignments On the first day of class you will be directed to complete an online survey to determine your lab section based on your academic schedule. Conflicts of an academic nature will be prioritized, followed by work and extracurricular activities. Your lab section assignment will be the same for the entire term and it is your responsibility to ensure that you will be in attendance for all sessions. Be sure to check all exams and X- hours for your other classes throughout the term. This term we will be offering four lab section times: Section 1: Tuesday Afternoon 2:00-6:00pm Section 2: Tuesday Evening 6:30-10:30pm Section 3: Wednesday Afternoon 4:00-8:00pm Section 4: Thursday Afternoon 2:00-6:00pm 2

8 Laboratory Calendar Below is a calendar outlining each laboratory session for the term and relevant assignment due dates. Lab Dates Assignment(s) Lab 1: Nervous System Lab 2: Visual System Lab 3: Cardiovascular System Lab 4: Cardiopulmonary System Lab 5: Independent Projects Lab 6: Gastrointestinal System Lab 7: Renal System Sept 21 st Sept 28 th Oct 12 th Oct 19 th Oct 26 th Nov 2 nd Nov 9 th Quiz on Primary Research Paper. Leech Heart Rate Mini- Lab Report due at the beginning of Cardiopulmonary Lab. Independent Project Proposal due at the beginning of Independent Project Lab. Quiz on Primary Research Paper. Independent Project Report due November 17 th at noon. 3

9 Laboratory Grades Your work in the laboratory will contribute to 25% of your overall grade in Bio14. The lab grade will be composed as follows: Component Percentage Description Post- lab questions Research Paper Discussion Questions 45% 10% Mini lab report 10% Independent project 35% A short assignment will be distributed at the beginning of each lab session to be handed in at the end of the lab session. The assignments will focus on your understanding of the dissections performed and how the specimens relate to broader physiology concepts. Students will read two research papers throughout the term and complete a short assignment related to each paper during the lab. One mini- lab report on data collected in Lab 3 (Cardiovascular Lab) comprising methods, results, and discussion. Students will design and conduct an experiment related to cardiorespiratory physiology. More details on this assignment will be given during the term. NOTE: While there are no laboratory exams, the material from the laboratory will be included on the lecture exams. Assignments For some laboratory assignments, you are required to prepare your assignments electronically and submit a hard copy of the assignment at the beginning of your laboratory session or at the indicated time in the Bio14 dropbox. Plan in advance to print your assignment before coming to lab. 4

10 Academic Honor Principle As stated in the Dartmouth College Student Handbook, Fundamental to the principle of independent learning are the requirements of honesty and integrity in the performance of academic assignments, both in the classroom and outside. Dartmouth operates on the principle of academic honor, without proctoring of examinations. Students who submit work which is not their own or who commit other acts of academic dishonesty forfeit the opportunity to continue at Dartmouth. The Academic Honor Principle also states that it is the responsibility of the faculty to (a) provide continuing guidance as to what constitutes academic honesty, (b) to promote procedures and circumstances which will reinforce the principle of academic honor; and (c) to review constantly the effective operation of this principle. In line with these obligations, we have outlined below how the Academic Honor Principle is fulfilled in the laboratory portion of your Bio14 course work. 1. Science is a collaborative field and we encourage collaboration during many aspects of the course while still requiring demonstration that each individual has an understanding of key concepts. You will work with partners during the laboratory sessions to perform all in- lab activities including dissections, data collection, and hypothesis generation. Any assignments about the lab dissections or discussions should be done by you alone. While you may have worked together to collect data, any analysis of the data you ve collected, including generating electronic graphs, and interpreting and drawing conclusions from your data, must be done individually. Most importantly, we require that the textual content of any lab report submitted for grading is prepared by you individually without the assistance of anyone else. 2. Frequently you will search the scientific literature and other sources in order to find support for your hypotheses or data interpretations. It is critical to cite all references used. We require that you use the citation style of the American Journal of Physiology, available at aps.org/mm/publications/info- For- Authors/Composition#references. For extensive lab reports, it is recommended that you use a reference manager program (ie. RefWorks, Papers, Endnote). Help with these is freely available to you through the Dana Biomedical Library. 3. Any attempt to mislead the laboratory instructor, TA, or other course personnel regarding late submission of assignments, absences from lab, or alterations in graded assignments will be considered academic dishonesty and will be considered a violation of the Academic Honor Principle. 5

11 Laboratory Policies Attendance Attendance is required at ALL of your assigned laboratory sessions. It is your responsibility to ensure that you are on time and in attendance for all of your assigned laboratory sessions for the entirety of the term. If you are unable to attend your assigned lab section due to unforeseen circumstances, you must notify Dr. Anderson as early as possible, before your assigned lab section time. The earlier you bring this to the attention of Dr. Anderson the greater the possibility that arrangements can be made for you to still complete all or portions of the laboratory activities. Due to time constraints, however, there are no arrangements for make- up labs and there is no guarantee you will be able to participate in or receive full credit for the lab. Attire We will typically be working with hazardous materials, preserved tissues, and laboratory equipment. Therefore it is critical that you come to the laboratory with appropriate attire to perform all laboratory procedures safely (whether you wear or bring appropriate clothing to change into in one of the nearby restrooms prior to the start of lab). You are required to wear closed- toe shoes and long pants or ankle- length skirts at all laboratory sessions. Shorts, capris, skirts above the ankle, and sandals are not allowed. Arrival at the laboratory with inappropriate attire will result in you being sent home to acquire the appropriate lab attire. We will provide lab coats, gloves, and goggles when necessary. The purpose of this personal protective equipment is to prevent the contamination of you and your belongings, therefore please remove all lab coats, goggles, and gloves if you leave the laboratory, (including going into the lab vestibule) for any reason during the laboratory session. Electronic Devices Due to the nature of the reagents and equipment used in the laboratory, it is critical that electronic devices are not used during the laboratory sessions. Cell phones are not permitted in the laboratory at any time and must be kept in the vestibule during the entire laboratory session. Laptop computers are permitted only during designated times (as indicated by your TA) and can only be used in designated areas to avoid contamination with hazardous reagents. 6

HUMAN ANATOMY AND PHYSIOLOGY II

BIO 202 FALL SEMESTER, 2015 HUMAN ANATOMY AND PHYSIOLOGY II Mesa Community College, Southern & Dobson Instructor: Dr. Pamela Harrison Office: NU 187 Phone: 480-461-7157 email: pamela.harrison@mesacc.edu