Manuel L. Penichet Erika Jensen-Jarolim Editors. Cancer and IgE. Introducing the Concept of AllergoOncology

Transcription

1 Cancer and IgE

2 Manuel L. Penichet Erika Jensen-Jarolim Editors Cancer and IgE Introducing the Concept of AllergoOncology

3 Editors Manuel L. Penichet Associate Professor Division of Surgical Oncology, Department of Surgery, and Department of Microbiology, Immunology, and Molecular Genetics David Geffen School of Medicine University of California at Los Angeles (UCLA) Le Conte Avenue Los Angeles, CA USA Erika Jensen-Jarolim Professor and Chair Department of Pathophysiology Center of Pathophysiology, Infectiology and Immunology Medical University of Vienna Waehringer G , 1090 Vienna, Austria ISBN e-isbn DOI / Springer New York Dordrecht Heidelberg London Library of Congress Control Number: Springer Science+Business Media, LLC 2010 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. While the advice and information in this book are believed to be true and accurate at the date of going to press, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Cover illustration: The logo of AllergoOncology created by Dr. Erika Jensen-Jarolim and Mr. Walter Jarolim to promote the first 1 st International AllergoOncology Symposium, which took place in Vienna, Austria, on April 16, Printed on acid-free paper Springer is part of Springer Science+Business Media (

4 Contents 1 Introduction... 1 Erika Jensen-Jarolim and Manuel L. Penichet 2 The Biology of IgE: Molecular Mechanism Restraining Potentially Dangerous High Serum IgE Titres In Vivo Gernot Achatz, Gertrude Achatz-Straussberger, Stefan Feichtner, Sebastian Koenigsberger, Stefan Lenz, Doris Peckl-Schmid, Nadja Zaborsky, and Marinus Lamers 3 The Biology of IgE: The Generation of High-Affinity IgE Antibodies Maria A. Curotto de Lafaille and Juan J. Lafaille 4 Epidemiological Evidence: IgE, Atopy, and Solid Tumors Michelle C. Turner 5 Epidemiological Evidence: IgE, Allergies, and Hematopoietic Malignancies Otoniel Martínez-Maza, Alan Duane Moreno, and Wendy Cozen 6 Mast Cells in Allergy and Tumor Disease Anna Wasiuk, Victor C. de Vries, Elizabeth C. Nowak, and Randolph J. Noelle 7 The IgE Antibody and Its Use in Cancer Immunotherapy Tracy R. Daniels, José A. Rodríguez, Elizabeth Ortiz-Sánchez, Gustavo Helguera, and Manuel L. Penichet 8 IgE Interacts with Potent Effector Cells Against Tumors: ADCC and ADCP Sophia N. Karagiannis, Frank O. Nestle, and Hannah J. Gould 9 IgE as Adjuvant in Tumor Vaccination Elisa A. Nigro, Antonio G. Siccardi, and Luca Vangelista v

5 vi Contents 10 The Targets of IgE: Allergen-Associated and Tumor-Associated Molecular Patterns Erika Jensen-Jarolim, Diana Mechtcheriakova, and Isabella Pali-Schoell 11 The Role of Th2-Mediated Anti-Tumor Immunity in Tumor Surveillance and Clearance Ljubov Simson, Julia I. Ellyard, and Christopher R. Parish Subject Index

