Supplementary Digital Content 1. Study Sites and Number of Randomized Subjects.

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1 Supplementary Digital Content 1. Study Sites and Number of Randomized Subjects. Site Name and Address Center for Clinical Trials, LLC Paramount Boulevard Paramount, CA California Research Foundation 2800 Third Avenue San Diego, CA 923 Clinical Research Center of Nevada 12 East Sahara Avenue Las Vegas, NV 894 Kentucky Pediatric/Adult Research 201 South Fifth Street Bardstown, KY The Vancouver Clinic 2525 Northeast 139th street Vancouver, WA Advanced Clinical Research Suite East Magic View Drive Meridian, ID West Coast Clinical Trials, LLC 5630 Cerritos Avenue Cypress, CA Lynn Institute of the Rockies Suite Medical Center Point Colorado Springs, CO Rapid Medical Research, Inc. Suite Park East Drive Cleveland, OH The Children's Clinic of Jonesboro, PA Suite South Church Street Jonesboro, AR Duke University Medical Center - Duke Health Center 4020 North Roxboro Street Durham, NC Cincinnati Children's Hospital Medical Center MLC Burnet Avenue Cincinnati, OH The Center for Pharmaceutical Research, PC Suite 426 Carondelet Drive Kansas City, MO Clinical Research Atlanta A 175 Country Club Drive Stockbridge, GA Number of Randomized Subjects

2 Wake Research Associates Suite Duraleigh Road Raleigh, NC Jean Brown Research 45 East 3900 South Salt Lake City, UT Miami Research Associates 6141 Sunset Drive South Miami, FL Clinical Research Associates of Tidewater 402 Medical Tower 400 Gresham Drive Norfolk, VA 207 Rochester Clinical Research, Inc. Suite L Helendale Road Rochester, NY The Office of Shelly David Senders, MD dba Senders Pediatrics 2054 South Green Road Cleveland, OH Pennridge Pediatric Associates 711 Lawn Avenue Sellersville, PA Northpoint Pediatrics, LLC Suite Clearvista Parkway Indianapolis, IN Oklahoma State University Center for Health Sciences - Pediatric Research Houston Center 717 South Houston Avenue Tulsa, OK Arkansas Pediatric Clinic Suite South University Avenue Little Rock, AR Pediatrics and Adolescent Medicine, P.A. 25 Post Oak Tritt Road Marietta, GA Cary Pediatric Center 01 Crescent Green Cary, NC Clinical Trials of Texas Suite Floyd Curl Drive San Antonio, TX Heartland Research Associates, LLC 1709 South Rock Road Wichita, KS

3 University of Texas Medical Branch at Galveston 301 University Boulevard Galveston, TX Murray Pediatrics Suite A East 5900 South Murray, UT 847 Coastal Clinical Research Annex Building - Suite 3B 0 Memorial Hospital Drive Mobile, AL Lynn Health Science Institute Suite Northwest 58th Street Oklahoma City, OK Lynn Institute of Norman (LION) Suite 1 24th Avenue Northwest Norman, OK Innovis Health, LLC - Innovis Health Fargo nd Avenue Fargo, ND 583 Liberty Family Practice 3413 Cherry Street Erie, PA SUNY Upstate Medical University Department of Pediatrics 750 East Adams Street Syracuse, NY 132 Omega Medical Research 400 Bald Hill Road Warwick, RI Advances In Health, Inc. Suite South Main Houston, TX Allina Health Bandana Square Clinic 21 Bandana Blvd East St. Paul, MN 558 Pediatric Research of Charlottesville, LLC Suite 3 11 East Jefferson Street Charlottesville, VA Advanced Pediatrics 0 East Street Southeast Vienna, VA Benchmark Research Suite 309 East 32nd Street Austin, TX

4 Benchmark Research 55 Knickerbocker Road San Angelo, TX Coastal Carolina Research Center Suite 2 16 Bowman Road Mount Pleasant, SC Texas Center for Drug Development, Inc. Suite Mapleridge Street Houston, TX Monroe Clinic 5 22nd Avenue Monroe, WI 566 PMG Research of Charleston Suite Wingo Way Mount Pleasant, SC Quality Clinical Research, Inc. Suite Regency Circle Omaha, NE Bayview Research Group, LLC Suite Paramount Boulevard Paramount, CA Bayview Research Group, LLC Suite Riverside Drive Valley Village, CA Mercy Health Research Suite Olive Boulevard St. Louis, MO Brownsboro Park Pediatrics 6002 Brownsboro Park Boulevard Louisville, KY Midwest Children's Health Research Institute 3262 Salt Creek Circle Lincoln, NE Clinical Research Associates, Inc. 00 Church Street Nashville, TN PMG Research of Raleigh, LLC 21 Haworth Drive Raleigh, NC Sundance Clinical Research, LLC Suite Old Ballas Road St. Louis, MO

5 Preferred Primary Care Physicians, Inc Greentree Road Carnegie, PA 6 Central Kentucky Research Associates, Inc. 3rd Floor 3475 Richmond Road Lexington, KY Loma Linda University Coleman Pavilion Room A Campus Street Loma Linda, CA 920 Pediatric Care Medical Group Suite Beach Boulevard Huntington Beach, CA Radiant Research, Inc. Suite 8122 Datapoint Drive San Antonio, TX Radiant Research, Inc. Suite West Frye Road Chandler, AZ Pediatric Healthcare of Northwest Houston, PA Tomball Pkwy Tomball, TX

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