OTTAWA HEART CONFERENCE

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1 6 TH INTERNATIONAL OTTAWA HEART CONFERENCE PRECISION MEDICINE IN CARDIOVASCULAR DISEASE CONFERENCE BROCHURE April 26-27, 2018 National Arts Centre, Ottawa Registration now open ottawaheartconference.ca

2 FOLLOW US FOR THE LATEST CONFERENCE INFORMATION TWITTER.COM/HEARTINSTITUTE FACEBOOK.COM/CWHHS FACEBOOK.COM/HEARTINSTITUTE

3 This 2 day event held April 26 and 27 at the National Arts Centre in downtown Ottawa will focus on Precision Medicine in Cardiovascular Disease and will highlight recent advancements and breakthroughs in preventing and treating cardiovascular disease in a precise targeted manner. The conference will feature some of the latest in gene therapy and biomarkers, disease-in-a-dish modelling, patient-tailored therapeutics, sex and gender effects and personalized health innovations. The science will address impacts on cardiometabolic diseases, atherosclerosis, cardiac arrhythmias and heart failure. This accredited event will bring together translational scientists, clinician scientists, cardiologists and trainees in cardiovascular science, and will facilitate scientific dialogue, exchange of information, and networking that will enable international collaborative opportunities. Additional sessions outside of plenary lectures will include a trainee career networking event and a public lecture.

4 PLANNING COMMITTEE Peter Liu, MD, FRCPC Conference Co-Chair Chief Scientific Officer Vice President of Research Director, Cardiac Function Laboratory Duncan Stewart, MD, FRCPC Conference Co-Chair Executive Vice-President Research The Ottawa Hospital CEO & Scientific Director Ottawa Hospital Research Institute The Evelyne & Rowell Laishley Chair Pablo Nery, MD Staff Electrophysiologist & Clinician Investigator Associate Professor, Faculty of Medicine University of Ottawa Mireille Ouimet, PhD Scientist Assistant Professor University of Ottawa Alison Hosey, PhD Manager Research Services Lisa Cotie, PhD Post Doctoral Fellow Judith Lachance Communications French Language Services Jean Bilodeau President, Patient Alumni Association Chair, Patient Engagement in Research Advisory Council Alison Conley Pre-award Officer Research Services Tina Hutchinson Conference Coordinator Research Administrative Officer Research Services

5 ACCREDITATION This event is an Accredited Group Learning Activity (Section 1) as defined by the Maintenance of Certification Program of the Royal College of Physicians and Surgeons of Canada for 9.50 hours. This program has been approved by the University of Ottawa s Office of Continuing Professional Development. DISCLOSURE Speakers will be requested to disclose to the audience any real or apparent conflict(s) of interest that may have a direct bearing on the subject matter of this program.

6 SPEAKERS Victor Dzau, MD President, US National Academy of Medicine Chancellor Emeritus and James B. Duke Professor of Medicine, Duke University Kiran Musunuru, MD, PhD, MPH, FAHA Associate Professor, Cardiovascular Medicine and Genetics Perelman School of Medicine, University of Pennsylvania Philadelphia, PA Joseph C. Wu, MD, PhD Director, Stanford Cardiovascular Institute Simon H. Stertzer Professor of Medicine (Cardiology) and Radiology at the Stanford School of Medicine Palo Alto, California Katey Rayner, PhD Scientist & Director, Cardiometabolic microrna Laboratory Assistant Professor Department of Biochemistry, Microbiology & Immunology University of Ottawa Ottawa, ON William (Bill) L. Stanford, PhD Director, Ottawa Human Pluripotent Stem Cell Facility Director of the High Content Imaging Core Facility Ottawa Hospital Research Institute Canada Research Chair, Tier 1, Integrative Stem Cell Biology Ottawa, ON Zachary Laksman, MD Atrial Fibrillation Clinic Director The University of British Columbia Vancouver, BC

7 Jeffrey S. Berger, MD, MS Director, Cardiovascular Thrombosis Associate Professor, Medicine and Surgery in the Divisions of Cardiology Hematology, and Vascular Surgery New York University School of Medicine New York, NY Pablo Nery, MD Staff Cardiac Electrophysiologist Associate Professor, Department of Medicine University of Ottawa Ottawa, ON Marlene Rabinovitch, MD Professor, Pediatric Cardiology Stanford University Stanford, CA Derek So, MD Program Director, Adult Interventional Cardiology Program Ottawa, ON Vesna Garovic, MD, PhD Nephrologist Professor of Medicine Consultant, Department of Medicine, Division of Nephrology and Hypertension and Department of Obstetrics and Gynecology Mayo Clinic Rochester, Minnesota, USA Thais Coutinho, MD Chief, Division of Prevention and Rehabilitation Chair, Canadian Women s Heart Health Centre Assistant Professor of Medicine University of Ottawa Ottawa, ON

