UC Davis CTSC Trainees and translational research
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1 UC Davis CTSC Trainees and translational research Lars Berglund, MD, PhD, FAHA Senior Associate Dean for Research UC Davis School of Medicine Director, UC Davis CTSC
2 Disclosures Consultant, Danone corporation
3 CTSC Renewal theme
4 CTSC training programs Training Program Who is Eligible? Program Length T32 MCRTP K12 CIRM Stem Cell Training Program HHMI/IMBS BIRCWH Medical student Scholars in translational research Junior faculty Clinical and pre-clinical fellows Post-doctoral scholars Junior faculty with clinical professional degrees who have completed MCRTP program. Pre-doctoral scholars Post-doctoral scholars and clinical fellows UC Davis graduate students who have completed their first year in a Ph.D. program Ph.D. faculty M.D. faculty One year Two year Up to 3 years Up to 3 years Up to 2 years One year Up to 2 years
5 Integration of UC Davis Research Training programs through the CTSC Diverse Disciplines Shared Programs Bridge to Success School of Medicine School of Veterinary Medicine College of Engineering College of Biological Sciences Graduate Studies PCOR SCTP CTSC T32 CTSC MCRTP CTSC Research Education Program HHMI BIRCWH K12 Oncology K12 Emergency Med MAS: Master s of Advanced Study in Clinical Research Common Training and Research Experiences DE: Designated Emphasis in Translational Research Outcomes New findings & developments (cures, therapies) New partnerships (community, industry, global)
6 Example of CTSC use: Junior faculty and career development CTSC Assistance Application for CTSC training programs Assistance with individual K-awards Mentoring academy Workshops and seminars Community of scholars peer mentoring
7 CTSC T32 MD/PhD scholars Randie Kim , Biochemistry, Prostate cancer therapeutics: role of ARG deprivation Mentor: R. Bold, Dept of Surgery Nicolas Prionas , Biomedical Engineering, Functional imaging in breast cancer diagnosis Mentor: J. Boone, Dept of Radiology Hillary Davis (received training award from NASA) , Biomedical Engineering, Gene delivery systems for tissue engineering Mentor: K. Leach, Dept of Biomedical Engineering Vidya Athuri , Microbiology, Brucella virulence factors Mentor: R. Tsolis, Dept of Medical Microbiology and Immunology Andrew Wong , Biomedical Engineering, Targeted delivery of sirna in a mouse model of FXTAS Mentor: K. Ferrara, Dept of Biomedical Engineering Can Sungur , Immunology, Role of NK cells in resistance to CMV after transplantation Mentor: W. Murphy, Dept of Dermatology
8 Pilot Grants Trainees Requirement to include a trainee in all pilot applications Trainee-specific pilot projects partnership with College of Engineering for device development; child health focus Children s Miracle Network To date funded 124 projects including 278 trainees Annual pilot grant retreats with trainee presence and keynote speakers from CTSA institutions fostering synergism
9 UC Davis CTSC Broader training opportunities Oncology K12 Emergency medicine K12 Multiple T32 grants Bioengineering Pharmacology Lung disease Metabolomics center grant - Trainee involvement
10 Examples of pilot calls involving trainees Lifespan Health Gestational Methyl Group Regulation of the Expression of Genes Related to Hepatic Steatosis in Offspring. Study in an Animal Model of Wilson Disease Pediatric Research Awards Mechanisms by Which Human Milk Peptides and N- Glycans Shape the Infant Intestinal Microbiota Highly Innovative Awards #5 The Development of a Novel Drug Delivery System that Targets the Blood-Brain Barrier Partnership with the Center for Health Care Policy and Research "Impact of an Automated Electronic Health Record Alert on the Diagnosis, Initial Treatment, and Clinical Outcome of Severe Sepsis
11 Evolved from 2007 CTSC Pilot Project Collaboration of faculty in College of Engineering and School of Medicine Detection of Novel Biomarkers of Asthma and COPD in Exhaled Breath (PI Davis, Co-I Kenyon) Capstone Course Prototyping Clinic Microscale sensor systems for mobile breath analysis 13 publications Funded extramural grants International workshops 5 trainees 4 patents
12 CTSC Trainee Timeline Example Training (Asst Professor level) 2004, K30/MCRTP, MAS - Clinical Research training 2006, K08 NHLBI, Role of Nitric oxide in severe asthma; mouse models CTSC Pilot Project Funding 2007, PI, Pilot study co-funded with NIEHS P30 Center Pilot Program (L-arginine in severe asthma) 2009, Co-I, Pilot clinical study (PI: C. Davis, COE), Novel Breath Biomarkers in Asthma and COPD 2011, Co-I, Device Development (PI: JP Delplanque, COE) Mobile Phone Spirometer for Asthma Monitoring Active Funding 2011, R01 NHLBI, L-arginine in severe asthma; clinical trial and mouse model drug development Co-I/ Team Research: 2011 Hartwell Foundation (PI: C.Davis, Breath Analysis), 2012 CA Air Resources Board (PI: Bennett, Pollution Intervention in CA Children), 2011 NIOSH (PI:Schenker, Worker Asthma) CTSC Resources Utilized CTSC Clinical Research Center, primary site for three clinical studies Bioinformatics, severe asthma clinic database Biostatistics, assistance with developing R01 grant and manuscripts Regulatory assistance - IND Submission in 2012, L-arginine in severe asthma, DSMB for NHLBI trial CTSC affiliated research cores, e.g. Western Metabolomics Center Conference support: Bay Area Breath Analysis Conf , International Conference 2012 Roles in CTSC T32 Director (5 yrs), Research Subject Advocate (3 yrs), Co-Organizer COE Capstone Pilot Projects (4 yrs) Academic Promotion, Tenured Professor from July 2013
13 Retreats bringing faculty together Education retreat UC DAVIS CTSC TRAINING PROGRAMS Eighth Annual Retreat Tuesday, March 27 - March 29, 2012 Pilot grant retreat UC DAVIS PILOT RETREAT Wednesday, July
14 Presentations at CTSC Education retreats Training Program T32 Predoctoral Training Program MCRTP K12 Training Program BIRCWH Training Program HHMI Integrating Medicine into Basic Science CIRM Stem Cell Training Program CTSC Pilot Grant Trainees Total
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