Diana M. Horrigan, Ph.D.

Transcription

1 Diana M. Horrigan, Ph.D. 1. Name, Position, Department Diana M. Horrigan, Ph.D. Lecturer Molecular Pharmacology, Physiology & Biotechnology Department Brown University Providence, RI Address: Office Biomedical Center Room Education: Degree: Ph.D. in Biomedical Sciences Thesis Title: Defining the Mechanism of Retinoid Inhibition of the Rod Cyclic Nucleotidegated Ion Channel Department: Molecular Pharmacology, Physiology, & Biotechnology Courses Taken: Biology of the Eukaryotic Cell (BIOL 2050); Mammalian Physiology (BIOL 1170); Neuropharmacology & Synaptic Transmission (NEUR 1670); Physiological Pharmacology (BIOL 1260); Molecular Genetics (BIOL 2540); Receptors, Channels, & Signaling (BIOL 2170); Cell Physiology & Biophysics (BIOL 1100); Principles of Neurobiology (NEUR 1020) Assumption College, Worcester, MA Degree: B.A. Major: Biology Minor: Spanish Concentration: Secondary Education, Biology (Initial Teacher Certification in MA; #369540) Honors: Presidential Scholarship for Excellence in Academics ( ) Graduated Cum Laude 4. Professional Appointments: 2011-present Lecturer, Department of Molecular Pharmacology, Physiology, & Biotechnology Assumption College, Worcester, MA Academic Years , Visiting Assistant Professor, Department of Natural Sciences September Research Assistant, Department of Molecular Pharmacology, Physiology, & Biotechnology Bridgewater State College, Bridgewater, MA Visiting Lecturer (adjunct), Department of Biological Sciences Fall 2008 Visiting Lab Instructor (adjunct) Spring 2008 Visiting Assistant Professor Academic Year Society for Amateur Scientists, East Greenwich, RI/Aurora, IL Director of Program Development, Labrats (an informal science education program for 6 th through 12 th graders) 1

2 5. Teaching September 2011-present Lecturer, Department of Molecular Pharmacology, Physiology, & Biotechnology BIOL 0800 Principles of Physiology (Course Director, Fall 2011) BIOL 1100 Cell Physiology & Biophysics (Co-instructor; Spring 2012, Spring 2013, Spring 2014, Spring 2015) BIOL 1160 Exercise Physiology (Course Director, Fall 2013) BIOL 2145 Molecular Targets of Drug Discovery (Course Director, Spring 2013, Spring 2014, Spring 2015) BIOL 2170 Molecular Pharmacology & Physiology (Course Director, Fall 2012, Fall 2013, Fall 2014, Fall 2015) BIO 2190 (formerly 2940A) MPP Professional Development Seminar (Course Director, Spring 2012; Spring 2013 combined with BIOL 2240 Biotech/BME Seminar; Spring 2014, Fall 2014, Fall 2015) Guest Lectures: BIOL 2170 (Fall 2011) o Respiratory Physiology I, II & III BIOL 1160 Exercise Physiology (Fall 2012) o Muscle Physiology I & II o Endocrinology I & II o Microgravity BIOL 1180 Comparative Animal Physiology (Spring 2013) o Blood Gas Transport Brown HHMI Summer Scholars Program, Morgan Lab (Summer 2013) o Drug Discovery CEBI 0958 Drug Discovery: Treating Human Disease Through Medicine o Avenues for Careers in Science (Summer 2013) o Cardiovascular Physiology & Disease (Summer 2015) Hamilton House, Providence, RI o Invited Lecture: Extreme Physiology of the Human Body Assumption College, Worcester, MA Academic Years , Visiting Assistant Professor, Department of Natural Sciences BIO 160 Concepts in Biology lab BIO 240 Mammalian Anatomy lecture and lab BIO 250 Microbiology lecture and lab BIO 340 Molecular and Cellular Biology lecture and lab BIO 102 Human Biology lecture and lab Bridgewater State College, Bridgewater, MA Visiting Lecturer (adjunct), Department of Biological Sciences Fall 2008 Visiting Lab Instructor (adjunct) Spring 2008 Visiting Assistant Professor Academic Year BIOL 100 Introduction to Biology lecture BIOL 102 Introduction to Zoology lecture BIOL 200 Cell Biology lab 2

3 6. Advising & Service First Year Advisor , , Academic advisor for 4-6 first year undergraduates each year Worked in conjunction with Meiklejohn Peer Advisors Sophomore Advisor Continuation of academic advising for first year advisees Concentration Advisor Biology concentration advisor for 12 advisees Worked with advisees on formulating a concentration plan 2013-present 2014-present Informal Advising Roles present Have met with several students outside of class time to discuss such topics as course selection, career options and post-graduation plans Have written letters of recommendation for graduate school, medical school, and summer internships Continuation of informal advising for two of my first year advisees from academic year TEAM: Team Enhanced Advising and Mentoring Meet with other TEAM members monthly to discuss topics related to advising Monthly readings related to TEAM meetings topic WE-Teach-STEM: Women Educators Teaching in STEM, Sarah Doyle Women s Center Thesis Committees Kent Leslie Brown University, earned MS degree (MPPB) Spring 2015 Jennifer Nedow Brown University, earned MS degree (MPPB) Spring 2015 Michelle Bookstaver Brown University, earned Master s degree Spring Conferences & Seminars Attended Recently How to Teach Students with Asperger s, SEAS Office, Brown University September 2015 Interactive Classrooms, Sheridan Center, Brown University September 2013 Learning and the Brain, Engaging Students in the Classroom, Boston, MA November Memberships & Societies Member of the National Science Teacher s Association Member of the Society for College Science Teacher s Member of the Biophysical Society ,