6 Contributors Gernot Achatz Department of Molecular Biology, University of Salzburg, Salzburg, Austria Gertrude Achatz-Straussberger Department of Molecular Biology, University of Salzburg, Salzburg, Austria Wendy Cozen Departments of Preventive Medicine and Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA Maria A. Curotto de Lafaille Molecular Pathogenesis Program, The Kimmel Center for Biology and Medicine of the Skirball Institute and Department of Pathology, New York University School of Medicine, New York, NY, USA Tracy R. Daniels Division of Surgical Oncology, Department of Surgery, University of California, Los Angeles (UCLA), Los Angeles, CA, USA Victor C. de Vries Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, NH, USA Julia I. Ellyard Division of Immunology and Genetics, John Curtin School of Medical Research, Australian National University, Canberra, ACT, Australia Stefan Feichtner Department of Molecular Biology, University of Salzburg, Salzburg, Austria Hannah J. Gould Randall Division of Cell and Molecular Biophysics, King s College London, Guy s Campus, London, UK Gustavo Helguera Division of Surgical Oncology, Department of Surgery, University of California, Los Angeles (UCLA), Los Angeles, CA, USA Erika Jensen-Jarolim IPP Department of Pathophysiology, Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria Sophia N. Karagiannis NIHR Biomedical Research Centre at Guy s and St. Thomas s Hospitals and King s College London, Cutaneous Medicine and Immunotherapy, St. John s Institute of Dermatology, Division of Genetics and vii

7 viii Contributors Molecular Medicine, King s College London School of Medicine, Guy s Hospital, London, UK Sebastian Koenigsberger Department of Molecular Biology, University of Salzburg, Salzburg, Austria Juan J. Lafaille Molecular Pathogenesis Program, The Kimmel Center for Biology and Medicine of the Skirball Institute and Department of Pathology, New York University School of Medicine, New York, NY, USA Marinus Lamers Max Planck Institute for Immunobiology, Freiburg, Germany Stefan Lenz Department of Molecular Biology, University of Salzburg, Salzburg, Austria Otoniel Martínez-Maza Departments of Obstetrics and Gynecology and Department of Microbiology, Immunology, and Molecular Genetics, Jonsson Comprehensive Cancer Center, AIDS Institute, David Geffen School of Medicine, University of California, Los Angeles (UCLA), Los Angeles, CA, USA Diana Mechtcheriakova IPP Department of Pathophysiology, Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria Alan Duane Moreno Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA Frank O. Nestle NIHR Biomedical Research Centre at Guy s and St. Thomas s Hospitals and King s College London, Cutaneous Medicine and Immunotherapy, St. John s Institute of Dermatology, Division of Genetics and Molecular Medicine, King s College London School of Medicine, Guy s Hospital, London, UK Elisa A. Nigro Department of Biology and Genetics, University of Milan and San Raffaele Scientific Institute, Milan, Italy Randolph J. Noelle Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, NH, USA Elizabeth C. Nowak Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, NH, USA Elizabeth Ortiz-Sánchez Division of Surgical Oncology, Department of Surgery, University of California, Los Angeles (UCLA), Los Angeles, CA, USA Isabella Pali-Schoell IPP Department of Pathophysiology, Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria Christopher R. Parish Division of Immunology and Genetics, John Curtin School of Medical Research, Australian National University, Canberra, ACT, Australia

8 Contributors ix Doris Peckl-Schmid Department of Molecular Biology, University of Salzburg, Salzburg, Austria Manuel L. Penichet Division of Surgical Oncology, Department of Surgery and Department of Microbiology, Immunology, and Molecular Genetics, Molecular Biology Institute, Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California, Los Angeles (UCLA), Los Angeles, CA, USA José A. Rodríguez Division of Surgical Oncology, Department of Surgery and Molecular Biology Institute, University of California, Los Angeles (UCLA), Los Angeles, CA, USA Antonio G. Siccardi Department of Biology and Genetics, University of Milan and San Raffaele Scientific Institute, Milan, Italy Ljubov Simson Centre for Biomedical, Molecular and Chemical Research, University of Canberra, ACT, Australia Michelle C. Turner McLaughlin Centre for Population Health Risk Assessment, Institute of Population Health, Faculty of Graduate and Post-Graduate Studies, University of Ottawa, Ottawa, ONT, Canada Luca Vangelista Department of Biology and Genetics, University of Milan and San Raffaele Scientific Institute, Milan, Italy Anna Wasiuk Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, NH, USA Nadja Zaborsky Department of Molecular Biology, University of Salzburg, Salzburg, Austria