Epidemiology 605: Introduction to Infectious Disease Epidemiology

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1 Epidemiology 605: Introduction to Infectious Disease Epidemiology Fall Term 2016: Monday, Wednesday 11:30 am - 1:00 pm SPH I room 1690 (Lane auditorium) Professor: Mark L. Wilson Professor of Epidemiology SPH II Room M5507 wilsonml@umich.edu Office hours: By Appointment Course Description: Introduction to diseases and transmission characteristics, and the descriptive epidemiology of infectious agents. This course will help students to understand the theoretical basis of pathogen transmission and what factors determine patterns of disease occurrence. Students will learn how to apply this understanding to disease prevention and control. Course Materials: Required: Control of Communicable Diseases Manual (20th Ed. 2014) (David L. Heymann, ed.). This is an excellent reference on the epidemiology of virtually all infectious diseases of public health concern. We will use this book as the primary reference for the diseases that you will be expected to know well. Also, many of the terms and concepts used in the course are defined in the back of the book. Available at Ulrich's and online. Highly Recommended: Infectious Disease Epidemiology: Theory and Practice (Third Ed. 2014) (K. E. Nelson, C. M. Williams, eds.). This book provides a very thorough and in-depth introduction to the epidemiology of infectious diseases, with chapters on fundamental principles and disease examples. It will serve as the text for most of the required reading and other material that will be covered in the course. Available at Ulrich's and online. Reading assignments for each session are described in the schedule below and refer to material that will be made available through Canvas, or refer to Chapters in Nelson and Williams Third Edition unless otherwise indicated. Pre-requisites: This course assumes students have successfully completed Epid 600 or Epid 503 or the equivalent. Course Goals: The overall goal is to introduce students to the special design, measurement, analysis and intervention issues associated with the epidemiology of infectious diseases. We will address contemporary infectious diseases of public health importance in the developed and underdeveloped world. Our intent is to present material in class that is aimed at helping students to comprehend, synthesize and analyze problems and processes in infectious disease epidemiology. 1

2 Objectives include: 1. Introduce students to disease and transmission characteristics, and the descriptive epidemiology of infectious agents. 2. Help students understand the theoretical basis of pathogen and transmission characteristic interactions and how they produce patterns of disease occurrence. 3. Enable the student to apply this understanding to disease prevention and control. Competencies: Upon completion of the course, the student should be able to: 1. Characterize the difference between viruses, fungi, bacteria, and parasites, their measurement, natural history and epidemiology. 2. Explain the different mechanisms of transmission as they relate to viruses, fungi, bacteria, and parasites, and use examples to illustrate these differences. 3. Explain the components of a surveillance system, describe different types and purposes of surveillance, and discuss the strengths and weaknesses of different surveillance systems. 4. Evaluate the pros and cons of different prevention and control measures, select the most appropriate measure, and be able to justify that selection. 5. Design control plans for diverse infectious disease problems in various settings. In addition, at the end of the course, you should possess the following skills and knowledge that are specific to each transmission system: an understanding of the general biology of that transmission system a familiarity with some paradigmatic diseases transmitted by this route an ability to construct informed hypotheses of causation based on the observed epidemiology and knowledge of that general pattern an understanding of socio-cultural and environmental factors that influence transmission by that route the capacity to propose appropriate responses and intervention strategies Course Requirements: Students are expected to acquire knowledge of the basic descriptive epidemiology of several diseases. Some of these diseases will be presented as examples in lectures, and others will be part of the readings. Students will be tested on their knowledge of these diseases, and an ability to apply such knowledge to the various problems presented. Lectures, discussion and homework exercises. Sessions will be led by Professor Wilson and various guest lecturers. During most classes, there will be discussions and brief summaries by students. Each session will have assigned readings. Three exams will occur during the days listed on the schedule below. is expected and will be part of the course grade. During the course there will be four "homeworks." These are intended to be individual assignments. Although you may consult with each other (and are encouraged to do so if that helps you to learn), the preparation of the assignment that you turn in is your individual responsibility. Those students who turn in identical homework will be considered in violation of ethical standards of our institution, and will receive no credit for that assignment. Larger classes tend to limit opportunities for class participation. We will use several different teaching strategies to keep the class as interactive as possible. In order to regularly evaluate our performance and keep in touch with your concerns, we will ask that, at the end of each class, you evaluate that session. The information that we will want includes: 2