4 10. Completed Publications REFEREED PUBLICATIONS Bruder JM, Pfeiffer ZA, Ciriello JM, Horrigan DM, Wicks NL, Flaherty B, Oancea E. Melanosomal Dynamics Assessed with a Live-cell Fluorescent Melanosomal Marker. PLoS One. 2012; 7(8). Tetreault ML, Horrigan DM, Kim JA, Zimmerman AL. Retinoids restore normal cgmp sensitivity of mutant ion channels associated with cone dystrophy. Mol Vis Dec 29;12: Tetreault ML, Henry D, Horrigan DM, Matthews G, Zimmerman AL. Characterization of novel cyclic nucleotide-gated channel from zebrafish brain: CNGA5. Biochem Biophys Res Commun Sep 22;348(2): Horrigan DM, Tetreault ML, Tsomaia N, Vasileiou C, Borhan B, Mierke DF, Crouch RK, Zimmerman AL. Defining the retinoid binding site in the rod cyclic nucleotide-gated channel. J Gen Physiol Nov; 126(5): McCabe SL, *Pelosi DM, Tetreault M, Miri A, Nguitragool W, Kovithvathanaphong P, Mahajan R, Zimmerman AL. All-trans-retinal is a closed state inhibitor of rod cyclic nucleotide-gated ion channels. J Gen Physiol May; 123(5): ABSTRACT PUBLICATIONS Biophysical Society Annual Meeting, Salt Lake City, UT February 2006 Horrigan, DM, Tetreault, ML, Tsomaia, N, Vasileiou, C, Borhan, B, Mierke, DF, Crouch, RK and Zimmerman, AL. Defining the retinoid binding site in the rod CNG (CNGA1) channel. Biophysical Journal 90: 1214A Biophysical Society Annual Meeting, Baltimore, MD February 2004 *Pelosi, DM, Tetreault, ML, McCabe, SL., Zimmerman, AL. All-trans-retinal is a closed-state inhibitor of rod cyclic nucleotide-gated (CNG) channels. Biophysical Journal 86: 292a. Biophysical Society Annual Meeting, San Antonio, TX March 2003 McCabe, SL, *Pelosi, DM, Miri, A, Nguitragool, W, Kovithvathanaphong, P, Mahajan, R, Zimmerman, AL. Inhibition of cyclic nucleotide-gated (CNG) channels by all-trans-retinal. Biophysical Journal 84: 400a. *Published under maiden name CURRICULUM PUBLICATIONS Lab Larceny: A Biotechnology Curriculum Intended for 9th through 12th grade Classroom Use. Bridgewater State College CityLab, August Pipetting 101: A Biotechnology Curriculum Intended for 5th through 12 th grade Classroom Use. Bridgewater State College CityLab, August 2008 Whale of a Mystery: A Biotechnology Curriculum Intended for Middle School Classroom Use. Bridgewater State College CityLab, August

5 INVITED SEMINARS AND PRESENTATIONS Characterization of a novel cyclic nucleotide-gated channel from zebrafish brain: CNGA5. Gordon Summer Research Conference on Ion Channels, Tilton, NH, July 2006 (Poster) Lipophilic channel modulators. Brown University, Cellular Physiology & Biophysics Course, Providence, RI, April 2006 (Invited class lecture) The truth about carrots: A novel role for Vitamin A in vision. Assumption College, Worcester, MA, March 2006 (Seminar) Structural characteristics of retinoids necessary for inhibition of rod cyclic nucleotide-gated (CNG) channels. FASEB Summer Research Conference on the Biology & Chemistry of Vision, Tucson, AZ, June 2005 (Poster) All-trans-retinal is a closed state inhibitor of rod cyclic nucleotide-gated (CNG) channels. Gordon Summer Research Conference on Ion Channels, Tilton, NH, July 2004 (Poster) All-trans-retinal is a closed state inhibitor of rod cyclic nucleotide-gated (CNG) channels. Biophysical Society Annual Meeting, Baltimore, MD, February 2004 (Poster) Inhibition of cyclic nucleotide-gated ion channels by all-trans-retinal. Biophysical Society Annual Meeting, San Antonio, TX, March 2003 (Poster) 11. Grants & Funding Wrote: Competing continuation grant proposal: Predoctoral Training Program in Trans-Disciplinary Pharmacological Sciences for consideration under the NIH Ruth L. Kirschstein National Research Service Award (NRSA) Institutional Research Training Grant (Parent T32), in response to PA PI: Julie Kauer, PhD Submitted: May 29,