City University of Hong Kong Course Syllabus. offered by Department of Biomedical Sciences with effect from Semester B, 2015 / 2016

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1 City University of Hong Kong Course Syllabus offered by Department of Biomedical Sciences with effect from Semester B, 2015 / 2016 Part I Course Overview Course Title: Medical Genetics Course Code: BMS3005 Course Duration: One Semester Credit Units: 3 Level: Proposed Area: (for GE courses only) B3 Arts and Humanities Study of Societies, Social and Business Organisations Science and Technology Medium of Instruction: English Medium of Assessment: Prerequisites: Precursors: Equivalent Courses: Exclusive Courses: English

2 Part II Course Details 1. Abstract (A 150-word description about the course) This course aimed to provide the student with an understanding of the principles of genetics as they apply to medicine. It will focus on the fundamental principles in human medical genetics; expression of genetic information, transmission of genetic information and DNA technologies. The concepts will be illustrated using relevant examples in different areas, e.g. hereditary disorders and the molecular basis of genetic diseases will be highlighted. Clinical training will allow students to develop problem solving skills by applying the theoretical knowledge into practice in a clinical environment. 2. Course Intended Learning Outcomes (CILOs) (CILOs state what the student is expected to be able to do at the end of the course according to a given standard of performance.) No. CILOs # Weighting* (if applicable) 1. Identify the structure of genetic material, chromosomes and the human genome 2. Explain the various mutations and genetic abnormalities Discovery-enriched curriculum related learning outcomes (please tick where appropriate) A1 A2 A3 which can result in genetic diseases 3. Apply recombinant DNA technology for research and medical use, including Genetic modification or transgenesis that involves creating artificial genetic material for repairing genetic disorders 4. Criticize the literature in Medical Genetics, extract relevant information and integrate new information with current knowledge 5. Use selected DNA technologies and gene cloning applications, genomic libraries, Southern and Northern blotting, Next Generation Sequencing (NGS), DNA sequencing including high throughput sequencing and DNA restriction mapping for molecular diagnosis * If weighting is assigned to CILOs, they should add up to 100%. 100% # Please specify the alignment of CILOs to the Gateway Education Programme Intended Learning outcomes (PILOs) in Section A of Annex. A1: Attitude Develop an attitude of discovery/innovation/creativity, as demonstrated by students possessing a strong sense of curiosity, asking questions actively, challenging assumptions or engaging in inquiry together with teachers. A2: Ability Develop the ability/skill needed to discover/innovate/create, as demonstrated by students possessing

3 critical thinking skills to assess ideas, acquiring research skills, synthesizing knowledge across disciplines or applying academic knowledge to self-life problems. A3: Accomplishments Demonstrate accomplishment of discovery/innovation/creativity through producing /constructing creative works/new artefacts, effective solutions to real-life problems or new processes. 3. Teaching and Learning Activities (TLAs) (TLAs designed to facilitate students achievement of the CILOs.) TLA Brief Description CILO No. Hours/week (if applicable) Lectures and tutorials Teaching and learning based on a combination of lectures and models to explain the fundamental principles in human medical genetics, expression of genetic information, transmission of genetic information and molecular diagnosis of genetic diseases Laboratory Practical 4. Assessment Tasks/Activities (ATs) (ATs are designed to assess how well the students achieve the CILOs.) Assessment Tasks/Activities CILO No. Weighting* Remarks Continuous Assessment: 40% Practical participation/ Lab report 20% Group project and presentation 20% Examination: 60% ( duration: 2-3 hours ) * The weightings should add up to 100%. 100% "Minimum Passing Requirement" for BMS courses: A minimum of 30% in coursework as well as in examination, in addition to a minimum of 40% in coursework and examination taken together.

4 5. Assessment Rubrics (Grading of student achievements is based on student performance in assessment tasks/activities with the following rubrics.) Assessment Task Criterion Excellent (A+, A, A-) Good (B+, B, B-) Adequate (C+, C, C-) Marginal (D) Failure (F) 1. Examination To test students application of High Significant Moderate Basic Not even material taught in class and evaluate their performance based on their performance on the exam 2. Group project and presentation Challenges students to collaborate, communicate and work together to solve problems High Significant Moderate Basic Not even 3. Practical/lab report Demonstrate subject-specific skills in carrying out experimental work High Significant Moderate Basic Not even

5 Part III Other Information (more details can be provided separately in the teaching plan) 1. Keyword Syllabus (An indication of the key topics of the course.) Chromosome structure The genetic code Mutagens and mutagenesis Mutations Gene inheritance Genetic disorders DNA analysis Molecular Diagnosis of gene disorders Molecular Diagnosis methods and practical skills Cytogenetic Clinical genetic Treatment of genetic diseases Ethical issues 2. Reading List 2.1 Compulsory Readings (Compulsory readings can include books, book chapters, or journal/magazine articles. There are also collections of e-books, e-journals available from the CityU Library.) 1. Thompson & Thompson Genetics in Medicine, 8e ISBN: Medical Genetics: With STUDENT CONSULT Online Access, 4e (MEDICAL GENETICS (JORDE)) ISBN-13: Additional Readings (Additional references for students to learn to expand their knowledge about the subject.)

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