8 AGENDA THURSDAY APRIL :30 Registration and Continental Breakfast 8:30 8:45 Welcome remarks Peter Liu, MD Chief Scientific Officer, Vice President, Research, Ottawa, ON Thierry Mesana, MD, PhD CEO and President, Ottawa, ON GENE THERAPY AND BIOMARKERS 8:45 9:30 DR. YVES MARCEL LECTURE Precision Genome Editing in Cardiovascular Diseases Kiran Musunuru MD, PhD, MPH Associate Professor of Cardiovascular Medicine and Genetics University of Pennsylvania, Philadelphia, PA 9:30 9:50 The Platelet Transcriptome and Platelet Activity in Cardiovascular Disease Jeffery Berger, MD Director of Cardiovascular Thrombosis New York University New York, NY 9:50 10:10 How Rapid Are We Going? An Update of Personalized Platelet Strategies Derek So, MD Program Director for the Adult Interventional Cardiology Program, Clinician Investigator, Ottawa, ON 10:10 10:25 Active Learning Q&A panel 10:25 10:40 Break

9 THERAPEUTIC STRATEGIES ON THE HORIZON 10:40 11:00 Friend and Foe: Inflammatory pathways that promote and repair vulnerable atherosclerosis Katey Rayner, PhD Scientist & Director, Cardiometabolic microrna Laboratory, Ottawa, ON 11:00 11:20 Pulmonary Hypertension and Small Molecule Inhibitors Marlene Rabinovitch, MD Professor of Pediatric Cardiology Stanford University School of Medicine, Stanford, CA 11:20 11:35 Active Learning Q&A panel 11:35 1:00 Lunch Trainee Mentorship event FROM PATIENT TO RESEARCH 1:00 1:20 Personalized Antiarrhythmic Drug Therapy for Atrial Fibrillation Zachary Laksman, MD Director, SPH Atrial Fibrillation Clinic and the SPH Inherited Arrhythmia Clinic, University of British Columbia, Vancouver, BC 1:20 1:40 Patient-tailored Catheter Ablation for Atrial Fibrillation Pablo Nery, MD Cardiac Electrophysiologist & Clinician Investigator, Ottawa, ON 1:40 1:55 Active Learning Q&A panel

10 AGENDA THURSDAY APRIL SEX AND GENDER 1:55 2:15 CV Disease After Hypertensive Disorders of Pregnancy; underlying mechanisms Vesna Garovic, MD, PhD Nephrologist, Mayo Clinic Rochester, Minnesota, USA 2:15 2:35 Cardiovascular Risk After Hypertensive Disorders of Pregnancy Thais Coutinho, MD Chair, Women s Heart Health Centre, Ottawa, ON 2:35 2:50 Active Learning Q&A panel 2:50 3:05 Break 3:05 4:30 Poster Session 4:30 5:30 Reception

11 AGENDA FRIDAY APRIL 27, :30 Registration 8:30 8:45 Welcome remarks Janet Rossant, MD President and Scientific Director Gairdner Foundation, Toronto, ON Duncan Stewart, MD CEO and Scientific Director, Ottawa Hospital Research Institute, Ottawa, ON REGENERATIVE MEDICINE 8:45 9:30 Stem Cells and Genomics for Precision Cardiovascular Medicine Joseph Wu, MD Director, Stanford Cardiovascular Institute, Stanford, CA 9:30 9:50 DNA Damage Response in Progeria Vascular Smooth Muscle Cells and the Implications on Normative Vascular Smooth Muscle Aging William Stanford, PhD Scientist & Tier 1 Canada Research Chair in Integrative Stem Cell Biology, Ottawa Hospital Research Institute, Ottawa, ON

