Presentation: SAMED Regulatory Conference Shirona Naidoo (Technical Advisor) : Institute for Regulatory Sciences Project Team
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1 Presentation: SAMED Regulatory Conference 2015 Shirona Naidoo (Technical Advisor) : Institute for Regulatory Sciences Project Team Date:2 nd December 2015
2 IRS Background Key Guiding Principles Value Proposition of the IRS Envisaged Mechanism of IRS capacity building mandate Proposes Legal Identity, Governance and Executive Functions Proposed Funding Model Next Steps Proposed Curriculum Framework
3 BACKGROUND: Multiple preceding enquiries (circa 1998 onwards) into structure and functioning of Medicines Control Council Medicines Amendment Act, 2008, passed in November 2015 SAHPRA - South African Health Products Regulatory Authority Intention is to strengthen the current medicines regulatory environment through the establishment of a new authority, the South African Health Product Regulatory Authority (SAHPRA) Expansion of functions to include regulation of medical devices and in-vitro diagnostics (IVDs)
4 BACKGROUND: Recognition of the need to develop national regulatory capacity, including anticipating and servicing SAHPRA s needs Intention to establish IRS announced Feb 2014 Feasibility study by EU Task Team (Mar 2014) IRS project team constituted March 2015 to prepare for establishment of IRS and tasks now almost complete
5 Key Guiding Principles: Additional regulatory capacity urgently required across the sector (beyond just the regulator). The capacity to deliver regulatory training in South Africa is both limited and fragmented. An increased skills base, efficient regulatory processes underpinned by a unifying regulatory philosophy, are all required to achieve the step change that will bring South Africa on par with International Peers.
6 Value Proposition of the IRS: Provide flexible access to quality assured, basic and advanced courses in regulatory science. [Value Proposition #1] Support the development and deployment of structured Work Integrated Learning / Mentorship programs. [Value Proposition #2] Provide a strategic / think-tank function in order to monitor / engage global policy developments and mobilize the appropriate constituencies and responses [Value Proposition #3]
7 Envisaged Mechanism of IRS capacity building mandate (1): Coordinate development of curriculum for web based accredited post graduate programs (NQF 8) yielding the National Occupational qualification as Regulatory Affairs Officer: Pharmaceuticals (or Medical Devices etc). Theoretical knowledge : ± 60% Experiential learning: ± 20% Work Integrated Learning: ± 20 % Broker partnership with academia, industry and other institutions to develop, quality assure and deliver components of these programs, based on Institutional Expertise and Capacity.
8
9 Envisaged Mechanism of IRS capacity building mandate (2): Initial focus on needs of SAHPRA and SA Industry, but project is scalable with established coherence with regional (SADC) and continental (African Medicine Regulatory Harmonization) endeavours. Strategic / think tank function will be institutionalized within the IRS, affording a multilevel platform for stakeholder engagement: a) IRS Committees b) High Level Roundtables c) Seminars and Workshops
10 Proposed Legal identity = A non profit Public Benefit Trust Governance = Board of Trustees comprising, Regulator, Industry, Academia & Higher Education, Science and Technology. Led by Chair appointed by Minister of Health. Executive functions delivered by secretariat headed by a CEO / Executive Director, appointed by Minister of Health on the recommendation of the Board.
11 Proposed Funding Model Ideally the IRS will be funded through lump sum contributions or multi-year pledges to the IRS Trust Fund Establishment phase Early 2016, (NDOH + Donors +?) Long term funding model a. SAHPRA b. Industry c. Donors d. Revenue generation Fees, seminars etc.
12 Next Steps: Establish the IRS as Public Benefit Trust Recruit IRS senior management team Formalize key partnership arrangements Complete course development and accreditation Establish e-learning platform and Complete conversion to online format. First strategic seminar / roundtable hosted (Q1 /Q2 2016) First accredited online courses offered ( Q3/Q4 2016)
13 Curriculum Framework development and Accreditation: Community of Expert Engagements formalized in Accreditation Framework Basic Level Training : (Importers and Manufacturers) Aligned to implementation of Medical Device and IVD Regulations
14 Proposed Curriculum Framework : IMDRF regulatory Framework Refined in extensive formalized stakeholder engagements (competency standards, learning outcomes, basic and advanced level courses, ) Key Aspects Medical Device and IVD definitions, types, concepts Lifecycle of Medical Device Medical Device and IVD Legal and Regulatory framework (Regional and Global) Key Principles Essential Principles of Safety and Performance Principles, Systems and Methods for Classification Conformity Assessment Framework,, Principles of a Quality Management System, Evaluation of Risk and pre and post marketing, market surveillance systems, Role and responsibilities of Authorized Representative, Licensing, Document Management system Key Quality System Frameworks and reference resources (ISO13485, ISO 9001, ICH Q10) Clinical investigations / trials ; Research Methodology and Statistics
15 Thank You Questions?... Shirona Naidoo
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