3 1) Your name and date 2) What were the most important points presented at the days session? 3) Do you have any questions about the content of the day s session? 4) What comments or suggestions on the lecture or material might improve it? These comments will not be graded, per se, but will be reviewed for content and used in planning upcoming course sessions and as a measure of your participation. To receive this participation credit, you must complete this evaluation. In addition, we expect your oral participation with questions and answers during the lecture. Grading: Class Participation: 5% Homework: 20% First examination: 20% Second examination: 25% Third examination: 30% Classroom Expectations/Etiquette: The usual! Cell phone off. Don't disturb others by talking while the lecturer is speaking. If you are using your computer, please do so to follow the lecture notes or to look up relevant information ( s and Facebook REALLY can wait!). If you have to leave early, sit near an exit to minimize disruption. In general, be considerate of your classmates and the person who is presenting. Academic Integrity: The faculty and staff of the School of Public Health believe that the conduct of a student registered or taking courses in the School should be consistent with that of a professional person. Courtesy, honesty, and respect should be shown by students toward faculty members, guest lecturers, administrative support staff, community partners, and fellow students. Similarly, students should expect faculty to treat them fairly, showing respect for their ideas and opinions and striving to help them achieve maximum benefits from their experience in the School. Student academic misconduct refers to behavior that may include plagiarism, cheating, fabrication, falsification of records or official documents, intentional misuse of equipment or materials (including library materials), and aiding and abetting the perpetration of such acts. Please visit visit Public Health Academic Integrity Training for the full SPH Code of Academic Integrity and further definition of these terms. Student Well-being: SPH faculty and staff believe it is important to support the physical and emotional well-being of our students. If you have a physical or mental health issue that is affecting your performance or participation in any course, and/or if you need help connecting with University services, please contact the instructor or the Office of Academic Affairs. Please visit for information on wellness resources available to you. Student Accommodations: 3

4 Students should speak with their instructors before or during the first week of classes regarding any special needs. Students can also visit the Office of Academic Affairs for assistance in coordinating communications around accommodations. Students seeking academic accommodations should register with Services for Students with Disabilities (SSD). SSD arranges reasonable and appropriate academic accommodations for students with disabilities. Please visit for more information on student accommodations. Students who expect to miss classes, examinations, or other assignments as a consequence of their religious observance shall be provided with a reasonable alternative opportunity to complete such academic responsibilities. It is the obligation of students to provide faculty with reasonable notice of the dates of religious holidays on which they will be absent. Please visit for the complete University policy. Diversity, Equity, and Inclusion: At SPH, our mission to promote population health worldwide is inseparable from our aim to develop more effective and socially just systems for creating and disseminating knowledge. As part of this, we recognize the histories of social discrimination globally, and seek to promote and extend opportunities for members of all groups that historically have been marginalized. We commit to developing the institutional mechanisms and norms necessary to promote the values of diversity, equity, and inclusion, both inside and outside our classrooms. To this end, SPH upholds the expectations that all courses will (1) be inclusive, (2) promote brave discussions, (3) follow multicultural ground rules and (4) abide by UM policies and procedures. 1) Inclusive courses, are those in which teachers and learners co-create and co-sustain environments that support and encourage all members to participate equitably. See for more resources. 2) Brave (rather than safe) discussions promote diversity and social justice learning by acknowledging dynamics of oppression and privilege both inside and outside the classroom. Read more at 3) Multicultural ground rules acknowledge diverse experiences in the classroom and offer strategies for holding one another appropriately accountable. See examples from the UM Program on Intergroup Relations and others at 4) UM policies and procedures can be found at with additional resources and instructions for reporting discrimination at Course Topics/Reading List: (see next page) 4

5 Tentative Course Outline - Fall Term 2016 Date Topic Read Before Lecture Assignments/Exams 7 Sept Introduction and overview IOM pp Special features of infectious disease IOM Chapt. 2 Chapt. 1* epidemiology 14 Introduction to transmission Chapt. 2* mechanisms 19 Characteristics of pathogens Chapt. 8,9* (Duane Newton, PhD) 21 Introduction to role of immunity: Chapt. 10* individual and population 26 Eradication vs. Control 28 Hospital Infections: Practice & Policy (Lisa Sturm, MPH) Chapt. 14* Homework 1 Due 3 Oct Vaccines: Disease Prevention Chapt. 11* 5 Examination I - - Examination 10 NO CLASS -75 th Celebration 12 Introduction to outbreak investigations Chapt. 5* Canvas readings 17 NO CLASS - Study Break 19 Outbreak Investigation in practice (Laura Bauman, MPH) Homework 2 Due 24 Introduction to Surveillance 26 Surveillance in practice - HIV/AIDS (Eve Mokotoff, MPH) 31 Antibiotic resistance 2 NOV Agent Factors/Disease Patterns 7 Environment and Disease Patterns 9 Social Factors and Disease Patterns Homework 3 due 14 Examination II - - Examination 16 Simulation Modeling: Applications Chapt. 6* (Marisa Eisenberg, PhD) 21 Airborne transmission Chapt. 15*, 19* 23 Sexually transmitted diseases Chapt. 24* 28 Fecal-Oral, Food/water transmitted Chapt. 20* diseases 30 Vector-borne disease transmission Chapt. 25* 5 DEC Emerging and re-emerging infections Chapt. 13* Homework 4 Due 7 Policy implications and development 12 Examination III - - Examination 5

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