12 AGENDA FRIDAY APRIL 27, :50 10:00 Active Learning Q&A Panel 10:00 10:15 Break WILBERT J. KEON ENDOWED LECTURESHIP Moderated by Thierry Mesana, MD, PhD 10:15 11:00 Rebuilding the Failing Heart: Molecular Approaches to Cardiac Regeneration Victor Dzau, MD President, US National Academy of Medicine Chancellor Emeritus and James B. Duke Professor of Medicine, Duke University About the Wilbert J. Keon Endowed Lectureship: Wilbert J. Keon, O.C., M.D., F.R.C.S.(C), founder of the University of Ottawa Heart Institute, was one of the finest cardiac surgeons of his generation. He exhibited extraordinary compassion and courage throughout his remarkable career. His vision and leadership resulted in the evolution of the Heart Institute to a Canadian leader in cardiac care. In 1990 he was appointed Senator of the Parliament of Canada. The Lectureship is a permanent fund that enables us, annually, to bring the world s foremost experts in cardiovascular medicine and research to the Heart Institute for a formal exchange of ideas. Dialogue, the exchange of information and research will ultimately lead to the end of heart disease. The generosity of an endowed lectureship permanently embeds this important process in the life of the Heart Institute by providing the resources required to maintain this rich exchange, year after year, until heart disease is eradicated. 11:00 11:15 Q&A 11:15 11:45 Awards Ceremony and Closing Remarks Peter Liu, MD Chief Scientific Officer, Vice President, Research, Ottawa, ON 11:45 12:45 Lunch

13 PUBLIC LECTURE in partnership with the Gairdner Foundation 1:00 1:15 Public lecture moderated by Peter Liu, MD Chief Scientific Officer, Vice President of Research, Ottawa, ON Introduction Janet Rossant, MD President and Scientific Director Gairdner Foundation, Toronto, ON 1:15 2:15 Medical Breakthroughs: What are the Possible Game-Changers in the Near Future? How will they impact health and society? Victor Dzau, MD President, US National Academy of Medicine, Chancellor Emeritus and James B. Duke Professor of Medicine, Duke University 2:15 3:15 Expert panel discussion Panelists to include: Janet Rossant, MD President and Scientific Director Gairdner Foundation, Toronto, ON Duncan Stewart, MD CEO and Scientific Director Ottawa Hospital Research Institute, Ottawa, ON Robert Bell, MD Deputy Minister, Ontario Ministry of Health and Long-Term Care Toronto, ON

14 REGISTRATION FEES Registration is now open. Register online at ottawaheartconference.ca. EARLY BIRD FEE (Register on or before February 26, 2018) REGULAR FEE (Register after February 26, 2018) *Trainee $99 $125 **Other/Allied Health Professional $175 $225 Regular Attendee $225 $275 *Trainee includes: undergraduate, masters, PhD, post-doc, medical students, residents and fellows with proof of status. If no proof is provided onsite, the regular attendee rate will apply. **Other/Allied Health Profesional includes: RN/RPN, medical technologist/technician, dietician, therapists and clinical research staff. Best Rapid-Fire Oral Presentation and Best Poster Awards The 6th International Ottawa Heart Conference Committee will be offering an award for Best Rapid-Fire Oral Presentation and Best Poster. Winners will each receive an award of recognition during the closing remarks on April 27 th, Please visit ottawaheartconference.ca for more details. Visit ottawaheartconference.ca for more details.

15 NETWORKING OPPORTUNITIES A networking lunch will be held on each day of the 2 day conference; Thursday April 26 th, 2018 and Friday, April 27 th, 2018, for registered delegates. This lunch is included in your registration fee. There will also be a trainee mentorship lunch on Thursday, April 26th, Kindly visit ottawaheartconference.ca for more details. Sponsorship Opportunities We invite you to become an important part of this incredible opportunity by participating as an Event Sponsor. A variety of sponsorship levels have been developed and will be available to government, corporate, community, and other healthcare agencies. Don t miss this chance to be part of something that will impact how we understand how cardiovascular disease develops, emerging targets, and therapies for the future. Please contact us directly at researchconference@ottawaheart.ca to discuss how you or your organization can get involved!

16 CONFERENCE LOCATION The National Arts Centre 1 Elgin Street Ottawa, ON Located in the heart of the city, the National Arts Centre is just steps away from the city s most popular attractions. Lose yourself in the energy of the bustling Byward Market; indulge in world-class shopping in the Rideau Centre; or explore the natural beauty of the Gatineau Hills. HOTEL ACCOMMODATION A limited block of guestrooms has been reserved at the Lord Elgin Hotel for conference delegates at a negotiated group rate. Conference delegates may reserve a room by calling the Reservations Department at 1-(800) (Canada & US) or online at ottawaheartconference.ca. In order to receive the negotiated group rate (available until March 26th), please reference 6 th International Ottawa Heart Conference.

17 NOTES

18 NOTES

19 FOLLOW US FOR THE LATEST CONFERENCE INFORMATION TWITTER.COM/HEARTINSTITUTE FACEBOOK.COM/CWHHS FACEBOOK.COM/HEARTINSTITUTE

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